Dental and Medical Problems最新文献

{"title":"Kinesio Taping as an alternative therapy for limited mandibular mobility with pain in female patients with temporomandibular disorders: A randomized controlled trial.","authors":"Magdalena Gębska, Bartosz Dalewski, Łukasz Pałka, Paweł Kiczmer, Łukasz Kołodziej","doi":"10.17219/dmp/173126","DOIUrl":"10.17219/dmp/173126","url":null,"abstract":"<p><strong>Background: </strong>Kinesio Taping (KT) is a non-invasive therapy commonly used in physiotherapy (PT). However, the available data on its effectiveness in patients with symptomatic temporomandibular disorders (TMD) remains scarce and contradictory.</p><p><strong>Objectives: </strong>The aim of the study was to evaluate the analgesic and myorelaxant effects of KT in TMD patients with limited mandibular mobility.</p><p><strong>Material and methods: </strong>A single-blind randomized controlled trial was conducted among female patients aged 20-45 years with Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) group Ib, using a parallel group design and equal randomization (1:1). All patients underwent surface electromyography (sEMG) of the masseter muscle (MAS), pain intensity was assessed using a Numeric Rating Scale (NRS), and temporomandibular joint mobility was measured before and after 6 and 12 days of treatment. The Perceived Stress Scale (PSS-10) questionnaire was administered on the first and last days of treatment. Statistical analysis was performed using analysis of variance (ANOVA). Mauchly's sphericity test determined changes over time and between groups for variables with a normal distribution. Bonferroni's correction was used for post hoc multiple comparisons. Variables with a non-normal distribution were analyzed using the nparLD package and multiple comparison post hoc test, while correlations were assessed using Spearman's coefficient.</p><p><strong>Results: </strong>Each treatment had a significant effect on the bioelectrical sEMG parameters (p = 0.05). Kinesio Taping had a superior analgesic effect compared to the controls (p < 0.001). The combination of KT with therapeutic exercise (TE) proved to be a more effective therapy for improving the maximal mouth opening (MMO) and reducing perceived stress than monotherapy (p < 0.001). Minimally significant clinical differences were observed for sEMG, MMO and PSS-10 parameters after both therapies.</p><p><strong>Conclusions: </strong>Kinesio Taping combined with TE may be considered an effective complementary noninvasive treatment modality for TMD, either as a stand-alone or as part of the therapeutic process in patients experiencing pain and limited mandibular ROM. Additionally, the use of KT and TE was found to have a beneficial effect on perceived stress levels.</p>","PeriodicalId":11191,"journal":{"name":"Dental and Medical Problems","volume":" ","pages":"659-670"},"PeriodicalIF":2.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141237556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between Behçet's disease and apical periodontitis: A cross-sectional study.","authors":"Meltem Sümbüllü, Ayhan Kul, Ertuğrul Karataş, Meltem Memiş","doi":"10.17219/dmp/163127","DOIUrl":"10.17219/dmp/163127","url":null,"abstract":"<p><strong>Background: </strong>The correlation between Behçet's disease (BD) and apical periodontitis (AP) has not been investigated.</p><p><strong>Objectives: </strong>The aim of the study was to evaluate the association between BD and AP using different variables.</p><p><strong>Material and methods: </strong>A total of 98 individuals (49 with BD and 49 controls) were recruited for the study. The presence of AP was confirmed through radiographic and clinical examination in all patients. The following data was evaluated in both the BD group and the control group: the presence of teeth with AP; the presence of root canal-treated (RCT) teeth; the presence of RCT teeth with AP; the severity of the disease; the types of medication taken; and the duration of the disease. The χ2 test and the logistic regression analysis were performed to ascertain the association between BD and AP.</p><p><strong>Results: </strong>A total of 32 patients in the BD group and 12 patients in the control group presented with AP. The prevalence of teeth with AP was significantly higher in the BD group than in the control group (odds ratio = 5.804, p < 0.05). The χ2 analysis demonstrated a statistically significant association between AP and both gender and BD activity (p < 0.05). Furthermore, the logistic regression analysis indicated that the severity of the disease was a predictor of BD (p < 0.05).</p><p><strong>Conclusions: </strong>A significantly higher prevalence of AP was observed in patients with BD. However, the success rate of endodontic treatment in patients with BD was comparable to that observed in healthy individuals.</p>","PeriodicalId":11191,"journal":{"name":"Dental and Medical Problems","volume":" ","pages":"679-685"},"PeriodicalIF":2.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142371247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of bond failure with resin-modified glass ionomer cement and visible light-cured composite bonding systems in orthodontic patients: A split-mouth randomized controlled trial.","authors":"Hafsa Qabool, Jaweriyah Qabool, Rashna Hoshang Sukhia, Mubassar Fida","doi":"10.17219/dmp/162970","DOIUrl":"10.17219/dmp/162970","url":null,"abstract":"<p><strong>Background: </strong>Resin-modified glass ionomer cement (RMGIC) is considered a fluoride-releasing bonding agent.</p><p><strong>Objectives: </strong>The aim of the study was to evaluate the rate of bracket bond failure with light-cured composite (LCC) and RMGIC, and to evaluate factors that contribute to the rate of bracket failure with both bonding agents.</p><p><strong>Material and methods: </strong>A randomized controlled trial was conducted on a sample size of 33 patients. The patients were randomly allocated for bonding with visible LCC (control group) or RMGIC (intervention group) using the lottery method. The study was double-blinded. The rate of bracket bond failure was assessed after a follow-up of minimum 3 months and evaluated using the survival regression analysis, taking into account the effects of bonding agents and other factors influencing bracket bond failure.</p><p><strong>Results: </strong>A total of 33 participants were recruited for the study, and 66 quadrants for the intervention and control groups were randomly selected and analyzed. The data was normally distributed and the mean age of the subjects was comparable between both bonding systems. The results of the regression analysis indicated that there was no statistically significant difference between the rate of bracket bond failure with RMGIC and LCC (p = 0.081). However, after analyzing the mean days of survival, it was found that bracket survival was negligibly low with RMGIC, with a mean of 216.00 ±133.72 days as compared to LCC, with a mean survival of 224.11 ±124.59 days. No adverse effects were observed during the course of the trial.</p><p><strong>Conclusions: </strong>There was no difference in the rate of bracket bond failure between the intervention and control groups. The survival rate of brackets treated with RMGIC was found to be comparable to that of LCC, with a minimal difference.</p>","PeriodicalId":11191,"journal":{"name":"Dental and Medical Problems","volume":" ","pages":"651-657"},"PeriodicalIF":2.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142371263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential diagnosis and treatment protocols for desquamative gingivitis: A systematic review.","authors":"Hamed Mortazavi, Reza Amid, Anahita Moscowchi, Amir-Ali Yousefi-Koma, Hannaneh Yousefi-Koma","doi":"10.17219/dmp/156167","DOIUrl":"10.17219/dmp/156167","url":null,"abstract":"<p><p>The occurrence of desquamation, shedding and erythema on marginal and attached gingiva is described as desquamative gingivitis (DG). Various autoimmune/dermatological disorders cause DG.The aim of the present systematic review was to gather information on all possible kinds of treatment for DG, based on specific DG diagnoses.The review was organized following the PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses) protocol. An electronic search was conducted in the PubMed, Scopus and Google Scholar databases, up to April 2022. Reviews, letters and studies with less than 2 participants were excluded.Fifteen publications matched the eligibility criteria: 6 case series; 5 clinical trials; 3 randomized clinical trials (RCTs), and 1 cohort study. A total of 330 patients were enrolled, mostly women (81.52%), with an average age of 57.6 years. Diagnostic characteristics corresponded to oral lichen planus (OLP) (n = 249), mucous membrane pemphigoid (MMP) (n = 30), pemphigus vulgaris (PV) (n = 19), plasma cell gingivitis (PCG) (n = 4), erythema multiforme (EM) (n = 1), and non-specified diseases (NSD) (n = 27). Oral lichen planus and MMP were eliminated using oral hygiene instructions with topical clobetasol and/or doxycycline monohydrate. Pemphigus vulgaris, PCG and EM were treated with topical clobetasol.To conclude, each DG case requires personalized treatment, depending on the diagnosis.</p>","PeriodicalId":11191,"journal":{"name":"Dental and Medical Problems","volume":"61 5","pages":"747-758"},"PeriodicalIF":4.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142557389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Color perception and its relation to dental anxiety in children.","authors":"Prabhadevi Chandrashekara Maganur, Satish Vishwanathaiah, Mir Faeq Ali Quadri, Manal Alsabi, Wafaa Modarba, Wejdan Aqeel, Natheer Al Rawi, Asmaa Uthman, Rodolfo Reda, Mohammad Jafer, Luca Testarelli, Shankargouda Patil","doi":"10.17219/dmp/145896","DOIUrl":"https://doi.org/10.17219/dmp/145896","url":null,"abstract":"<p><strong>Background: </strong>One of the major causes of dental anxiety in children is their first impression of the dental environment. Even minor details, such as the choice of color in a dental setting and the color of dental equipment, can positively influence a child's behavior.</p><p><strong>Objectives: </strong>The aim of the study was to assess the relationship between the emotions in children and color combinations in a pediatric setting.</p><p><strong>Material and methods: </strong>The study involved 200 children (99 boys and 101 girls) aged between 6 and 12 years who visited the dental clinics at the College of Dentistry, Jazan University, for the first time between November 2017 and January 2018. The participants were divided into 2 groups based on age. The younger children group included participants aged from 6 to 9 years, while the older children group included participants aged from 10 to 12 years. Anxiety levels were recorded using the Modified Dental Anxiety Scale. Colored pencils and images of emoticons were provided to all children, who were instructed to color the negative and positive emoticons with their preferred colors.</p><p><strong>Results: </strong>The analysis of anxiety levels among children in both groups revealed statistically significant differences across sexes in the younger age group, with girls being more anxious than boys (p = 0.003). Additionally, a statistically significant difference was observed in the choice of colors by children of both sexes in 2 age groups (p = 0.001). Most children were inclined towards bright colors and used them to express their emotions.</p><p><strong>Conclusions: </strong>The incorporation of colors in a dental setting could invoke positive emotions in children. Hence, the use of colors in the workplace has the potential to ease anxiety.</p>","PeriodicalId":11191,"journal":{"name":"Dental and Medical Problems","volume":"61 5","pages":"671-677"},"PeriodicalIF":2.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142496853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiorespiratory and circadian clock markers in intensive care unit patients.","authors":"José Manuel Jiménez-Pastor, Francisco Rodríguez-Cortés, Pablo López-Soto, Luna López-Coleto, Miguel Meira E Cruz","doi":"10.17219/dmp/191537","DOIUrl":"10.17219/dmp/191537","url":null,"abstract":"<p><strong>Background: </strong>Biological synchronized rhythmicity is a critical physiological process. The lack of synchronized rhythms, mainly those showing a circadian basis, like sleep, the heart rate (HR) and arterial blood pressure (BP), often leads to several organic challenges, usually associated with adverse outcomes.</p><p><strong>Objectives: </strong>The aim of the study was to investigate whether the intensive care unit (ICU) environment favors clock genes and cardiorespiratory changes.</p><p><strong>Material and methods: </strong>A total of 22 critically ill patients (16 males; 72.73%) with a mean age of 60.82 ±20.07 years and well-established cardiovascular conditions were selected from ICU. Blood samples were obtained, and total RNA was isolated and reverse-transcribed into complementary DNA (cDNA). A quantitative polymerase chain reaction (qPCR) was performed to assess the target gene expression levels. The urinary concentration levels of melatonin (MEL) were assessed. The heart rate, BP (systolic - SBP, diastolic - DBP and mean - MBP) and the oxygen saturation (SpO2) levels were assessed as continuous variables.</p><p><strong>Results: </strong>The urinary MEL and Brain and muscle Arnt-like protein-1 (BMAL1) levels were shown to have a non-linear relationship with HR (coefficient (coef): 2.318, p = 0.032; coef: 2.722, p = 0.006, respectively) and SBP (coef: 1.000, p = 0.008; coef: 2.000, p = 0.037, respectively), with an explanatory power of up to 50.3% and 39.7% of the HR and SBP variability, respectively. Melatonin, but not BMAL1, was also shown to have a non-linear relationship with MBP (coef: 1.000, p = 0.007), with an explanatory power of up to 31.3% regarding the MBP variability. The HR and SBP oscillatory dynamics was shown to be related to changes in the genetic expression of BMAL1 and the urinary MEL concentrations. To a lower degree, MEL also impacted the variation of MBP.</p><p><strong>Conclusions: </strong>Our results suggest that not only are circadian functional matrices crucial for the dynamics of vital parameters in critically ill patients, but also that routinely assessed cardiovascular parameters like HR and BP may constitute important markers for the circadian timing system function. These parameters are easy to assess and have a relevant prognostic value regarding recovery outcomes, as well as the morbidity and mortality rates in ICU.</p>","PeriodicalId":11191,"journal":{"name":"Dental and Medical Problems","volume":"61 5","pages":"797-801"},"PeriodicalIF":2.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142557387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficiency of cannabis and cannabidiol in managing chronic pain syndromes: A comprehensive narrative review.","authors":"Marta Bort, Cyprian Olchowy, Anna Olchowy, Izabela Nawrot-Hadzik, Joanna Smardz, Mieszko Wieckiewicz","doi":"10.17219/dmp/193020","DOIUrl":"https://doi.org/10.17219/dmp/193020","url":null,"abstract":"<p><p>Chronic pain affects up to 40% of adults, contributing to high medical expenses, the loss of productivity, reduced quality of life (QoL), and disability. Chronic pain requires detailed diagnostic assessment, treatment and rehabilitation, yet approx. 80% of patients report inadequate pain management. As new treatment options are needed, we aimed to explore the effectiveness of medical cannabis-based products in managing chronic pain, with a particular focus on treatment patterns.We searched the PubMed, Scopus and Web of Science databases using keywords related to cannabinoids and chronic pain syndromes. In total, 3,954 articles were identified, and 74 studies involving 12,562 patients were included. The effectiveness of cannabis-based products varied across studies. Cannabinoids were most effective in treating chronic secondary headache and orofacial pain, chronic secondary musculoskeletal pain, chronic secondary visceral pain, and chronic neuropathic pain. Properly qualifying patients is the first crucial step in managing chronic pain, considering pain characteristics, comorbidities and other treatment options. Treatment should start with low doses of cannabinoids, which are then increased to achieve the desired therapeutic effect while minimizing adverse effects.This narrative review revealed significant gaps in the evidence regarding precise treatment patterns, particularly for the long-term maintenance treatment needed by patients with chronic pain. Medical cannabis can be considered an option for carefully selected patients with chronic pain syndromes when other treatment options fail to achieve an adequate response, and when the potential benefits outweigh the risks. However, there is still a need for well-designed clinical research to establish the long-term efficacy and safety of cannabinoids.</p>","PeriodicalId":11191,"journal":{"name":"Dental and Medical Problems","volume":"61 5","pages":"765-782"},"PeriodicalIF":2.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142581670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revisiting peri-implant diseases in order to rethink the future of compromised dental implants: Considerations, perspectives, treatment, and prognosis.","authors":"Gustavo Vicentis De Oliveira Fernandes, Bruno Gomes Dos Santos Martins, Javier Flores Fraile","doi":"10.17219/dmp/187215","DOIUrl":"10.17219/dmp/187215","url":null,"abstract":"<p><p>Once present, peri-implantitis is difficult to fully eliminate. Surgical interventions show some promising results in fighting the disease, but for the time being, prevention remains the strongest tool.</p>","PeriodicalId":11191,"journal":{"name":"Dental and Medical Problems","volume":"61 5","pages":"637-640"},"PeriodicalIF":2.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142496855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Smokeless tobacco- and quid-associated localized lesions of the oral cavity: A cross-sectional study from a dental institute.","authors":"Virender Gombra, Mandeep Kaur, Shamimul Hasan, Shahnaz Mansoori","doi":"10.17219/dmp/152439","DOIUrl":"10.17219/dmp/152439","url":null,"abstract":"<p><strong>Background: </strong>There is a well-established link between the use of smokeless tobacco (ST) and the development of oral cancer. This study was conducted to evaluate the impact of tobacco use, quid use, and other adverse habits related to smoking and alcohol consumption on ST-induced localized lesions.</p><p><strong>Objectives: </strong>The aim of the study was to examine the demographic data, frequency and contact duration of ST on the lesion, as well as to conduct a clinical evaluation of these parameters.</p><p><strong>Material and methods: </strong>A total of 13,442 patients who had been experiencing oral and dental symptoms for a period of at least 6 months were screened. Of these, 334 patients were diagnosed with STor quid-induced localized lesions and had a positive history of ST or quid use. A structured questionnaire was employed to conduct interviews with participants regarding their use of ST and other adverse habits, including smoking and alcohol consumption. Other information related to the use of ST or quid and clinical findings were also recorded, along with the patients' demographic details. A statistical analysis was carried out using the χ2 test and the regression analysis.</p><p><strong>Results: </strong>The overall prevalence of ST-induced localized lesions was found to be 2.48%. In the study population, the majority of participants (58.7%) reported a habit of using khaini, while 26.8% reported using gutkha. The study found significant differences in the severity of ST-induced localized lesions and contact duration, frequency of the habit, and the presence of additional habits such as smoking and/or alcohol consumption. Based on this study, we proposed a modified Greer and Poulson's classification of ST-induced lesions, dividing them into 4 clinical types.</p><p><strong>Conclusions: </strong>Smokeless tobacco-induced localized lesions frequently remain asymptomatic, with patients unaware of their presence. Other adverse habits, including smoking and alcohol consumption, as well as increased ST contact duration were associated with the development of more severe ST-induced localized lesions.</p>","PeriodicalId":11191,"journal":{"name":"Dental and Medical Problems","volume":" ","pages":"687-696"},"PeriodicalIF":2.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142460203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Avelumab reduces STAT3 expression with effects on IL-17RA and CD15.","authors":"Wojciech Kacper Szlasa, Natalia Julia Sauer, Jakub Karwacki, Anna Szewczyk, Julita Kulbacka, Tomasz Szydełko, Jolanta Saczko, Bartosz Malkiewicz","doi":"10.17219/dmp/176374","DOIUrl":"10.17219/dmp/176374","url":null,"abstract":"<p><strong>Background: </strong>Avelumab is a human antibody that targets the programmed cell death ligand-1 (PD-L1) protein in cancer cells. Novel anticancer therapies for renal cell carcinoma (RCC) consider cluster of differentiation 15 (CD15) and interleukin 17 receptor A (IL-17RA) as potential targets. Notably, the expression of PD-L1, CD15 and IL-17RA is dependent on signal transducer and activator of transcription 3 (STAT3).</p><p><strong>Objectives: </strong>The aim of the study was to investigate whether targeting PD-L1 with avelumab alters the expression levels of CD15 and IL-17RA, and to assess the STAT3-mediated regulation of CD15 and IL-17RA.</p><p><strong>Material and methods: </strong>We applied immunocytochemistry (ICC) and confocal laser scanning (CLS) microscopy to assess the expression and localization of the immunotherapy targets in 3 renal cancer cell lines and 1 healthy renal cell line.</p><p><strong>Results: </strong>After treatment with 20 ng/mL avelumab, renal cancer cells showed a reduction in STAT3 expression. The expression of CD15 increased in cancer cells that exhibited a high level of IL-17RA, and the membrane signal of CD15 was reduced. In other renal cancer cell lines, the expression of CD15 decreased. Conversely, the level of IL-17RA changed only in healthy renal cells after treatment with avelumab, with no impact on renal cancer cells.</p><p><strong>Conclusions: </strong>Our study suggests that the targeting of PD-L1 with avelumab alters the expression of CD15 and IL-17RA, which play an important prognostic and therapeutic role in novel anticancer therapy.</p>","PeriodicalId":11191,"journal":{"name":"Dental and Medical Problems","volume":"61 5","pages":"713-720"},"PeriodicalIF":2.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142557385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}