Digital Biomarkers最新文献

{"title":"GPS and Smartphone Technology for Real-World Measurement of Community Mobility in Healthcare.","authors":"Sara Nataletti, Megan K O'Brien, Rachel Maronati, Francesco Lanotte, Shreya Aalla, Christian Poellabauer, Brad D Hendershot, John M Looft, Arun Jayaraman","doi":"10.1159/000548017","DOIUrl":"https://doi.org/10.1159/000548017","url":null,"abstract":"<p><strong>Introduction: </strong>A primary goal of physical medicine and rehabilitation is restoring community mobility after injury or illness. However, there is no clinically accepted real-world method to measure community mobility, which fundamentally limits our ability to evaluate treatment effectiveness. This study aimed to develop and validate a digital framework using GPS-enabled smartphones and inertial sensors to monitor community mobility and estimate clinical function in individuals with chronic stroke or lower limb amputation (LLA).</p><p><strong>Methods: </strong>Ninety individuals with chronic stroke or LLA underwent remote monitoring for 3-9 months. Participants completed standard clinical assessments, and daily mobility data were extracted from GPS and step count features. We conducted four analyses: (1) characterization of group- and individual-level community mobility, (2) evaluation of mobility changes following a mobility-targeted intervention in a single case participant, (3) development of machine-learned models to predict clinical gait outcomes using community data, and (4) estimation of the minimum number of days needed to reliably predict functional outcomes.</p><p><strong>Results: </strong>Community mobility measures revealed substantial variability both across and within individuals, reflecting diverse functional profiles. In a case study, a participant with LLA demonstrated increased activity and movement diversity following a personalized intervention. Machine-learned models estimated 6-Minute Walk Test and 10-Meter Walk Test scores with clinically acceptable error margins (7-10%) using as few as 14 days of community data. Reliable predictions were achievable with just 3-6 days of monitoring.</p><p><strong>Conclusions: </strong>GPS- and smartphone-based monitoring offer a feasible and scalable approach to assess real-world mobility. This approach could close a critical gap in the care continuum and enable us to fully evaluate the real-world impact of treatment interventions while also reducing reliance on frequent in-person evaluations.</p>","PeriodicalId":11242,"journal":{"name":"Digital Biomarkers","volume":"9 1","pages":"155-170"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12503853/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145250284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monitoring Mobility at Home: The GAIT-HUB Sensor-Based Protocol for Remote Gait Analysis.","authors":"Giuseppina Pilloni, Timothy Sung Hyuk Ko, Erica Kreisberg, Josh Geel, Josef Maxwell Gutman, Carrie Sammarco, Cheongeun Oh, Leigh Charvet","doi":"10.1159/000547176","DOIUrl":"10.1159/000547176","url":null,"abstract":"<p><strong>Introduction: </strong>Gait is a critical indicator of neurological health, with changes often signaling underlying decline. We developed a remote gait monitoring protocol using off-the-shelf shoe-based sensors (RunScribe) to assess gait parameters in real-world home settings. This protocol, known as Gait Assessment with Innovative Technologies - Home-based Use and Benefit (GAIT-HUB), was tested in individuals with multiple sclerosis (MS), a population at high risk for gait impairment due to the disease's variable progression.</p><p><strong>Methods: </strong>Participants with MS completed an in-clinic baseline gait assessment using a validated sensor (G-Sensor®) and three weekly, remotely supervised gait assessments at home using the RunScribe sensors. Gait parameters were compared across devices using intra-class correlation coefficients (ICCs) and Bland-Altman analyses. Longitudinal reliability of remote assessments and system usability score (SUS) were evaluated.</p><p><strong>Results: </strong>Twenty-nine participants (76% women, ages 19-67, PDDS range 0-5) successfully completed the home-based assessments. High agreement between devices was observed for gait speed, stride length, and cadence (ICCs >0.90), though phases like stance and swing showed more variability. Bland-Altman analyses indicated minimal bias in most parameters. Longitudinal assessments demonstrated strong reliability (ICCs >0.87) for key metrics, and SUS indicated good-to-excellent usability of the remote protocol.</p><p><strong>Conclusion: </strong>The GAIT-HUB protocol enables reliable and feasible home-based gait monitoring using wearable sensors that patients can easily self-apply. This approach provides valuable insights into daily mobility patterns beyond clinical visits, supporting more precise and timely assessments of functional status between appointments and offering the potential for seamless integration into telemedicine routine care.</p>","PeriodicalId":11242,"journal":{"name":"Digital Biomarkers","volume":"9 1","pages":"140-154"},"PeriodicalIF":0.0,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12310191/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Pilot Study of Smartphone Eye Tracking for Detection of Positional Nystagmus.","authors":"Vidith Phillips, Pouya B Bastani, Hector Rieiro, David E Hale, Jorge Otero-Millan, David S Zee, David E Newman-Toker, Ali Saber Tehrani","doi":"10.1159/000547008","DOIUrl":"10.1159/000547008","url":null,"abstract":"<p><strong>Introduction: </strong>Detecting positional nystagmus is essential for diagnosing benign paroxysmal positional vertigo (BPPV). Therefore, developing methods to streamline this diagnosis can improve timely patient management and help prevent unnecessary emergency department visits. We aimed to evaluate the accuracy of a smartphone eye-tracking application in quantifying eye movements during positional testing to detect positional nystagmus.</p><p><strong>Methods: </strong>We recruited patients with positional dizziness suspected of having BPPV from the vestibular rehabilitation clinic and the consult service for dizzy patients (Tele-Dizzy) at Johns Hopkins Hospital. Using an in-house smartphone app (EyePhone), we recorded eye movements during the Dix-Hallpike and supine roll tests. Two expert clinicians reviewed the videos, and a third one adjudicated the disagreements. Eye position data obtained from the EyePhone app were analyzed with an embedded algorithm to identify positional nystagmus. Using the adjudicated expert review as the reference standard, we evaluated EyePhone's accuracy in detecting positional nystagmus by calculating the sensitivity, specificity, and predictive values.</p><p><strong>Results: </strong>We recruited ten participants, 60% women, with an average age of 61.8 years. We reviewed 23 positional eye movement videos of participants while undergoing positional testing. The final adjudicated expert review identified positional nystagmus in 3 (13%) videos. The phone application traces indicated nystagmus in all 3 of these videos (sensitivity = 100% [95% CI = 44-100%]) and correctly ruled it out in 20 traces (specificity = 100% [95% CI = 84-100%]). The app demonstrated a positive predictive value of 100% (95% CI = 43-100%) and a negative predictive value of 100% (95% CI = 84-100%).</p><p><strong>Conclusions: </strong>This small pilot study shows proof-of-concept that a smartphone eye-tracking app without special phone attachments can detect positional nystagmus.</p>","PeriodicalId":11242,"journal":{"name":"Digital Biomarkers","volume":"9 1","pages":"124-129"},"PeriodicalIF":0.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12274059/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144674093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypertension Screening Using Acoustic Analysis and Machine Learning of Random Speech Samples: A Feasibility Study.","authors":"Behrad TaghiBeyglou, Jaycee Kaufman, Yan Fossat","doi":"10.1159/000547077","DOIUrl":"10.1159/000547077","url":null,"abstract":"<p><strong>Introduction: </strong>Hypertension is the leading risk factor for cardiovascular disorders. Early detection and initiation of treatment have been identified as the most effective ways to reduce the burden of hypertension. The most common method for detecting hypertension is blood pressure measurement, typically performed with cuff-based devices, where systolic pressure (SBP) and diastolic pressure (DBP) are measured through Korotkoff sounds. Although this method is accurate and non-invasive, it requires technical expertise and is often inaccessible in rural and remote areas. In this study, we investigated the feasibility of using overt speech (random speech corpora) through multiple short recordings for hypertension screening based on two hypertension guidelines: (1) SBP ≥135 mm Hg OR DBP ≥85 mm Hg, and (2) SBP ≥140 mm Hg OR DBP ≥90 mm Hg.</p><p><strong>Methods: </strong>We incorporated speech recordings from 573 participants (197 women) with diverse ages and body mass index and extracted temporal, spectral, and nonlinear acoustic features through three different frameworks, all of which are based on classical and boosted machine learning models. The models were evaluated using a leave-one-subject-out cross-validation scheme.</p><p><strong>Results: </strong>Our proposed pipeline achieved a balanced accuracy (BACC) of 61% for males and 70% for females under the relaxed criterion (SBP ≥135 OR DBP ≥85), and a BACC of 71% for males and 78% for females under the stricter European Society of Hypertension (ESH) guidelines (SBP ≥140 OR DBP ≥90).</p><p><strong>Conclusion: </strong>These results demonstrate the potential of employing overt speech alongside acoustic analysis for hypertension screening.</p>","PeriodicalId":11242,"journal":{"name":"Digital Biomarkers","volume":"9 1","pages":"130-139"},"PeriodicalIF":0.0,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12286592/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144697782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Smartphone Application to Measure Walking Cadence before Major Abdominal Surgery in Older Adults.","authors":"Daniel Steven Rubin, Marcin Straczkiewicz, Emi Yamamoto, Maria Lucia L Madariaga, Mark Ferguson, Jennifer S Brach, Nancy W Glynn, Sang Mee Lee, Margaret Danilovich, Megan Huisingh-Scheetz","doi":"10.1159/000545982","DOIUrl":"10.1159/000545982","url":null,"abstract":"<p><strong>Introduction: </strong>Preoperative physical functional assessments (i.e., assessments that measure capability to perform physical activity) are integral to estimate perioperative risk for older adults. However, these assessments are not routinely performed in-clinic prior to surgery. Walking cadence, or the number of steps walked in a specified amount of time (i.e., steps/min), measures activity intensity and may be able to identify high-risk patients prior to surgery. Smartphones can measure walking characteristics and guide patients through remote functional assessments. Here, we assess feasibility, acceptability, and accuracy of Walk Test, a smartphone application designed to measure walking cadence.</p><p><strong>Methods: </strong>We performed a prospective cohort study of older adults prior to abdominal surgery and enrolled them remotely to perform at-home usual- and fast-paced walks with subsequent validation in-clinic. Each walk (usual- and fast-paced) was 2 min in duration. Feasibility was assessed if 80% of patients could perform all study procedures; acceptability was measured using the Post-Study Survey Usability Questionnaire (PSSUQ); accuracy of our approach was assessed with Lin's concordance coefficient (CCC). activPAL thigh worn accelerometer worn during the in-clinic walk served as a gold standard comparison. We used the CCC to compare the at-home and in-clinic walks as performed by Walk Test.</p><p><strong>Results: </strong>We enrolled 41 participants (mean age 69 ± 5 years, 26 (63%) female); 88% (36/41) successfully completed entire study protocol including independent installation of the application, walk tests (at-home and in-clinic) and questionnaires. Median (interquartile range) overall score of PSSUQ was 1 (1, 1) indicating strong acceptability and usability. The Lin's CCC between the in-clinic activPAL and Walk Test for usual-paced walk was 0.97 (95% CI: 0.96, 0.99, <i>p</i> < 0.001) and for fast-paced walks 0.96 (95% CI: 0.93, 0.98, <i>p</i> < 0.001). The CCC between the at-home and in-clinic walks for usual-paced walks was 0.70 (95% CI: 0.53, 0.86) and for fast-paced walks was 0.46 (95% CI: 0.21, 0.72).</p><p><strong>Conclusion: </strong>We successfully demonstrated the feasibility, acceptability and accuracy of Walk Test to measure walking cadence. Future work is needed to standardize walk test performance at-home to ensure consistency between in-clinic and at-home measures.</p>","PeriodicalId":11242,"journal":{"name":"Digital Biomarkers","volume":"9 1","pages":"113-123"},"PeriodicalIF":0.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12240576/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144599658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of On- and Off-Medication Periods on Walking Performance in Parkinson's Disease: Insights from Movement Synergies.","authors":"Arunee Promsri, Peter Federolf","doi":"10.1159/000546733","DOIUrl":"10.1159/000546733","url":null,"abstract":"<p><strong>Introduction: </strong>Impaired walking performance significantly impacts the quality of life in individuals with Parkinson's disease (PD). This study aimed to examine the effects of medication \"on\" and \"off\" periods on walking performance, focusing on an alternative aspect of traditional gait analysis by assessing movement components or synergies (i.e., principal movements, PMs).</p><p><strong>Methods: </strong>Principal component analysis was used to decompose kinematic marker data from 22 PD patients (64.1 ± 10.5 years) during self-selected speed overground walking into a set of PMs that cooperatively contribute to the locomotion task. Gait adaptation between medication periods was assessed using two PM-based variables: relative explained variance (rVAR) of the PM's position, reflecting movement structure, and root mean square (RMS) of the PM's acceleration, indicating movement acceleration magnitude and reflecting changes in force or speed.</p><p><strong>Results: </strong>The on-medication condition increased the contribution (greater rVAR) of PM₂, representing the swing-phase movement component (<i>p</i> = 0.001), and enhanced movement acceleration magnitudes (greater RMS) in PM₄, characterizing the single-leg support phase coupled with trunk rotation (<i>p</i> = 0.026).</p><p><strong>Conclusion: </strong>Although medication enhances propulsion by increasing the contribution of swing-phase movement components, thereby improving forward movement and walking efficiency, it may also lead to instability during the single-leg stance phase.</p>","PeriodicalId":11242,"journal":{"name":"Digital Biomarkers","volume":"9 1","pages":"104-112"},"PeriodicalIF":0.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12215196/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144552596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility of Using Smartphone Eye Tracking for Self-Recording Positional Tests.","authors":"Pouya B Bastani, Vidith Phillips, Hector Rieiro, Jorge Otero-Millan, David S Zee, David E Newman-Toker, Ali Saber Tehrani","doi":"10.1159/000545720","DOIUrl":"10.1159/000545720","url":null,"abstract":"<p><strong>Introduction: </strong>Benign paroxysmal positional vertigo (BPPV) is a common cause of dizziness that is diagnosed by detecting nystagmus through positional maneuvers. Limited access to expert clinicians to correctly perform and interpret the eye movement findings of positional tests can hamper the diagnosis and delay the treatment. We aimed to assess the usability of a smartphone-based eye-tracking application (EyePhone) for self-recording eye movements during positional testing.</p><p><strong>Methods: </strong>Healthy volunteers were enrolled and provided instructions to perform Dix-Hallpike and Supine Roll tests using the EyePhone application to record themselves. A study team member was instructed to observe the process without interfering. They recorded the time each section took and the accuracy of performing positional tests. Usability was assessed using the mHealth App Usability Questionnaire (MAUQ), and expert evaluation of recorded videos determined quality.</p><p><strong>Results: </strong>All participants successfully performed the tests and recorded their eye movements. On average, after watching the instruction, it took participants 3 min 31 s to record the Dix-Hallpike test and 3 min 4 s to record the Supine Roll test. Nine participants completed Dix-Hallpike without major errors, and all completed the Supine Roll successfully. An expert review found that 95% of videos had clear eye visibility. Participants rated the app as easy to use and stated that they would use the app again.</p><p><strong>Conclusion: </strong>We demonstrated the usability and feasibility of the EyePhone app for self-recording positional tests. This application offers the potential for remote BPPV diagnosis and improved patient access to care.</p>","PeriodicalId":11242,"journal":{"name":"Digital Biomarkers","volume":"9 1","pages":"98-103"},"PeriodicalIF":0.0,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12176362/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chair-Rising Power as Digital Biomarker: Validation against Jumping Power and Chair-Rising Time in Adults Aged 32-92 Years.","authors":"Jörn Rittweger, Maik Gollasch, Roswitha Dietzel, Gabriele Armbrecht","doi":"10.1159/000545395","DOIUrl":"10.1159/000545395","url":null,"abstract":"<p><strong>Introduction: </strong>The chair-rising test (CRT) is being widely used to assess lower body power. The test provides valuable information about functional capacity and other health outcomes. However, most centers use timing-based outcomes, which may compromise its suitability in younger people and fitter geriatric patients, and which may also introduce confounding effects of body height. We, therefore, aimed to compare the traditional use of timing-based outcome with digitally assessed measurements of neuromuscular power.</p><p><strong>Methods: </strong>Data were collected from a longitudinal population-based study that examined changes in muscle and bone health. CRT and jumping mechanography were performed on a ground reaction force plate. In 346 people (age: 32-92 years), chair-rising rate (fCRT) was manually assessed, and peak chair-rising power (PCRT) and jumping power (PJMG) were computed. Statistical analyses targeted breakpoints in the relationships between fCRT, PCRT, and PJMG. Effects of age, body height, and sex were assessed with linear and partial regression analyses.</p><p><strong>Results: </strong>Breakpoints were found at (fCRT = 0.778 Hz, PJMG = 35.2 Watt/kg, <i>p</i> < 0.001) and at (fCRT = 0.669 Hz, PCRT = 9.9 Watt/kg, <i>p</i> < 0.001). Slow chair-risers, defined by fCRT <0.669 Hz, were older than fast chair-risers (<i>p</i> < 0.001), albeit with a largely overlapping age range (fast chair-risers: 32-90 years, slow chair-risers: 32-92 years). Body height was correlated with fCRT (<i>p</i> < 0.001) and PCRT (<i>p</i> = 0.009) but not with PJMG (<i>p</i> = 0.59).</p><p><strong>Conclusion: </strong>Timing-based CRT does not unequivocally reflect neuromuscular power. Its association with chair-rising power holds only in people who take more than 75 s for 5 stand-ups. For jumping power, the cutoff is at 6.4 s. Slow and fast chair-risers cannot be easily discerned by age. Bias by body height can substantially obscure age effects in timing-based CRT assessments. We conclude that chair-rising power represents a more universally applicable biomarker and is less influenced by body height compared to timing-based chair-rising assessments.</p>","PeriodicalId":11242,"journal":{"name":"Digital Biomarkers","volume":"9 1","pages":"88-97"},"PeriodicalIF":0.0,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12119073/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-World Postural Transitions as Biomarkers of Functional Impairment in Duchenne Muscular Dystrophy.","authors":"Cailin J Gramling, Dheeraj Dhanvee Kairamkonda, Jamie L Marshall, Carl Morris, Jennifer Marlowe, Brett M Meyer, Paolo DePetrillo, Jaime Franco Betegon, Ellen W McGinnis, Donna M Rizzo, Reed D Gurchiek, Ryan S McGinnis","doi":"10.1159/000545617","DOIUrl":"10.1159/000545617","url":null,"abstract":"<p><p>Duchenne muscular dystrophy (DMD) is a progressive neuromuscular disorder that impairs daily functioning and results in premature death. Current clinical assessments are widely used for characterizing functional impairment but have limitations due to their subjective and effort-based nature and because they only capture a snapshot of symptoms at a single point in time. Digital health technologies, such as wearable devices, allow continuous collection of movement and physiological data during daily life and could provide objective measures of the impact of DMD symptoms on daily functioning. For example, measurement of the 95th centile of stride velocity has recently gained endorsement by European regulators as an endpoint for evaluating functional changes in DMD, but the use of wearables for this purpose is just beginning. In this study, we present preliminary investigations of candidate digital biomarkers of functional impairment using real-world data and further explore the relationships between these parameters and established clinical assessments. We found nine candidate biomarkers for detecting DMD-related functional impairment, all exhibiting large to very large effect sizes in our sample of 14 boys with DMD and matched controls (9 DMDs, 5 controls, age 4-12 years). Each candidate biomarker was moderately or strongly associated with clinical measures of function in DMD. Six of the biomarkers are novel and/or understudied in DMD including objective measures of gait acceleration and variability; postural control immediately before and after a postural transition; and the smoothness of postural transitions. Notably, postural transition measures were more sensitive to DMD-related impairment than gait, activity, and cardiac measures. These results suggest that the quality of postural transitions could serve as a sensitive and objective measure of functional impairment in DMD and point toward the need for further exploration of these measures.</p>","PeriodicalId":11242,"journal":{"name":"Digital Biomarkers","volume":"9 1","pages":"75-87"},"PeriodicalIF":0.0,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12101821/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measuring Respiration Rate from Speech.","authors":"Sidharth Abrol, Biswajit Das, Srikanth Nallanthighal, Okke Ouweltjes, Ulf Grossekathofer, Aki Härmä","doi":"10.1159/000544913","DOIUrl":"https://doi.org/10.1159/000544913","url":null,"abstract":"<p><p>The physical basis of speech production in humans requires the coordination of multiple anatomical systems, where inhalation and exhalation of air through lungs is at the core of the phenomenon. Vocalization happens during exhalation, while inhalation typically happens between speech pauses. We use deep learning models to predict respiratory signals during speech-breathing, from which the respiration rate is estimated. Bilingual data from a large clinical study (<i>N</i> = 1,005) are used to develop and evaluate a multivariate time series transformer model with speech encoder embeddings as input. The best model shows the predicted respiration rate from speech within ±3 BPM for 82% of test subjects. A <i>noise-aware</i> algorithm was also tested in a simulated hospital environment with varying noise levels to evaluate the impact on performance. This work proposes and validates speech as a virtual sensor for respiration rate, which can be an efficient and cost-effective enabler for remote patient monitoring and telehealth solutions.</p>","PeriodicalId":11242,"journal":{"name":"Digital Biomarkers","volume":"9 1","pages":"67-74"},"PeriodicalIF":0.0,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11999658/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143957760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}