Designed Monomers and Polymers最新文献_第7页

Effect of synthesized sulfonate derivatives as nucleating agents on crystallization behavior of poly(lactic acid) 合成磺酸酯衍生物作为成核剂对聚乳酸结晶行为的影响

IF 1.6 4区化学

Designed Monomers and Polymers Pub Date : 2022-05-06 DOI: 10.1080/15685551.2022.2072697

Pasawat Jongpanya-Ngam, R. Khankrua, M. Seadan, S. Suttiruengwong

{"title":"Effect of synthesized sulfonate derivatives as nucleating agents on crystallization behavior of poly(lactic acid)","authors":"Pasawat Jongpanya-Ngam, R. Khankrua, M. Seadan, S. Suttiruengwong","doi":"10.1080/15685551.2022.2072697","DOIUrl":"https://doi.org/10.1080/15685551.2022.2072697","url":null,"abstract":"ABSTRACT The improvement of the crystallization of poly(lactic acid) (PLA) is one of the key areas to allow PLA to perform better at higher temperature and load bearing. Due to its slow crystallization rate, either organic or inorganic nucleating agents (NAs) can be used to improve the crystallization rate of PLA. In the case of organic NAs, aromatic sulfonate salt and bisamide compounds are promising ones because they can control better clarity. The aim of this work was to study the crystallization behavior of PLA using as-synthesized dimethyl 5-sulfoisophthalate sodium salt (SSIPA) as a nucleating agent in comparison with the commercial sulfonate salt (LAK-301). Two grades of PLA (PLA L105 and PLA 3251D) were used in this study. PLA samples were prepared by internal mixer and compression molding. All samples were investigated by DSC and POM. The results from DSC showed that after introducing the nucleating agents into PLA, the crystallinity in all samples was improved. The highest crystallinity at 57.48% was obtained from PLA L105/SSIPA1.0. Isothermal crystallization kinetics showed the improvement in overall crystallization rate of PLA with nucleating agents. The lowest half time crystallization obtained was 1.19 min for PLA L105/SSIPA1.0 at 135 °C. The results from POM indicated the substantial increase of the nucleus density and smaller spherulite size upon adding nucleating agents.","PeriodicalId":11170,"journal":{"name":"Designed Monomers and Polymers","volume":"25 1","pages":"115 - 127"},"PeriodicalIF":1.6,"publicationDate":"2022-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41511879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Dexamethasone-Loaded biodegradable magnetic microparticles for treatment of CFA-induced chronic pain in rats 负载地塞米松的可生物降解磁微粒治疗慢性疼痛大鼠慢性疼痛

IF 1.6 4区化学

Designed Monomers and Polymers Pub Date : 2022-04-28 DOI: 10.1080/15685551.2022.2068743

Jin Xin, Jichun Zheng, Yonghai Sun

{"title":"Dexamethasone-Loaded biodegradable magnetic microparticles for treatment of CFA-induced chronic pain in rats","authors":"Jin Xin, Jichun Zheng, Yonghai Sun","doi":"10.1080/15685551.2022.2068743","DOIUrl":"https://doi.org/10.1080/15685551.2022.2068743","url":null,"abstract":"ABSTRACT Traditional drug solutions or suspensions, have been shown to treat pain in complete Freund’s adjuvant (CFA)-induced chronic inflammatory pain in rats, with or without combination with magnetic therapy. In this study, we aimed to prepare, characterize, and evaluate the therapeutic effects of microparticles containing dexamethasone for local administration and treatment of chronic inflammatory pain. The results showed the following; a) Preparation and characterization: two ratios of poly(lactic-co-glycolic acid) (PLGA)/poly(lactic acid) (PLA) were used. The prepared batches were similar in size and magnetic responsiveness. The microparticle size distribution assessed via electron microscopy suggested a homogeneous distribution and absence of aggregates. Dexamethasone release profiles (microparticles synthesized with a feed ratio of 1:4) showed a sustained release in vitro and good biocompatibility with tissues. b) Therapeutic effect: the treatment effect of dexamethasone-PLGA magnetic microspheres + magnetic therapy was substantially better than that observed for other groups on day 4, as monitored by appearance, mechanical pain threshold, and histological analysis. This type of carrier could be a suitable magnetically retainable local drug delivery system for treating chronic pain.","PeriodicalId":11170,"journal":{"name":"Designed Monomers and Polymers","volume":"25 1","pages":"98 - 114"},"PeriodicalIF":1.6,"publicationDate":"2022-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45386036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polymerization of aniline hydrochloride in reverse of microemulsion by batch and semicontinuous process using ionic and nonionic surfactants 离子表面活性剂和非离子表面活性剂在反相微乳液中间歇和半连续聚合盐酸苯胺

IF 1.6 4区化学

Designed Monomers and Polymers Pub Date : 2022-04-12 DOI: 10.1080/15685551.2022.2063011

G. Pier Villegas, A. G. Alvarado Mendoza, L. G. Guerrero Ram U EDrez, L. C. Rosales-Rivera, J. Aguilar, F. J. Moscoso S U E Nchez

{"title":"Polymerization of aniline hydrochloride in reverse of microemulsion by batch and semicontinuous process using ionic and nonionic surfactants","authors":"G. Pier Villegas, A. G. Alvarado Mendoza, L. G. Guerrero Ram U EDrez, L. C. Rosales-Rivera, J. Aguilar, F. J. Moscoso S U E Nchez","doi":"10.1080/15685551.2022.2063011","DOIUrl":"https://doi.org/10.1080/15685551.2022.2063011","url":null,"abstract":"ABSTRACT The polymerization of aniline hydrochloride by inverse microemulsion in a batch process and the semicontinuous process was studied as a function of the surfactant ionic and nonionic. Polymerizations were carried out at 60°C for 4 h with a yield polymer of circa 67 and 27% wt. for ionic and nonionic surfactants. The conductivity of synthesized polyaniline by the semicontinuous process is higher up to three orders of magnitude than that of the batch process for both surfactants. The calculating degree of oxidation by UV-Vis showed the relative intensities of the quinoid to benzenoid unit around one. The morphology was determined by Scanning Electron Microscopy (SEM) and observed that the formation of the different morphologies is due to the self-assembly behavior of surfactant. The diameter z-average particle size (Dz) was studied by Transmission Electron Microscopy (TEM), which determined that the diameter particle in a semicontinuous state is larger than the one produced in a batch; this is due to the control of monomer addition in the system. These findings suggest that the polymerization process and the type of surfactant influence the properties of polyaniline.","PeriodicalId":11170,"journal":{"name":"Designed Monomers and Polymers","volume":"25 1","pages":"89 - 97"},"PeriodicalIF":1.6,"publicationDate":"2022-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48517427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Quantitative analysis of degree of substitution/molar substitution of etherified polysaccharide derivatives. 定量分析醚化多糖衍生物的取代度/摩尔取代度。

IF 1.8 4区化学

Designed Monomers and Polymers Pub Date : 2022-03-23 eCollection Date: 2022-01-01 DOI: 10.1080/15685551.2022.2054118

Xue-Li Liu, Chun-Feng Zhu, Han-Chun Liu, Jia-Ming Zhu

{"title":"Quantitative analysis of degree of substitution/molar substitution of etherified polysaccharide derivatives.","authors":"Xue-Li Liu, Chun-Feng Zhu, Han-Chun Liu, Jia-Ming Zhu","doi":"10.1080/15685551.2022.2054118","DOIUrl":"10.1080/15685551.2022.2054118","url":null,"abstract":"<p><p>Due to the unique properties such as nontoxicity, biodegradability, availability from renewable resources, and cost-effectiveness, polysaccharides play a very important part in the science and technology field. The various chemically modified derivatives of these offer a wide range of high value-added in both food and non-food industries. Among the chemical modification, etherified polysaccharide is one of the most widespread derivatives by introducing an ether group which is commonly stable in both acidic and alkaline conditions. Hydroxyalkylation, alkylation, carboxymethylation, cationization, and cyanoethylation are some of the modifications commonly employed to prepare polysaccharides ethers derivatives. There also has been a growing tendency for creating new types of modification by combining the different means of chemical techniques. The correct determination of degree of substitution (DS)/molar substitution (MS) is crucially important. The objective of this article is to summarize developments in synthetic etherified polysaccharides, involving analytical methods for determination of MS/DS, measurement processes, and the associated mechanisms.</p>","PeriodicalId":11170,"journal":{"name":"Designed Monomers and Polymers","volume":"25 1","pages":"75-88"},"PeriodicalIF":1.8,"publicationDate":"2022-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8956314/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10615106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis and evaluation of chitosan based controlled release nanoparticles for the delivery of ticagrelor 壳聚糖控释纳米颗粒的合成与评价

IF 1.6 4区化学

Designed Monomers and Polymers Pub Date : 2022-03-20 DOI: 10.1080/15685551.2022.2054117

Nariman Shahid, Alia Erum, Muhammad Zaman, U. Tulain, Qurat-ul-ain Shoaib, N. Malik, R. Kausar, A. Rashid, Umaira Rehman

{"title":"Synthesis and evaluation of chitosan based controlled release nanoparticles for the delivery of ticagrelor","authors":"Nariman Shahid, Alia Erum, Muhammad Zaman, U. Tulain, Qurat-ul-ain Shoaib, N. Malik, R. Kausar, A. Rashid, Umaira Rehman","doi":"10.1080/15685551.2022.2054117","DOIUrl":"https://doi.org/10.1080/15685551.2022.2054117","url":null,"abstract":"ABSTRACT The aim of this contemporary work was to formulate a controlled release mucoadhesive nanoparticle formulation for enhancing the oral bioavailability of Ticagrelor (TG), a BCS class IV drug, having low oral bioavailability of about 36%. The nanoparticles can act as efficient carriers for hydrophobic drugs, due to having high surface area and hence can improve their aqueous solubility due to their hydrophilic nature. The nanoparticles (NPs) of TG were formulated using chitosan (CH) as polymer and sodium tripolyphosphate (TPP) as cross-linker, by ionic gelation technique with varying concentrations of polymer with respect to TG and TPP. Characterization of prepared nanoparticles was carried out to assess zeta potential, size, shape, entrapment efficiency (EE) and loading capacity (LC), using zeta sizer, surface morphology and chemical compatibility analysis. Drug release was observed using UV-Spectrophotometer. By increasing concentration of CH the desired size of particles (106.9 nm), zeta potential (22.6 mv) and poly dispersity index (0.364) was achieved. In vitro profiles showed a controlled and prolonged release of TG in both lower pH-1.2 and neutral pH-7.4 mediums, with effective protection of entrapped TG in simulated gastric conditions. X-ray diffraction patterns (XRD) showed the crystalline nature of formed NPs. Hence, this effort showed that hydrophobic drugs can be effectively encapsulated in nanoparticulate systems to enhance their solubility and stability, ultimately improving their bioavailability and effectiveness with better patient compliance by reducing dosing frequencies as well.","PeriodicalId":11170,"journal":{"name":"Designed Monomers and Polymers","volume":"25 1","pages":"55 - 63"},"PeriodicalIF":1.6,"publicationDate":"2022-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41595996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Novelty in the development of biodegradable polymer coatings for biomedical devices: paclitaxel grafting on PDMMLA derivatives 生物降解聚合物涂层在生物医学设备中的发展新进展：PDMMLA衍生物上的紫杉醇接枝

IF 1.6 4区化学

Designed Monomers and Polymers Pub Date : 2022-03-20 DOI: 10.1080/15685551.2022.2054116

Elnaz Gholizadeh, Meriem Naim, R. Belibel, H. Hlawaty, C. Barbaud

{"title":"Novelty in the development of biodegradable polymer coatings for biomedical devices: paclitaxel grafting on PDMMLA derivatives","authors":"Elnaz Gholizadeh, Meriem Naim, R. Belibel, H. Hlawaty, C. Barbaud","doi":"10.1080/15685551.2022.2054116","DOIUrl":"https://doi.org/10.1080/15685551.2022.2054116","url":null,"abstract":"ABSTRACT Biocompatible and biodegradable polymers are widely used in the medical field. In some cases, the biopolymer is accompanied by an active drug, which is delivered locally in a controlled manner in order to improve the healing conditions. Poly([R,S]-3,3-dimethylmalic acid) (PDMMLA) is a synthetic amphiphilic biodegradable polymer, which unlike PLA, can be chemically modified to adapt hydrophilic/hydrophobic balance, degradation kinetics, and physicochemical and biological properties. It may contain a lateral alkyl group or a functional group for coupling bioactive molecules to release during its degradation. In this work, we realized the chemical grafting of paclitaxel (PTX), a microtubule stabilizing anti-cancer agent on PDMMLA derivatives bio-polyesters following a Steglich esterification protocol. 1D and 2D NMR analyses validated the reaction with 10% (using 0.1 equivalent) of PTX on the copolymer PDMMLAH40-co-Hex60 (PDMMLA 40/60) and a maximal PTX grafting rate of 55% on the homopolymer PDMMLAH (PDMMLA 100/0). In vitro adhesion and cytotoxicity assays were carried out on HUVEC cells with PDMMLA 40/60, PDMMLA-PTX 30/10/60 and PLA.","PeriodicalId":11170,"journal":{"name":"Designed Monomers and Polymers","volume":"25 1","pages":"64 - 74"},"PeriodicalIF":1.6,"publicationDate":"2022-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49487033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Two new supramolecular Ag(I) coordination polymers: luminescent properties and treatment activity on glioblastoma 两种新型超分子Ag（I）配位聚合物的发光性能及其对胶质母细胞瘤的治疗作用

IF 1.6 4区化学

Designed Monomers and Polymers Pub Date : 2022-02-25 DOI: 10.1080/15685551.2022.2041785

Xiao-Feng Yan, Yu-Qiang Sun, Qing-Wei Li

引用次数: 0

Synthesis of glycerol carbonate from glycerin with CaCO₃ in a batch reactor. 用CaCO3在间歇反应器中由甘油合成碳酸甘油。

IF 1.6 4区化学

Designed Monomers and Polymers Pub Date : 2022-02-10 eCollection Date: 2022-01-01 DOI: 10.1080/15685551.2022.2037215

Ana Beatriz Morales Cepeda, Luis A Macclesh Del Pino, Claudia Esmeralda Ramos Galvan, Eric Joaquín González Pedraza, Luciano Aguilera Vazquez

引用次数: 1

Therapeutic effect of two transition metal coordination polymers on ovarian cancer by regulating the expression of estrogen receptor. 两种过渡金属配位聚合物通过调节雌激素受体表达对卵巢癌的治疗作用。

IF 1.6 4区化学

Designed Monomers and Polymers Pub Date : 2022-02-09 eCollection Date: 2022-01-01 DOI: 10.1080/15685551.2022.2033432

Jin Zhao, Lan Du

引用次数: 0

A new 3D heterometallic coordination polymer: luminescent property and nursing application value on acute cerebral infarction. 一种新型三维异金属配位聚合物：发光性能及在急性脑梗死中的护理应用价值。

IF 1.6 4区化学

Designed Monomers and Polymers Pub Date : 2022-02-02 eCollection Date: 2022-01-01 DOI: 10.1080/15685551.2022.2033431

Li Cong, Yun-Zhi Pan, Ying-Hui Qin, Ji-Na Jiang

引用次数: 0