2型糖尿病发病年龄与心血管疾病风险和死亡率之间的关系：来自英国和香港的两项队列研究

IF 4.6 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes & metabolism Pub Date : 2025-01-18 DOI:10.1016/j.diabet.2025.101607

Boyuan Wang , Ivy Lynn Mak , Kiki Sze Nga Liu , Edmond Pui Hang Choi , Cindy Lo Kuen Lam , Eric Yuk Fai Wan

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引用次数: 0

摘要

目的：本研究评估2型糖尿病（T2DM）发病年龄与心血管疾病（CVD）风险和死亡率之间的关系。方法：采用英国（UK）和香港（HK）（2008-2013）的电子健康记录对无心血管疾病的成年人进行了两项回顾性队列研究。T2DM组新诊断T2DM患者128,918例，185,646例，对照组无T2DM患者分别为英国和香港队列的5,052,770例和3,159,396例。根据基线年龄、精细分层权重和多变量Cox回归校正基线特征和权重，将各组分为6组。结果：在英国和香港队列中，中位随访时间分别为11.6年和9.5年，T2DM与CVD和死亡风险增加相关，但风险随着年龄的增长而降低。在英国队列中，18-39岁CVD合并T2DM发病的风险(风险比（HR）（95%可信区间（CI）： 3.22(2.80, 3.71)）高于60-69岁组（1.21(1.15,1.26)）和≥80岁组（0.99(0.93,1.05)）。同样，年龄在18-39岁的年轻T2DM患者的死亡风险（2.41(2.06,2.83)）高于年龄在60-69岁（1.40(1.34,1.46)）和年龄≥80岁（1.12(1.08,1.16)）的T2DM患者。香港队列的结果显示了类似的模式。结论：年轻发病的T2DM对以后的心血管健康有很大的影响。这突出了预防年轻成人糖尿病的重要性。(247字)。

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Association between Type 2 Diabetes onset age and risk of cardiovascular disease and mortality: Two cohort studies from United Kingdom and Hong Kong

Objective

This study aimed to evaluate the association between type 2 diabetes mellitus (T2DM) onset age and risk of cardiovascular disease (CVD) and mortality.

Method

Two retrospective cohort studies were conducted using the electronic health records from the United Kingdom (UK) and Hong Kong (HK) on adults without CVD. During 2008-2013, 128,918 and 185,646 patients with new-onset T2DM were assigned to the T2DM group, and 5,052,770 and 3,159,396 patients without T2DM were included as controls in the UK and HK cohort, respectively. Patients were stratified into six age groups. Multivariable Cox regression, adjusted for baseline characteristics and fine stratification weights, was used to estimate the hazard ratios (HRs) and 95 % confidence intervals (CIs) for each outcome.

Results

New-onset T2DM was associated with increased CVD and mortality risk, but the risks decreased with age. Compared to those without T2DM in the same age groups, the HR (95 % CI) for CVD in the UK cohort was 3.22 (2.80, 3.71), 1.21 (1.15, 1.26), and 0.99 (0.93, 1.05) for T2DM individuals at ages 18–39, 60–69, and ≥ 80, respectively. Similarly, the HR (95 % CI) for mortality among new-onset T2DM patients was 2.41 (2.06, 2.83) for age 18–39, 1.40 (1.34, 1.46) for age 60–69, and 1.12 (1.08, 1.16) for age ≥ 80. Results from the HK cohort showed a similar pattern.

Conclusion

Young onset of T2DM is associated with a significant impact on cardiovascular health later in life. This highlights the importance of the prevention of DM in young adults.

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来源期刊

Diabetes & metabolism 医学-内分泌学与代谢

CiteScore

12.00

自引率

4.20%

发文量

审稿时长

13 days

期刊介绍： A high quality scientific journal with an international readership Official publication of the SFD, Diabetes & Metabolism, publishes high-quality papers by leading teams, forming a close link between hospital and research units. Diabetes & Metabolism is published in English language and is indexed in all major databases with its impact factor constantly progressing. Diabetes & Metabolism contains original articles, short reports and comprehensive reviews.