Effects of On- and Off-Medication Periods on Walking Performance in Parkinson's Disease: Insights from Movement Synergies.

Q1 Computer Science
Digital Biomarkers Pub Date : 2025-06-02 eCollection Date: 2025-01-01 DOI:10.1159/000546733
Arunee Promsri, Peter Federolf
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Abstract

Introduction: Impaired walking performance significantly impacts the quality of life in individuals with Parkinson's disease (PD). This study aimed to examine the effects of medication "on" and "off" periods on walking performance, focusing on an alternative aspect of traditional gait analysis by assessing movement components or synergies (i.e., principal movements, PMs).

Methods: Principal component analysis was used to decompose kinematic marker data from 22 PD patients (64.1 ± 10.5 years) during self-selected speed overground walking into a set of PMs that cooperatively contribute to the locomotion task. Gait adaptation between medication periods was assessed using two PM-based variables: relative explained variance (rVAR) of the PM's position, reflecting movement structure, and root mean square (RMS) of the PM's acceleration, indicating movement acceleration magnitude and reflecting changes in force or speed.

Results: The on-medication condition increased the contribution (greater rVAR) of PM2, representing the swing-phase movement component (p = 0.001), and enhanced movement acceleration magnitudes (greater RMS) in PM4, characterizing the single-leg support phase coupled with trunk rotation (p = 0.026).

Conclusion: Although medication enhances propulsion by increasing the contribution of swing-phase movement components, thereby improving forward movement and walking efficiency, it may also lead to instability during the single-leg stance phase.

服药和停药期对帕金森病患者行走表现的影响:来自运动协同作用的见解。
导言:行走能力受损显著影响帕金森病(PD)患者的生活质量。本研究旨在研究药物“开”和“关”期间对步行表现的影响,重点关注传统步态分析的另一个方面,即通过评估运动成分或协同作用(即主要运动,pm)。方法:采用主成分分析方法,将22例PD患者(64.1±10.5岁)在自行选择速度地上行走过程中的运动标记数据分解为一组协同运动任务的pm。使用两个基于PM的变量来评估用药期间的步态适应性:PM位置的相对解释方差(rVAR),反映运动结构,PM加速度的均方根(RMS),表明运动加速度大小,反映力或速度的变化。结果:未服药状态增加了代表摇摆相运动分量的pmm2的贡献(较大的rVAR) (p = 0.001),增强了代表单腿支撑相和躯干旋转的PM4的运动加速度幅度(较大的RMS) (p = 0.026)。结论:虽然药物通过增加摆动阶段运动成分的贡献来增强推进力,从而提高向前运动和行走效率,但也可能导致单腿站立阶段的不稳定。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Digital Biomarkers
Digital Biomarkers Medicine-Medicine (miscellaneous)
CiteScore
10.60
自引率
0.00%
发文量
12
审稿时长
23 weeks
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