Diabetic Medicine最新文献

{"title":"The cardio-renal-metabolic role of the nod-like receptor protein-3 and senescence-associated secretory phenotype in early sodium/glucose cotransporter-2 inhibitor therapy in people with diabetes who have had a myocardial infarction.","authors":"M U Shah, C L Cliff, P E Squires, K Lee, C E Hills","doi":"10.1111/dme.70059","DOIUrl":"https://doi.org/10.1111/dme.70059","url":null,"abstract":"<p><strong>Aims: </strong>Following an acute myocardial infarction (AMI), individuals with type 2 diabetes (T2DM) have a 2-to-3 fold increased risk of mortality compared to those without diabetes, and globally cardiorenal complications account for 50% of diabetes-related deaths. The use of sodium/glucose cotransporter-2 inhibitors (SGLT2i) in people with T2DM-AMI is associated with decreased inflammatory burden and improved cardiorenal outcomes. The mechanisms behind this protection are unclear and form the basis of this study.</p><p><strong>Methods: </strong>This single centre, prospective study with randomisation will utilise plasma and monocyte-derived macrophages from patients with T2DM who have recently had an AMI and are prescribed Empagliflozin (SGLT2i) either immediately following the acute cardiac event or at 3 months post-AMI.</p><p><strong>Results: </strong>The study will test the hypothesis that Empagliflozin provides anti-inflammatory protection by suppressing systemic NOD-like receptor protein-3 (NLRP3) inflammasome activation and the pro-inflammatory senescence-associated secretory phenotype (SASP), perpetrators of sterile (non-pathogen evoked) inflammation linked to poor clinical outcomes in T2DM-AMI patients. The study will also assess the benefits of early intervention on these parameters.</p><p><strong>Conclusions: </strong>Elucidating a role for an SGLT2i in suppressing sterile inflammation will enhance understanding of how they can be used effectively to treat cardiorenal complications and will identify novel pathways for future intervention. Furthermore, the optimal timing of when to initiate SGLT2i therapy post-AMI is unclear. Correlating the level of protection to the onset of therapy in individuals with T2DM, AMI and at cardiovascular risk will establish if Empagliflozin provides greater benefit when intervention is initiated earlier.</p>","PeriodicalId":11251,"journal":{"name":"Diabetic Medicine","volume":" ","pages":"e70059"},"PeriodicalIF":3.2,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HLA haplotype diversity, islet autoantibody status and discriminative ability of type 1 diabetes genetic risk score in Indians.","authors":"Alagu Sankareswaran, Pooja Kunte, Diane P Fraser, Mobeen Shaik, Dimple Lavanuru, Michael N Weedon, Richard A Oram, Chittaranjan S Yajnik, Giriraj R Chandak","doi":"10.1111/dme.70041","DOIUrl":"https://doi.org/10.1111/dme.70041","url":null,"abstract":"<p><strong>Aims: </strong>We have reported that a 9SNPs type 1 diabetes (T1D) Genetic Risk Score (GRS) developed from European data had a lower power in Indians to distinguish T1D from type 2 diabetes (T2D). We explore the performance of an improved (67SNPs) T1DGRS and also the potential reasons for lower discriminative ability to classify types of diabetes in Indians.</p><p><strong>Methods: </strong>We studied the discriminative ability of a 67SNPs European T1DGRS in 611 clinically diagnosed T1D and 1153 T2D patients, and 321 non-diabetic controls, using receiver operating characteristic (ROC) area under the curve (AUC). We also compared the frequency and effect sizes of HLA risk haplotypes between Indians and Europeans.</p><p><strong>Results: </strong>The T1DGRS was discriminative of T1D from T2D and controls. However, the ability is lower in Indians than Europeans (AUC, Europeans 0.92, Indians all T1D 0.83, AA-positive 0.86). The T1DGRS was higher in AA-positive than in AA-negative persons [13.01 (12.79-13.23) vs. 12.09 (11.64-12.56)], p < 0.0001. The association of common HLA-DQA1 ~ HLA-DQB1 haplotypes was broadly similar; however, important differences were noted in the frequency, direction and magnitude of effect for some haplotypes between Indians and Europeans.</p><p><strong>Conclusions: </strong>We confirm broad applicability of European 67SNPs T1DGRS to Indian T1D persons. However, differences in HLA allele frequencies, magnitude and directional differences reduced the predictive value. Our results stress the need to generate ancestry-specific GRS, which we plan to do in the near future.</p>","PeriodicalId":11251,"journal":{"name":"Diabetic Medicine","volume":" ","pages":"e70041"},"PeriodicalIF":3.2,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143977540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Skin reactions to Freestyle Libre Pro among individuals with and without diabetes.","authors":"Suresh Rama Chandran, Karen Jui Lin Choo, Hong Chang Tan, May Zin Oo, Celine Yu Hui Wong, Wei Mian Ang, Daphne Gardner","doi":"10.1111/dme.70062","DOIUrl":"https://doi.org/10.1111/dme.70062","url":null,"abstract":"","PeriodicalId":11251,"journal":{"name":"Diabetic Medicine","volume":" ","pages":"e70062"},"PeriodicalIF":3.2,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143985679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age- and sex-dependent lipid trajectories in children and adolescents with type 1 diabetes-A Danish nationwide registry-based study.","authors":"Emma Lund, Dorte Vistisen, Jannet Svensson, Niels H Birkebaek, Pernille F Rønn","doi":"10.1111/dme.70055","DOIUrl":"https://doi.org/10.1111/dme.70055","url":null,"abstract":"<p><strong>Aims: </strong>To examine age and sex differences in lipid trajectories in paediatric type 1 diabetes. Secondly, to examine the effect of HbA_1c and BMI on low-density lipoprotein (LDL-C) trajectories and the proportion of children meeting the LDL-C threshold for intervention according to ISPAD guidelines.</p><p><strong>Methods: </strong>Information on children and adolescents with type 1 diabetes was retrieved from DanDiabKids from 2005 to 2019. All individuals <19 years with at least two lipid measurements were included. Linear mixed effects models were used to model lipid trajectories over age with adjustment for potential confounders. Sex differences were examined as interactions.</p><p><strong>Results: </strong>We analysed 1188 girls and 1,288 boys with a total of 8563 lipid measurements and a median (Q1-Q3) diabetes duration of 6.4 years (4-9.6 years) at last visit. Total cholesterol (TC), LDL-C and triglycerides increased across all ages for girls, while high-density lipoprotein (HDL-C) declined slightly. In boys, TC, LDL-C and HDL-C decreased from around 12 years, while triglycerides increased over the entire age scale. Higher HbA_1c and BMI z-scores were associated with higher LDL-C. Depending on age and sex, 19%-42% of individuals had LDL-C values above the limit for intervention.</p><p><strong>Conclusions: </strong>TC, LDL-C, HDL-C and triglycerides vary with age and sex in children and adolescents with type 1 diabetes. In addition, a high proportion of adolescents, particularly girls, have LDL-C levels above the intervention threshold. The results call for more research on age- and sex-specific levels of LDL-C that should lead to intervention to prevent future cardiovascular events.</p>","PeriodicalId":11251,"journal":{"name":"Diabetic Medicine","volume":" ","pages":"e70055"},"PeriodicalIF":3.2,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accelerating diabetes innovation for real-world community impact through interdisciplinary research: Who is at the table?","authors":"Elizabeth Holmes-Truscott, Joanne Jordan, Leonid Churilov, Wendy Davis, Sarah Glastras, Marlena Klaic, Meaghan Read, An Tran-Duy, David O'Neal, Elif Ekinci","doi":"10.1111/dme.70057","DOIUrl":"https://doi.org/10.1111/dme.70057","url":null,"abstract":"","PeriodicalId":11251,"journal":{"name":"Diabetic Medicine","volume":" ","pages":"e70057"},"PeriodicalIF":3.2,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143968288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Simplera Sync™ sensors and Extended™ Wear Infusion Sets on glycaemia and system performance of the MiniMed™ 780G system in children and young adults with previously high HbA1c.","authors":"Venus R Michaels, Alisa Boucsein, Yongwen Zhou, Shirley D Jones, Ryan G Paul, Esko Wiltshire, Craig Jefferies, Martin I de Bock, Benjamin J Wheeler","doi":"10.1111/dme.70048","DOIUrl":"https://doi.org/10.1111/dme.70048","url":null,"abstract":"<p><strong>Aims: </strong>The MiniMed™ 780G improves glycaemia and reduces burden in type 1 diabetes. We investigated how new all-in-one \"Simplera Sync™\" sensors and 7-day Extended™ Wear Infusion Sets (EIS) affect glycaemia and system performance in young people with previously elevated HbA1c levels (≥69 mmol/mol [≥8%]) after transitioning from 780G with Guardian 4™ sensors and 3-day infusion sets.</p><p><strong>Methods: </strong>We conducted an extension phase analysis in 75 participants (aged 7-25 years) initially enrolled in the CO-PILOT randomised controlled trial. For this analysis, baseline was defined as the period following the use of 780G with Guardian 4™ sensors and 3-day infusion sets. Participants then transitioned to 780G with Simplera Sync™ and EIS. We compared glycaemic and system performance outcomes from baseline to those after the transition to 780G with Simplera Sync™ and EIS.</p><p><strong>Results: </strong>Baseline HbA1c was 66.1 mmol/mol ± 14.2 mmol/mol and remained stable at 66.7 mmol/mol ± 11.2 mmol/mol after the transition (p = 0.38). Time in range (3.9-10.0 mmol/L [70-180 mg/dL]) at baseline was 58.5% ± 14.9% and 60.4% ± 15.7% after transition (p = 0.09). Time in tight range (3.9-7.8 mmol/L [70-140 mg/dL]) increased from 38.1% ± 13.1% at baseline to 40.5% ± 13.6% after the transition (p = 0.04). While using 780G with Simplera Sync™ and EIS, automation time increased from baseline 79.2% ± 25.9% to 85.8% ± 21.8% (p = 0.007), and sensor wear time from 80.7% ± 22.4% at baseline to 88.4% ± 17.2% (p < 0001).</p><p><strong>Conclusions: </strong>Simplera Sync™ and EIS improved time in automation and sensor wear time when using 780G AHCL in this high-risk young population. This was associated with incremental improvement in time in tight range despite the challenges of this population.</p>","PeriodicalId":11251,"journal":{"name":"Diabetic Medicine","volume":" ","pages":"e70048"},"PeriodicalIF":3.2,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between sleep duration and obesity in patients with type 2 diabetes: A longitudinal study","authors":"Esraa A. Makhdom,&nbsp;Alisha Maher,&nbsp;Ryan Ottridge,&nbsp;Mathew Nicholls,&nbsp;Asad Ali,&nbsp;Brendan G. Cooper,&nbsp;Ramzi A. Ajjan,&nbsp;Srikanth Bellary,&nbsp;Wasim Hanif,&nbsp;Fahmy Hanna,&nbsp;David Hughes,&nbsp;Vijay Jayagopal,&nbsp;Rajni Mahto,&nbsp;Mayank Patel,&nbsp;James Young,&nbsp;Ananth U. Nayak,&nbsp;Mimi Z. Chen,&nbsp;Julie Kyaw-Tun,&nbsp;Susana Gonzalez,&nbsp;Ravikanth Gouni,&nbsp;Anuradhaa Subramanian,&nbsp;Nicola J. Adderley,&nbsp;Abd A. Tahrani","doi":"10.1111/dme.70051","DOIUrl":"10.1111/dme.70051","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Obesity is prevalent in patients with type 2 diabetes (T2D) and negatively impacts diabetes outcomes. While studies in the general population have established a link between sleep duration and obesity, this relationship in T2D remains unclear.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To assess the association between sleep duration and adiposity in patients with T2D.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This prospective study of adults enrolled in the SLEEP T2D study from 13 UK NHS Trusts. Sleep duration was self-reported using the Pittsburgh Sleep Quality Index (PSQI) and categorized as short (≤ 6 h/ night), long (&gt; 9 h/night) or (normal &gt; 6-9 h/night). Adiposity was assessed using body mass index (BMI) and waist circumference.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among 229 patients (61% male, mean age 61.2 (<span></span><math>\u0000 <semantics>\u0000 <mrow>\u0000 <mo>±</mo>\u0000 </mrow>\u0000 </semantics></math>11.7) years, 63.7% with BMI ≥ 30 kg/m²). At baseline, sleep duration negatively correlated with BMI (<i>r</i> = −0.27, <i>p</i> &lt; 0.001) and waist circumference (<i>r</i> = −0.25, <i>p</i> = 0.001). After adjusting for potential confounders in different models, short sleep duration was associated with higher BMI (β = −1.01; <i>p</i> = 0.006) and waist circumference (β = −1.91; <i>p</i> = 0.01). Following a median follow-up of 26.5 months, short sleep at baseline was associated with a 5% or more gain in BMI (adjusted OR 10.03; 95% CI 1.55–64.84; <i>p</i> = 0.01).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Short sleep duration is associated with higher adiposity measures (BMI and waist circumference) and weight gain in patients with T2D. Addressing sleep duration may reduce the burden of obesity in T2D, and future studies in this area are warranted.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11251,"journal":{"name":"Diabetic Medicine","volume":"42 6","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/dme.70051","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143997156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical implications of a history of pre-eclampsia in women with type two diabetes mellitus","authors":"Madeline C. Pearson,&nbsp;Huan Wang,&nbsp;Colin E. Murdoch,&nbsp;Alexander S. F. Doney","doi":"10.1111/dme.70046","DOIUrl":"10.1111/dme.70046","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>The consequences of pre-eclampsia (PE) are not limited to pregnancy; a single episode predisposes mothers to serious future health outcomes. Little is known about how PE impacts the course of type 2 diabetes (T2D) and associated microvascular diseases.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The Scottish Care Information for Diabetes data for individuals with diabetes in NHS Tayside and Fife was linked with Scottish maternity morbidity records. A nested case–control study compared BMI, HDL cholesterol, systolic blood pressure(SBP) and HbA1c measures at T2D diagnosis between women with prior pregnancies from 1921 to 2022 affected or unaffected by PE using linear regression and adjusted for the other aforementioned variables. Cox regression models assessed how a PE history influenced the risk of future microvascular complications following T2D diagnosis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In total, 6055 women were eligible: 726 (12%) had a PE-pregnancy and 5329 (88%) had only PE-free pregnancies, with ~20 years between pregnancy and T2D diagnosis. At T2D diagnosis, women with a PE history had higher BMI (38.3 kg/m² vs. 35.7 kg/m², <i>p</i> &lt; 0.001), higher SBP (139 mmHg vs. 135 mmHg, <i>p</i> &lt; 0.001), lower HDL cholesterol (1.18 mmol/L vs. 1.21 mmol/L, <i>p</i> = 0.002) and were diagnosed 3.2 years earlier (<i>p</i> &lt; 0.001). A PE history was associated with increased microvascular disease risk (HR 1.26 95% CI 1.12–1.42, <i>p</i> &lt; 0.001): diabetic retinopathy (HR 1.22 95% CI 1.07–1.38, <i>p</i> = 0.003); chronic kidney disease (HR 1.35 95% CI 1.06–1.71, <i>p</i> = 0.016); diabetic proteinuric kidney disease (HR 2.45 95% CI 1.03–5.81, <i>p</i> &lt; 0.001). Women with a PE history were ~5 years younger when they developed cardiovascular disease (55.7 years vs. 60.6 years, <i>p</i> &lt; 0.001) and all-cause death (60.1 years vs. 65.6 years, <i>p</i> &lt; 0.0001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>At T2D diagnosis, women with a PE history are younger, with more severe clinical presentations and increased risk of developing T2D microvascular complications. This highlights the crucial need for changes to the long-term care of this high-risk group, with aggressive risk-factor management and continued clinical assessment.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11251,"journal":{"name":"Diabetic Medicine","volume":"42 6","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/dme.70046","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143997158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe hypertriglyceridaemia and lipaemia retinalis in a child presenting with diabetic ketoacidosis","authors":"Kathryn Kimber,&nbsp;Eleanor Crawley,&nbsp;Stephanie Jones","doi":"10.1111/dme.70026","DOIUrl":"10.1111/dme.70026","url":null,"abstract":"","PeriodicalId":11251,"journal":{"name":"Diabetic Medicine","volume":"42 6","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143987472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obesity-related glomerulopathy: How it happens and future perspectives","authors":"Jian-Wen Samuel Lee-Boey,&nbsp;Jia-Kai Tan,&nbsp;Zhan-Foong Lim,&nbsp;Francesco Zaccardi,&nbsp;Kamlesh Khunti,&nbsp;Majid Ezzati,&nbsp;Edward W. Gregg,&nbsp;Lee-Ling Lim","doi":"10.1111/dme.70042","DOIUrl":"10.1111/dme.70042","url":null,"abstract":"<p>Obesity-related glomerulopathy (ORG) is an emerging complication of excess adiposity. Its incidence rises alongside the obesity pandemic. Up to 40% of individuals can be affected by ORG, irrespective of the status of glomerular filtration rate and albuminuria. ORG is a distinct histological diagnosis based on kidney biopsy, showing classical features of an enlarged glomerulus with and without focal segmental glomerulosclerosis in the perihilar region seen with all categories of obesity. About 10% of individuals with ORG may progress to end-stage kidney disease. The invasive nature of kidney biopsy highlights the need for non-invasive biomarkers for improved screening, diagnosis and risk prediction of ORG. These biomarkers may narrow the gaps in the management of ORG by improving: (1) screening, diagnosis and differentiation of ORG from non-ORG conditions; (2) risk prediction and stratification of individuals at risk of progression to end-stage kidney disease including the detection of trajectories of progression; (3) monitoring of treatment safety and effectiveness and (4) development of novel therapeutic targets. In the present review, we discussed the pathophysiology, emerging biomarkers (such as kidney injury molecule-1 [KIM-1], uromodulin, klotho, circulating microRNA-21 [miR-21]) and future treatment strategies (metabolic surgery, sodium-glucose cotransporter-2 inhibitors, incretin-based therapy and non-steroidal mineralocorticoid antagonists) of ORG.</p>","PeriodicalId":11251,"journal":{"name":"Diabetic Medicine","volume":"42 6","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/dme.70042","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}