S. Taeko, Yoshimoto Issei, Oketani Naoya, Okui Hideki, Iriki Yasuhisa, Ichiki Hitoshi, Maenosono Ryuichi, Namino Fuminori, M. Miyata, Ohishi Mitsuru
{"title":"Predictors of Heart Failure Caused by Volume Overload Using an Irrigation Catheter during Catheter Ablation for Atrial Fibrillation","authors":"S. Taeko, Yoshimoto Issei, Oketani Naoya, Okui Hideki, Iriki Yasuhisa, Ichiki Hitoshi, Maenosono Ryuichi, Namino Fuminori, M. Miyata, Ohishi Mitsuru","doi":"10.23937/2378-2951/1410155","DOIUrl":"https://doi.org/10.23937/2378-2951/1410155","url":null,"abstract":"Background: Predictors of heart failure caused by volume overload are unclear. This study to investigate the predictors of heart failure caused by volume overload using an irrigation catheter during atrial fibrillation (AF) ablation. Methods: This study included 431 consecutive patients with AF who underwent ablation in their first session from April 2009 to December 2015. According to right ventricular systolic pressure (RVSP) after AF ablation, patients were divided into high (≥ 40 mmHg, n = 62) or normal RVSP (< 40 mmHg, n = 312) groups. Results: There were significant differences in the rates of age ≥ 65-years-old (53.2% vs. 32.1%), history of congestive heart failure (16.1% vs. 8.0%), hypertension (67.7% vs. 50%), and diabetes mellitus (25.8% vs. 6.4%), as well as serum creatinine concentrations (0.92 vs. 0.83 mg/dl), B-type natriuretic peptide levels (165.9 vs. 109.0 pg/ml), left atrial dimension (44.4 vs. 41.0 mm), mitral inflow E wave velocity before ablation (E wave, 76.6 vs. 70.2 cm/sec), and the total amount of injection (3591 vs. 3282 ml) between the high and normal RVSP groups. There were no significant differences in sex, body mass index, left ventricular ejection fraction, and radiofrequency duration. Age ≥ 65-years-old (p = 0.004), history of diabetes mellitus (p < 0.001), left atrial dimension (p = 0.021), and E wave (p = 0.049) showed significant differences in multiple analysis between the high and normal RVSP groups. Conclusions: Close observation is mandatory with an older age, greater left atrial dimension and mitral E wave, and/or a history of diabetes mellitus to avoid heart failure after AF ablation using irrigation catheters.","PeriodicalId":112011,"journal":{"name":"International Journal of Clinical Cardiology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128620594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Naqvi Syed Hassan Raza, Tun Han Naung, Razzaq Abdul, Zaffar Zubair, Ali Syed Nauman, B. Haroon, Abbas Tariq
{"title":"Angiographic Pattern of Coronary Artery Disease in Diabetic Patients Having Abnormal Ankle Brachial Index","authors":"Naqvi Syed Hassan Raza, Tun Han Naung, Razzaq Abdul, Zaffar Zubair, Ali Syed Nauman, B. Haroon, Abbas Tariq","doi":"10.23937/2378-2951/1410154","DOIUrl":"https://doi.org/10.23937/2378-2951/1410154","url":null,"abstract":"Introduction: An abnormal ankle-brachial index (ABI) is associated with higher risk for future cardio-vascular (CV) events; however, it is unknown whether this association is true in patients with associated diabetes mellitus (DM). Objectives: The objective of this study was to determine frequency of coronary artery disease in terms of number of vessels involved using angiography in diabetic patients with abnormal ankle brachial index. Subjects and methods: This Cross Sectional Study was done at Department of Adult Cardiology, CPE institute of Cardiology Multan. ABI was measured using the standard method. After measuring the ABI, angiography was done on patients with abnormal ABI and pattern of Coronary Artery Disease (CAD) was recoded noting the number of vessels involved. Results: A total of 115 patients were included in the study. The mean age of patients was 62.40 years with standard deviation of 2.78 years. Majority of the patients in the study were male (68.7%). Mean ABI was of study participants was 1.2 with standard deviation of 0.58 while mean duration of disease was 3.2 years with standard deviation of 0.7 years. 97 of the study participants were hypertensive and 18 were smokers. A total of 28 patients (24.3%) did not have CAD as per angiography while the rest had 1 vessel disease (33.4%), 2 vessel disease (29.5%), and 3 vessel disease (20.9%). Stratification of patients by age, gender, duration of disease, hypertension and low/high ABI showed p value > 0.05 in all cases showing statistically insignificant difference between various subgroups. Conclusion: It is concluded that there is high frequency of CAD in diabetic patients with abnormal ABI.","PeriodicalId":112011,"journal":{"name":"International Journal of Clinical Cardiology","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134231227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Afşin Abdulmecit, K. Veysi, Ulutaş Zeynep, K. Hakan, A. Erdal, S. Arif, Ermiş Necip
{"title":"The Impact of Transcatheter Aortıc Valve Implantatıon on Neutrophıl to Lymphocyte Ratıo: A Retrospective Study","authors":"Afşin Abdulmecit, K. Veysi, Ulutaş Zeynep, K. Hakan, A. Erdal, S. Arif, Ermiş Necip","doi":"10.23937/2378-2951/1410153","DOIUrl":"https://doi.org/10.23937/2378-2951/1410153","url":null,"abstract":"","PeriodicalId":112011,"journal":{"name":"International Journal of Clinical Cardiology","volume":"1933 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128017797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Nicolò, Mandoli Giulia Elena, P. Antonio, G. Giuseppe, Sciaccaluga Carlotta, Cameli Matteo, Mondillo Sergio, Valente Serafina
{"title":"Left Main Coronary Artery Dissection during Breastfeeding Treated with CABG Complicated by Severe Ventricular Disfunction and Left Ventricular Thrombosis","authors":"S. Nicolò, Mandoli Giulia Elena, P. Antonio, G. Giuseppe, Sciaccaluga Carlotta, Cameli Matteo, Mondillo Sergio, Valente Serafina","doi":"10.23937/2378-2951/1410152","DOIUrl":"https://doi.org/10.23937/2378-2951/1410152","url":null,"abstract":"","PeriodicalId":112011,"journal":{"name":"International Journal of Clinical Cardiology","volume":"78 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126248629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Grebmer Christian, Lennerz Carsten, Brkic Amir, B. Patrick, W. Severin, Semmler Verena, Kottmaier Marc, Bourier Felix, F. Lena, R. Elena, B. Stephanie, Kornmayer Marie, Telishevska Marta, Reents Tilko, K. Christof, Hessling Gabriele, Deisenhofer Isabel
{"title":"Prevalence and Clinical Correlates of Spontaneous Echo Contrast in Patients on Oral Anticoagulation Undergoing Catheter Ablation for Atrial Fibrillation","authors":"Grebmer Christian, Lennerz Carsten, Brkic Amir, B. Patrick, W. Severin, Semmler Verena, Kottmaier Marc, Bourier Felix, F. Lena, R. Elena, B. Stephanie, Kornmayer Marie, Telishevska Marta, Reents Tilko, K. Christof, Hessling Gabriele, Deisenhofer Isabel","doi":"10.23937/2378-2951/1410151","DOIUrl":"https://doi.org/10.23937/2378-2951/1410151","url":null,"abstract":"Background: Spontaneous echo contrast (SEC) in the left atrial appendage (LAA) is associated with an increased risk of cerebral embolism in patients with atrial fibrillation (AF). Novel oral anticoagulants (NOACs) are increasingly prescribed as first-line therapy and have shown a comparable benefit-risk ratio compared to vitamin K antagonists (VKAs). The aim of this study was to investigate whether NOACs decrease the incidence of SEC compared to VKA. Methods: We retrospectively analysed 542 patients who underwent transoesophageal echocardiography (TEE) prior to AF ablation at our institution. SEC was characterised by dynamic, smoke-like echoes within the LA cavity or LAA on TEE. Results: SEC was detected in 58 patients (10.7%) and occurred significantly more often in patients on VKA (n = 39; 13.6%) compared to patients on NOACs (n = 19, 7.5%; p = 0.02). Decreased left ventricular function (p < 0.001), arterial hypertension (p < 0.001), LA enlargement (p < 0.001) and AF during TEE (p < 0.001) were significantly more often observed in patients showing SEC. Transient ischemic attack or stroke did not occur in any patient during AF ablation. Conclusion: The incidence of SEC on TEE in patients prior to AF ablation was significantly lower in patients treated with NOACs as compared to patients treated with VKA. Patients with multiple risk factors showed a higher SEC incidence. The results support the recommendation of NOACs as firstline oral anticoagulation in non-valvular AF.","PeriodicalId":112011,"journal":{"name":"International Journal of Clinical Cardiology","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114318611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E Franco-FuenmayorMaria, A AleemNumra, D SalazarJorge, M AlyAshraf
{"title":"Unroofed Coronary Sinus Syndrome Presenting with Early Pulmonary Hypertension","authors":"E Franco-FuenmayorMaria, A AleemNumra, D SalazarJorge, M AlyAshraf","doi":"10.23937/2378-2951/1410150","DOIUrl":"https://doi.org/10.23937/2378-2951/1410150","url":null,"abstract":"Isolated partial or complete absence of the coronary sinus roof hemodynamically behaves like an atrial septal defect and rarely causes pulmonary hypertension. We report a case of unroofed coronary sinus (URCS) presenting with post-operative cyanosis due to pulmonary hypertensive crisis following surgical repair of a ventricular septal defect at 6 months of age. He had progressively decreased stamina with gradual increase in pulmonary pressure requiring surgical closure of the URCS by 6 years of age with resolution of symptoms and normalization of the RV pressure.","PeriodicalId":112011,"journal":{"name":"International Journal of Clinical Cardiology","volume":"120 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116257997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I. Ibrahim, Ahmed S. Eldamanhory, M. Abdelaziz, Abdelrashid Abdelaziz
{"title":"Impact of Low-Dose Intracoronary Alteplase Infusion after Successful Primary Percutaneous Coronary Intervention","authors":"I. Ibrahim, Ahmed S. Eldamanhory, M. Abdelaziz, Abdelrashid Abdelaziz","doi":"10.23937/2378-2951/1410149","DOIUrl":"https://doi.org/10.23937/2378-2951/1410149","url":null,"abstract":"Background and aim: In ST elevation myocardial infarction (STEMI), intracoronary thrombolysis after primary percutaneous coronary intervention (PPCI) was found to improve microvascular perfusion, yet without improvement in left ventricular (LV) remodeling. Our study aimed to find out possible effect on LV longitudinal function. Methods and results: 102 anterior STEMI patients eligible for PPCI were divided into: Alteplase group (53 patients; received intracoronary 0.3 mg/kg alteplase after PPCI) and control group (49 patients; treated with PPCI only). LV longitudinal function was assessed using tissue Doppler imaging (to measure mean S' and maximum Q-S' time difference) and speckle tracking (to measure global longitudinal strain (GLS)) 48 hours and 6 months after PPCI. In alteplase group, epicardial (p value < 0.001 for corrected TIMI frame count) and myocardial perfusion (p value for myocardial blush grade 0.03) were significantly higher. GLS and LV synchrony were better in alteplase group both at 48 hours (p value 0.02 and < 0.001 respectively) and at 6 months (p value < 0.001 for each). No difference in bleeding rates was noted between groups. Conclusion: Adjunctive low-dose alteplase infusion after PPCI improves microvascular perfusion and LV longitudinal function without increasing bleeding risk. ReseARch ARtIcle [2] and LV function [3-7]. In addition to the metabolic derangement of reperfusion injury [8,9], both proximal embolization [10,11] and microvascular in-situ thrombosis [12] play role in microvascular damage. The use of intra-coronary thrombolysis (e.g. Alteplase) immediately after PPCI was tested and showed improved epicardial and microvascular coronary flow [12-14]. Recently, global longitudinal strain (GLS) has emerged as a readily accessible and reproducible tool for estimation of microvascular damage [15] and final infarct size [16] comparable to the gold standard cardiac magnetic resonance (CMR). To the best of our knowledge, we are the first to study the acute and intermediate term effects of intra-coronary alteplase on GLS. Patients and Methods We included 106 consecutive STEMI patients eligible for PPCI. They were divided into 2 groups: Alteplase group (53 patients who received intracoronary alteplase after successful PPCI) and control group (53 patients who were treated with successful PPCI only). All patients were given the necessary information about the study. Zagazig University, Faculty of Medicine ethics committee approved our study, and written informed consent was obtained from all patients.","PeriodicalId":112011,"journal":{"name":"International Journal of Clinical Cardiology","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122085320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Hyperlipidemia Management in Proprotein Convertase Subtilisin- Kexin Type 9 (PCSK 9) Inhibitors Era","authors":"A. Kinsara","doi":"10.23937/2378-2951/1410146","DOIUrl":"https://doi.org/10.23937/2378-2951/1410146","url":null,"abstract":"Significant improvement in control of cardiovascular risk factors has been driven by performance measurement that focused on attainment of specific risk factor thresholds for blood glucose, lipids and blood pressure. Diet, statin and ezetimibe have reasonably controlled hyperlipidemia. However the discovery of proprotein convertase subtilisin-kexin type 9 inhibitors has given new hope of reaching the target lipid profile especially in the high-risk group and familial hypercholesterolemia. Herewith we reviewed the current data and explore the cardiovascular prevention effect of this group.","PeriodicalId":112011,"journal":{"name":"International Journal of Clinical Cardiology","volume":"62 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115101622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}