Exploring the Epigenetic and Metabolic Pathways for Antioxidant and Anti-Inflammatory Potentials of Tart Cherry Juice Concentrate.

Q1 Biochemistry, Genetics and Molecular Biology

Current Pharmacology Reports Pub Date : 2025-01-01 Epub Date: 2025-07-26 DOI:10.1007/s40495-025-00422-1

Jiawei Xu, Yuxin Pan, Rebecca Mary Peter, Pochung Jordan Chou, Parv Dushyant Dave, Ahmad Shanner, Md Shahid Sarwar, Lugui Brunetti, James E Simon, Ah-Ng Tony Kong

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Abstract

Tart cherry (TC; Prunus cerasus) has high antioxidant and anti-inflammatory potentials due to its rich bioactive components like anthocyanins, polyphenols, vitamins, beta-carotene, ellagic acid, and chlorogenic acid. Oxidative damage and inflammation are underlying reasons to chronic disease pathogenesis. Oxidative stress usually caused by the imbalance between antioxidants and pro-oxidants. Additionally, a chronic inflammatory state is typically modulated by oxidative stress. Inflammation plays a critical role in chronic health conditions, such as cardiovascular diseases, hypertension, insulin resistance, arthritis and cancer. Numerous studies indicate that there is a strong relationship between TC and the inhibition of inflammation and oxidative damage by regulating different epigenetic and metabolic pathways. In this review, the recent developments of TC components and their metabolites on inflammatory and oxidative damages will be discussed, and the challenges and limitations to better support future research, including clinical trials to confirm these findings.

Graphical abstract:

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酸樱桃浓缩汁抗氧化和抗炎潜能的表观遗传和代谢途径探讨。

酸樱桃(TC；由于其丰富的生物活性成分，如花青素、多酚、维生素、β -胡萝卜素、鞣花酸和绿原酸，樱李具有很高的抗氧化和抗炎潜力。氧化损伤和炎症是慢性疾病发病的根本原因。氧化应激通常由抗氧化剂和促氧化剂之间的不平衡引起。此外，慢性炎症状态通常由氧化应激调节。炎症在心血管疾病、高血压、胰岛素抵抗、关节炎和癌症等慢性疾病中起着至关重要的作用。大量研究表明，TC通过调节不同的表观遗传和代谢途径与炎症和氧化损伤的抑制有密切的关系。在这篇综述中，将讨论TC成分及其代谢物对炎症和氧化损伤的最新进展，以及更好地支持未来研究的挑战和局限性，包括临床试验来证实这些发现。图形化的简介:

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Pharmacology Reports Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

9.30

自引率

0.00%

发文量

期刊介绍： Current Pharmacology Reports will: publish cutting-edge reviews on subjects pertinent to all aspects of pharmacology, including drug discovery and development.provide incisive, insightful, and balanced contributions from international leading experts.interest a wide readership of basic scientists and translational investigators in academia and in industry. The Current Pharmacology Reports journal accomplishes its goal by appointing international authorities to serve as Section Editors in key subject areas, such as: epigenetics and epigenomics, chemoinformatics and rational drug design and target discovery, drug delivery and biomaterial, pharmacogenomics and molecular targets and biomarkers, chemical/drug/molecular toxicology, absorption, distribution, metabolism and elimination (ADME), pharmacokinetics (PK) and pharmacodynamics (PD), Modeling & Simulation (M&S) and pharmacometrics, and other related topics in pharmacology including neurology/central nervous system (CNS), cardiovascular, metabolic diseases, cancer, among others. Section Editors for Current Pharmacology Reports select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An Editorial Board of internationally diverse members suggests topics of special interest to their country/region and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided. This journal publishes on a bi-monthly schedule.Please submit here: https://www.editorialmanager.com/phar/default.aspx