Emma Lund, Dorte Vistisen, Jannet Svensson, Niels H Birkebaek, Pernille F Rønn
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引用次数: 0
Abstract
Aims: To examine age and sex differences in lipid trajectories in paediatric type 1 diabetes. Secondly, to examine the effect of HbA1c and BMI on low-density lipoprotein (LDL-C) trajectories and the proportion of children meeting the LDL-C threshold for intervention according to ISPAD guidelines.
Methods: Information on children and adolescents with type 1 diabetes was retrieved from DanDiabKids from 2005 to 2019. All individuals <19 years with at least two lipid measurements were included. Linear mixed effects models were used to model lipid trajectories over age with adjustment for potential confounders. Sex differences were examined as interactions.
Results: We analysed 1188 girls and 1,288 boys with a total of 8563 lipid measurements and a median (Q1-Q3) diabetes duration of 6.4 years (4-9.6 years) at last visit. Total cholesterol (TC), LDL-C and triglycerides increased across all ages for girls, while high-density lipoprotein (HDL-C) declined slightly. In boys, TC, LDL-C and HDL-C decreased from around 12 years, while triglycerides increased over the entire age scale. Higher HbA1c and BMI z-scores were associated with higher LDL-C. Depending on age and sex, 19%-42% of individuals had LDL-C values above the limit for intervention.
Conclusions: TC, LDL-C, HDL-C and triglycerides vary with age and sex in children and adolescents with type 1 diabetes. In addition, a high proportion of adolescents, particularly girls, have LDL-C levels above the intervention threshold. The results call for more research on age- and sex-specific levels of LDL-C that should lead to intervention to prevent future cardiovascular events.
期刊介绍：
Diabetic Medicine, the official journal of Diabetes UK, is published monthly simultaneously, in print and online editions.
The journal publishes a range of key information on all clinical aspects of diabetes mellitus, ranging from human genetic studies through clinical physiology and trials to diabetes epidemiology. We do not publish original animal or cell culture studies unless they are part of a study of clinical diabetes involving humans. Categories of publication include research articles, reviews, editorials, commentaries, and correspondence. All material is peer-reviewed.
We aim to disseminate knowledge about diabetes research with the goal of improving the management of people with diabetes. The journal therefore seeks to provide a forum for the exchange of ideas between clinicians and researchers worldwide. Topics covered are of importance to all healthcare professionals working with people with diabetes, whether in primary care or specialist services.
Surplus generated from the sale of Diabetic Medicine is used by Diabetes UK to know diabetes better and fight diabetes more effectively on behalf of all people affected by and at risk of diabetes as well as their families and carers.”
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