Dementia and Geriatric Cognitive Disorders最新文献

{"title":"Interactions between Subjective Memory Complaint and Cognitive Impairment in an Elderly Indigenous Population in Brazil.","authors":"Michele Melo Bautista, Fabia Lima, Sandra Brotto, Milena Belarmino Delgado Dos Santos, Ulisses Ramos Montarroyos, Katia Petribu","doi":"10.1159/000547380","DOIUrl":"10.1159/000547380","url":null,"abstract":"<p><strong>Introduction: </strong>This article aimed to analyze the association between subjective memory complaints (SMCs) and cognitive performance in elderly indigenous individuals of the Xukuru do Ororubá ethnicity in Brazil.</p><p><strong>Methods: </strong>This was a population-based, cross-sectional, analytical survey with data collected from 2015 to 2018. Participants answered questionnaires on sociodemographic and economic aspects, chronic diseases, habits, memory complaint, cognitive assessment, symptoms of depression, and activities of daily living.</p><p><strong>Results: </strong>Overall, 559 older individuals participated in the study (71.3 ± 8.8 years; 55.8% female); the majority were illiterate (67.6%), whereas 24.3% received up to 4 years of education. Regarding clinical aspects, 8.7% reported polypharmacy, 25.6% exercised, 66.9% had hypertension, 15.2% had diabetes, 65% had vision problems, 27.7% had hearing problems, 53.1% had cognitive impairment, and 37.2% had symptoms of depression. The frequency of memory complaints was 54.4% (95% CI: 50.2-58.5). Cognitive deficits were not significantly associated with SMCs (OR, 1.09; 95% CI: 0.76-1.55; p = 0.645). In the multivariate analysis, significance was found for females (OR: 1.49 [95% CI: 1.04-2.14]; p = 0.03), self-reported falling with loss of consciousness (OR: 1.79 [95% CI: 1.08-2.98]; p = 0.025) and falling within the last year (OR: 1.79 [95% CI: 1.19-2.71]; p = 0.005), and visual (OR: 2.33 [95% CI: 1.64-3.33]; p = 0.001) and hearing impairment (OR: 2.44 [95% CI: 1.64-3.62]; p = 0.001), with a two-fold increase in both. Regular exercise was protective with a 36% reduction in chance. The chances of SMCs were higher in individuals with up to 4 years of schooling, but did not increase with more than 5 years of schooling; however, this variable had a small sample size.</p><p><strong>Conclusion: </strong>No significant association was found between memory complaints and cognitive decline, but SMCs were associated with several factors, such as female sex, falling, and sensory loss, while exercising was found to be protective.</p>","PeriodicalId":11126,"journal":{"name":"Dementia and Geriatric Cognitive Disorders","volume":" ","pages":"106-115"},"PeriodicalIF":1.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144682204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Group Live Music Reminiscence Therapy for People with Dementia: A Mixed-Method Systematic Review.","authors":"Shu Yi Chung, Justine Jian Ai Thong, Alwin Ru Kiet Wong, Heng Wei Moh, Ming Hao Lee, Shean Yih Soh, Donald Hong Huang Yeo, Kah Hui Yap","doi":"10.1159/000547312","DOIUrl":"10.1159/000547312","url":null,"abstract":"<p><strong>Introduction: </strong>Group music reminiscence therapy is often a preferred option for people with dementia owing to its efficacy in evoking autobiographical memories. Live music performances may further enhance interpersonal connections and social relationships, leading to a more meaningful participation. While an updated review on the efficacy of group music reminiscence therapy was published recently, only studies with pre-recorded music were included.</p><p><strong>Methods: </strong>This systematic review focused on the effects of group live music reminiscence therapy on the cognition, behavioural and psychological symptoms, and quality of life of people with dementia. We conducted the initial search on September 1, 2024, following the PRISMA guidelines using PubMed and Scopus. We then reran searches prior to the final analysis on March 20, 2025. We assessed the risk of bias using Cochrane Collaboration's tool and assigned level of recommendations according to the American Academy of Neurology guideline.</p><p><strong>Results: </strong>Of 1,846 articles, six studies involving 330 people with dementia and 10 caregivers were included. We assigned Level B recommendations for depression and anxiety in people with dementia. Findings on cognition, other behavioural and psychological symptoms, and quality of life were either limited or preliminary. Four studies reported qualitative findings and were synthesised into the following themes: (1) psychological well-being and improvements in mood; (2) engagement and participation.</p><p><strong>Conclusion: </strong>Studies on group live music reminiscence therapy showed beneficial effects on depression and anxiety symptoms in people with dementia, while evidence for managing agitation and wandering, and improving the quality of life of people with dementia remains scarce and generally inconclusive. This warrants further investigation for meaningful clinical translation.</p>","PeriodicalId":11126,"journal":{"name":"Dementia and Geriatric Cognitive Disorders","volume":" ","pages":"150-160"},"PeriodicalIF":1.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144607724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Esports Interventions for Dementia and Mild Cognitive Impairment: A Rapid Scoping Review.","authors":"Kohei Okuyama, Yuichi Isaji, Katsuyoshi Tanaka, Kosuke Suzuki, Yasuyuki Kurasawa, Takao Kaneko, Takashi Kitagawa","doi":"10.1159/000547651","DOIUrl":"10.1159/000547651","url":null,"abstract":"<p><strong>Introduction: </strong>Conventional non-pharmacological interventions for dementia and mild cognitive impairment (MCI) often face challenges related to motivation and adherence. Esports may offer a more intrinsically motivating alternative, but the evidence base remains limited. We aimed to map the existing evidence on esports interventions in individuals with clinically diagnosed dementia or MCI.</p><p><strong>Methods: </strong>This rapid scoping review followed PRISMA-ScR, Joanna Briggs Institute, and Cochrane rapid review methods guidance. Searches were conducted in six bibliographic databases (MEDLINE, CENTRAL, Embase, PsycINFO, Web of Science, CINAHL). We also searched one gray-literature database (BASE) and two trial registries (WHO ICTRP, <ext-link ext-link-type=\"uri\" xlink:href=\"http://ClinicalTrials.gov\" xmlns:xlink=\"http://www.w3.org/1999/xlink\">ClinicalTrials.gov</ext-link>) for records up to 8 April 2025. Eligible studies included primary research evaluating esports interventions.</p><p><strong>Results: </strong>Six studies, including three randomized controlled trials (intervention group: n = 84), were included. All interventions utilized exergames delivered via commercial gaming consoles (Nintendo Wii or Switch, Microsoft Xbox Kinect). Samples were small (n = 3-23). Participants frequently reported favorable psychosocial effects - such as enjoyment and program satisfaction; however, objective end points were seldom assessed. Across the limited quantitative data, no trial demonstrated significant gains in global cognition, and findings for physical performance were inconsistent. No serious adverse events were reported; however, safety monitoring was inconsistently described.</p><p><strong>Conclusion: </strong>Current evidence is insufficient to support esports as a therapeutic approach for dementia or MCI. Although participants consistently enjoyed the sessions, these subjective benefits alone do not establish clinical efficacy. Larger, well-controlled trials with validated cognitive and physical outcomes are needed before esports can be considered for routine care.</p>","PeriodicalId":11126,"journal":{"name":"Dementia and Geriatric Cognitive Disorders","volume":" ","pages":"161-171"},"PeriodicalIF":2.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Apolipoprotein E, Executive Function, and Falls across Cognitive Status: A Cross-Sectional Study.","authors":"Ferdinand Delgado, Fang Yu, Daniel S Peterson, Edward Ofori, David P MacKinnon, Christine Belden, Charles H Adler, Thomas G Beach, Cheryl Der Ananian","doi":"10.1159/000548084","DOIUrl":"10.1159/000548084","url":null,"abstract":"<p><strong>Introduction: </strong>Falls are a critical public health issue, with executive function (EF) impairment being a contributing factor. However, whether apolipoprotein E4 (ApoE4) influences the relationship between EF and falls is unclear. This study investigated the potential moderating effect of ApoE4 on the EF and falls relationship in older adults with unimpaired cognition, mild cognitive impairment (MCI), and Alzheimer's disease (AD) dementia.</p><p><strong>Methods: </strong>We analyzed cross-sectional data from 486 participants in the Brain and Body Donation Program of the Arizona Study of Aging and Neurodegenerative Disorders database. EF was assessed through a composite latent variable using the Trail Making Test, Stroop Interference, Digit Span, Clock Drawing test, and verbal fluency tests. ApoE genotypes were categorized as carriers and noncarriers of ApoE4. Logistic regression was used with fall history and future falls as outcomes.</p><p><strong>Results: </strong>ApoE4 did not moderate the EF and falls relationship (p ≥ 0.05). A significant interaction effect revealed that EF is associated with fall history for individuals with unimpaired cognition and MCI but not with AD dementia (OR = 1.658, p = 0.032). Significantly associated covariates with fall history included elements from the Unified Parkinson's Disease Rating Scale, medical conditions, and depression (p < 0.05), while medical conditions and fall history were significantly associated with future falls (p < 0.05).</p><p><strong>Conclusion: </strong>ApoE4 did not significantly moderate the relationship between EF and falls. However, EF's impact on falls varied by cognitive status.</p>","PeriodicalId":11126,"journal":{"name":"Dementia and Geriatric Cognitive Disorders","volume":" ","pages":"187-196"},"PeriodicalIF":2.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144945801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence and Risk of Stroke following Dementia: A Nationwide Cohort Study in South Korea.","authors":"Chaeyoon Kang, Seung Won Lee, Hohyun Jung, Youngoh Bae","doi":"10.1159/000549405","DOIUrl":"10.1159/000549405","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to evaluate the long-term risk of stroke following dementia diagnosis and compare stroke risk across dementia subtypes using nationwide cohort data.</p><p><strong>Methods: </strong>We performed a retrospective cohort study using Korean National Health Insurance Service data (2002-2013). Patients with newly diagnosed dementia (n = 2,820) were matched 1:10 with controls (n = 28,200) by age, sex, and health screening year. Stroke incidence was evaluated over up to 10 years of follow-up. Adjusted hazard ratios (aHRs) were calculated using Cox regression.</p><p><strong>Results: </strong>During a mean follow-up of 2.49 years (median, 1.99; standard deviation, 2.07; interquartile range, 2.66), dementia was significantly associated with increased stroke risk (aHR, 3.19; 95% confidence interval, 2.84-3.57). The highest risk was observed in patients with vascular dementia (VaD; aHR, 3.58), followed by Alzheimer's disease (AD; aHR, 2.73) and other dementias (aHR, 2.61). Ischemic stroke (IS) was more common than hemorrhagic stroke (HS) across all subtypes. The relative risk was greater in individuals aged <60 years and in males with AD or other dementias, whereas sex differences were not evident in VaD.</p><p><strong>Conclusion: </strong>Dementia, especially VaD, is a strong risk factor for both IS and HS. These findings support the need for dementia subtype-specific cerebrovascular risk assessment and long-term prevention strategies.</p>","PeriodicalId":11126,"journal":{"name":"Dementia and Geriatric Cognitive Disorders","volume":" ","pages":"303-313"},"PeriodicalIF":2.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145444280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma Homocysteine Levels Are Associated with Cognitive Impairment: A Population-Based Cross-Sectional Study in a Rural Area of Xi'an, China.","authors":"Yi Zhao, Suhang Shang, Ling Gao, Liangjun Dang, Shan Wei, Xiaojuan Guo, Jingyi Wang, Qiumin Qu, Jin Wang","doi":"10.1159/000549220","DOIUrl":"10.1159/000549220","url":null,"abstract":"<p><strong>Introduction: </strong>High plasma homocysteine (Hcy) is a well-established risk factor for cardiovascular disease and stroke, but its role in cognitive impairment (CogI) remains unclear. This study investigated the relationship between plasma Hcy levels and CogI in middle-aged and elderly Chinese adults.</p><p><strong>Methods: </strong>This community-based cross-sectional study included 1,805 participants (≥40 years) from a village in Xi'an, China. CogI was diagnosed using a three-step protocol. Plasma Hcy was measured via chemiluminometric assay and categorized into tertiles: low-level group (<12.50 μmol/L), moderate-level group (12.5-16.10 μmol/L), and high-level group (>16.10 μmol/L). Multivariable logistic regression and subgroup analyses were performed to assess the relationship between Hcy and CogI. Nonlinear relationships were explored using restricted cubic splines (RCSs).</p><p><strong>Results: </strong>Among 1,805 subjects, 145 (8.0%) met the criteria for CogI. The prevalence of CogI increased across Hcy tertiles (low-level group: 4.9%; moderate-level group: 7.0%; high-level group: 12.2%). Multivariable logistic regression analysis showed that each 1 μmol/L increase in Hcy was associated with a 3.1% higher risk of CogI (OR = 1.031, 95% CI: 1.013-1.049, p < 0.001). Participants in the high-level Hcy group had a significantly higher risk than the low-level group (OR = 1.894, 95% CI: 1.162-3.055, p = 0.010). RCS analysis indicated no significant nonlinear relationship (p_nonlinear = 0.317). Interaction analyses showed sex, age, stroke history, diabetes, BMI, and SBP did not modify this association.</p><p><strong>Conclusion: </strong>Elevated plasma Hcy is independently associated with increased risk of CogI in middle-aged and elderly adults. Further cohort and interventional studies are needed to confirm these findings.</p>","PeriodicalId":11126,"journal":{"name":"Dementia and Geriatric Cognitive Disorders","volume":" ","pages":"253-264"},"PeriodicalIF":2.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145387741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formal and Informal Care Utilization in Mild Cognitive Impairment and Mild Dementia due to Alzheimer's Disease: Cross-Sectional and Longitudinal Analyses of RUD-Lite Data from the Tauriel Study.","authors":"Edmond Teng, Yihao Li, Mira Blendstrup, Claire J Lansdall","doi":"10.1159/000549652","DOIUrl":"10.1159/000549652","url":null,"abstract":"<p><p><p>Introduction: Evaluating formal and informal care utilization in Alzheimer's disease (AD) is crucial for assessing the economic impact of novel disease-modifying treatments. The Resource Utilization in Dementia-Lite (RUD-Lite) scale is widely used to measure care utilization in dementia; however, RUD-Lite data are limited for mild cognitive impairment (MCI) and mostly from observational studies. We analyzed RUD-Lite data from a study of semorinemab (NCT03289143) in MCI (i.e., prodromal AD) and mild AD dementia (i.e., mild AD) to explore potential differences in care utilization between observational and interventional studies.</p><p><strong>Methods: </strong>We analyzed cross-sectional and longitudinal RUD-Lite indices in prodromal (pAD: n = 160) and mild (mAD: n = 288) AD groups, examining formal care usage and informal caregiver time. Unadjusted and adjusted analyses were performed on longitudinal data. North American and European cohorts were compared to explore potential regional differences.</p><p><strong>Results: </strong>More informal caregiving assistance was required for mAD versus pAD participants at baseline and the mAD group demonstrated significant greater increases over 18 months. Cross-sectional data indicated more caregiver assistance for instrumental activities of daily living in North America versus Europe, with comparable longitudinal increases in caregiver assistance across regions.</p><p><strong>Conclusion: </strong>Longitudinal RUD-Lite changes in interventional early AD studies are detectable but smaller than in observational studies, possibly due to differences in cohort characteristics. These factors, along with subtle regional differences in care utilization, should be considered when using observational data to guide interventional trials. </p>.</p>","PeriodicalId":11126,"journal":{"name":"Dementia and Geriatric Cognitive Disorders","volume":" ","pages":"319-329"},"PeriodicalIF":2.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12782609/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145602875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship between Age and Cognitive Subtypes of Alzheimer Syndrome and Related Dementias.","authors":"Bruna Seixas-Lima, Malcolm Binns, Sandra E Black, Morris Freedman, Sanjeev Kumar, Durjoy Lahiri, Carlos Tyler Roncero, Stephen Strother, David F Tang-Wai, Maria Carmela Tartaglia, Howard Chertkow","doi":"10.1159/000547124","DOIUrl":"10.1159/000547124","url":null,"abstract":"<p><strong>Introduction: </strong>We aimed to identify cognitive subgroups of clinically diagnosed Alzheimer's disease (Alzheimer syndrome) and related dementias and test if age of presentation influences patterns of cognitive impairment.</p><p><strong>Methods: </strong>Participants were individuals with mild cognitive impairment (n = 360), vascular mild cognitive impairment (n = 73), Alzheimer syndrome (n = 127), vascular dementia (n = 32), mixed dementia (n = 23), and healthy controls (n = 305). Principal component analysis was run on 25 cognitive variables measured by the Toronto Cognitive Assessment (TorCA). We used hierarchical clustering to identify cognitive subgroups.</p><p><strong>Results: </strong>We identified seven subgroups. The youngest group was characterized by the lowest scores on the overall TorCA mean, and also on executive function, visuospatial function, and attention, while showing the highest scores on Memory, Orientation, and Language. The oldest clusters had low scores on Memory and Orientation but higher scores on attention. The intermediary clusters had similar age and severity distributions.</p><p><strong>Conclusion: </strong>The results demonstrate that patterns of cognitive impairment are different in different age groups.</p>","PeriodicalId":11126,"journal":{"name":"Dementia and Geriatric Cognitive Disorders","volume":" ","pages":"38-48"},"PeriodicalIF":1.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Life's Crucial 9 Score and Cognitive Performance in Older Adults: The Mediating Role of Biological Aging.","authors":"Qiuran Zheng, Mei Luo, Zhengyun Ren, Yang Guo","doi":"10.1159/000548982","DOIUrl":"10.1159/000548982","url":null,"abstract":"<p><strong>Introduction: </strong>Cognitive decline is a pressing public health concern in older adults. The recently proposed Life's Crucial 9 (LC9) score, which integrates cardiovascular and mental health metrics, may offer a novel framework for predicting cognitive impairment.</p><p><strong>Methods: </strong>We analyzed data from 2,180 participants aged ≥60 years from 2011 to 2014 National Health and Nutrition Examination Survey (NHANES). LC9 was computed based on eight cardiovascular health metrics and depressive symptoms. Cognitive performance was assessed using the Animal Fluency Test (AFT), Consortium to Establish a Registry for Alzheimer's Disease (CERAD) test, and Digit Symbol Substitution Test (DSST). Biological age (BA) and biological age acceleration (BAcel) were derived using a validated algorithm. Weighted logistic regression, receiver operating characteristic (ROC), restricted cubic spline (RCS) models, and mediation analyses were performed to evaluate the associations.</p><p><strong>Results: </strong>Higher LC9 scores were significantly associated with lower odds of poor performance on the AFT (p = 1.5 × 10-2) and DSST (p = 1.4 × 10-2), but not CERAD (p = 1.2 × 10-1). ROC analysis showed that LC9 significantly outperformed Life's Essential 8 (LE8) in predicting low AFT and DSST performance (AUC: 0.599 vs. 0.588 for AFT; 0.632 vs. 0.614 for DSST). The RCS models indicated no statistically significant nonlinear relationship between the LC9 and cognitive performance. Mediation analysis revealed that BA and BAcel accounted for 7.48% and 4.53% of the total effect of LC9 on DSST performance, respectively. The subgroup and sensitivity analyses confirmed the robustness of these findings.</p><p><strong>Conclusion: </strong>LC9 is significantly associated with cognitive performance in older adults. This association with DSST is partially mediated by biological aging.</p>","PeriodicalId":11126,"journal":{"name":"Dementia and Geriatric Cognitive Disorders","volume":" ","pages":"233-241"},"PeriodicalIF":1.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145307176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Influencing Cognitive Impairment in Patients Undergoing Hemodialysis: Based on Health Ecological Model.","authors":"Yan Song, Jianxia Lu, Yuyue Wu, Xuanrui Zhang, Yan Zhuang, Qian Fang, Xinyi Zhang","doi":"10.1159/000547516","DOIUrl":"10.1159/000547516","url":null,"abstract":"<p><strong>Introduction: </strong>Cognitive impairment represents a prevalent issue among patients undergoing hemodialysis (HD). Nevertheless, the majority of existing studies have predominantly focused on its influencing factors from a single-dimensional perspective. This study aimed to comprehensively investigate the multifaceted factors contributing to cognitive impairment in patients undergoing HD by applying the health ecological model.</p><p><strong>Method: </strong>Data of 172 patients undergoing HD from the HD unit from China were collected from June 2022 to October 2022. A total of 24 variables were collected across the five dimensions of the health ecological model. The Montreal Cognitive Assessment (MoCA) scale was used to assess cognitive function. LASSO regression was utilized to select relevant variables, and binary logistic regression was employed to determine the independent risk factors associated with cognitive impairment.</p><p><strong>Results: </strong>Gender, age, protein intake, and cholesterol were independently associated with cognitive impairment in patients undergoing HD. The predictive model incorporating these factors achieved a moderate goodness-of-fit (Nagelkerke R2 = 0.543), reflecting their combined contribution to cognitive risk.</p><p><strong>Conclusion: </strong>Cognitive impairment is highly prevalent among Chinese patients undergoing HD, influenced by factors such as aging, female sex, insufficient protein intake, and low cholesterol levels. These findings underscore the multifactorial nature of cognitive decline in patients undergoing HD within the framework of a health ecological model, highlighting the need for comprehensive interventions that address biological, behavioral, psychological, disease-related, and social domains.</p>","PeriodicalId":11126,"journal":{"name":"Dementia and Geriatric Cognitive Disorders","volume":" ","pages":"173-186"},"PeriodicalIF":1.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144788530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}