Developmental Neurobiology最新文献_第8页

Origin, molecular specification, and stemness of astrocytes 星形胶质细胞的起源、分子特征和干性

IF 3 4区医学

Developmental Neurobiology Pub Date : 2022-01-10 DOI: 10.1002/dneu.22863

Kang Zheng, Hao Huang, Junlin Yang, Mengsheng Qiu

{"title":"Origin, molecular specification, and stemness of astrocytes","authors":"Kang Zheng, Hao Huang, Junlin Yang, Mengsheng Qiu","doi":"10.1002/dneu.22863","DOIUrl":"10.1002/dneu.22863","url":null,"abstract":"Astrocytes are the most abundant cell type in the central nervous system, carrying out a wide spectrum of biological functions. During early development, neural progenitor cells in the ventricular zone first produce neurons, followed by macroglia in the form of astrocytes or oligodendrocytes. Although the lineage progression of oligodendrocytes has been well understood, the developmental staging of astrocytes has not been defined and the molecular mechanisms underlying their fate specification and differentiation remain largely unknown. The recent advent of sophisticated molecular biology technology, especially single-cell sequencing, has enabled a deeper understanding of the patterning and molecular specification of astrocyte lineage. Based on the recent single-cell sequencing data, we provide an up-to-date and mechanistic review of the early development and heterogeneity of astrocyte lineage in the developing cortex, and compile a list of stage-specific markers for astrocyte development. In addition, emerging evidence suggests that under physiological conditions, mature astrocytes are partially specialized progenitor cells that have functionally adapted to local neuronal microenvironment. Under pathological or injury conditions, astrocytes are capable of reentering cell cycles and differentiating into other neural cell types under the influence of both intrinsic factors and environmental cues.","PeriodicalId":11300,"journal":{"name":"Developmental Neurobiology","volume":"82 2","pages":"149-159"},"PeriodicalIF":3.0,"publicationDate":"2022-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39805058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

The Effects of Wnt, BMP and Notch Signaling Pathways on Cell Proliferation and Neural Differentiation in a Song Control Nucleus (HVC) of Lonchura Striata Wnt、BMP和Notch信号通路对纹状体松控制核(HVC)细胞增殖和神经分化的影响

IF 3 4区医学

Developmental Neurobiology Pub Date : 2022-01-01 DOI: 10.2139/ssrn.4239427

Jie Bing, Jing Sun, Rui Zhao, Lina Sun, Chao Xi, Jin Liu, Shaoju Zeng

引用次数: 0

Regulation of axon pruning of mossy fiber projection in hippocampus by CRMP2 and CRMP4 CRMP2和CRMP4调控海马苔藓纤维突起轴突修剪

IF 3 4区医学

Developmental Neurobiology Pub Date : 2021-12-21 DOI: 10.1002/dneu.22865

Yurika Nakanishi, Satoshi Akinaga, Koki Osawa, Natusmi Suzuki, Ayaka Sugeno, Papachan Kolattukudy, Yoshio Goshima, Toshio Ohshima

{"title":"Regulation of axon pruning of mossy fiber projection in hippocampus by CRMP2 and CRMP4","authors":"Yurika Nakanishi, Satoshi Akinaga, Koki Osawa, Natusmi Suzuki, Ayaka Sugeno, Papachan Kolattukudy, Yoshio Goshima, Toshio Ohshima","doi":"10.1002/dneu.22865","DOIUrl":"10.1002/dneu.22865","url":null,"abstract":"Axon pruning facilitates the removal of ectopic and misguided axons and plays an important role in neural circuit formation during brain development. Sema3F and its receptor neuropilin-2 (Nrp2) have been shown to be involved in the stereotyped pruning of the infrapyramidal bundle (IPB) of mossy fibers of the dentate gyrus (DG) in the developing hippocampus.Collapsin response mediator proteins (CRMPs) were originally identified as an intracellular mediator of semaphorin signaling, and the defective pruning of IPB was recently reported in CRMP2-/- and CRMP3-/- mice. CRMP1 and CRMP4 have high homology to CRMP2 and CRMP3, and their expression in the developing mouse brain overlaps; however, their role in IPB pruning has not yet been examined.In this study, we report that CRMP4, but not CRMP1, is involved in IPB pruning during neural circuit formation in the hippocampus. Our genetic interaction analyses indicated that CRMP2 and CRMP4 have distinct functions and that CRMP2 mediates IPB pruning via Nrp2. We also observed the altered synaptic terminals of mossy fibers in CRMP2 and CRMP4 mutant mice. These results suggest that CRMP family members have a distinct function in the axon pruning and targeting of mossy fibers of the hippocampal DG in the developing mouse brain.","PeriodicalId":11300,"journal":{"name":"Developmental Neurobiology","volume":"82 1","pages":"138-146"},"PeriodicalIF":3.0,"publicationDate":"2021-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/dneu.22865","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39744111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The origin and repopulation of microglia 小胶质细胞的起源和再生

IF 3 4区医学

Developmental Neurobiology Pub Date : 2021-12-07 DOI: 10.1002/dneu.22862

Lijuan Zhang, Yue Cao, Xin Zhang, Xinyang Gu, Ying Mao, Bo Peng

引用次数: 15

Microglial TREM2 in amyotrophic lateral sclerosis 肌萎缩性侧索硬化症的小胶质细胞TREM2

IF 3 4区医学

Developmental Neurobiology Pub Date : 2021-12-07 DOI: 10.1002/dneu.22864

Manling Xie, Shunyi Zhao, Dale B. Bosco, Aivi Nguyen, Long-Jun Wu

{"title":"Microglial TREM2 in amyotrophic lateral sclerosis","authors":"Manling Xie, Shunyi Zhao, Dale B. Bosco, Aivi Nguyen, Long-Jun Wu","doi":"10.1002/dneu.22864","DOIUrl":"10.1002/dneu.22864","url":null,"abstract":"Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is an aggressive motor neuron degenerative disease characterized by selective loss of both upper and lower motor neurons. The mechanisms underlying disease initiation and progression are poorly understood. The involvement of nonmotor neuraxis emphasizes the contribution of glial cells in disease progress. Microglia comprise a unique subset of glial cells and are the principal immune cells in the central nervous system (CNS). Triggering receptor expressed on myeloid cell 2 (TREM2) is a surface receptor that, within the CNS, is exclusively expressed on microglia and plays crucial roles in microglial proliferation, migration, activation, metabolism, and phagocytosis. Genetic evidence has linked TREM2 to neurodegenerative diseases including ALS, but its function in ALS pathogenesis is largely unknown. In this review, we summarize how microglial activation, with a specific focus on TREM2 function, affects ALS progression clinically and experimentally. Understanding microglial TREM2 function will help pinpoint the molecular target for ALS treatment.","PeriodicalId":11300,"journal":{"name":"Developmental Neurobiology","volume":"82 1","pages":"125-137"},"PeriodicalIF":3.0,"publicationDate":"2021-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8898078/pdf/nihms-1768807.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39789047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Effect of lncRNA H19 on nerve degeneration and regeneration after sciatic nerve injury in rats lncRNA H19对大鼠坐骨神经损伤后神经变性和再生的影响

IF 3 4区医学

Developmental Neurobiology Pub Date : 2021-11-24 DOI: 10.1002/dneu.22861

Yuting Li, Min Cai, Yumei Feng, Bryant Yung, Yi Wang, Nannan Gao, Xi Xu, Huanhuan Zhang, Huiwei Huang, Dengbing Yao

{"title":"Effect of lncRNA H19 on nerve degeneration and regeneration after sciatic nerve injury in rats","authors":"Yuting Li, Min Cai, Yumei Feng, Bryant Yung, Yi Wang, Nannan Gao, Xi Xu, Huanhuan Zhang, Huiwei Huang, Dengbing Yao","doi":"10.1002/dneu.22861","DOIUrl":"10.1002/dneu.22861","url":null,"abstract":"Hundreds of millions of people worldwide suffer from peripheral nerve damage resulting from car accidents, falls, industrial accidents, residential accidents, and wars. The purpose of our study was to further investigate the effects of Wallerian degeneration (WD) after rat sciatic nerve injury and to screen for critical long noncoding RNAs (lncRNAs) in WD. We found H19 to be essential for nerve degeneration and regeneration and to be highly expressed in the sciatic nerves of rats with WD. lncRNA H19 potentially impaired the recovery of sciatic nerve function in rats. H19 was mainly localized in the cytoplasm of Schwann cells (SCs) and promoted their migration. H19 promoted the apoptosis of dorsal root ganglion (DRG) neurons and slowed the growth of DRG axons. The lncRNA H19 may play a role in WD through the Wnt/β-catenin signaling pathway and is coexpressed with a variety of crucial mRNAs during WD. These data provide further insight into the molecular mechanisms of WD.","PeriodicalId":11300,"journal":{"name":"Developmental Neurobiology","volume":"82 1","pages":"98-111"},"PeriodicalIF":3.0,"publicationDate":"2021-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/dneu.22861","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39922209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Interferon regulatory factor-7 is required for hair cell development during zebrafish embryogenesis 干扰素调节因子-7是斑马鱼胚胎发育过程中毛细胞发育所必需的

IF 3 4区医学

Developmental Neurobiology Pub Date : 2021-11-14 DOI: 10.1002/dneu.22860

Song-Qun Hu, Hui-Min Xu, Fu-Ping Qian, Chang-Sheng Chen, Xin Wang, Dong Liu, Lei Cheng

{"title":"Interferon regulatory factor-7 is required for hair cell development during zebrafish embryogenesis","authors":"Song-Qun Hu, Hui-Min Xu, Fu-Ping Qian, Chang-Sheng Chen, Xin Wang, Dong Liu, Lei Cheng","doi":"10.1002/dneu.22860","DOIUrl":"10.1002/dneu.22860","url":null,"abstract":"Interferon regulatory factor-7 (IRF7) is an essential regulator of both innate and adaptive immunity. It is also expressed in the otic vesicle of zebrafish embryos. However, any role for irf7 in hair cell development was uncharacterized. Does it work as a potential deaf gene to regulate hair cell development? We used whole-mount in situ hybridization (WISH) assay and morpholino-mediated gene knockdown method to investigate the role of irf7 in the development of otic vesicle hair cells during zebrafish embryogenesis. We performed RNA sequencing to gain a detailed insight into the molecules/genes which are altered upon downregulation of irf7. Compared to the wild-type siblings, knockdown of irf7 resulted in severe developmental retardation in zebrafish embryos as well as loss of neuromasts and damage to hair cells at an early stage (within 3 days post fertilization). Coinjection of zebrafish irf7 mRNA could partially rescued the defects of the morphants. atp1b2b mRNA injection can also partially rescue the phenotype induced by irf7 gene deficiency. Loss of hair cells in irf7-morphants does not result from cell apoptosis. Gene expression profiles show that, compared to wild-type, knockdown of irf7 can lead to 2053 and 2678 genes being upregulated and downregulated, respectively. Among them, 18 genes were annotated to hair cell (HC) development or posterior lateral line (PLL) development. All results suggest that irf7 plays an essential role in hair cell development in zebrafish, indicating that irf7 may be a member of deafness gene family.","PeriodicalId":11300,"journal":{"name":"Developmental Neurobiology","volume":"82 1","pages":"88-97"},"PeriodicalIF":3.0,"publicationDate":"2021-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/49/fd/DNEU-82-88.PMC9305156.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39878281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Novel localizations of TRPC5 channels suggest novel and unexplored roles: A study in the chick embryo brain TRPC5通道的新定位提示了新的和未被探索的作用:鸡胚胎大脑的一项研究

IF 3 4区医学

Developmental Neurobiology Pub Date : 2021-10-27 DOI: 10.1002/dneu.22857

Sharifuddin Rifat Ahmed, Elise Liu, Alissa Yip, Yuqi Lin, Evan Balaban, Maria Pompeiano

{"title":"Novel localizations of TRPC5 channels suggest novel and unexplored roles: A study in the chick embryo brain","authors":"Sharifuddin Rifat Ahmed, Elise Liu, Alissa Yip, Yuqi Lin, Evan Balaban, Maria Pompeiano","doi":"10.1002/dneu.22857","DOIUrl":"10.1002/dneu.22857","url":null,"abstract":"Mammalian TRPC5 channels are predominantly expressed in the brain, where they increase intracellular Ca2+ and induce depolarization. Because they augment presynaptic vesicle release, cause persistent neural activity, and show constitutive activity, TRPC5s could play a functional role in late developmental brain events. We used immunohistochemistry to examine TRPC5 in the chick embryo brain between 8 and 20 days of incubation, and provide the first detailed description of their distribution in birds and in the whole brain of any animal species. Stained areas substantially increased between E8 and E16, and staining intensity in many areas peaked at E16, a time when chick brains first show organized patterns of whole-brain metabolic activation like what is seen consistently after hatching. Areas showing cell soma staining match areas showing Trpc5 mRNA or protein in adult rodents (cerebral cortex, hippocampus, amygdala, cerebellar Purkinje cells). Chick embryos show protein staining in the optic tectum, cerebellar nuclei, and several brainstem nuclei; equivalent areas in the Allen Institute mouse maps express Trpc5 mRNA. The strongest cell soma staining was found in a dorsal hypothalamic area (matching a group of parvicellular arginine vasotocin neurons and a pallial amygdalohypothalamic cell corridor) and the vagal motor complex. Purkinje cells showed strong dendritic staining at E20. Unexpectedly, we also describe neurite staining in the septum, several hypothalamic nuclei, and a paramedian raphe area; the strongest neurite staining was in the median eminence. These novel localizations suggest new unexplored TRPC5 functions, and possible roles in late embryonic brain development.","PeriodicalId":11300,"journal":{"name":"Developmental Neurobiology","volume":"82 1","pages":"41-63"},"PeriodicalIF":3.0,"publicationDate":"2021-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/dneu.22857","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39562877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-lasting implications of embryonic exposure to alcohol: Insights from zebrafish research 胚胎接触酒精的长期影响:来自斑马鱼研究的见解

IF 3 4区医学

Developmental Neurobiology Pub Date : 2021-10-23 DOI: 10.1002/dneu.22855

José Henrique Cararo, Eduardo Pacheco Rico

{"title":"Long-lasting implications of embryonic exposure to alcohol: Insights from zebrafish research","authors":"José Henrique Cararo, Eduardo Pacheco Rico","doi":"10.1002/dneu.22855","DOIUrl":"10.1002/dneu.22855","url":null,"abstract":"The harmful consumption of ethanol is associated with significant health problems and social burdens. This drug activates a complex network of reward mechanisms and habit formation learning that is supposed to contribute to the consumption of increasingly high and frequent amounts, ultimately leading to addiction. In the context of fetal alcohol spectrum disorders, fetal alcohol syndrome (FAS) is a consequence of the harmful use of alcohol during pregnancy, which affects the embryonic development of the fetus. FAS can be easily reproduced in zebrafish by exposing the embryos to different concentrations of ethanol in water. In this regard, the aim of the present review is to discuss the late pathological implications in zebrafish exposed to ethanol at the embryonic stage, providing information in the context of human fetal alcoholic spectrum disorders. Experimental FAS in zebrafish is associated with impairments in the metabolic, morphological, neurochemical, behavioral, and cognitive domains. Many of the pathways that are affected by ethanol in zebrafish have at least one ortholog in humans, collaborating with the wider adoption of zebrafish in studies on alcohol disorders. In fact, zebrafish present validities required for the study of these conditions, which contributes to the use of this species in research, in addition to studies with rodents.","PeriodicalId":11300,"journal":{"name":"Developmental Neurobiology","volume":"82 1","pages":"29-40"},"PeriodicalIF":3.0,"publicationDate":"2021-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/dneu.22855","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39550881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Expression of Maf family proteins in glutamatergic neurons of the mouse olfactory bulb Maf家族蛋白在小鼠嗅球谷氨酸能神经元中的表达

IF 3 4区医学

Developmental Neurobiology Pub Date : 2021-10-22 DOI: 10.1002/dneu.22859

Ayako Ito, Fumiaki Imamura

{"title":"Expression of Maf family proteins in glutamatergic neurons of the mouse olfactory bulb","authors":"Ayako Ito, Fumiaki Imamura","doi":"10.1002/dneu.22859","DOIUrl":"10.1002/dneu.22859","url":null,"abstract":"The fate of neurons in the developing brain is largely determined by the combination of transcription factors they express. In particular, stem cells must follow different transcriptional cascades during differentiation in order to generate neurons with different neurotransmitter properties, such as glutamatergic and GABAergic neurons. In the mouse cerebral cortex, it has been shown that large Maf family proteins, MafA, MafB and c-Maf, regulate the development of specific types of GABAergic interneurons but are not expressed in glutamatergic neurons. In this study, we examined the expression of large Maf family proteins in the developing mouse olfactory bulb (OB) by immunohistochemistry and found that the cell populations expressing MafA and MafB are almost identical, and most of them express Tbr2. As Tbr2 is expressed in glutamatergic neurons in the OB, we further examined the expression of glutamatergic and GABAergic neuronal markers in MafA and MafB positive cells. The results showed that in the OB, MafA and MafB are expressed exclusively in glutamatergic neurons, but not in GABAergic neurons. We also found that few cells express c-Maf in the OB. These results indicate that, unlike the cerebral cortex, MafA and/or MafB may regulate the development of glutamatergic neurons in the developing OB. This study advances our knowledge about the development of glutamatergic neurons in the olfactory bulb, and also might suggest that mechanisms for the generation of projection neurons and interneurons differ between the cortex and the olfactory bulb, even though they both develop from the telencephalon.","PeriodicalId":11300,"journal":{"name":"Developmental Neurobiology","volume":"82 1","pages":"77-87"},"PeriodicalIF":3.0,"publicationDate":"2021-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9148588/pdf/nihms-1808816.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39541591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1