Discover. Oncology最新文献_第8页

Strategies for managing EMA/CO resistant in gestational trophoblastic neoplasia a systematic review and meta analysis. 管理妊娠滋养细胞瘤中EMA/CO耐药的策略：系统回顾和荟萃分析。

IF 2.9 4区医学

Discover. Oncology Pub Date : 2025-10-14 DOI: 10.1007/s12672-025-03707-5

Febia Erfiandi, Setyo Teguh Waluyo, Candra Novi Ricardo Sibarani, Gatot Nyarumenteng Adhipurnawan Winarno, Aini Sofa Haniah, Nicholas Adrianto

引用次数: 0

Advances and challenges in immunotherapy and molecular imaging for hepatocellular carcinoma. 肝细胞癌免疫治疗和分子影像学的进展与挑战。

IF 2.9 4区医学

Discover. Oncology Pub Date : 2025-10-14 DOI: 10.1007/s12672-025-03682-x

Tu Haibin

引用次数: 0

Endometrial cancer: from clinical reality to molecular treatment. 子宫内膜癌：从临床现实到分子治疗。

IF 2.9 4区医学

Discover. Oncology Pub Date : 2025-10-14 DOI: 10.1007/s12672-025-03652-3

Léa-Isabelle Renaud, Elisabeth St-Laurent, Coralie Compare, Raphaëlle Proulx, Jasmine Nolan, Eric Asselin

{"title":"Endometrial cancer: from clinical reality to molecular treatment.","authors":"Léa-Isabelle Renaud, Elisabeth St-Laurent, Coralie Compare, Raphaëlle Proulx, Jasmine Nolan, Eric Asselin","doi":"10.1007/s12672-025-03652-3","DOIUrl":"10.1007/s12672-025-03652-3","url":null,"abstract":"Endometrial cancer (EC) is the most prevalent gynecological malignancy in developed countries, with incidence rates steadily increasing due to factors such as obesity, aging populations, and changes in reproductive behavior. While mortality rates have remained relatively stable, survival outcomes have improved little in recent years, underscoring the need for advancements in prevention, diagnosis, and treatment strategies. This review provides a comprehensive overview of both the clinical and fundamental aspects of EC, aiming to bridge the gap between biological research and clinical practice. On the clinical side, we assess genetic predispositions, hormonal and metabolic risk factors, classification systems, detection methods, treatment options, and their impact on survival and quality of life. From a research perspective, we highlight the models commonly used to study EC, including cell lines and animal models, and delve into the PI3K/AKT/mTOR signaling pathway, a critical driver of tumor progression and a promising therapeutic target. By synthesizing these insights, this review aims to inform future efforts to improve patient outcomes and advance the understanding of EC.","PeriodicalId":11148,"journal":{"name":"Discover. Oncology","volume":"16 1","pages":"1874"},"PeriodicalIF":2.9,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12521687/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145285855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bibliometric analysis reveals global thymoma research trends collaborations and emerging frontiers from 2010 to 2024. 文献计量分析揭示了2010年至2024年全球胸腺瘤研究趋势、合作和新兴领域。

IF 2.9 4区医学

Discover. Oncology Pub Date : 2025-10-14 DOI: 10.1007/s12672-025-03732-4

Zhen Yu, Yu-Han Li, Qi Han, Xin-Peng Wang, Xin-Tao Yu, Jian Cui, Xiang Gao, Xing-Guo Yang, Lei Yu

{"title":"Bibliometric analysis reveals global thymoma research trends collaborations and emerging frontiers from 2010 to 2024.","authors":"Zhen Yu, Yu-Han Li, Qi Han, Xin-Peng Wang, Xin-Tao Yu, Jian Cui, Xiang Gao, Xing-Guo Yang, Lei Yu","doi":"10.1007/s12672-025-03732-4","DOIUrl":"10.1007/s12672-025-03732-4","url":null,"abstract":"Objective: To map global thymoma research trends (2010-2024) through bibliometric analysis.Methods: Analysis of 2,078 publications from Web of Science/PubMed using Bibliometrix, VOSviewer, and CiteSpace. Metrics included productivity (countries/institutions/authors), thematic evolution, collaboration networks, and citation impact.Results: The analysis reveals a steady increase (6.2% CAGR) in the volume of thymoma-related publications over the past decade. Key journals included Journal of Thoracic Oncology and Annals of Thoracic Surgery. Prolific authors like Marx Alexander (25 publications) and institutions such as Fudan University (67 publications) dominated the field. Keyword analysis revealed sustained focus on \"myasthenia gravis,\" \"surgery,\" and \"thymectomy,\" with emerging interest in \"immunotherapy\" and \"molecular biology.\" High-impact articles addressed autoimmune associations and novel therapies (e.g., sunitinib). Global collaboration networks highlighted strong partnerships among the U.S., Europe, and Asia, though logistical and policy barriers may have limited China's broader international engagement.Conclusion: Thymoma research has evolved toward molecular and therapeutic innovation, emphasizing immunotherapy and precision medicine. Despite growth, geographical disparities and understudied areas (e.g., long-term outcomes) persist. Future efforts should prioritize multidisciplinary collaboration, biomarker discovery, and multicenter trials to optimize clinical strategies.","PeriodicalId":11148,"journal":{"name":"Discover. Oncology","volume":"16 1","pages":"1867"},"PeriodicalIF":2.9,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12521727/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145285865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Causal association between mitochondrial genes and colorectal cancer: a multi-omics Mendelian randomization study. 线粒体基因与结直肠癌的因果关系：一项多组学孟德尔随机研究。

IF 2.9 4区医学

Discover. Oncology Pub Date : 2025-10-14 DOI: 10.1007/s12672-025-03699-2

Zhandong Zhang, Shuaibing Lu, Liangqun Peng, Fusheng Ge, Bin Zhang, Yonglei Zhang, Fei Ma, Yawei Hua, Xiaobing Chen, Wei Yang

{"title":"Causal association between mitochondrial genes and colorectal cancer: a multi-omics Mendelian randomization study.","authors":"Zhandong Zhang, Shuaibing Lu, Liangqun Peng, Fusheng Ge, Bin Zhang, Yonglei Zhang, Fei Ma, Yawei Hua, Xiaobing Chen, Wei Yang","doi":"10.1007/s12672-025-03699-2","DOIUrl":"10.1007/s12672-025-03699-2","url":null,"abstract":"Objective: Colorectal cancer (CRC) is the leading cause of cancer-related morbidity and mortality globally. Despite the established link between mitochondrial dysfunction and various cancers, including CRC, the precise role of mitochondrial genes remains unclear. This study aimed to elucidate the influence of mitochondrial-related genes on CRC through a multi-omics approach.Methods: The MitoCarta3.0 database, methylation quantitative trait loci (mQTL), expression QTL (eQTL), and protein QTL (pQTL) data from multiple sources were utilized. CRC-related genetic data were obtained from the IEU OpenGWAS project and FinnGen database. The MR analysis employed five regression models. Integration of the results from three levels of gene regulation revealed significant associations between mitochondrial-related gene regulation and CRC.Results: We identified 21 genes that exhibit multi-omics evidence associated with CRC. Tier 1 gene PNKD showed significant associations with CRC across multiple omics levels. Tier 2 genes, RBFA, COX15, TXN2, and ACSF3, were linked to CRC at the mQTL-eQTL level. Sixteen tier 3 genes were also identified. A total of eight genes, including COX15, had been identified as potential therapeutic and drug targets. A total of eight genes, including COX15, had been identified as potential drug targets. Additionally, the final structures of the corresponding eight proteins and their respective drugs had been successfully determined.Conclusions: The multi-omics approach identified several mitochondrial-related genes significantly associated with CRC risk, providing new insights into the role of mitochondrial dysfunction in CRC pathogenesis, and potentially providing further investigation and future therapeutic strategies targeting mitochondrial pathways in CRC management.","PeriodicalId":11148,"journal":{"name":"Discover. Oncology","volume":"16 1","pages":"1864"},"PeriodicalIF":2.9,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12521712/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145285883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of palmitoylation-related lncRNAs as prognostic biomarkers and immune modulators in HCC. 棕榈酰化相关lncrna在HCC中作为预后生物标志物和免疫调节剂的鉴定

IF 2.9 4区医学

Discover. Oncology Pub Date : 2025-10-14 DOI: 10.1007/s12672-025-03710-w

Yongkang Zou, Xuejun Zhao, Shengpeng Yang, Yan Liu, Shuaimin Zhang, Xiangang Xu, Gen Chen, Yi Zhang

{"title":"Identification of palmitoylation-related lncRNAs as prognostic biomarkers and immune modulators in HCC.","authors":"Yongkang Zou, Xuejun Zhao, Shengpeng Yang, Yan Liu, Shuaimin Zhang, Xiangang Xu, Gen Chen, Yi Zhang","doi":"10.1007/s12672-025-03710-w","DOIUrl":"10.1007/s12672-025-03710-w","url":null,"abstract":"Hepatocellular carcinoma (HCC) has a high mortality rate. Current immunotherapy and targeted treatments have limited effectiveness. Palmitoylation, a reversible lipid modification, is increasingly recognized for its role in tumor progression and immune regulation. However, the function of palmitoylation-related long non-coding RNAs (lncRNAs) in HCC remains unclear. Using The Cancer Genome Atlas (TCGA) data, we identified key palmitoylation-related lncRNAs and developed a prognostic model based on NRAV and AL031985.3. Patients were stratified into high- and low-risk groups. Immune cell infiltration, immune checkpoint gene expression, tumor mutation burden (TMB), and drug sensitivity were analyzed. Furthermore, quantitative reverse transcription polymerase chain reaction (qRT-PCR) was performed to validate lncRNA expression in clinical liver tissue samples from healthy organ donors (normal liver) and HCC patients (tumor tissue). The model effectively distinguished survival differences. High-risk patients exhibited increased Treg cells and immune checkpoint expression, indicating an immunosuppressive phenotype. Functional enrichment analysis revealed associations with cell cycle, immune response, and inflammatory pathways. Combining TMB with the risk score improved prognostic accuracy. Both NRAV and AL031985.3 were significantly up-regulated in tumor tissues compared to normal liver tissues, confirming their diagnostic and prognostic potential. NRAV and AL031985.3 represent promising prognostic biomarkers and immunotherapy targets in HCC. This study provides novel insights into the role of palmitoylation-related lncRNAs in HCC immune regulation.","PeriodicalId":11148,"journal":{"name":"Discover. Oncology","volume":"16 1","pages":"1878"},"PeriodicalIF":2.9,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12521701/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145285898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endoscopic therapy versus surgical resection for rectal gastrointestinal stromal tumors: a population-based comparative analysis of long-term survival outcomes. 内镜治疗与手术切除直肠胃肠道间质瘤：基于人群的长期生存结果比较分析。

IF 2.9 4区医学

Discover. Oncology Pub Date : 2025-10-14 DOI: 10.1007/s12672-025-03720-8

Jiayi Ding, Luojie Liu, Ye Ye

{"title":"Endoscopic therapy versus surgical resection for rectal gastrointestinal stromal tumors: a population-based comparative analysis of long-term survival outcomes.","authors":"Jiayi Ding, Luojie Liu, Ye Ye","doi":"10.1007/s12672-025-03720-8","DOIUrl":"10.1007/s12672-025-03720-8","url":null,"abstract":"Background: Rectal gastrointestinal stromal tumors (GISTs) are relatively rare, and the long-term survival outcomes of endoscopic therapy (ET) versus surgical resection (SR) remain uncertain. This study aims to assess the long-term survival in patients with rectal GISTs treated with either ET or SR.Methods: Patients were selected from the Surveillance, Epidemiology, and End Results (SEER) database. Propensity score matching (PSM) was implemented to reduce selection bias in the comparative analyses. The impact of demographic and clinical features on overall survival (OS) and cancer-specific survival (CSS) was evaluated through Kaplan-Meier analyses and the use of multivariate Cox proportional hazards models.Results: A total of 239 patients were included, with 146 undergoing ET and 93 undergoing SR. After PSM, 164 patients were evenly matched for comparison. There was no significant distinction between ET and SR regarding long-term OS (P = 0.592) and CSS (P = 0.832). Furthermore, subgroup analysis considering factors like age, tumor size, year of diagnosis, and sex also found no variance in OS and CSS outcomes between the groups. The multivariate Cox analysis identified advanced age as the sole independent risk factor impacting the prognosis of patients with rectal GISTs.Conclusions: Our findings suggest that ET and SR offer comparable long-term survival outcomes for patients with rectal GISTs, indicating that ET could be considered a viable treatment option.","PeriodicalId":11148,"journal":{"name":"Discover. Oncology","volume":"16 1","pages":"1871"},"PeriodicalIF":2.9,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12521689/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145285866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In vitro assessment of benzothiadiazole-based photoactive polymers against ovarian, prostate and bladder cancer cell lines for photodynamic therapy. 以苯并噻二唑为基础的光活性聚合物对卵巢癌、前列腺癌和膀胱癌细胞光动力治疗的体外评估。

IF 2.9 4区医学

Discover. Oncology Pub Date : 2025-10-14 DOI: 10.1007/s12672-025-03654-1

Rolan Mansour, Fawziye Tarhini, Nicolas Bruce, Jamie Blanche, Mahmoud Wagih, Ahmad Taha, Karin Williams, Jonathan Copper, Muhammad Imran, Karin Oien, Hadi Heidari, David Flynn

{"title":"In vitro assessment of benzothiadiazole-based photoactive polymers against ovarian, prostate and bladder cancer cell lines for photodynamic therapy.","authors":"Rolan Mansour, Fawziye Tarhini, Nicolas Bruce, Jamie Blanche, Mahmoud Wagih, Ahmad Taha, Karin Williams, Jonathan Copper, Muhammad Imran, Karin Oien, Hadi Heidari, David Flynn","doi":"10.1007/s12672-025-03654-1","DOIUrl":"10.1007/s12672-025-03654-1","url":null,"abstract":"There are unmet clinical needs of bladder cancer associated with its late detection, limited treatment options, and high mortality rate. In response to this, we present the results of the in-vitro assessment of photodynamic polymers, prior to their integration into a wireless biomedical implant for in-situ photodynamic therapy (PDT). PDT selectively activates light-sensitive photosensitizers, to kill cancer cells without the adverse effects associated with systemic therapies, such as chemotherapy. PDT offers significant advantages in hypoxic tumors, including oxygen-independent cytotoxicity known to impede the curative efficiency of radiotherapy. Accordingly, we report on the design methodology and microfabrication process of an in-situ PDT wireless microsystem as a novel treatment modality. We present the preliminary results from three benzothiadiazole-based polymers that are evaluated as solid support photosensitizers for the inhibition of cancer growth in three cell lines. Cell lines represent ovarian, prostate and bladder cancer, the reduction in cell number was assessed with Sulforhodamine B assays. Following Polyamide, aminophenyl- (PA-ABT) treatment, cells were subjected to a range of 420 nm light exposures and fluorimetry was used to determine cell growth. PA-ABT was shown to cause growth inhibition only at higher concentrations in all tested cell lines. PA-ABT can be considered as a promising candidate for in-situ PDT treatment due to its inhibitory effects in cancer cell lines open new possibilities for mono or combination light-based therapy in cancer treatment for previously inaccessible cancers.","PeriodicalId":11148,"journal":{"name":"Discover. Oncology","volume":"16 1","pages":"1863"},"PeriodicalIF":2.9,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12521685/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145285856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Single-cell transcriptomic insights into ccRCC: a stemness gene signature for prognosis and treatment response prediction. 单细胞转录组学洞察ccRCC：一个用于预后和治疗反应预测的干性基因标记。

IF 2.9 4区医学

Discover. Oncology Pub Date : 2025-10-14 DOI: 10.1007/s12672-025-03664-z

Jianhui Chen, Xinyi Wu, Guo Han, Chao Xu

{"title":"Single-cell transcriptomic insights into ccRCC: a stemness gene signature for prognosis and treatment response prediction.","authors":"Jianhui Chen, Xinyi Wu, Guo Han, Chao Xu","doi":"10.1007/s12672-025-03664-z","DOIUrl":"10.1007/s12672-025-03664-z","url":null,"abstract":"Clear cell renal cell carcinoma (ccRCC), the most prevalent renal malignancy, exhibits remarkable intratumoral heterogeneity that challenges precise prognostication and treatment stratification. Leveraging single-cell RNA sequencing (scRNA-seq) and an advanced artificial intelligence (AI)-driven analytical framework, we comprehensively dissected the cellular complexity of ccRCC and developed a robust prognostic model. Analyzing scRNA-seq data from 44 ccRCC samples, we identified a distinct proliferative epithelial cell subtype strongly correlated with adverse clinical outcomes. Through a sophisticated LASSO-XGBoost machine learning approach, we constructed a novel stemness-related gene signature (SGS) that demonstrated exceptional predictive capabilities across multiple independent cohorts. The SGS effectively stratified patients into high-risk and low-risk groups, with high-risk individuals experiencing significantly reduced overall survival. Notably, our model outperformed conventional clinicopathological parameters and existing prognostic signatures. Critically, patients with elevated SGS scores exhibited diminished responsiveness to targeted therapies and immune checkpoint inhibitors, suggesting its potential as a predictive biomarker for treatment efficacy. Our findings not only illuminate the pivotal role of proliferative epithelial cells in ccRCC progression but also underscore the transformative potential of AI-driven approaches in precision oncology. This study provides a foundational framework for enhanced patient stratification and personalized therapeutic interventions in ccRCC.","PeriodicalId":11148,"journal":{"name":"Discover. Oncology","volume":"16 1","pages":"1862"},"PeriodicalIF":2.9,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12521704/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145285914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Circulating metabolites and bladder cancer: a Mendelian randomization and multi-omics study. 循环代谢物和膀胱癌：一项孟德尔随机和多组学研究。

IF 2.9 4区医学

Discover. Oncology Pub Date : 2025-10-14 DOI: 10.1007/s12672-025-03709-3

Zhe Chang, Jirong Wang, Li Wang, Zongjian Hu, Siyu Chen, Li Yang

{"title":"Circulating metabolites and bladder cancer: a Mendelian randomization and multi-omics study.","authors":"Zhe Chang, Jirong Wang, Li Wang, Zongjian Hu, Siyu Chen, Li Yang","doi":"10.1007/s12672-025-03709-3","DOIUrl":"10.1007/s12672-025-03709-3","url":null,"abstract":"Background: The mechanisms by which various circulating metabolites influence bladder cancer (BLCA) progression via differentially expressed metabolic pathway genes remain unclear.Methods: This study employed a bidirectional two-sample Mendelian randomization (MR) method to investigate potential causal relationships between circulating metabolites and the risk of BLCA. Thorough methodological assessments were conducted alongside extensive sensitivity analyses to guarantee robustness. The subsequent KEGG pathway enrichment analysis identified biologically significant metabolic pathways, which were subsequently cross-referenced with differentially expressed gene-associated metabolic pathways from TCGA and GEO datasets. Ultimately, we developed graphic representations of the interconnections between metabolic and genetic pathways.Results: Our study identified 27 circulating metabolites with causal associations to BLCA, comprising 18 risk variables and 9 protective factors. Sensitivity analyses were conducted to validate the robustness of the results. Reverse Mendelian Randomization analysis eliminated metabolite-level influences from bladder cancer. Pathway enrichment analysis of these metabolites revealed 41 pathways, with 3 consistently modified in TCGA and GEO datasets. The visualizations of the pathways clarified potential mechanistic connections between metabolic dysregulation and chromosomal changes in the pathogenesis of BLCA.Conclusion: This work explored causal links between specific circulating metabolites and BLCA, uncovering functionally significant metabolic pathways through combined metabolomic and Transcriptomic studies. The identified correlations between metabolites and genes provided a new understanding of BLCA metabolomics and laid the groundwork for the development of tailored metabolic treatments.","PeriodicalId":11148,"journal":{"name":"Discover. Oncology","volume":"16 1","pages":"1859"},"PeriodicalIF":2.9,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12521714/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145285821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0