Fabian Bamberg, Christopher L Schlett, Svenja Caspers, Steffen Ringhof, Matthias Günther, Jochen G Hirsch, Julia Rüdebusch, Pavlína Miklánková, Nora Bittner, Christiane Jockwitz, Michael Forsting, Norbert Hosten, Rudolph Kaaks, Hans-Ulrich Kauczor, Thomas Kroenke, Thoralf Niendorf, Annette Peters, Tobias Pischon, Andreas Stang, Klaus Berger, Henry Völzke
{"title":"Baseline MRI Examination in the NAKO Health Study—Findings on Feasibility, Participation and Dropout Rates, Comfort, and Image Quality.","authors":"Fabian Bamberg, Christopher L Schlett, Svenja Caspers, Steffen Ringhof, Matthias Günther, Jochen G Hirsch, Julia Rüdebusch, Pavlína Miklánková, Nora Bittner, Christiane Jockwitz, Michael Forsting, Norbert Hosten, Rudolph Kaaks, Hans-Ulrich Kauczor, Thomas Kroenke, Thoralf Niendorf, Annette Peters, Tobias Pischon, Andreas Stang, Klaus Berger, Henry Völzke","doi":"10.3238/arztebl.m2024.0151","DOIUrl":"10.3238/arztebl.m2024.0151","url":null,"abstract":"<p><strong>Background: </strong>Magnetic resonance imaging (MRI) yields important information on the development and current status of many different diseases. Whole-body MRI was accordingly made a part of the multicenter, population-based NAKO Health Study. The present analysis concerns the feasibility of the baseline MRI examination and various aspects of quality assurance over the period 2014-2019.</p><p><strong>Methods: </strong>32 252 participants in the NAKO Health Study, aged 20 to 74, who had no contraindication to MRI were invited to undergo scanning in one of five MRI study centers across Germany. The whole-body MRI scan took about one hour and consisted of sequences for the visualization of structural and functional features of the brain, musculoskeletal system, cardiovascular system, and thoracoabdominal system. A comprehensive quality-assurance assessment was carried out, with evaluation of adverse events, the completeness of the MRI protocols, the participants' subjective perceptions, and image quality.</p><p><strong>Results: </strong>31 578 participants (97.9%) were successfully included in the MRI study. They reported a high level of comfort and suffered no severe adverse events (mild adverse events occurred in only four participants). Depending on the imaging sequence, the image quality was rated as excellent in 80.2% to 96.8% of cases. Quality assessment with respect to structural features of the brain revealed high consistency across study centers, as well as with regard to age- and sex-based differences in brain volume (men, 1203.81 ± 102.06 cm³; women, 1068.10 ± 86.69 cm³).</p><p><strong>Conclusion: </strong>Whole-body MRI was successfully implemented in the NAKO baseline examination and was associated with high patient comfort and very good image quality. The imaging biomarkers of the brain confirmed previously observed differences based on age and sex, underscoring the feasibility of data pooling.</p>","PeriodicalId":11258,"journal":{"name":"Deutsches Arzteblatt international","volume":" Forthcoming","pages":"587-593"},"PeriodicalIF":6.5,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141999530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jan Hoffmann, Angela Kribs, Martin Dübbers, Carsten Hagenbeck, Nadine Scholten
{"title":"Implementation of the Joint Federal Committee's Quality Assurance Guideline for Premature and Full-Term Neonates—The Allocation of Newborn Infants by Hospital Care Level in Germany.","authors":"Jan Hoffmann, Angela Kribs, Martin Dübbers, Carsten Hagenbeck, Nadine Scholten","doi":"10.3238/arztebl.m2024.0108","DOIUrl":"https://doi.org/10.3238/arztebl.m2024.0108","url":null,"abstract":"","PeriodicalId":11258,"journal":{"name":"Deutsches Arzteblatt international","volume":"121 18","pages":"608-609"},"PeriodicalIF":6.5,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142805797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Benedikt Kolbrink, Nassim Kakavand, Jakob C Voran, Helena U Zacharias, Axel Rahmel, Serge Vogelaar, Silke Schicktanz, Felix Braun, Roland Schmitt, Friedrich A von Samson-Himmelstjerna, Kevin Schulte
{"title":"Allocation Rules and Age-Dependent Waiting Times for Kidney Transplantation.","authors":"Benedikt Kolbrink, Nassim Kakavand, Jakob C Voran, Helena U Zacharias, Axel Rahmel, Serge Vogelaar, Silke Schicktanz, Felix Braun, Roland Schmitt, Friedrich A von Samson-Himmelstjerna, Kevin Schulte","doi":"10.3238/arztebl.m2024.0137","DOIUrl":"10.3238/arztebl.m2024.0137","url":null,"abstract":"<p><strong>Background: </strong>Rigid age limits in the current allocation system for post-mortem donor kidneys in Germany may have problematic effects. The new German national transplantion registry enables data analysis with respect to this question.</p><p><strong>Methods: </strong>Using anonymized data from the German national transplantion registry, we extracted and evaluated information on the recipients and postmortem donors of kidneys that were allocated in Germany through Eurotransplant over the period 2006-2020.</p><p><strong>Results: </strong>Data on 19 664 kidney transplantations in Germany from 2006 to 2020 were analyzed. The median waiting time for kidney transplantation was 5.8 years. Persons under age 18 waited a median of 1.7 years; persons aged 18 to 64, 7.0 years; and persons aged 65 and older, 3.8 years. Over the period of observation, postmortem kidneys were transplanted into 401 people of age 64 (2.0% of all organ recipients) and 1,393 people of age 65 (7.1% of all organ recipients). The difference in waiting times between allocation programs for persons under age 65 (ETKAS, \"Eurotransplant Kidney Allocation System\") and those aged 65 and older (ESP, \"Eurotransplant Senior Program\") increased over the period of observation, from 2.6 years in 2006-2010 to 4.1 years in 2017-2020.</p><p><strong>Conclusion: </strong>The rigid age limits in the current allocation rules for post-mortem kidney donations in Germany are prolonging the waiting times for transplants among patients aged 18 to 64. We think these rules need to be fundamentally reassessed.</p>","PeriodicalId":11258,"journal":{"name":"Deutsches Arzteblatt international","volume":" Forthcoming","pages":"559-565"},"PeriodicalIF":6.5,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11551543/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141901277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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