Doklady Akademii nauk最新文献_第4页

Improvement bases of the theory basing with account for the development of traditional and additive technologies 改进理论基础，兼顾传统工艺和增材工艺的发展

Doklady Akademii nauk Pub Date : 2020-11-05 DOI: 10.29235/1561-8323-2020-64-5-617-623

B. Bazrov, M. Kheifetz

{"title":"Improvement bases of the theory basing with account for the development of traditional and additive technologies","authors":"B. Bazrov, M. Kheifetz","doi":"10.29235/1561-8323-2020-64-5-617-623","DOIUrl":"https://doi.org/10.29235/1561-8323-2020-64-5-617-623","url":null,"abstract":"It is proposed that the design and production of individual elements of parts and products as a whole be carried out from the standpoint of operation and monitoring of its condition, both in traditional and additive manufacturing using the modular principle in engineering and technology. The way of unification of design decisions for the design of the product, equipment and technological and metrological equipment during its manufacture is discussed, to ensure, regardless of the type of production (single, serial, mass), the transition from standard and group to modular technologies. The basics of basing theory are updated taking into account the revision of the existing description from theoretical mechanics by means of the position of three coordinate points; to go to a new description from the theory of machines and mechanisms by depriving a subject of basing degrees of freedom (mobility) in a technical system (design, technological, measuring). It is shown how the design of the technology for manufacturing the product and measuring its characteristics is carried out in a system that includes equipment and equipment as mechanisms, the closing link of which are basing objects.","PeriodicalId":11227,"journal":{"name":"Doklady Akademii nauk","volume":"155 ","pages":"617-623"},"PeriodicalIF":0.0,"publicationDate":"2020-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91466975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Effects of adipose-derived mesenchymal stem cells on nociceptive sensitivity and repair processes at achilles tendon injury model in rats 脂肪源性间充质干细胞对大鼠跟腱损伤模型伤害感觉敏感性和修复过程的影响

Doklady Akademii nauk Pub Date : 2020-11-05 DOI: 10.29235/1561-8323-2020-64-5-574-582

A.-M. V. Yerofeyeva, I. P. Zhavoronok, O. Antipova, E. L. Ryzhkovskaya, T. Kuznetsova, I. V. Vasilevich, S. Pinchuk, I. D. Volotovsky, A. Molchanova

引用次数: 2

The upper devonian magmatic complexes of the South-East Belarus 白俄罗斯东南部的上泥盆世岩浆复合体

Doklady Akademii nauk Pub Date : 2020-11-05 DOI: 10.29235/1561-8323-2020-64-5-599-608

O. Kuzmenkova, A. Laptsevich, A. Nosova

{"title":"The upper devonian magmatic complexes of the South-East Belarus","authors":"O. Kuzmenkova, A. Laptsevich, A. Nosova","doi":"10.29235/1561-8323-2020-64-5-599-608","DOIUrl":"https://doi.org/10.29235/1561-8323-2020-64-5-599-608","url":null,"abstract":"For the first time, the authors determined lateral-temporal series of magmatic complexes of the Late Frasnian-Early Famennian Pripyat-Dnieper Magmatic Area according to the results of petrological and geochemical study of rocks of the Pripyat-Dnieper Magmatic Area (north-western part of the Pripyat-Dnieper-Donetsk Magmatic Province) in the southwest of the East European Platform using the principles of structural-material analysis and taking into account previous studies. The series consists of four complexes, formed during stages of magmatic activity, separated by time intervals: Zhlobin Complex (Rechitsa Time, the beginning of the Late Frasnian), Uvarovichi complex (Late Voronezh Time, the middle of the Late Frasnian), Pripyat Complex (Skolodin (Skolodin-Chernin?) Time, the end of the Late Frasnian) and Loev complex (Yelets (Yelets- Petrikov?) Time, Early Famennian). The rocks of the Zhlobin Complex belong to the alkaline-ultramafic (carbonatite-kimberlite-nephelinite) formation; Uvarovichi Complex - to the alkaline-mafic formation (basaltoids and phonolites); Pripyat Complex - to the alkaline-mafic-salic formation (trachyandesites); Loev Complex - to the alkaline-ultramafic (nepheline) formation.","PeriodicalId":11227,"journal":{"name":"Doklady Akademii nauk","volume":"120 1","pages":"599-608"},"PeriodicalIF":0.0,"publicationDate":"2020-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79427284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Effect of large-scale modes of total variability of the atmosphere and ocean in the Atlantic-European region on the climate of Belarus 大西洋-欧洲地区大气和海洋总变率的大尺度模态对白俄罗斯气候的影响

Doklady Akademii nauk Pub Date : 2020-11-04 DOI: 10.29235/1561-8323-2020-64-5-609-616

S. Lysenko, V. Loginov, I. V. Buyakov

{"title":"Effect of large-scale modes of total variability of the atmosphere and ocean in the Atlantic-European region on the climate of Belarus","authors":"S. Lysenko, V. Loginov, I. V. Buyakov","doi":"10.29235/1561-8323-2020-64-5-609-616","DOIUrl":"https://doi.org/10.29235/1561-8323-2020-64-5-609-616","url":null,"abstract":"We have established the relationships of quasicyclic components in changes of air temperature and precipitation in Belarus with large-scale modes of general variability of the atmosphere and ocean in the Atlantic-European region. When the summer air temperature changes in Belarus and in Eastern Europe, a quasi-60-year oscillation is identified, which coincides in phase with the Atlantic multi-decadal oscillation. It is shown that the time series of winter air temperature in Belarus contain a quasi-8-year component synchronized with a similar component of the North Atlantic Oscillation. Moreover, the periods of acceleration and deceleration of winter warming in Belarus coincide with the upward and downward quasi-30-year phases of the North Atlantic Oscillation, respectively. The latter are also consistent with fluctuations in moisture content in Belarus and Europe. Based on the established patterns, we have concluded that the rapid rise in winter temperatures, slowing down of summer warming and deterioration in water supply in the southern regions of Belarus observed in the last decade are part of a natural cycle lasting about 30 years, developing against the background of a long-term trend of anthropogenic global warming.","PeriodicalId":11227,"journal":{"name":"Doklady Akademii nauk","volume":"6 1","pages":"609-616"},"PeriodicalIF":0.0,"publicationDate":"2020-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79518882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Влияние методов экстракорпоральной детоксикации на уровни заменимых аминокислот в плазме крови у пациентов с сепсисом (Представлено членом-корреспондентом Н.С. Сердюченко) 败血症患者血液中可替代氨基酸水平(由记者n . s . seryuchenko介绍)

Doklady Akademii nauk Pub Date : 2020-08-30 DOI: 10.29235/1561-8323-2020-64-4-457-465

Р. Э. Якубцевич, Н. В. Белявский, А. А. Глазев, С. Д. Клиса

{"title":"Влияние методов экстракорпоральной детоксикации на уровни заменимых аминокислот в плазме крови у пациентов с сепсисом (Представлено членом-корреспондентом Н.С. Сердюченко)","authors":"Р. Э. Якубцевич, Н. В. Белявский, А. А. Глазев, С. Д. Клиса","doi":"10.29235/1561-8323-2020-64-4-457-465","DOIUrl":"https://doi.org/10.29235/1561-8323-2020-64-4-457-465","url":null,"abstract":"Some disadvantages of the extracorporeal blood purification (EBP) methods as reducing plasma levels of different important metabolites are described. Disorders of amino acid metabolism in sepsis are manifested into microcirculation interruptions, a decreased immune response and an increased mortality. The aim of the study is to investigate the EBP influence on the levels of nonessential amino acids in the blood plasma of patients with sepsis. 28 patients diagnosed with “sepsis” were selected. Standard treatment protocols of plasma filtration, hemofiltration and hemadsorption with various sorbents were used. A significant decrease in the levels of asparagine, phosphoethanolamine, proline; α -aminobutyric acid showed a significant increase in these levels in patients who underwent “Proteasosorb” sorbent hemadsorption. A significant decrease in the levels of ornithine, aspartic acid, 3-methylhistidine, 1-methylhistidine in patients treated with hemofiltration was found. The EBP methods significantly influence the amino acid metabolism.","PeriodicalId":11227,"journal":{"name":"Doklady Akademii nauk","volume":"13 1","pages":"457-465"},"PeriodicalIF":0.0,"publicationDate":"2020-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90796654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Исследование биоэквивалентности лекарственных средств Флутриксан и Нексавар

Doklady Akademii nauk Pub Date : 2020-08-30 DOI: 10.29235/1561-8323-2020-64-4-466-476

Елена Николаевна Калиниченко, И. В. Понтелеева, С. А. Прадун, Виктория Анатольевна Трушко, Сергей Александрович Беляев, А. М. Федорова, О. С. Зиматкина, А. Ю. Тетерюкова, А. В. Коноплич

{"title":"Исследование биоэквивалентности лекарственных средств Флутриксан и Нексавар","authors":"Елена Николаевна Калиниченко, И. В. Понтелеева, С. А. Прадун, Виктория Анатольевна Трушко, Сергей Александрович Беляев, А. М. Федорова, О. С. Зиматкина, А. Ю. Тетерюкова, А. В. Коноплич","doi":"10.29235/1561-8323-2020-64-4-466-476","DOIUrl":"https://doi.org/10.29235/1561-8323-2020-64-4-466-476","url":null,"abstract":"А replicate designed open-label, randomized, crossover single-dose bioequivalence study using three periods and three sequences was conducted to assess the comparative bioavailability of the sorafenib-containing medicinal products Flutrixan (200 mg tablet, Institute of Bioorganic Chemistry of NAS of Belarus, Belarus) and Nexavar (200 mg tablet, Bayer Pharma AG, Germany), in healthy volunteers under fasting conditions. It was shown that all criteria used to assess the bioequivalence of compared medicinal products were fulfilled. The Test/Reference geometric mean ratios obtained for the pharmacokinetic parameters C max and AUC 0-72 and the corresponding 90 % confidence intervals were within the acceptance range of 80.0-125.0 %. Both sorafenib products were well tolerated and had a favorable safety profile. Therefore, it can be concluded that the generic medicinal product Flutrixan is bioequivalent to the reference medicinal product Nexavar.","PeriodicalId":11227,"journal":{"name":"Doklady Akademii nauk","volume":"49 1","pages":"466-476"},"PeriodicalIF":0.0,"publicationDate":"2020-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90320979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Spherically symmetric wave solution of Einstein's equations in the weak field approximation (Communicated by Corresponding Member Lev M. Tomilchik) 弱场近似下爱因斯坦方程的球对称波解(通讯委员Lev M. Tomilchik传播)

Doklady Akademii nauk Pub Date : 2020-08-30 DOI: 10.29235/1561-8323-2020-64-4-399-402

Yu. P. Vyblyi, A. A. Leonovich

引用次数: 0

Confinement in the two-dimensional yukawa theory with the Higgs mass generation mechanism 二维汤川理论中的约束与希格斯质量产生机制

Doklady Akademii nauk Pub Date : 2020-07-09 DOI: 10.29235/1561-8323-2020-64-3-282-286

D. A. Shohonov, R. Shulyakovsky

引用次数: 0

Identification of potential inhibitors of coronavirus SARS-CoV-2 using the methods of virtual screening and molecular modeling 利用虚拟筛选和分子建模方法鉴定冠状病毒SARS-CoV-2的潜在抑制剂

Doklady Akademii nauk Pub Date : 2020-07-09 DOI: 10.29235/1561-8323-2020-64-3-308-316

A. Andrianov, Yuri V. Kornoushenko, A. D. Karpenko, A. Tuzikov

引用次数: 0

microspheres made by crosslinking of polyvinyl alcohol with glutaraldehyde functionalized with yeast lysate 聚乙烯醇与戊二醛交联制备微球

Doklady Akademii nauk Pub Date : 2020-07-09 DOI: 10.29235/1561-8323-2020-64-3-287-292

K. Laznev, Zh. V. Ignatovich, V. Agabekov

引用次数: 0