Disease and Diagnosis最新文献

{"title":"Comparison of the Effect of Eight Weeks of Strength Training, Aquatic Exercise, and Omega-3 Supplement Consumption on Motor Function of Diabetic Men With Peripheral Neuropathy","authors":"Alireza Saadatifar, T. Bagherpour, Nematullah Nemati","doi":"10.34172/ddj.2023.479","DOIUrl":"https://doi.org/10.34172/ddj.2023.479","url":null,"abstract":"Background: Diabetes leads to some motor function dysfunction. The aim of this research was to compare the effect of eight weeks of strength training, water exercise, and omega-3 consumption on the motor function of diabetic men with peripheral neuropathy. Materials and Methods: Among the diabetic patients with peripheral neuropathy (30-60 years old), 80 people were purposefully selected and then randomly divided into four groups, including 8 weeks of taking omega-3 supplements, 8 weeks of strength training, 8 weeks of water training, and control (20 people in each group). Eventually, a one-way analysis of variance was used for the group comparison of variables. Results: In terms of simple reaction time, strength training (P=0.03) and water training (P=0.01) were lower than the control group. In addition, the water exercises (P=0.04) and strength training (P=0.04) were lower than the consumption of omega-3. However, in terms of the balance score, strength training (P=0.001), water training (P=0.001), and omega-3 consumption (P=0.01) were higher than the control group. Similarly, water exercises (P=0.02) and strength training (P=0.03) were higher than the average consumption of omega-3. Regarding the leg muscle strength score, the strength training (P=0.001), water training (P=0.001), and omega-3 consumption (P=0.003) were higher than the control group. Finally, the strength training (P=0.012) was higher than the mean consumption of omega-3 (P=0.012). Conclusion: In general, strength training, water exercise, and omega-3 consumption improved motor performance in diabetic neuropathy men.","PeriodicalId":11143,"journal":{"name":"Disease and Diagnosis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84168357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determining the Synergistic Effect of Magnetic Fields on the Induction of Apoptosis by Folic Acid Targeted Iron Superparamagnetic Nanoparticles Loaded With Lomustine on U87-MG Cell Line","authors":"Zeinolabedin Shrifian Dastjerdi, Elias Kargar Abargouei, Fahimeh Zamani Rarani, Ebrahim Eftekhar, Mohammad Zamani Rarani, Dariush Hooshyar, Reza Afzalipour","doi":"10.34172/ddj.2023.450","DOIUrl":"https://doi.org/10.34172/ddj.2023.450","url":null,"abstract":"Background: Brain cancer is recognized as one of the deadliest cancers due to late detection and limitations of therapies. Glioblastoma occurs in different parts of the central nervous system and is the second leading cause of cancer death in people. There are many problems for the treatment of cancer cells. One of the limiting factors is the resistance of cancer cells to chemotherapy drugs. The use of nanoparticles (NPs) is an effective method for overcoming this problem. Materials and Methods: Fe3 O4 NPs were synthesized, and the size and morphology of NPs were determined by transmission electron microscopy, X-ray photoelectron spectroscopy, and Dynamic Light Scattering. The U87-MG cell line was cultured in Dulbecco’s modified Eagle medium and treated with nano, nano-lomustine, lomustine, and complex with/without magnetic fields. Finally, half maximal inhibitory concentration (IC50), MTT assay, and caspase8 and caspase9 expression were evaluated, and the data were analyzed with SPSS software. Results: Our results demonstrated that cell apoptosis increased in lomustine and complex groups, especially with the magnetic field (P>0.05). Based on caspase9 expression analysis, this rate was increased with the magnetic field vs. its absence (P>0.05). Conclusion: These findings indicated that a magnetic field, in addition to reducing the effective dose of lomustine, affects apoptosis with a change in the expression of genes involved in this process.","PeriodicalId":11143,"journal":{"name":"Disease and Diagnosis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134955266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Duration of Hospitalization According to the Type of Treatment in Patients Diagnosed With Schizophrenia: A Retrospective Cross-sectional Study","authors":"A. Massoudifar, Rayehe Jahangiri, S. Namazi, Zeinab Haghighi Fini, Nozhan Alimi, MohammadHosein Sheybani-Arani","doi":"10.34172/ddj.2023.461","DOIUrl":"https://doi.org/10.34172/ddj.2023.461","url":null,"abstract":"Background: Schizophrenia is a complex mental disorder with the most severe and devastating effect on a person’s life. Given that schizophrenia treatments have different effects on the duration of hospitalization and reduction of positive and negative symptoms, we decided to conduct a study to evaluate the duration of hospitalization according to the type of treatment in patients diagnosed with schizophrenia in Ebn-e-Sina hospital in Bandar Abbas. Materials and Methods: In this retrospective descriptive cross-sectional study, the files of 75 patients with schizophrenia admitted to the psychiatric ward of Ebn-e-Sina hospital in 2019-2020 were included after obtaining the approval of the ethics committee. A group of patients was treated with electroconvulsive therapy (ECT) and typical antipsychotic drugs, and another with ECT and atypical antipsychotic medications until the acute phase of the disease subsided. The patient’s file information was summarized and arranged in a checklist prepared by the researcher and then statistically analyzed using SPSS version 22.0. Results: The patients’ most commonly received treatment was typical and atypical antipsychotic medications combined with ECT (60.0%), followed by combination therapy (29.30%), atypical antipsychotic medications (8.00%), and typical antipsychotic medications (2.70%), respectively. Considering the specific objectives of this study, it was found that the mean length of hospital stay in the 4 treatment groups was significantly different (P=0.006). Conclusion: The duration of hospitalization in the combined with ECT group was significantly longer compared to the others.","PeriodicalId":11143,"journal":{"name":"Disease and Diagnosis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80818738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Expression Intensity of Glucose Transporter-1 Marker and its Diagnostic Value in Differentiating Between Borderline and Malignant Ovarian Epithelial Tumors","authors":"Siamak Naji Hadadi, H. Ayatollahi, Masoumeh Noushyar","doi":"10.34172/ddj.2023.441","DOIUrl":"https://doi.org/10.34172/ddj.2023.441","url":null,"abstract":"Background: Ovarian cancer ranks second among gynecological cancers worldwide. This study aimed to compare the glucose transporter-1 (GLUT-1) expression in benign, borderline, and malignant ovarian epithelial tumors and evaluate GLUT-1 expression as a diagnostic tool for distinguishing tumors in the ovary. Materials and Methods: This descriptive-analytical cross-sectional study analyzed 69 pathological samples of patients diagnosed with ovarian epithelial tumors who underwent oophorectomy. Immunohistochemical staining was performed using GLUT-1 antibody. The intensity of cell membrane staining and the proportion of positive neoplastic cells were graded to score immunostaining. Chi-square/Fisher’s exact test was used to analyze the data. The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV), and staining accuracy for GLUT-1 in distinguishing borderline from invasive tumors were calculated by standard methods (P<0.05). Results: In all benign tumors, GLUT-1 staining was negative. In addition, weak staining intensity was observed in 38.5% of borderline tumors, and 96% of invasive tumors had strong staining intensity (P<0.001). Strong GLUT-1 staining was found in 94.7% of Papillary Serous Carcinoma, 9/1% of Borderline Serous tumors, 100% of Brenner tumors, and clear cell carcinoma. The results demonstrated a high diagnostic value of GLUT-1 expression intensity in differentiating between borderline and malignant ovarian epithelial tumors (Accuracy: 97.10, Sensitivity: 96%, Specificity: 97.73). Conclusion: Overall, GLUT-1 expression could help distinguish benign from borderline, especially borderline from malignant ovarian epithelial tumors. Thus, it seems that it provides useful prognostic information, particularly for the borderline category.","PeriodicalId":11143,"journal":{"name":"Disease and Diagnosis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81131172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Could Basal Uric Acid Levels Be an Important Biomarker for Prediction of Acute Renal Injury in Patients With Sepsis in the Intensive Care Unit?","authors":"H. Düğeroğlu, Murat Özgenoğlu","doi":"10.34172/ddj.2023.490","DOIUrl":"https://doi.org/10.34172/ddj.2023.490","url":null,"abstract":"Background: Sepsis is an important risk factor for the development of acute renal injury (ARI) among patients admitted to the intensive care unit (ICU). There are limited studies showing that increased uric acid level is an important risk factor for the development of ARI. The present study was carried out to find out whether increased basal uric acid levels play an important role in predicting the development of ARI and whether it could be used as a biomarker for this. Materials and Methods: This retrospective study included patients aged≥18 years who were admitted to the ICU of Yüzüncü Yıl University Medical Faculty Hospital from September 2018 to December 2020. Group 1 comprised 100 patients developing ARI and group 2 comprised 110 patients who did not develop ARI. Laboratory test values and Simplified Acute Physiologic Score II (SAPS II) data on the first day of ICU admission were obtained from archive records. Results: During the 10-day follow-up of patients included in the study, the ARI development rate was 57.3%. Basal serum uric acid levels were higher in group 1 compared to group 2 (P=0.001). Based on the results of the multivariate logistic regression analysis, basal serum uric acid values and albumin and SAPS II values had independent correlations with ARI (P<0.001). Conclusion: We believe that increased basal uric acid levels examined in patients admitted to the ICU with sepsis diagnosis may be an important biomarker for the prediction of ARI.","PeriodicalId":11143,"journal":{"name":"Disease and Diagnosis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83442380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comparison Between the Efficacy of Venlafaxine and Duloxetine in Improving Chemotherapy-Induced Chronic Neurotoxicity in Cancer Patients","authors":"Hanzaleh Jour Ebrahimiyan, Nafiseh Ansarinejad, F. Fardad","doi":"10.34172/ddj.2023.389","DOIUrl":"https://doi.org/10.34172/ddj.2023.389","url":null,"abstract":"Background: Chemotherapy-induced peripheral neuropathy is one of the most common side effects of chemotherapy. This study aimed to determine the effectiveness of venlafaxine and duloxetine in improving chronic neurotoxicity induced by chemotherapy in cancer patients. Materials and Methods: The study was performed on cancer patients undergoing outpatient chemotherapy or hospitalization in Rasoul Akram hospital. The admitted patients were blindly divided into two groups. The first group was treated with venlafaxine, and the second group was treated with duloxetine. The treatment lasted up until the patients’ full recovery up to 10 weeks. Different intensities of the patients’ neuropathy were measured on all days of treatment based on NCI Common Terminology Criteria for Adverse Events (CTCAE) v 3.0 criteria. At the end of the treatment, the side effects of venlafaxine and duloxetine were identified. Results: A total of 30 patients in two groups (n=15 for each group) were treated with venlafaxine and duloxetine. There was no significant difference between the two groups in terms of age and gender. The severity of neuropathy was significantly reduced in the venlafaxine compared to the duloxetine group from 7 to 10 weeks. The results indicated that 75% and 85.7% fall asleep in the venlafaxine group and the duloxetine group, respectively. Further, there was no significant difference between the two groups in terms of drug side effects. Conclusion: This study showed that venlafaxine is a suitable drug for the treatment of chronic neurotoxicity in patients with relatively fewer side effects compared to other used drugs. Although these results require further prospective studies due to the small sample size, future drug regimens may preferably contain venlafaxine.","PeriodicalId":11143,"journal":{"name":"Disease and Diagnosis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77925714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship Between SpO2 and Laboratory Diagnostic Markers of Cardiovascular Patients with COVID-19","authors":"A. Bagheri, Naser Kamyari, Maryam Ban, Khadijeh Kanani, S. Mobarak, E. Radmanesh","doi":"10.34172/ddj.2023.466","DOIUrl":"https://doi.org/10.34172/ddj.2023.466","url":null,"abstract":"Background: In December 2019, a new virus, the coronavirus disease 2019 (COVID-19) was identified as the cause of a cluster of cases of pneumonia of unknown etiology in Wuhan, China. The COVID-19 disease increases cardiovascular events both directly and indirectly. This study aimed to investigate the laboratory diagnostic markers of cardiovascular patients with COVID-19 in Ayatollah Taleghani hospital in Abadan from March 20, 2019 to March 19, 2020. Materials and Methods: This study is a cross-sectional analytical study. Some demographic, laboratory, and clinical information of 200 cardiovascular patients with COVID-19 admitted to Taleghani hospital, Abadan, was received randomly by referring to the medical records section and medical records section and health information system (HIS) as well as searching in the patient records. Inclusion criteria included cardiovascular patients with COVID-19 who had been admitted to Ayatollah Taleghani hospital in Abadan with the diagnosis of a cardiologist and infectious disease specialist, and those whose information was available in HIS. The results were analyzed using SPSS software version 24. Results: The mean age of cardiovascular patients with COVID-19 was reported to be 66.98±18.14. The results revealed that the mean of fasting blood sugar (FBS), serum glutamic oxaloacetic transaminase (SGOT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), creatinine (Cr), blood urea nitrogen (BUN), and erythrocyte sedimentation rate (ESR) was higher than the normal level in these patients. In addition, the mean oxygen saturation (SpO2) was observed to be lower than normal. Reducing the level of SpO2 to less than 90% was significantly related to increasing age, death, patients with a history of lung disease, the duration of hospitalization in ICU, and intubation. This reduction also led to an increase in respiratory rate (RR), LDH, ESR, and C-reactive protein (CRP+1) in cardiovascular patients with COVID-19. Conclusion: In cardiovascular patients with COVID-19, FBS, some kidney markers, liver markers, and inflammatory markers were observed to be higher than normal, and a significant relationship was observed between the reduction of SpO2 and some laboratory diagnostic markers, which requires extensive studies with larger sample size.","PeriodicalId":11143,"journal":{"name":"Disease and Diagnosis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90769085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Olfactory Dysfunction in Patients with Coronavirus Disease 2019: A Narrative Review","authors":"Mehdi Askari","doi":"10.34172/ddj.2023.449","DOIUrl":"https://doi.org/10.34172/ddj.2023.449","url":null,"abstract":"Background: The global public health and economic systems have been severely damaged by the coronavirus disease 2019 (COVID-19) pandemic. Olfactory dysfunction (OD) is one of the most prevalent symptoms experienced by COVID-19 patients, documented in clinical practice. In some individuals, OD is the first or the sole clinical symptom. In this review, the clinical characteristics, causes, evaluation procedures, prognosis, and available treatments of COVID-19-induced OD were examined. Methods: The PubMed, Scopus, Web of Sciences, and Google Scholar databases were searched for the related articles from inception until August 2022. Results: OD appears to be common in COVID-19, particularly in younger individuals and women and those with milder disease. Even though the issue is still unresolved, current research suggests that COVID-19-related OD is not caused by direct injury to olfactory sensory neurons but instead is a result of indirect injury to these cells. Moreover, effective therapeutic methods are inadequate despite the high prevalence of COVID-19-related OD. Conclusion: The focus of medical practice regarding COVID-19-related OD should be on identifying individuals with a poor prognosis who may benefit from early management to prevent complications, e.g., depression and anxiety, because COVID-19 OD generally has a good prognosis and quick recovery time.","PeriodicalId":11143,"journal":{"name":"Disease and Diagnosis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135672156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood Pressure Status and Its Indicators in Individuals Covered by Integrated Health Centers in Bandar Abbas, Iran","authors":"S. Fallahi, Shideh Rafati, Hesamaddin Kamalzadeh, T. Aghamolaei, Hossein Farshidi, Masoud Dadras, Seyedeh Masoumeh Mousavinejad, Farideh Dastsouz, M. Nikparvar","doi":"10.34172/ddj.2023.431","DOIUrl":"https://doi.org/10.34172/ddj.2023.431","url":null,"abstract":"Background: Controlling hypertension is a key component in the management of cardiovascular risk factors and is an essential part of the prevention strategy. Materials and Methods: This descriptive cross-sectional study was conducted in seven integrated health centers covering most families in Bandar Abbas from July 2019 to February 2020. The sample size was estimated to include 968 individuals. Independent samples t-test and Chi-square test were used to compare groups. In addition, some factors affecting uncontrolled blood pressure were identified using logistic regression. Results: In this study, 68.4% and 31.6% were women and men, respectively, of whom 136 cases were single, while 756 cases were married. With an increase in age, the prevalence of uncontrolled hypertension in both genders showed a significant increase (P<0.001). Univariate logistic regression (crude odds ratios, ORs) demonstrated that age over 60 years, smoking, diabetes mellitus, physical inactivity, and the use of salt were the most important factors influencing the presence of uncontrolled hypertension. According to the results of the multivariable logistic regression model, smoking was the most important factor affecting the inability to control hypertension since controlling the effect of other variables triggered the chance of not controlling hypertension in smokers as 2.76 times higher than in non-smokers (adjusted OR: 2.76, 95% confidence interval: 1.05-7.26). Conclusion: Since using table salt, a sedentary lifestyle, and smoking count as risk factors for cardiovascular diseases, necessary prevention and treatment planning are strongly recommended to control modifiable risk factors in this city through public education.","PeriodicalId":11143,"journal":{"name":"Disease and Diagnosis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75759398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adrenal Incidentaloma With the Diagnosis of Normotensive Pheochromocytoma: A Case Report","authors":"A. Atashabparvar, Feysal Yousefzade, S. Kheirandish, Sepehr Rasekhi, Ghazal Zoghi, Masoumeh Kheirandish","doi":"10.34172/ddj.2023.392","DOIUrl":"https://doi.org/10.34172/ddj.2023.392","url":null,"abstract":"Background: Pheochromocytomas (PCCs) are catecholamine-producing neuroendocrine tumors that originate from the adrenal medulla. Their clinical presentations most commonly include hypertension, headache, palpitations, and sweating; however, PCCs are sometimes normotensive and clinically silent. Case Presentation: A female patient with abdominal pain as well as persistent and crushing left flank pain for the past six months was examined. The imaging studies revealed a mass in the upper pole of the left kidney indicative of a potential adrenal gland tumor; however, she had normal blood pressure (BP). Histopathologic examination of the mass from exploratory laparotomy showed that it was a PCC. Findings from sonography and computed tomography (CT) scan of the left adrenal tumor, along with elevated urinary normetanephrine level and positive iodine-123 metaiodobenzylguanidine (MIBG) scan led to preoperative diagnosis of PCC in our case. Conclusion: This study highlighted the importance of imaging and biochemical testing in diagnosing PCCs in patients with adrenal incidentalomas (AIs), even though they were normotensive and entirely asymptomatic.","PeriodicalId":11143,"journal":{"name":"Disease and Diagnosis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75416501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}