Designed Monomers and Polymers最新文献_第7页

Quantitative analysis of degree of substitution/molar substitution of etherified polysaccharide derivatives. 定量分析醚化多糖衍生物的取代度/摩尔取代度。

IF 1.8 4区化学

Designed Monomers and Polymers Pub Date : 2022-03-23 eCollection Date: 2022-01-01 DOI: 10.1080/15685551.2022.2054118

Xue-Li Liu, Chun-Feng Zhu, Han-Chun Liu, Jia-Ming Zhu

{"title":"Quantitative analysis of degree of substitution/molar substitution of etherified polysaccharide derivatives.","authors":"Xue-Li Liu, Chun-Feng Zhu, Han-Chun Liu, Jia-Ming Zhu","doi":"10.1080/15685551.2022.2054118","DOIUrl":"10.1080/15685551.2022.2054118","url":null,"abstract":"Due to the unique properties such as nontoxicity, biodegradability, availability from renewable resources, and cost-effectiveness, polysaccharides play a very important part in the science and technology field. The various chemically modified derivatives of these offer a wide range of high value-added in both food and non-food industries. Among the chemical modification, etherified polysaccharide is one of the most widespread derivatives by introducing an ether group which is commonly stable in both acidic and alkaline conditions. Hydroxyalkylation, alkylation, carboxymethylation, cationization, and cyanoethylation are some of the modifications commonly employed to prepare polysaccharides ethers derivatives. There also has been a growing tendency for creating new types of modification by combining the different means of chemical techniques. The correct determination of degree of substitution (DS)/molar substitution (MS) is crucially important. The objective of this article is to summarize developments in synthetic etherified polysaccharides, involving analytical methods for determination of MS/DS, measurement processes, and the associated mechanisms.","PeriodicalId":11170,"journal":{"name":"Designed Monomers and Polymers","volume":"25 1","pages":"75-88"},"PeriodicalIF":1.8,"publicationDate":"2022-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8956314/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10615106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis and evaluation of chitosan based controlled release nanoparticles for the delivery of ticagrelor 壳聚糖控释纳米颗粒的合成与评价

IF 1.6 4区化学

Designed Monomers and Polymers Pub Date : 2022-03-20 DOI: 10.1080/15685551.2022.2054117

Nariman Shahid, Alia Erum, Muhammad Zaman, U. Tulain, Qurat-ul-ain Shoaib, N. Malik, R. Kausar, A. Rashid, Umaira Rehman

{"title":"Synthesis and evaluation of chitosan based controlled release nanoparticles for the delivery of ticagrelor","authors":"Nariman Shahid, Alia Erum, Muhammad Zaman, U. Tulain, Qurat-ul-ain Shoaib, N. Malik, R. Kausar, A. Rashid, Umaira Rehman","doi":"10.1080/15685551.2022.2054117","DOIUrl":"https://doi.org/10.1080/15685551.2022.2054117","url":null,"abstract":"ABSTRACT The aim of this contemporary work was to formulate a controlled release mucoadhesive nanoparticle formulation for enhancing the oral bioavailability of Ticagrelor (TG), a BCS class IV drug, having low oral bioavailability of about 36%. The nanoparticles can act as efficient carriers for hydrophobic drugs, due to having high surface area and hence can improve their aqueous solubility due to their hydrophilic nature. The nanoparticles (NPs) of TG were formulated using chitosan (CH) as polymer and sodium tripolyphosphate (TPP) as cross-linker, by ionic gelation technique with varying concentrations of polymer with respect to TG and TPP. Characterization of prepared nanoparticles was carried out to assess zeta potential, size, shape, entrapment efficiency (EE) and loading capacity (LC), using zeta sizer, surface morphology and chemical compatibility analysis. Drug release was observed using UV-Spectrophotometer. By increasing concentration of CH the desired size of particles (106.9 nm), zeta potential (22.6 mv) and poly dispersity index (0.364) was achieved. In vitro profiles showed a controlled and prolonged release of TG in both lower pH-1.2 and neutral pH-7.4 mediums, with effective protection of entrapped TG in simulated gastric conditions. X-ray diffraction patterns (XRD) showed the crystalline nature of formed NPs. Hence, this effort showed that hydrophobic drugs can be effectively encapsulated in nanoparticulate systems to enhance their solubility and stability, ultimately improving their bioavailability and effectiveness with better patient compliance by reducing dosing frequencies as well.","PeriodicalId":11170,"journal":{"name":"Designed Monomers and Polymers","volume":"25 1","pages":"55 - 63"},"PeriodicalIF":1.6,"publicationDate":"2022-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41595996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Novelty in the development of biodegradable polymer coatings for biomedical devices: paclitaxel grafting on PDMMLA derivatives 生物降解聚合物涂层在生物医学设备中的发展新进展：PDMMLA衍生物上的紫杉醇接枝

IF 1.6 4区化学

Designed Monomers and Polymers Pub Date : 2022-03-20 DOI: 10.1080/15685551.2022.2054116

Elnaz Gholizadeh, Meriem Naim, R. Belibel, H. Hlawaty, C. Barbaud

{"title":"Novelty in the development of biodegradable polymer coatings for biomedical devices: paclitaxel grafting on PDMMLA derivatives","authors":"Elnaz Gholizadeh, Meriem Naim, R. Belibel, H. Hlawaty, C. Barbaud","doi":"10.1080/15685551.2022.2054116","DOIUrl":"https://doi.org/10.1080/15685551.2022.2054116","url":null,"abstract":"ABSTRACT Biocompatible and biodegradable polymers are widely used in the medical field. In some cases, the biopolymer is accompanied by an active drug, which is delivered locally in a controlled manner in order to improve the healing conditions. Poly([R,S]-3,3-dimethylmalic acid) (PDMMLA) is a synthetic amphiphilic biodegradable polymer, which unlike PLA, can be chemically modified to adapt hydrophilic/hydrophobic balance, degradation kinetics, and physicochemical and biological properties. It may contain a lateral alkyl group or a functional group for coupling bioactive molecules to release during its degradation. In this work, we realized the chemical grafting of paclitaxel (PTX), a microtubule stabilizing anti-cancer agent on PDMMLA derivatives bio-polyesters following a Steglich esterification protocol. 1D and 2D NMR analyses validated the reaction with 10% (using 0.1 equivalent) of PTX on the copolymer PDMMLAH40-co-Hex60 (PDMMLA 40/60) and a maximal PTX grafting rate of 55% on the homopolymer PDMMLAH (PDMMLA 100/0). In vitro adhesion and cytotoxicity assays were carried out on HUVEC cells with PDMMLA 40/60, PDMMLA-PTX 30/10/60 and PLA.","PeriodicalId":11170,"journal":{"name":"Designed Monomers and Polymers","volume":"25 1","pages":"64 - 74"},"PeriodicalIF":1.6,"publicationDate":"2022-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49487033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Two new supramolecular Ag(I) coordination polymers: luminescent properties and treatment activity on glioblastoma 两种新型超分子Ag（I）配位聚合物的发光性能及其对胶质母细胞瘤的治疗作用

IF 1.6 4区化学

Designed Monomers and Polymers Pub Date : 2022-02-25 DOI: 10.1080/15685551.2022.2041785

Xiao-Feng Yan, Yu-Qiang Sun, Qing-Wei Li

引用次数: 0

Synthesis of glycerol carbonate from glycerin with CaCO₃ in a batch reactor. 用CaCO3在间歇反应器中由甘油合成碳酸甘油。

IF 1.6 4区化学

Designed Monomers and Polymers Pub Date : 2022-02-10 eCollection Date: 2022-01-01 DOI: 10.1080/15685551.2022.2037215

Ana Beatriz Morales Cepeda, Luis A Macclesh Del Pino, Claudia Esmeralda Ramos Galvan, Eric Joaquín González Pedraza, Luciano Aguilera Vazquez

引用次数: 1

Therapeutic effect of two transition metal coordination polymers on ovarian cancer by regulating the expression of estrogen receptor. 两种过渡金属配位聚合物通过调节雌激素受体表达对卵巢癌的治疗作用。

IF 1.6 4区化学

Designed Monomers and Polymers Pub Date : 2022-02-09 eCollection Date: 2022-01-01 DOI: 10.1080/15685551.2022.2033432

Jin Zhao, Lan Du

引用次数: 0

A new 3D heterometallic coordination polymer: luminescent property and nursing application value on acute cerebral infarction. 一种新型三维异金属配位聚合物：发光性能及在急性脑梗死中的护理应用价值。

IF 1.6 4区化学

Designed Monomers and Polymers Pub Date : 2022-02-02 eCollection Date: 2022-01-01 DOI: 10.1080/15685551.2022.2033431

Li Cong, Yun-Zhi Pan, Ying-Hui Qin, Ji-Na Jiang

引用次数: 0

Aceclofenac-loaded pluronic F108/L81 mixed polymeric micelles: effect of HLB on solubilization. 负载acclofenac的pluronic F108/L81混合聚合物胶束:HLB对增溶作用的影响。

IF 1.6 4区化学

Designed Monomers and Polymers Pub Date : 2022-01-28 eCollection Date: 2022-01-01 DOI: 10.1080/15685551.2022.2028373

M Senthilkumar, Sasmita Dash, R Vigneshwari, E Paulraj

{"title":"Aceclofenac-loaded pluronic F108/L81 mixed polymeric micelles: effect of HLB on solubilization.","authors":"M Senthilkumar, Sasmita Dash, R Vigneshwari, E Paulraj","doi":"10.1080/15685551.2022.2028373","DOIUrl":"https://doi.org/10.1080/15685551.2022.2028373","url":null,"abstract":"Pluronic block copolymers have phase behavioural characteristics which are extensively studied for drug delivery applications. In this study, we explored hydrophilic pluronic F108 (HLB = 27), hydrophobic pluronic L81 (HLB = 2) and their mixed micelles acting as solubilising mediums for model drug aceclofenac. The drug solubilisation and interactions have been analysed using UV-visible spectroscopy, Fluorescence spectroscopy, Rheology studies, Fourier-transform infrared spectroscopy, Scanning electron microscope, Dynamic light scattering, Cloud point and partition coefficient measurements. The investigation from UV-spectrophotometry demonstrated that mixed pluronic entrapped greater number of aceclofenac molecules than both the neat pluronics at same concentration. Excimer formation was evidenced from fluorescence spectra with pyrene as a probe. The rheological studies showed difference in viscosity over low shear range. Studies on FTIR demonstrated probable bonding between the aceclofenac and mixed pluronic molecules. The DLS studies on mixed pluronic showed swelling of micellar diameter from 317.6 nm to 413.5 nm. Thermodynamic parameters of the above system revealed higher partition coefficient value for mixed pluronic and spontaneity in drug solubilisation. This study can be exploited to use a hydrophobic copolymeric micelle in mixed pluronic formulation for better drug solubilisation.","PeriodicalId":11170,"journal":{"name":"Designed Monomers and Polymers","volume":" ","pages":"1-11"},"PeriodicalIF":1.6,"publicationDate":"2022-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8803101/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39882524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Low dielectric resins derived from hyperbranched carbosilane oligmers functionalized by benzocyclobutene groups. 由苯并环丁烯基团官能化的超支化碳硅烷低聚物衍生的低介电树脂。

IF 1.6 4区化学

Designed Monomers and Polymers Pub Date : 2021-12-09 eCollection Date: 2021-01-01 DOI: 10.1080/15685551.2021.2003556

Xian Li, Yawen Huang, Xu Ye, Quan Long, Wen Yuan, Li Fan, Qiuxia Peng, Jiajun Ma, Junxiao Yang

引用次数: 0

Fabrication, Characterization and Toxicity Evaluation of Chemically Cross linked Polymeric Network for Sustained Delivery of Metoprolol Tartrate. 用于酒石酸美托洛尔持续给药的化学交联聚合物网络的制造、表征和毒性评估

IF 1.6 4区化学

Designed Monomers and Polymers Pub Date : 2021-12-09 eCollection Date: 2021-01-01 DOI: 10.1080/15685551.2021.2003995

Sumaira, Ume Ruqia Tulain, Alia Erum, Muhammad Ajaz Hussain, Sidra, Nadia Shamshad Malik, Ayesha Rashid, Rizwana Kausar, Nitasha Gohar, Nariman Shahid, Mahwish Siddiqui

{"title":"Fabrication, Characterization and Toxicity Evaluation of Chemically Cross linked Polymeric Network for Sustained Delivery of Metoprolol Tartrate.","authors":"Sumaira, Ume Ruqia Tulain, Alia Erum, Muhammad Ajaz Hussain, Sidra, Nadia Shamshad Malik, Ayesha Rashid, Rizwana Kausar, Nitasha Gohar, Nariman Shahid, Mahwish Siddiqui","doi":"10.1080/15685551.2021.2003995","DOIUrl":"10.1080/15685551.2021.2003995","url":null,"abstract":"Natural mucilages are auspicious biodegradable polymeric materials. The aim of the present research work was to elucidate the characteristics of quince mucilage-based polymeric network for sustained delivery of metprolol tartrate and its toxicity evaluation. Mucilage was extracted by hot water extraction, and characterization of quince mucilage was accomplished by using Fourier transform infrared (FTIR) spectroscopy. Different batches of quince mucilage polymeric network were prepared by free radical polymerization by utilizing varying ratios of quince mucilage, acrylamide and crosslinker. Degree of swelling depends on concentration of mucilage, monomer and also on crosslinking density of polymeric network. FTIR illustrates proficient grafting, and morphological (scanning electron microscopy) analysis signified porous design. Hence, quince mucilage-based design was encouraging for sustained delivery of metprolol tartrate and acute toxicity evaluation proved that mucilage-based network was safe for oral drug delivery system.","PeriodicalId":11170,"journal":{"name":"Designed Monomers and Polymers","volume":"24 1","pages":"351-361"},"PeriodicalIF":1.6,"publicationDate":"2021-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8667954/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39817779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0