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Pharmacodynamics (PD), Pharmacokinetics (PK) and PK-PD Modeling of NRF2 Activating Dietary Phytochemicals in Cancer Prevention and in Health. NRF2激活膳食植物化学物质在癌症预防和健康中的药效学（PD）、药代动力学（PK）和PK-PD模型
Current Pharmacology Reports Pub Date : 2025-01-01 Epub Date: 2024-12-05 DOI: 10.1007/s40495-024-00388-6
Ahmad Shannar, Pochung Jordan Chou, Rebecca Peter, Parv Dushyant Dave, Komal Patel, Yuxin Pan, Jiawei Xu, Md Shahid Sarwar, Ah-Ng Kong
{"title":"Pharmacodynamics (PD), Pharmacokinetics (PK) and PK-PD Modeling of NRF2 Activating Dietary Phytochemicals in Cancer Prevention and in Health.","authors":"Ahmad Shannar, Pochung Jordan Chou, Rebecca Peter, Parv Dushyant Dave, Komal Patel, Yuxin Pan, Jiawei Xu, Md Shahid Sarwar, Ah-Ng Kong","doi":"10.1007/s40495-024-00388-6","DOIUrl":"10.1007/s40495-024-00388-6","url":null,"abstract":"<p><strong>Purpose of review: </strong>Dietary phytochemicals, bioactive compounds derived from plants, have gained increasing attention for their potential role in cancer prevention. Among these, NRF2 (nuclear factor erythroid 2-related factor 2) activating dietary phytochemicals such as curcumin, sulforaphane, ursolic acid, and cyanidin have demonstrated significant antioxidant and anti-inflammatory properties, making them promising agents in chemoprevention. This review examines the pharmacokinetic (PK) and pharmacodynamic (PD) profiles of these dietary phytochemicals, with a focus on their NRF2-mediated effects in cancer prevention.</p><p><strong>Recent findings: </strong>Preclinical studies have highlighted the potential of these dietary phytochemicals to modulate oxidative stress and inflammation, key drivers of carcinogenesis. We explore the complexity of their PK/PD properties, influenced by factors such as bioavailability, metabolism, and drug interactions. While most of these phytochemicals follow two compartmental PK, their anti-oxidant and anti-inflammatory effects follow the indirect response (IDR) model. Furthermore, we discuss the application of physiologically based pharmacokinetic (PBPK) modeling to simulate the behavior of these compounds in humans, providing insights for clinical translation.</p><p><strong>Summary: </strong>The integration of PK-PD analysis into the development of dietary phytochemical-based therapies offers a pathway to optimize dosing strategies, enhance therapeutic efficacy, and improve safety. This review underscores the importance of these compounds as part of cancer interception strategies, particularly in the early stages of cancer development, where they may offer a natural, less toxic alternative to conventional therapies.</p><p><strong>Graphical abstract: </strong></p>","PeriodicalId":11139,"journal":{"name":"Current Pharmacology Reports","volume":"11 1","pages":"6"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11618211/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Harnessing Nutritional Powerhouse: Millets and Probiotics in Anticancer Therapy 利用营养力量：抗癌疗法中的小米和益生菌
Current Pharmacology Reports Pub Date : 2024-07-22 DOI: 10.1007/s40495-024-00360-4
Reshma Muthuvel, Selvaraj Jagannathan, Naseera Kannanthodi Pariyapurath, Rahul Gandhi Pachamuthu, M. Mathanmohun, Suresh Sagadevan
{"title":"Harnessing Nutritional Powerhouse: Millets and Probiotics in Anticancer Therapy","authors":"Reshma Muthuvel, Selvaraj Jagannathan, Naseera Kannanthodi Pariyapurath, Rahul Gandhi Pachamuthu, M. Mathanmohun, Suresh Sagadevan","doi":"10.1007/s40495-024-00360-4","DOIUrl":"https://doi.org/10.1007/s40495-024-00360-4","url":null,"abstract":"","PeriodicalId":11139,"journal":{"name":"Current Pharmacology Reports","volume":"30 49","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141814015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mental Health and the Microbiome: A Review of Psychological Impacts of Gut Microflora 心理健康与微生物组：肠道微生物群的心理影响综述
Current Pharmacology Reports Pub Date : 2024-06-01 DOI: 10.1007/s40495-024-00357-z
Ananya Gupt, Sonal Naudiyal, Anju Rani, Sunil Kumar
{"title":"Mental Health and the Microbiome: A Review of Psychological Impacts of Gut Microflora","authors":"Ananya Gupt, Sonal Naudiyal, Anju Rani, Sunil Kumar","doi":"10.1007/s40495-024-00357-z","DOIUrl":"https://doi.org/10.1007/s40495-024-00357-z","url":null,"abstract":"","PeriodicalId":11139,"journal":{"name":"Current Pharmacology Reports","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141235065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Redoxification (of the Organism) Through Diet and Supplementation with a Focus on Natural Polymeric Redox Modulators 通过饮食和补充剂实现（生物体的）氧化还原，重点关注天然聚合氧化还原调节剂
Current Pharmacology Reports Pub Date : 2024-03-26 DOI: 10.1007/s40495-024-00353-3
N. Sahakyan, M. J. Nasim, Claus Jacob
{"title":"Redoxification (of the Organism) Through Diet and Supplementation with a Focus on Natural Polymeric Redox Modulators","authors":"N. Sahakyan, M. J. Nasim, Claus Jacob","doi":"10.1007/s40495-024-00353-3","DOIUrl":"https://doi.org/10.1007/s40495-024-00353-3","url":null,"abstract":"","PeriodicalId":11139,"journal":{"name":"Current Pharmacology Reports","volume":"34 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140378202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessing the Clinical Correlation between Alzheimer's disease and Type-2 Diabetes Mellitus: Current Strategies and Emerging Perspectives 评估阿尔茨海默病与 2 型糖尿病之间的临床相关性：当前策略与新视角
Current Pharmacology Reports Pub Date : 2024-03-18 DOI: 10.1007/s40495-024-00354-2
Janvi Parekh, Himani Shende, Ajay Kumar, H. Tuli, Ginpreet Kaur
{"title":"Assessing the Clinical Correlation between Alzheimer's disease and Type-2 Diabetes Mellitus: Current Strategies and Emerging Perspectives","authors":"Janvi Parekh, Himani Shende, Ajay Kumar, H. Tuli, Ginpreet Kaur","doi":"10.1007/s40495-024-00354-2","DOIUrl":"https://doi.org/10.1007/s40495-024-00354-2","url":null,"abstract":"","PeriodicalId":11139,"journal":{"name":"Current Pharmacology Reports","volume":"74 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140234143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmacological Profile of FDA-Approved Orphan Drugs in the Year 2022 2022 年美国 FDA 批准的孤儿药药理概况
Current Pharmacology Reports Pub Date : 2024-01-30 DOI: 10.1007/s40495-024-00351-5
P. K. Goyal, Kavita Sangwan
{"title":"Pharmacological Profile of FDA-Approved Orphan Drugs in the Year 2022","authors":"P. K. Goyal, Kavita Sangwan","doi":"10.1007/s40495-024-00351-5","DOIUrl":"https://doi.org/10.1007/s40495-024-00351-5","url":null,"abstract":"","PeriodicalId":11139,"journal":{"name":"Current Pharmacology Reports","volume":"286 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140480666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy and Safety of Topical Sirolimus for the Treatment of Angiofibromas in Tuberous Sclerosis: a Systematic Review and Meta-analysis 局部使用西罗莫司治疗结节性硬化症血管纤维瘤的疗效和安全性：系统综述与 Meta 分析
Current Pharmacology Reports Pub Date : 2023-12-13 DOI: 10.1007/s40495-023-00350-y
Eleni Paschalidou, Philippos Tasioudis, Georgios N. Katsaras, Thomas Papoulakis, Dorothea Kapoukranidou, T. Papamitsou
{"title":"Efficacy and Safety of Topical Sirolimus for the Treatment of Angiofibromas in Tuberous Sclerosis: a Systematic Review and Meta-analysis","authors":"Eleni Paschalidou, Philippos Tasioudis, Georgios N. Katsaras, Thomas Papoulakis, Dorothea Kapoukranidou, T. Papamitsou","doi":"10.1007/s40495-023-00350-y","DOIUrl":"https://doi.org/10.1007/s40495-023-00350-y","url":null,"abstract":"","PeriodicalId":11139,"journal":{"name":"Current Pharmacology Reports","volume":"117 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139003512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Comprehensive Review on the Effect of Natural Products on Colorectal Cancer 天然产品对结直肠癌影响的全面综述
Current Pharmacology Reports Pub Date : 2023-12-13 DOI: 10.1007/s40495-023-00349-5
V. A. Afrose Farzana, Sekar Kumaran, A. Pandurangan
{"title":"A Comprehensive Review on the Effect of Natural Products on Colorectal Cancer","authors":"V. A. Afrose Farzana, Sekar Kumaran, A. Pandurangan","doi":"10.1007/s40495-023-00349-5","DOIUrl":"https://doi.org/10.1007/s40495-023-00349-5","url":null,"abstract":"","PeriodicalId":11139,"journal":{"name":"Current Pharmacology Reports","volume":"83 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139004384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biological Activities of Carrageenan from Red Algae: a Mini Review 红藻卡拉胶的生物活性：微型综述
Current Pharmacology Reports Pub Date : 2023-12-06 DOI: 10.1007/s40495-023-00348-6
Saranya Udayakumar, A. Girigoswami, K. Girigoswami
{"title":"Biological Activities of Carrageenan from Red Algae: a Mini Review","authors":"Saranya Udayakumar, A. Girigoswami, K. Girigoswami","doi":"10.1007/s40495-023-00348-6","DOIUrl":"https://doi.org/10.1007/s40495-023-00348-6","url":null,"abstract":"","PeriodicalId":11139,"journal":{"name":"Current Pharmacology Reports","volume":"51 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138597440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analgesic and Anti-inflammatory Potential of Ricinus communis Linn.: Evidence from Pharmacology to Clinical Studies 林蓖麻的镇痛和抗炎潜力：从药理学到临床研究的证据
Current Pharmacology Reports Pub Date : 2023-12-02 DOI: 10.1007/s40495-023-00347-7
Rashmi Gupta, Anand K. Chaudhary, Rohit Sharma
{"title":"Analgesic and Anti-inflammatory Potential of Ricinus communis Linn.: Evidence from Pharmacology to Clinical Studies","authors":"Rashmi Gupta, Anand K. Chaudhary, Rohit Sharma","doi":"10.1007/s40495-023-00347-7","DOIUrl":"https://doi.org/10.1007/s40495-023-00347-7","url":null,"abstract":"","PeriodicalId":11139,"journal":{"name":"Current Pharmacology Reports","volume":"36 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138606768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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