Diabetes & metabolism最新文献

{"title":"Association between nonalcoholic fatty liver disease and left ventricular diastolic dysfunction: A 7-year retrospective cohort study of 3,380 adults using serial echocardiography","authors":"Gyuri Kim ,&nbsp;Tae Yang Yu ,&nbsp;Jae Hwan Jee ,&nbsp;Ji Cheol Bae ,&nbsp;Mira Kang ,&nbsp;Jae Hyeon Kim","doi":"10.1016/j.diabet.2024.101534","DOIUrl":"https://doi.org/10.1016/j.diabet.2024.101534","url":null,"abstract":"<div><h3>Aim</h3><p>Left ventricular diastolic dysfunction (LVDD) has been observed in people with nonalcoholic fatty liver disease (NAFLD) in cross-sectional studies but the causal relationship is unclear. This study aimed to investigate the impact of NAFLD and the fibrotic progression of the disease on the development of LVDD, assessed by serial echocardiography, in a large population over a 7-year longitudinal setting.</p></div><div><h3>Methods</h3><p>This retrospective cohort study included the data of 3,380 subjects from a medical health check-up program. We defined subjects having NAFLD by abdominal ultrasonography and assessed significant liver fibrosis by the aspartate transaminase (AST) to platelet ratio index (APRI), the NAFLD fibrosis score (NFS), and the fibrosis-4 (FIB-4) index. LVDD was defined using serial echocardiography. A parametric Cox proportional hazards model was used.</p></div><div><h3>Results</h3><p>During 11,327 person-years of follow-up, there were 560 (16.0 %) incident cases of LVDD. After adjustment for multiple risk factors, subjects with NAFLD showed an increased adjusted hazard ratio (aHR) of 1.21 (95 % confidence interval [CI]=1.02–1.43) for incident LVDD compared to those without. The risk of LV diastolic dysfunction increased progressively with increasing degree of hepatic steatosis (<em>P</em> <em>&lt;</em> 0.001). Compared to subjects without NAFLD, the multivariable-aHR (95 % CI) for LVDD in subjects with APRI &lt; 0.5 and APRI ≥ 0.5 were 1.20 (1.01–1.42) and 1.36 (0.90–2.06), respectively (<em>P</em> <em>=</em> 0.036), while other fibrosis prediction models (NFS and FIB-4 index) showed insignificant results.</p></div><div><h3>Conclusions</h3><p>This study demonstrated that NAFLD was associated with an increased risk of LVDD in a large cohort. More severe forms of hepatic steatosis and/or significant liver fibrosis may increase the risk of developing LVDD.</p></div>","PeriodicalId":11334,"journal":{"name":"Diabetes & metabolism","volume":"50 3","pages":"Article 101534"},"PeriodicalIF":7.2,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140622215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"No association of endothelial lipase and aldose reductase polymorphisms with proliferative diabetic retinopathy: Results of the French prospective multicenter REDIAGEN study","authors":"Adrien HENRY ,&nbsp;Tiffany BOIGELOT ,&nbsp;Thomas FERREIRA DE MOURA ,&nbsp;Isabelle LECLERCQ ,&nbsp;Coralie BARBE ,&nbsp;Aurore THIERY ,&nbsp;Zoubir DJERADA ,&nbsp;Pierre NAZEYROLLAS ,&nbsp;Christine CLAVEL ,&nbsp;Pascale CORNILLET-LEFEBVRE ,&nbsp;Jean-Paul BERROD ,&nbsp;Catherine CREUZOT-GARCHER ,&nbsp;Laurent MEYER ,&nbsp;David GAUCHER ,&nbsp;Bruno GUERCI ,&nbsp;Patrick LENOBLE ,&nbsp;Solange MILAZZO ,&nbsp;Jean-Marc PERONE ,&nbsp;Carl ARNDT ,&nbsp;Vincent DURLACH","doi":"10.1016/j.diabet.2024.101533","DOIUrl":"https://doi.org/10.1016/j.diabet.2024.101533","url":null,"abstract":"","PeriodicalId":11334,"journal":{"name":"Diabetes & metabolism","volume":"50 3","pages":"Article 101533"},"PeriodicalIF":7.2,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140540483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trajectories of social isolation and loneliness and the risk of incident type 2 diabetes mellitus across genetic risk score","authors":"Yilin Chen ,&nbsp;Huachen Xue ,&nbsp;Sizhi Ai ,&nbsp;Yaping Liu ,&nbsp;Yu Nie ,&nbsp;Qi-Yong H. Ai ,&nbsp;Jihui Zhang ,&nbsp;Yannis Yan Liang","doi":"10.1016/j.diabet.2024.101526","DOIUrl":"10.1016/j.diabet.2024.101526","url":null,"abstract":"<div><h3>Aim</h3><p>This study aimed to investigate the association of social isolation, loneliness, and their trajectory with the risk of developing type 2 diabetes mellitus (T2DM) across genetic risk.</p></div><div><h3>Methods</h3><p>We included 439,337 participants (mean age 56.3 ± 8.1 years) enrolled in the UK Biobank study who were followed up until May 31, 2021. Social isolation and loneliness were self-reported and were further categorized into never, transient, incident, and persistent patterns.</p></div><div><h3>Results</h3><p>During a median follow-up of 12.7 years, 15,258 incident T2DM cases were documented. Social isolation (versus no social isolation: hazard ratio (HR) 95 % confidence interval (CI) 1.04 [1.00;1.09]) and loneliness (versus no loneliness: 1.26 [1.19;1.34]) were associated with an increased T2DM risk, independent of the genetic risk for T2DM. The interactions existed between social isolation and loneliness (<em>P</em> _interaction &lt; 0.05); the increased T2DM risk associated with social isolation was only significant among participants without loneliness. In the longitudinal analysis, only persistent social isolation (versus never social isolation: 1.22 [1.02;1.45]) was associated with an increased T2DM risk, whereas incident loneliness (versus never loneliness: 1.95 [1.40;2.71]) and persistent loneliness (2.00 [1.31;3.04]) were associated with higher T2DM risks.</p></div><div><h3>Conclusion</h3><p>Social isolation and loneliness, especially their persistent pattern, were independently associated with an increased incident T2DM risk, irrespective of an individual's genetic risk. Loneliness modified the association between social isolation and incident T2DM.</p></div>","PeriodicalId":11334,"journal":{"name":"Diabetes & metabolism","volume":"50 3","pages":"Article 101526"},"PeriodicalIF":7.2,"publicationDate":"2024-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140055893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of ketone bodies with incident CKD and death: A UK Biobank study","authors":"Chan-Young Jung ,&nbsp;Hee Byung Koh ,&nbsp;Ga Young Heo ,&nbsp;Byounghwi Ko ,&nbsp;Hyung Woo Kim ,&nbsp;Jung Tak Park ,&nbsp;Tae-Hyun Yoo ,&nbsp;Shin-Wook Kang ,&nbsp;Seung Hyeok Han","doi":"10.1016/j.diabet.2024.101527","DOIUrl":"10.1016/j.diabet.2024.101527","url":null,"abstract":"<div><h3>Aims</h3><p>Although cellular and animal models have suggested a protective effect of ketone bodies (KBs), clinical data are still lacking to support these findings. This study aimed to investigate the association of KB levels with incident chronic kidney disease (CKD) and death.</p></div><div><h3>Methods</h3><p>This was a prospective cohort study of 87,899 UK Biobank participants without baseline CKD who had plasma levels of β-hydroxybutyrate, acetoacetate, and acetone levels measured at the time of enrollment. The main predictor was plasma total KB, which was the sum of the aforementioned three KBs. The primary outcome was a composite of incident CKD, or all-cause mortality. Secondary outcomes included the individual components of the primary outcome.</p></div><div><h3>Results</h3><p>During a median follow-up of 11.9 years, a total of 8,145 primary outcome events occurred (incidence rate 8.0/1,000 person-years). In the multivariable Cox model, a 1-standard deviation increase in log total KB was associated with a 7 % [adjusted hazard ratio (aHR), 1.07; 95 % confidence interval (CI), 1.05–1.10] higher risk of the primary outcome. When stratified into quartiles, the aHR (95 % CI) for Q4 versus Q1 was 1.18 (1.11–1.27). This association was consistent for incident CKD (aHR, 1.04; 95 % CI, 1.01–1.07), and all-cause mortality (aHR, 1.10; 95 % CI, 1.07–1.13). Compared with Q1, Q4 was associated with a 12 % (aHR 1.12; 95 % CI 1.02–1.24) and 26 % (aHR 1.26; 95 % CI 1.15–1.37) higher risk of incident CKD and all-cause mortality, respectively.</p></div><div><h3>Conclusions</h3><p>Higher KB levels were independently associated with higher risk of incident CKD and death.</p></div>","PeriodicalId":11334,"journal":{"name":"Diabetes & metabolism","volume":"50 3","pages":"Article 101527"},"PeriodicalIF":7.2,"publicationDate":"2024-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140051443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BedBiopsy: Diagnostic performance of bedside ultrasound-guided bone biopsies for the management of diabetic foot infection","authors":"Nolan Hassold ,&nbsp;Hélène Bihan ,&nbsp;Yolène Pambo Moumba ,&nbsp;Isabelle Poilane ,&nbsp;Frédéric Méchaï ,&nbsp;Nabil Assad ,&nbsp;Véronique Labbe-Gentils ,&nbsp;Meriem Sal ,&nbsp;Omar Nouhou Koutcha ,&nbsp;Antoine Martin ,&nbsp;Dana Radu ,&nbsp;Emmanuel Martinod ,&nbsp;Hugues Cordel ,&nbsp;Nicolas Vignier ,&nbsp;Sopio Tatulashvili ,&nbsp;Narimane Berkane ,&nbsp;Etienne Carbonnelle ,&nbsp;Olivier Bouchaud ,&nbsp;Emmanuel Cosson","doi":"10.1016/j.diabet.2024.101525","DOIUrl":"10.1016/j.diabet.2024.101525","url":null,"abstract":"<div><h3>Objective</h3><p>We aimed to assess the feasibility and diagnostic performance of ultrasound-guided bone biopsies at the bedside of diabetic patients admitted for suspected foot osteitis not requiring surgery.</p></div><div><h3>Research Design and Methods</h3><p>In this retrospective monocentric study, we compared the performance of ultrasound-guided (<em>n</em> = 29 consecutive patients, Dec.2020-Oct.2022) versus surgical (<em>n</em> = 24 consecutive patients, Jan.2018-Nov.2020) bone biopsies at confirming or ruling out diabetic foot osteitis (primary outcome).</p></div><div><h3>Results</h3><p>Patient characteristics were similar in the two intervention groups, including arteritis prevalence (62.3 %), SINBAD score, and wound location (phalanges 36 %, metatarsus 43 %, and calcaneus 21 %). However, the ultrasound-guided group was older (67 ± 11 versus 60 ± 13 years respectively, <em>P</em> = 0.047) and had more type 2 diabetes (97 % versus 75 %, <em>P</em> = 0.038). Diagnostic performance (i.e., capacity to confirm or rule out suspected osteitis) was similar for ultrasound-guided (28/29 cases: 25 confirmations, 3 invalidations) and surgical (24 confirmations/24) biopsies, <em>P</em> = 0.358. No biopsy-related side effect or complication was observed for either intervention, even for patients on antiaggregation and/or anticoagulation therapy. The mean (± standard deviation) time necessary to perform the biopsy was shorter in the ultrasound-guided group (2.6 ± 3.0 versus 7.2 ± 5.8 days, respectively, <em>P</em> &lt; 0.001) and wound evolution at three months was more favorable (83.3 versus 41.2 %, <em>P</em> = 0.005) (94.4 % versus 66.7 %, respectively, patients with new surgical procedure within six months excluded; <em>P</em> = 0.055). Even though not statistically significant, healing rates in terms of wound and osteitis at six months were also better in the ultrasound-guided group (wound: 40.9 % versus 36.8 %; <em>P</em> = 0.790, and osteitis: 81.8 vs 55.6 % <em>P</em> = 0.071).</p></div><div><h3>Conclusion</h3><p>In diabetic patients with suspected foot osteitis not requiring surgery, bedside ultrasound-guided bone biopsies may constitute a promising alternative to surgical biopsies. This intervention provided excellent tolerance and microbiological documentation, short lead-times, and more favorable wound prognosis.</p></div>","PeriodicalId":11334,"journal":{"name":"Diabetes & metabolism","volume":"50 3","pages":"Article 101525"},"PeriodicalIF":7.2,"publicationDate":"2024-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S126236362400017X/pdfft?md5=9cd9269cb51ef1e69ce6f23096a21c4b&pid=1-s2.0-S126236362400017X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140041223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Skin autofluorescence of advanced glycation end-products relates to new cardiovascular events in type 2 diabetes: A longitudinal observational study","authors":"Fadi Alkhami,&nbsp;Gauthier Borderie,&nbsp;Ninon Foussard,&nbsp;Alice Larroumet,&nbsp;Laurence Blanco,&nbsp;Marie-Amélie Barbet-Massin,&nbsp;Amandine Ferriere,&nbsp;Claire Ducos,&nbsp;Kamel Mohammedi,&nbsp;Sami Fawaz,&nbsp;Thierry Couffinhal,&nbsp;Vincent Rigalleau","doi":"10.1016/j.diabet.2024.101524","DOIUrl":"10.1016/j.diabet.2024.101524","url":null,"abstract":"<div><h3>Background</h3><p>Cardiovascular disease is frequent in type 2 diabetes mellitus (T2DM). We investigated the relationship between skin autofluorescence (SAF) of advanced glycation end-products and later cardiovascular events (CVEs) in patients with T2DM.</p></div><div><h3>Research design and methods</h3><p>We conducted a retrospective analysis of 504 patients hospitalized for uncontrolled and/or complicated T2DM between 2009 and 2017. SAF was measured using an AGE-Reader. Participants were followed up from admission to December 2020, for the onset of a CVE (myocardial infarction, stroke, revascularization procedures or cardiovascular death). The relationship between SAF and CVE was analyzed by multivariable Cox regression. Log-rank curves were used to compare CVE-free survival in patients whose SAF at admission was above versus below the whole-population median. The analysis was repeated in subjects without/with macroangiopathy (defined as myocardial infarction, stroke, peripheral revascularization) at baseline.</p></div><div><h3>Findings</h3><p>During 54 months of follow-up, 69 (13.7%) patients had a CVE. Baseline SAF was significantly higher in patients with T2DM who later experienced a CVE (2.89 ± 0.70 arbitrary units versus 2.64 ± 0.62 in others, <em>P</em> = 0.002). This relationship was significant after adjusting for age, sex, conventional risk factors (diabetes duration, HbA1c, arterial hypertension, dyslipidemia, smoking, body mass index), vascular complications, C-reactive protein, and treatments for diabetes. The CVE-free survival curves differed between subjects whose SAF was above the whole-population median (log-rank: <em>P</em> = 0.002) and those whose SAF was above the macroangiopathy-free sub-population median (log-rank: <em>P</em> = 0.016).</p></div><div><h3>Conclusion</h3><p>SAF of advanced glycation end-products was related to a higher incidence of later CVE in patients with T2DM.</p></div>","PeriodicalId":11334,"journal":{"name":"Diabetes & metabolism","volume":"50 2","pages":"Article 101524"},"PeriodicalIF":7.2,"publicationDate":"2024-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139725618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between blood urea nitrogen-to-creatinine ratio and insulin sensitivity","authors":"JaeHyuck Lee ,&nbsp;In Cheol Hwang ,&nbsp;Hong Yup Ahn","doi":"10.1016/j.diabet.2024.101521","DOIUrl":"10.1016/j.diabet.2024.101521","url":null,"abstract":"","PeriodicalId":11334,"journal":{"name":"Diabetes & metabolism","volume":"50 2","pages":"Article 101521"},"PeriodicalIF":7.2,"publicationDate":"2024-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139716807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High serum total bilirubin as a potential protective factor for gestational diabetes mellitus: A retrospective cohort study of 92,885 Chinese pregnant women","authors":"Yan Zhao ,&nbsp;Wenyu Zhu ,&nbsp;Miao Wang ,&nbsp;Luyi Cai ,&nbsp;Xueying Zheng ,&nbsp;Liping Jin","doi":"10.1016/j.diabet.2024.101523","DOIUrl":"10.1016/j.diabet.2024.101523","url":null,"abstract":"<div><h3>Aims</h3><p>Identifying physiological factors that could reduce pregnant women's risk for developing gestational diabetes mellitus (GDM) is crucial for early prevention and intervention. We aimed to examine whether higher serum levels of total bilirubin (TBIL) were associated with a decreased risk of GDM.</p></div><div><h3>Methods</h3><p>We conducted a retrospective cohort study in a tertiary care hospital in Shanghai, China. A total of 92,885 pregnant women were included. Serum TBIL levels were determined during the first antenatal visit before 24 weeks of gestation and GDM was diagnosed with a 75-g oral glucose tolerance test (OGTT) at 24–28 weeks of gestation.</p></div><div><h3>Results</h3><p>A total of 13,037 GDM cases were identified, a prevalence of 14.0 % (13,037/92,885). These women had a higher median TBIL concentration 7.9 versus 7.6 mmol/l (<em>P</em> &lt; 0.001). For the 91,051 women with TBIL within the physiologically normal range (≤ 17.1 μmol/l), a one interquartile range increase in TBIL (3.4 μmol/l) was associated with a decreased risk of GDM: adjusted odds ratio (OR)=0.89 [95 % CI 0.87;0.92]. For these women, the adjusted ORs for GDM across TBIL quartiles were: 0.92 [0.88;0.97] for the second, 0.85 [0.81;0.90] for the third, and 0.78 [0.74;0.83] for the fourth quartile in comparison with the first quartile.</p></div><div><h3>Conclusion</h3><p>Our study demonstrated that elevated serum TBIL levels were associated with decreased risk of GDM and supported its potential role in the prevention and early intervention of GDM.</p></div>","PeriodicalId":11334,"journal":{"name":"Diabetes & metabolism","volume":"50 2","pages":"Article 101523"},"PeriodicalIF":7.2,"publicationDate":"2024-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139716808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of rotator cuff tear and rotator cuff repair surgery comparison between sodium-glucose cotransporter 2 inhibitors and glucagon like peptide-1 receptor agonists: A real-world study","authors":"Yu-Chi Su ,&nbsp;Pei-Chun Hsieh ,&nbsp;Edward Chia-Cheng Lai ,&nbsp;Yu-Ching Lin","doi":"10.1016/j.diabet.2024.101522","DOIUrl":"10.1016/j.diabet.2024.101522","url":null,"abstract":"<div><h3>Aim</h3><p>Theoretically, sodium-glucose cotransporter 2 inhibitors (SGLT2is) reduce the risk of rotator cuff tear through an anti-inflammatory mechanism. To clarify this association, in this study, we compared SGLT2is users and glucagon-like peptide-1 receptor agonists (GLP-1RAs) users in terms of the risk of rotator cuff tear and the risk of receiving rotator cuff repair surgery.</p></div><div><h3>Methods</h3><p>A retrospective cohort analysis was conducted using data from the TriNetX platform. A target trial design was adopted to identify patients with type 2 diabetes mellitus who started receiving SGLT2is or GLP-1RAs. Propensity score matching was used to form two homogeneous groups. The study outcomes were the risk of rotator cuff tear and the risk of receiving rotator cuff repair surgery. Hazard ratios (HRs) with 95 % confidence intervals (CIs) were calculated within the TriNetX platform.</p></div><div><h3>Results</h3><p>Initially, 351,800 SGLT2is users and 387,616 GLP-1RAs users were identified. After propensity score matching, each group comprised 274,026 patients. The mean age was 59.5 years in both groups; the proportions of women in the SGLT2is and GLP-1RAs groups were 46.9 % and 46.7 %, respectively. Compared with the GLP-1RAs group, the SGLT2is group had significantly reduced risks of rotator cuff tear (HR 0.812 [0.761;0.867]) and rotator cuff repair surgery (HR 0.900 [0.815;0.994]).</p></div><div><h3>Conclusion</h3><p>SGLT2is appear to reduce the risk of rotator cuff tear and the risk of receiving rotator cuff repair surgery in patients with type 2 diabetes mellitus. Further prospective studies are needed to validate our findings.</p></div>","PeriodicalId":11334,"journal":{"name":"Diabetes & metabolism","volume":"50 2","pages":"Article 101522"},"PeriodicalIF":7.2,"publicationDate":"2024-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139716809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glycemic Risk Index (GRI) variability in type 1 diabetes adults with HbA1c ≤ 7%: Insights for clinical evaluation and intervention","authors":"Philippe Oriot ,&nbsp;Michel P Hermans ,&nbsp;Antoine Vandelaer ,&nbsp;Jean Christophe Philips ,&nbsp;Gaëtan Prévost","doi":"10.1016/j.diabet.2024.101520","DOIUrl":"10.1016/j.diabet.2024.101520","url":null,"abstract":"","PeriodicalId":11334,"journal":{"name":"Diabetes & metabolism","volume":"50 2","pages":"Article 101520"},"PeriodicalIF":7.2,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139666478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}