发布求助
文献互助 智能选刊 最新文献

Current Pharmacology Reports最新文献

筛选
英文 中文
Pharmacodynamics (PD), Pharmacokinetics (PK) and PK-PD Modeling of NRF2 Activating Dietary Phytochemicals in Cancer Prevention and in Health. NRF2激活膳食植物化学物质在癌症预防和健康中的药效学（PD）、药代动力学（PK）和PK-PD模型
Current Pharmacology Reports Pub Date : 2025-01-01 Epub Date: 2024-12-05 DOI: 10.1007/s40495-024-00388-6
Ahmad Shannar, Pochung Jordan Chou, Rebecca Peter, Parv Dushyant Dave, Komal Patel, Yuxin Pan, Jiawei Xu, Md Shahid Sarwar, Ah-Ng Kong
{"title":"Pharmacodynamics (PD), Pharmacokinetics (PK) and PK-PD Modeling of NRF2 Activating Dietary Phytochemicals in Cancer Prevention and in Health.","authors":"Ahmad Shannar, Pochung Jordan Chou, Rebecca Peter, Parv Dushyant Dave, Komal Patel, Yuxin Pan, Jiawei Xu, Md Shahid Sarwar, Ah-Ng Kong","doi":"10.1007/s40495-024-00388-6","DOIUrl":"10.1007/s40495-024-00388-6","url":null,"abstract":"<p><strong>Purpose of review: </strong>Dietary phytochemicals, bioactive compounds derived from plants, have gained increasing attention for their potential role in cancer prevention. Among these, NRF2 (nuclear factor erythroid 2-related factor 2) activating dietary phytochemicals such as curcumin, sulforaphane, ursolic acid, and cyanidin have demonstrated significant antioxidant and anti-inflammatory properties, making them promising agents in chemoprevention. This review examines the pharmacokinetic (PK) and pharmacodynamic (PD) profiles of these dietary phytochemicals, with a focus on their NRF2-mediated effects in cancer prevention.</p><p><strong>Recent findings: </strong>Preclinical studies have highlighted the potential of these dietary phytochemicals to modulate oxidative stress and inflammation, key drivers of carcinogenesis. We explore the complexity of their PK/PD properties, influenced by factors such as bioavailability, metabolism, and drug interactions. While most of these phytochemicals follow two compartmental PK, their anti-oxidant and anti-inflammatory effects follow the indirect response (IDR) model. Furthermore, we discuss the application of physiologically based pharmacokinetic (PBPK) modeling to simulate the behavior of these compounds in humans, providing insights for clinical translation.</p><p><strong>Summary: </strong>The integration of PK-PD analysis into the development of dietary phytochemical-based therapies offers a pathway to optimize dosing strategies, enhance therapeutic efficacy, and improve safety. This review underscores the importance of these compounds as part of cancer interception strategies, particularly in the early stages of cancer development, where they may offer a natural, less toxic alternative to conventional therapies.</p><p><strong>Graphical abstract: </strong></p>","PeriodicalId":11139,"journal":{"name":"Current Pharmacology Reports","volume":"11 1","pages":"6"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11618211/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Application of Metabolomics in Carcinogenesis and Cancer Prevention by Dietary Phytochemicals.
Current Pharmacology Reports Pub Date : 2025-01-01 Epub Date: 2025-02-06 DOI: 10.1007/s40495-025-00396-0
Rebecca Mary Peter, Xiaoyang Su, Ah-Ng Kong
{"title":"Application of Metabolomics in Carcinogenesis and Cancer Prevention by Dietary Phytochemicals.","authors":"Rebecca Mary Peter, Xiaoyang Su, Ah-Ng Kong","doi":"10.1007/s40495-025-00396-0","DOIUrl":"10.1007/s40495-025-00396-0","url":null,"abstract":"<p><strong>Purpose of review: </strong>In this review article, specific emphasis is on evolution of metabolomics in cancer research, metabolomics workflow, general understanding of liquid chromatography - mass spectrometry (LC-MS) based platform for quantitation of metabolites, their biological interpretation and the application in carcinogenesis and cancer prevention by dietary phytochemicals.</p><p><strong>Recent findings: </strong>Metabolomics is increasingly becoming a preferred approach for next generation metabolic screening and has profound impact on medical practice. Metabolomics describes the end products of biochemical processes which are greatly influenced by genetic and environmental factors. Metabolic alterations can be linked to potential biochemical reactions/enzymes and their corresponding genes. Thus, these results can be further validated via multi-omics approach including genomics, transcriptomics and proteomics. However, challenges exist within and between omic-domain data integration considering complex biochemical regulation including organism versus tissue versus cellular level processes, epigenetics, transcriptional and post translational modifications. Metabolomics can reflect the steady state or dynamic state of metabolism because metabolites are highly dynamic in space and time.</p><p><strong>Summary: </strong>Metabolomic analysis of biological samples exhibit the possibility to determine mechanism of action of anti-cancer agents, biomarker discovery and impact of genetic alterations.</p>","PeriodicalId":11139,"journal":{"name":"Current Pharmacology Reports","volume":"11 1","pages":"12"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11889054/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Harnessing Nutritional Powerhouse: Millets and Probiotics in Anticancer Therapy 利用营养力量：抗癌疗法中的小米和益生菌
Current Pharmacology Reports Pub Date : 2024-07-22 DOI: 10.1007/s40495-024-00360-4
Reshma Muthuvel, Selvaraj Jagannathan, Naseera Kannanthodi Pariyapurath, Rahul Gandhi Pachamuthu, M. Mathanmohun, Suresh Sagadevan
{"title":"Harnessing Nutritional Powerhouse: Millets and Probiotics in Anticancer Therapy","authors":"Reshma Muthuvel, Selvaraj Jagannathan, Naseera Kannanthodi Pariyapurath, Rahul Gandhi Pachamuthu, M. Mathanmohun, Suresh Sagadevan","doi":"10.1007/s40495-024-00360-4","DOIUrl":"https://doi.org/10.1007/s40495-024-00360-4","url":null,"abstract":"","PeriodicalId":11139,"journal":{"name":"Current Pharmacology Reports","volume":"30 49","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141814015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mental Health and the Microbiome: A Review of Psychological Impacts of Gut Microflora 心理健康与微生物组：肠道微生物群的心理影响综述
Current Pharmacology Reports Pub Date : 2024-06-01 DOI: 10.1007/s40495-024-00357-z
Ananya Gupt, Sonal Naudiyal, Anju Rani, Sunil Kumar
{"title":"Mental Health and the Microbiome: A Review of Psychological Impacts of Gut Microflora","authors":"Ananya Gupt, Sonal Naudiyal, Anju Rani, Sunil Kumar","doi":"10.1007/s40495-024-00357-z","DOIUrl":"https://doi.org/10.1007/s40495-024-00357-z","url":null,"abstract":"","PeriodicalId":11139,"journal":{"name":"Current Pharmacology Reports","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141235065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Redoxification (of the Organism) Through Diet and Supplementation with a Focus on Natural Polymeric Redox Modulators 通过饮食和补充剂实现（生物体的）氧化还原，重点关注天然聚合氧化还原调节剂
Current Pharmacology Reports Pub Date : 2024-03-26 DOI: 10.1007/s40495-024-00353-3
N. Sahakyan, M. J. Nasim, Claus Jacob
{"title":"Redoxification (of the Organism) Through Diet and Supplementation with a Focus on Natural Polymeric Redox Modulators","authors":"N. Sahakyan, M. J. Nasim, Claus Jacob","doi":"10.1007/s40495-024-00353-3","DOIUrl":"https://doi.org/10.1007/s40495-024-00353-3","url":null,"abstract":"","PeriodicalId":11139,"journal":{"name":"Current Pharmacology Reports","volume":"34 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140378202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessing the Clinical Correlation between Alzheimer's disease and Type-2 Diabetes Mellitus: Current Strategies and Emerging Perspectives 评估阿尔茨海默病与 2 型糖尿病之间的临床相关性：当前策略与新视角
Current Pharmacology Reports Pub Date : 2024-03-18 DOI: 10.1007/s40495-024-00354-2
Janvi Parekh, Himani Shende, Ajay Kumar, H. Tuli, Ginpreet Kaur
{"title":"Assessing the Clinical Correlation between Alzheimer's disease and Type-2 Diabetes Mellitus: Current Strategies and Emerging Perspectives","authors":"Janvi Parekh, Himani Shende, Ajay Kumar, H. Tuli, Ginpreet Kaur","doi":"10.1007/s40495-024-00354-2","DOIUrl":"https://doi.org/10.1007/s40495-024-00354-2","url":null,"abstract":"","PeriodicalId":11139,"journal":{"name":"Current Pharmacology Reports","volume":"74 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140234143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmacological Profile of FDA-Approved Orphan Drugs in the Year 2022 2022 年美国 FDA 批准的孤儿药药理概况
Current Pharmacology Reports Pub Date : 2024-01-30 DOI: 10.1007/s40495-024-00351-5
P. K. Goyal, Kavita Sangwan
{"title":"Pharmacological Profile of FDA-Approved Orphan Drugs in the Year 2022","authors":"P. K. Goyal, Kavita Sangwan","doi":"10.1007/s40495-024-00351-5","DOIUrl":"https://doi.org/10.1007/s40495-024-00351-5","url":null,"abstract":"","PeriodicalId":11139,"journal":{"name":"Current Pharmacology Reports","volume":"286 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140480666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy and Safety of Topical Sirolimus for the Treatment of Angiofibromas in Tuberous Sclerosis: a Systematic Review and Meta-analysis 局部使用西罗莫司治疗结节性硬化症血管纤维瘤的疗效和安全性：系统综述与 Meta 分析
Current Pharmacology Reports Pub Date : 2023-12-13 DOI: 10.1007/s40495-023-00350-y
Eleni Paschalidou, Philippos Tasioudis, Georgios N. Katsaras, Thomas Papoulakis, Dorothea Kapoukranidou, T. Papamitsou
{"title":"Efficacy and Safety of Topical Sirolimus for the Treatment of Angiofibromas in Tuberous Sclerosis: a Systematic Review and Meta-analysis","authors":"Eleni Paschalidou, Philippos Tasioudis, Georgios N. Katsaras, Thomas Papoulakis, Dorothea Kapoukranidou, T. Papamitsou","doi":"10.1007/s40495-023-00350-y","DOIUrl":"https://doi.org/10.1007/s40495-023-00350-y","url":null,"abstract":"","PeriodicalId":11139,"journal":{"name":"Current Pharmacology Reports","volume":"117 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139003512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Comprehensive Review on the Effect of Natural Products on Colorectal Cancer 天然产品对结直肠癌影响的全面综述
Current Pharmacology Reports Pub Date : 2023-12-13 DOI: 10.1007/s40495-023-00349-5
V. A. Afrose Farzana, Sekar Kumaran, A. Pandurangan
{"title":"A Comprehensive Review on the Effect of Natural Products on Colorectal Cancer","authors":"V. A. Afrose Farzana, Sekar Kumaran, A. Pandurangan","doi":"10.1007/s40495-023-00349-5","DOIUrl":"https://doi.org/10.1007/s40495-023-00349-5","url":null,"abstract":"","PeriodicalId":11139,"journal":{"name":"Current Pharmacology Reports","volume":"83 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139004384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biological Activities of Carrageenan from Red Algae: a Mini Review 红藻卡拉胶的生物活性：微型综述
Current Pharmacology Reports Pub Date : 2023-12-06 DOI: 10.1007/s40495-023-00348-6
Saranya Udayakumar, A. Girigoswami, K. Girigoswami
{"title":"Biological Activities of Carrageenan from Red Algae: a Mini Review","authors":"Saranya Udayakumar, A. Girigoswami, K. Girigoswami","doi":"10.1007/s40495-023-00348-6","DOIUrl":"https://doi.org/10.1007/s40495-023-00348-6","url":null,"abstract":"","PeriodicalId":11139,"journal":{"name":"Current Pharmacology Reports","volume":"51 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138597440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信