Drug Invention Today最新文献

{"title":"Evaluation of hepatoprotective potential of ethanolic extract of Ixora pavetta against isoniazid and rifampicin induced hepatotoxicity in rats","authors":"Gangavaram Jyothi Reddy ,&nbsp;Vara Prasanth Reddy ,&nbsp;Mungura Sreepavani ,&nbsp;Cuddapa Rajaram ,&nbsp;Sadhu Nelson Kumar ,&nbsp;Rupesh S. Kanhere","doi":"10.1016/j.dit.2013.06.007","DOIUrl":"10.1016/j.dit.2013.06.007","url":null,"abstract":"<div><h3>Objective</h3><p>The aim of present study was to demonstrate the hepatoprotective effect of ethanolic extract of <em>Ixora pavetta</em> (EEIP) against isoniazid and rifampicin induced hepatotoxicity in rats.</p></div><div><h3>Method</h3><p>Rats were divided into five groups each group containing 6 animals. All rats were treated with INH + RIF in saline water at the dose of 100 mg/kg b.w., p.o. to the experimental animals for 21 days. Group I served as control administered with distilled water. In order to study the effect of EEIP in rats, 200 mg/kg b.w. and 400 mg/kg b.w. of extracts were administered to the rats in group IV and V by oral route. Silymarin (2.5 mg/kg b.w., p.o.) was used as a standard drug in this study. After the course of treatment the animals were sacrificed and blood and liver samples were collected for biochemical and histopathological studies respectively.</p></div><div><h3>Results</h3><p>Biochemical parametric evaluation of both the standard and EEIP (200 mg and 400 mg/kg b. wt) treated rats showed significant decrease in SGOT, SGPT, ALP, Total Bilirubin, Direct Bilirubin, and Total cholesterol. And the level of Total protein was significantly increased in both standard and EEIP treated rats when compared to toxic control group rats. The changes in biochemical parameters were supported by histological profile.</p></div><div><h3>Conclusion</h3><p>It is concluded that the ethanolic extract of <em>Ixora pavetta</em> protects against rifampicin and Isoniazid-induced oxidative liver injury in rats.</p></div>","PeriodicalId":11284,"journal":{"name":"Drug Invention Today","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.dit.2013.06.007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85209976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis and biological activity of some pyrimidine derivatives","authors":"Kikkeri N. Mohana ,&nbsp;Basavapatna N. Prasanna Kumar ,&nbsp;Lingappa Mallesha","doi":"10.1016/j.dit.2013.08.004","DOIUrl":"10.1016/j.dit.2013.08.004","url":null,"abstract":"<div><h3>Objectives</h3><p>To synthesize a variety of pyrimidine analogs, <strong>3</strong>, <strong>4</strong>, <strong>5</strong>, <strong>6(a–d)</strong>, <strong>7(a–d)</strong> and their anticonvulsant and antioxidant activity was determined.</p></div><div><h3>Methods</h3><p>Using 5-bromo-2,4-dichloropyrimidine and hydrazine hydrate, new compounds were synthesized. The structures of all the new compounds are established on the basis of FT-IR, ¹H NMR and mass spectral data. Anticonvulsant study was done by MES seizure model and rotorod method was employed to determine the neurotoxicity. Antioxidant activity was done by DPPH method.</p></div><div><h3>Results</h3><p>All the compounds were synthesized in good yield. Among the new compounds, <strong>6c</strong> and <strong>7c</strong> are found to be most potent and showed no neurotoxicity. All the compounds showed DPPH radical scavenging activity, where compounds <strong>7b</strong>, <strong>7a</strong> and <strong>6b</strong> were the best radical scavengers.</p></div><div><h3>Conclusions</h3><p>The results obtained justify the usage of these compounds from their promising anticonvulsant and antioxidant activity. Therefore, the nature of groups is very important for anticonvulsant activity in MES model.</p></div>","PeriodicalId":11284,"journal":{"name":"Drug Invention Today","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.dit.2013.08.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81885961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In silico screening of chalcone derivatives as potential inhibitors of dihydrofolate reductase: Assessment using molecular docking, paired potential and molecular hydrophobic potential studies","authors":"Dhanaji S. Gond ,&nbsp;Rohan J. Meshram ,&nbsp;Sharad G. Jadhav ,&nbsp;Gulshan Wadhwa ,&nbsp;Rajesh N. Gacche","doi":"10.1016/j.dit.2013.08.003","DOIUrl":"10.1016/j.dit.2013.08.003","url":null,"abstract":"<div><h3>Objectives</h3><p>Enzyme dihydro foliate reductase (DHFR) is involved in synthesis of DNA and consequently, has long been recognized to have utmost therapeutic significance, since its inactivation can be targeted in numerous infectious as well as noninfectious diseases. In the present studies molecular docking of chalcone derivatives with human as well as <em>Mycobacterial</em> DHFR, followed by paired potential and hydrophobic potential analysis were carried out to understand the novel chalcone–DHFR interactions.</p></div><div><h3>Methods</h3><p>Molecular docking was carried out using GOLD and AutoDock software, paired potential analysis was performed employing on-line program DSX-ONLINE and molecular hydrophobic potential (MHP) analysis was done using web-based program PLATINUM.</p></div><div><h3>Results</h3><p>Results obtained from docking study, drug score potential and MHP analysis coincide with experimental findings. Molecular property analysis indicates that given compounds follows Lipinski's rule of five. Compound number 1 exhibited best binding energy (−8.02 kcal/mol) in human DHFR while compound number 6 (−7.36 kcal/mol), 9 (−7.32 kcal/mol), 10 (−7.31 kcal/mol) and 11 (−8.25 kcal/mol) demonstrated favorable binding score in <em>Mycobacterial</em> DHFR.</p></div><div><h3>Conclusions</h3><p>Per atom score contribution of chalcone derivatives obtained by paired potential analysis indicate participation of conserved as well as few new residues are expected to be involved in inhibition of DHFR. MHP analysis of chalcone–DHFR complexes revealed important role of hydrophobic contact in inhibition; additionally, individual chemical scaffold on chalcone derivatives that contribute in lipophilicity has been identified. This data is expected to be further explored for the design and development of novel class of DHFR inhibitors using chalcone scaffold.</p></div>","PeriodicalId":11284,"journal":{"name":"Drug Invention Today","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.dit.2013.08.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77950095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antioxidant and protective effect of Curculigo orchioides on liver, pancreas and kidney tissue in alloxan induced diabetic experimental rats","authors":"Elumalai Anandakirouchenane ,&nbsp;Irisappan Sarath Chandiran ,&nbsp;Veerasamy Kanimozhi ,&nbsp;Balamuthu Kadalmani","doi":"10.1016/j.dit.2013.08.002","DOIUrl":"10.1016/j.dit.2013.08.002","url":null,"abstract":"<div><h3>Background</h3><p>The aim of this study was to investigate the antioxidant activity of <em>Curculigo orchioides</em> in alloxan induced diabetic rats.</p></div><div><h3>Methods</h3><p>Diabetes was induced experimentally in 12-h fasted rats by intraperitoneal injections of alloxan (120 mg/kg b.w.) and <em>C. orchioides</em> (200 mg/kg b.w.) was administered orally for 21 days.</p></div><div><h3>Results</h3><p>Untreated diabetic rats in comparison with normal rats showed significantly lower mean activities of antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase), lower mean levels of non-enzymatic antioxidants (reduced glutathione, vitamin C, vitamin E), elevated mean levels of pancreatic malondialdehyde (MDA), elevated mean activities of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP). Following oral administration of <em>C. orchioides</em> (200 mg/kg b.w./day) to diabetic rats for 21 days exhibited significant improvement of the above parameters. Histopathological studies showed significant changes like cytoplasmic vacuolization of hepatocytes, leukocytic infiltration and edema in the liver and kidney of alloxan-induced diabetic rats. These histopathological abnormalities were found to be normalized after treatment with <em>C. orchioides</em> extract.</p></div><div><h3>Conclusion</h3><p>These results suggest that the methanolic extract <em>C. orchioides</em> enhanced the antioxidant defense against reactive oxygen species produced under hyperglycemic conditions, hence protecting the liver, pancreatic and kidney tissue injuries.</p></div>","PeriodicalId":11284,"journal":{"name":"Drug Invention Today","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.dit.2013.08.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82404775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formulation and evaluation of Pioglitazone loaded Bovine serum albumin nanoparticles along with Piperine","authors":"Bindu Madhavi Boddupalli ,&nbsp;Prasad Masana ,&nbsp;Ravinder Nath Anisetti ,&nbsp;Siri Vennela Kallem ,&nbsp;Bhavana Madipoju","doi":"10.1016/j.dit.2013.05.011","DOIUrl":"10.1016/j.dit.2013.05.011","url":null,"abstract":"<div><h3>Aim</h3><p>To formulate and optimize the process parameters of Pioglitazone and Piperine loaded BSA nanoparticles. This will serve the purpose avoiding the adverse effects of Pioglitazone by combining with herbal principle, Piperine.</p></div><div><h3>Methods</h3><p>Modified desolvation and coacervation method was selected for the formulation of nanoparticles. Method of cross linking, concentration of glutaraldehyde and pH were optimized.</p></div><div><h3>Results</h3><p>BSA nanoparticles loaded with Pioglitazone and Piperine were prepared. The loading efficiency was found to be maximum (81.5 ± 1.7) with chemical cross linking at 10% of glutaraldehyde and in alkaline pH. The size of the nanoparticles was in nano range and minimum with cocervation at alkaline pH. The drug release was found to be sustained upto 24 h and was efficient with nanoparticles formed at alkaline pH due to more surface area for dissolution.</p></div><div><h3>Conclusion</h3><p>The formed BSA nanoparticles loaded with Piperine and Pioglitazone will be beneficial for the treatment of diabetes.</p></div>","PeriodicalId":11284,"journal":{"name":"Drug Invention Today","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.dit.2013.05.011","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84696003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preliminary phytochemical and preclinical toxicity studies of Grewia serrulata DC","authors":"Irisappan Sarath Chandiran ,&nbsp;Korlakunta Narasimha Jayaveera ,&nbsp;Shaik Karimulla","doi":"10.1016/j.dit.2013.06.010","DOIUrl":"10.1016/j.dit.2013.06.010","url":null,"abstract":"<div><h3>Background</h3><p>The present study was aimed to evaluate phytochemical constituents and the safety of aqueous and ethanolic extracts of aerial parts of <em>Grewia serrulata</em> DC (AEGS &amp; EEGS) by determining their potential toxicity after acute and 28-day repeated dose administration in Wistar Albino rats.</p></div><div><h3>Methods</h3><p>The phytochemical analysis was done by standard laboratory grade reagents. Acute and 28-day repeated dose oral toxicity studies were performed by the following OECD test guide lines 423 and 407 respectively.</p></div><div><h3>Results</h3><p>The present study reveals the presence of complex phytochemical constituents like flavanoids, saponins, glycosides, terpenoids, steroids and phenols. In acute toxicity study no treatment related death or toxic signs were observed with AEGS and EEGS administration. In repeated dose study no significant differences in body weight changes and hemotological paremeters were observed between control and AEGS and EEGS groups. Conversely there was a decrease in serum glucose and cholesterol levels and an increase in protein levels in treated rats compared to control. No gross pathological findings and difference in relative organ weights were observed between control and treated rats. Histopathological examination revealed no abnormalities with the test drug treatment.</p></div><div><h3>Conclusion</h3><p>Preliminary phytochemical evaluation shows the presence of various bioactive constituents. Acute toxicity study reveals that LD₅₀ of AEGS and EEGS is greater than 2000 mg/kg body weight (b wt) in fasted female rats and can be classified under category 5. The 28-day repeated oral toxicity study justified that the No Observed Adverse Effect Level (NOAEL) of <em>G. serrulata</em> DC (GS) is greater than 800 mg/kg b wt/day P.O in rats. There were no delayed effects in GS satellite group. In conclusion GS was found to be non-toxic in tested doses and experimental conditions.</p></div>","PeriodicalId":11284,"journal":{"name":"Drug Invention Today","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.dit.2013.06.010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82859285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antiparkinson's and free radical scavenging study of ethyl acetate fraction of ethanolic extract of Leucas lanata","authors":"Ramalingam Ramani ,&nbsp;Ravinder Nath Anisetti ,&nbsp;Bindu Madhavi Boddupalli ,&nbsp;Nagulu Malothu ,&nbsp;Bala Subramaniam Arumugam","doi":"10.1016/j.dit.2013.07.001","DOIUrl":"10.1016/j.dit.2013.07.001","url":null,"abstract":"<div><h3>Objective</h3><p>Oxidative stress is the major reason for most of the neurodegenerative disorders. Our study aimed to know the <em>in vitro</em> free radical scavenging ability and <em>in vivo</em> antiparkinson's activity of ethyl acetate fraction of ethanolic extract of <em>Leucas lanata</em> (LLEA).</p></div><div><h3>Methods</h3><p>LLEA was initially screened for <em>in vitro</em> free radical scavenging ability and then the effect of LLEA was studied in rotenone induced Parkinson's disorder in mice.</p></div><div><h3>Results</h3><p>The IC₅₀ values for superoxide anion, hydroxyl radical and nitric oxide scavenging activity were 64.053 ± 11.90 μg/ml, 289.486 ± 66.57 μg/ml and 402.909 ± 43.22 μg/ml respectively. In catalepsy activity, fall of time for rotenone was found to be 39.5 ± 1.996 sec and it was decreased when animals were treated with LLEA (11.17 ± 0.6 sec). In locomotor activity, there was an increase from 40 ± 1.26 counts/5 min (rotenone) to 222.7 ± 1.87 counts/5 min (LLEA alone) and to 148.8 ± 1.95 counts/5 min (LLEA along with rotenone). In muscle relaxant activity, the fall off time was found to be increased from 43.83 ± 1.6 sec to 211.8 ± 1.22 sec and 147.3 ± 2.39 sec with LLEA alone and LLEA in combination with rotenone respectively.</p></div><div><h3>Conclusion</h3><p>The oxidative damage induced by rotenone was reduced by the administration of LLEA in all the concentrations linearly. The protective effect of LLEA might be due to its free radical scavenging ability. For the oxidative stress induced neurodegenerative disorders, natural herbs with free radical scavenging potential are going to be the better option of treatment.</p></div>","PeriodicalId":11284,"journal":{"name":"Drug Invention Today","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.dit.2013.07.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74891849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Invitro evaluation of piperine enclosed erythrocyte carriers","authors":"Boddupalli Bindu Madhavi ,&nbsp;Madupoju Bhavana ,&nbsp;Anisetti Ravinder Nath ,&nbsp;Masana Prasad ,&nbsp;Kallem Siri Vennela","doi":"10.1016/j.dit.2013.04.006","DOIUrl":"10.1016/j.dit.2013.04.006","url":null,"abstract":"<div><h3>Background</h3><p>Resealed erythrocytes are the promising drug delivery systems in targeting drug delivery system. In our present work, hepato protective agent piperine was encapsulated into erythrocyte carriers in order to target it to liver.</p></div><div><h3>Methods</h3><p>Resealed erythrocytes were prepared by following hypotonic dilution technique. The effects of NaCl in hypotonic and hypertonic solutions, drug concentration, freezing and solvent were studied on encapsulation and hemoglobin release. After optimizing, the erythrocytes were evaluated for hematological parameters, osmotic shock, turbulence shock, size and <em>invitro</em> release studies.</p></div><div><h3>Results</h3><p>From the results it was found that, the prepared erythrocytes were with ≈200 μm size. After optimization of the various parameters the carrier erythrocytes were found to have higher drug content and hemoglobin release at 0.25% NaCl of hypotonic, 2% NaCl of hypertonic, 1.5% initial drug concentration and after freezing for a day. The optimized erythrocyte carriers were found to be stable for external shocks with no significant change in haemotological parameters and with first order release of piperine.</p></div><div><h3>Conclusion</h3><p>The piperine enclosed carrier erythrocytes are going to be the promising option for treating hepatic toxicity.</p></div>","PeriodicalId":11284,"journal":{"name":"Drug Invention Today","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.dit.2013.04.006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87248057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design and development of microparticulate drug delivery system of Glimepiride for controlled release","authors":"Irisappan Sarath Chandiran ,&nbsp;Balagani Pavan Kumar ,&nbsp;Korlakanti Narasimha Jayaveera","doi":"10.1016/j.dit.2013.06.006","DOIUrl":"10.1016/j.dit.2013.06.006","url":null,"abstract":"<div><h3>Objective</h3><p>The objective of the present investigation was to develop Glimepiride loaded cellulose acetate controlled release micro particulates.</p></div><div><h3>Methods</h3><p>The Glimepiride micro particles were prepared by emulsion solvent evaporation method. The effects of different parameters on the drug content and on the release of the drug from the micro particulates were investigated. Micro particulates were characterized in terms of encapsulation efficiency, particle size, drug loading, FTIR, DSC, SEM analysis and drug release studies.</p></div><div><h3>Results</h3><p>An increase in core:coat ratio from 1:1 to 1:3 caused an increase in the encapsulation efficiency and average particle size. FTIR and DSC studies exhibited there is no interaction between drug and excipients. The SEM studies clearly showed that the micro particles exhibited good spherical nature. The in vitro release of Glimepiride from micro particles in phosphate buffer of pH 7.8 was found to be dependent on molecular weight and copolymer type. The release kinetics of Glimepiride from optimized formulation followed zero order and peppas mechanism. The release exponent showed that the values of ‘<em>n</em>’ were between 0.95 and 1.07 indicating that the release from micro particulates was predominantly by non-fickian transport mechanism. The dissolution profiles of optimized formulation before and after stability studies were evaluated as per ICH guidelines.</p></div><div><h3>Conclusion</h3><p>The results demonstrate the feasibility of the model in the development of extended release dosage form.</p></div>","PeriodicalId":11284,"journal":{"name":"Drug Invention Today","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.dit.2013.06.006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75318792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review on transfer factor an immune modulator","authors":"Marimuthu Krishnaveni","doi":"10.1016/j.dit.2013.04.002","DOIUrl":"10.1016/j.dit.2013.04.002","url":null,"abstract":"<div><h3>Aim</h3><p>To understand what is transfer factor and its significance in stimulating immune system which is necessary for the general maintenance of health.</p></div><div><h3>Methods</h3><p>Articles were collected from net sources.</p></div><div><h3>Results</h3><p>Basics, mechanism of action, safety aspects of transfer factor were discussed in this review. Diseases showing positive result with transfer factor treatment are tabulated.</p></div><div><h3>Conclusion</h3><p>From this it is concluded that it is a dialyzable, active protein initiator molecule able to transfer cell mediated immunity from healthy donor to recipient who is non-immune thus keeping one away from infection.</p></div>","PeriodicalId":11284,"journal":{"name":"Drug Invention Today","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.dit.2013.04.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73476225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}