Diseases of the Colon & Rectum最新文献

{"title":"Organ Preservation in Rectal Cancer Management: A Prospective GRECCAR Snapshot.","authors":"Barbara Noiret, Gilles Manceau, Benjamin Fernandez, Philippe Rouanet, Etienne Buscail, Bertrand Trilling, Hélène Meillat, Jérémie H Lefèvre, Guillaume Meurette, Stephanie Benoist, Mehdi Karoui, Nicolas Peru, Léon Maggiori, Aurélien Venara, Mehdi Ouaissi, Dahbia Djelil, Adeline Germain, Eddy Cotte, Charles Sabbagh, Simone Manfredelli, Jean Jacques Tuech, Laura Beyer-Berjot, Arnaud Alves, Diane Mege, Frédéric Marchal, Jean Michel Fabre, Constance C Houlzé-Laroye, Christophe Taoum, Michel Rivoire, Quentin Denost","doi":"10.1097/DCR.0000000000004206","DOIUrl":"https://doi.org/10.1097/DCR.0000000000004206","url":null,"abstract":"<p><strong>Background: </strong>Organ preservation strategies, including watch and wait and local excision, are increasingly adopted in rectal cancer management. Total neoadjuvant therapy improves complete response rates, potentially expanding organ preservation indications.</p><p><strong>Objective: </strong>To evaluate the real-world implementation of organ preservation strategies and short-term oncologic outcomes in patients with non-metastatic mid- and low-rectal cancer in France.</p><p><strong>Design: </strong>Prospective, multicenter, observational cohort study.</p><p><strong>Settings: </strong>Twenty-seven French GRECCAR centers were included.</p><p><strong>Patients: </strong>Patients with biopsy-proven, non-metastatic rectal adenocarcinoma (<12 cm from anal verge) treated with neoadjuvant therapy managed with organ preservation intent across 27 French GRECCAR centers (October 2022-March 2023) were included. Patients were categorized into selective (early-stage) or opportunistic (advanced-stage) strategies and managed with either watch-and-wait or local excision.</p><p><strong>Main outcome measures: </strong>Rates of organ preservation, watch and wait vs local excision use, and oncologic outcomes at 1 and 2 years, including overall survival, disease-free survival, local recurrence-free survival, total mesorectal excision-free survival, and distant metastasis.</p><p><strong>Results: </strong>Of the 457 patients, 117 (26%) underwent organ preservation, more frequently with the selective strategy (51% vs. 18.1%; p < 0.001). Watch and wait was the predominant organ preservation method (78% vs. 22%), used similarly across both groups (p = 0.728). Total neoadjuvant therapy was the most common neoadjuvant regimen (67%), predominantly via induction chemotherapy (56%). Overall survival at 2 years exceeded 95% across groups. No significant differences between watch and wait and local excision in disease-free survival, local recurrence-free survival or total mesorectal excision-free survival. Local regrowth occurred in 14 watch-and-wait patients and 3 after local excision, mostly within the first year, with salvage surgery successfully performed. Distant metastases were more frequent in patients treated under the opportunistic strategy.</p><p><strong>Limitations: </strong>The short follow-up period limits the assessment of long-term outcomes and late recurrences.</p><p><strong>Conclusions: </strong>In this nationwide French cohort, organ preservation strategies-supported by total neoadjuvant therapy-were feasible and safe across tumor stages. Both watch and wait and local excision demonstrated comparable short-term oncologic outcomes, supporting their role as viable options within individualized, response-adapted treatment pathways. See Video Abstract.</p>","PeriodicalId":11299,"journal":{"name":"Diseases of the Colon & Rectum","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147765648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ChatGPT Answers to Patient Questions Regarding Fecal Incontinence: Consideration.","authors":"Hinpetch Daungsupawong, Viroj Wiwanitkit","doi":"10.1097/DCR.0000000000004273","DOIUrl":"https://doi.org/10.1097/DCR.0000000000004273","url":null,"abstract":"","PeriodicalId":11299,"journal":{"name":"Diseases of the Colon & Rectum","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147765529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mesenteric Adipose Radiomics for Structural Damage Stratification in Chronic Ulcerative Colitis.","authors":"Junjie Xing, Zubing Mei","doi":"10.1097/DCR.0000000000004275","DOIUrl":"https://doi.org/10.1097/DCR.0000000000004275","url":null,"abstract":"","PeriodicalId":11299,"journal":{"name":"Diseases of the Colon & Rectum","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147765555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Randomized Contrast to Enriched Observation: Methodological Considerations of SANLARS.","authors":"Alp Omer Canturk, Yasemin Yildirim","doi":"10.1097/DCR.0000000000004276","DOIUrl":"https://doi.org/10.1097/DCR.0000000000004276","url":null,"abstract":"","PeriodicalId":11299,"journal":{"name":"Diseases of the Colon & Rectum","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147765620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clarifying Methodologic Rigor and Equity Considerations in Evaluating ChatGPT Responses to Patient Questions on Fecal Incontinence.","authors":"Lindsay L Welton, Melissa A Gunderson, Geetanjali Rajamani, Ying Liu, Karen Trang, Lauren Weaver, Alexander M Troester, Rui Zhang, Wolfgang B Gaertner, Mark L Welton, Elizabeth C Wick, Genevieve B Melton","doi":"10.1097/DCR.0000000000004274","DOIUrl":"https://doi.org/10.1097/DCR.0000000000004274","url":null,"abstract":"","PeriodicalId":11299,"journal":{"name":"Diseases of the Colon & Rectum","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147765463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"REPLY.","authors":"Franco Marinello, Gianluca Pellino, Eloy Espin-Basany","doi":"10.1097/DCR.0000000000004277","DOIUrl":"https://doi.org/10.1097/DCR.0000000000004277","url":null,"abstract":"","PeriodicalId":11299,"journal":{"name":"Diseases of the Colon & Rectum","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147765570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Being a Colorectal Psychologist.","authors":"James Church","doi":"10.1097/DCR.0000000000004173","DOIUrl":"https://doi.org/10.1097/DCR.0000000000004173","url":null,"abstract":"","PeriodicalId":11299,"journal":{"name":"Diseases of the Colon & Rectum","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147765538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expert Commentary on Colonic Stenting in Obstructed Colorectal Cancer as a Bridge to Surgery.","authors":"Jennifer Erin Hrabe","doi":"10.1097/DCR.0000000000004270","DOIUrl":"https://doi.org/10.1097/DCR.0000000000004270","url":null,"abstract":"","PeriodicalId":11299,"journal":{"name":"Diseases of the Colon & Rectum","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147765572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Upfront Surgery in Stage II/III Rectal Cancer: clarifying the role of Neoadjuvant Therapy.","authors":"Zachary Bunjo, Tarik Sammour","doi":"10.1097/DCR.0000000000004269","DOIUrl":"https://doi.org/10.1097/DCR.0000000000004269","url":null,"abstract":"","PeriodicalId":11299,"journal":{"name":"Diseases of the Colon & Rectum","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147765609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Colonic Stenting in Obstructed Colorectal Cancer as a Bridge to Surgery.","authors":"Sarah Z L Tham, Edwin Yang","doi":"10.1097/DCR.0000000000004257","DOIUrl":"10.1097/DCR.0000000000004257","url":null,"abstract":"","PeriodicalId":11299,"journal":{"name":"Diseases of the Colon & Rectum","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147728587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}