Effects of Aerobic Exercise and Resistance Training on Cognitive Function: Comparative Study Based on FNDC5/Irisin/BDNF Pathway.

IF 2.2 4区医学 Q3 CLINICAL NEUROLOGY

Dementia and Geriatric Cognitive Disorders Pub Date : 2024-08-26 DOI:10.1159/000541093

Sho Izawa, Kazuhiro Nishii, Naoki Aizu, Takumi Kito, Daiki Iwata, Takeshi Chihara, Hirohide Sawada, Runhong Yao, Kouji Yamada

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引用次数: 0

Abstract

Introduction: Exercise has been recommended to suppress or prevent cognitive decline. Aerobic exercise (AE) may suppress cognitive decline via the fibronectin type III domain-containing protein 5 (FNDC5)/irisin/brain-derived neurotrophic factor (BDNF) pathway, and resistance training (RT) has a preventive effect on cognitive decline. However, the underlying mechanism remains unclear. This study verified the differences in the effects of AE and RT in suppressing and preventing cognitive decline based on the FNDC5/irisin/BDNF pathway.

Methods: We divided senescence-accelerated mouse-prone 8 into three groups: control (CON), AE, and RT and evaluated their memory during exercise intervention through a novel object recognition (NOR) task. We quantified FNDC5/irisin, mBDNF, and TrkB in the hippocampus using enzyme-linked immunosorbent assay and FNDC5 in skeletal muscle using Western blotting (WB).

Results: Behavioral analysis using NOR showed that values for both AE and RT were significantly greater than those for CON. WB analysis showed that the peripheral FNDC5 expression in the skeletal muscle was increased in AE. The expression levels of FNDC5/irisin and mBDNF in the hippocampus were significantly increased in both AE and RT compared with that in CON but that if TrkB was increased only in AE.

Conclusion: No significant difference was observed between AE and RT in the inhibitory effect on age-related cognitive decline, and both groups were effective. The FNDC5/Irisin/BDNF pathway, which was the focus of this experiment, may be specific to AE. The mechanism that suppresses cognitive decline may differ depending on the type of exercise.

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有氧运动和阻力训练对认知功能的影响：基于 FNDC5/irisin/BDNF 通路的比较研究

导言：人们建议通过运动来抑制或预防认知能力下降。有氧运动（AE）可通过纤连蛋白Ⅲ型结构域含蛋白5（FNDC5）/鸢尾素/脑源性神经营养因子（BDNF）途径抑制认知能力下降，而阻力训练（RT）则对认知能力下降有预防作用。然而，其潜在机制仍不清楚。本研究根据 FNDC5/irisin/BDNF 通路验证了 AE 和 RT 在抑制和预防认知功能衰退方面的作用差异。方法我们将衰老加速的小鼠易感基因8分为三组：对照组（CON）、AE组和RT组，并通过新物体识别（NOR）任务评估它们在运动干预期间的记忆力。我们使用酶联免疫吸附法对海马中的 FNDC5/鸢尾素、mBDNF 和 TrkB 进行了定量分析，并使用免疫印迹法（WB）对骨骼肌中的 FNDC5 进行了定量分析。结果使用 NOR 进行的行为分析表明，AE 和 RT 的值明显高于 CON。WB 分析表明，AE 中骨骼肌中外周 FNDC5 的表达增加。海马中 FNDC5/irisin 和 mBDNF 的表达水平在 AE 和 RT 中都比在 CON 中明显增加，但 TrkB 的表达水平仅在 AE 中增加。结论 AE 和 RT 对老年性认知功能衰退的抑制作用无明显差异，两组均有效。本实验所关注的 FNDC5/Irisin/BDNF 通路可能是有氧运动所特有的。抑制认知衰退的机制可能因运动类型而异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Dementia and Geriatric Cognitive Disorders 医学-精神病学

CiteScore

4.70

自引率

0.00%

发文量

审稿时长

2 months

期刊介绍： As a unique forum devoted exclusively to the study of cognitive dysfunction, ''Dementia and Geriatric Cognitive Disorders'' concentrates on Alzheimer’s and Parkinson’s disease, Huntington’s chorea and other neurodegenerative diseases. The journal draws from diverse related research disciplines such as psychogeriatrics, neuropsychology, clinical neurology, morphology, physiology, genetic molecular biology, pathology, biochemistry, immunology, pharmacology and pharmaceutics. Strong emphasis is placed on the publication of research findings from animal studies which are complemented by clinical and therapeutic experience to give an overall appreciation of the field.