Diabetology & Metabolic Syndrome最新文献

{"title":"Brown adipose tissue: a potential therapeutic target for preventing cardiovascular disease in metabolic disorders.","authors":"Tamara Egan Beňová, Matúš Sýkora, Katarína Ondreják Andelová, Veronika Farkašová, Marek Lepáček, Marta Šoltésová Prnová, Pavel Babál, Dávid Janko, Natália Andelová, Miroslav Ferko, Barbara Szeiffová Bačová","doi":"10.1186/s13098-025-01892-5","DOIUrl":"10.1186/s13098-025-01892-5","url":null,"abstract":"<p><strong>Background: </strong>Obesity and Type 2 diabetes (T2D) remain significant health challenges contributing to cardiovascular complications. This study aimed to investigate brown adipose tissue (BAT) and connexin43 (Cx43) in obese T2D rats and evaluate the effects of antioxidant Cemtirestat. Cx43 plays a crucial role in both BAT and heart function, yet its expression in T2D hearts remains underexplored.</p><p><strong>Materials and methods: </strong>Forty male Zucker diabetic fatty (ZDF) rats were divided into four groups: (1) lean nondiabetic (ZDF lean), (2) Cemtirestat-treated lean nondiabetic (ZDF lean + C), (3) obese diabetic (ZDF T2D), and (4) Cemtirestat-treated obese diabetic (ZDF T2D + C). After 6 months, biometric and biochemical parameters were measured and Cx43, selected protein kinases and batokines were analyzed in the BAT and left ventricle. Echocardiograms were recorded prior to study completion.</p><p><strong>Results: </strong>Obese T2D rats exhibited increased body weight, heart weight, visceral fat, BAT mass, glucose, insulin, cholesterol and triglycerides. Cx43 was decreased in BAT but increased in the left ventricles of T2D rats. Cemtirestat increased Cx43 in BAT of lean rats but not in the left ventricles of obese T2D rats. Protein kinase C epsilon was reduced in BAT, while protein kinase C delta was increased in both BAT and left ventricles of T2D rats and partially normalized by Cemtirestat. BAT whitening together with reduced mitochondrial uncoupling protein 1 and fibroblast growth factor 21 were observed in T2D rats. Echocardiography revealed diastolic dysfunction in T2D rats, which was attenuated by Cemtirestat.</p><p><strong>Conclusion: </strong>These findings support the role of BAT as a therapeutic target in metabolic disease and identify Cx43 as a molecular mediator linking adipose tissue dysfunction to cardiac impairment. Although low-dose Cemtirestat showed limited efficacy, it demonstrates potential for cardiometabolic intervention, justifying further investigation.</p>","PeriodicalId":11106,"journal":{"name":"Diabetology & Metabolic Syndrome","volume":"17 1","pages":"311"},"PeriodicalIF":3.9,"publicationDate":"2025-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12317635/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144768530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends and comparisons of diabetes burden in China and the world from 1990 to 2021,with forecasts to 2050:a systematic analysis of the global burden of disease study 2021.","authors":"Chenqing Liu, Yun Li, Nan Wang, Yandong Wu, Jiaqi Liu, Mengjie Ding, Shuhan Liu, Yibing Hao, Ying Wu, Shaopeng Liu","doi":"10.1186/s13098-025-01885-4","DOIUrl":"10.1186/s13098-025-01885-4","url":null,"abstract":"<p><strong>Background: </strong>Diabetes is a major global public health issue. This study investigated the trends in the age-and gender-specific burden of diabetes in China and worldwide from 1990 to 2021, and predicted the prevalence of diabetes in 2050.</p><p><strong>Methods: </strong>Using publicly available data from the Global Burden of Disease (GBD) database from 1990 to 2021, we comprehensively applied Joinpoint regression and age-period-cohort (APC) analysis to reveal the epidemiological characteristics, conducted decomposition analysis to identify the driving factors of burden changes, and used the autoregressive integrated moving average (ARIMA) model to project the disease burden of diabetes from 2022 to 2050.</p><p><strong>Results: </strong>From 1990 to 2021, both in China and globally, the age-standardized incidence rate (ASIR), age-standardized prevalence rate (ASPR), and age-standardized disability-adjusted life year rate (ASDR) of diabetes showed an upward trend. In contrast, China's age-standardized mortality rate (ASMR) of diabetes decreased, while the global ASMR increased. The average annual percentage changes (AAPC) of China's ASIR, ASPR, ASMR, and ASDR were 1.29, 1.76,- 0.30, and 0.76% respectively, compared with 1.74, 2.10, 0.25, and 1.05% for the global diabetes burden.</p><p><strong>Conclusions: </strong>In China, the incidence, prevalence, and Disability-Adjusted Life Years (DALYs) of diabetes increased, while the mortality rate decreased. It is projected that by 2050, the number of diabetes patients in China will reach 84.01 million, and globally, it will reach 1038.2 million. Given China's large population and the trend of population aging, it is essential to formulate targeted prevention and control strategies to address the challenge of diabetes.</p>","PeriodicalId":11106,"journal":{"name":"Diabetology & Metabolic Syndrome","volume":"17 1","pages":"309"},"PeriodicalIF":3.9,"publicationDate":"2025-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12317625/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144768532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying pyroptosis-related genes as novel therapeutic targets in diabetic foot ulceration.","authors":"Kang Liu, Lei Lei, Xin-Lei Yang, Xin-He Zhang","doi":"10.1186/s13098-025-01880-9","DOIUrl":"10.1186/s13098-025-01880-9","url":null,"abstract":"<p><p>Diabetic foot ulcer (DFU) is considered one of the most challenging chronic complications for individuals with diabetes, and its global incidence continues to rise, imposing a substantial burden on society. During the treatment of DFU, the locally intense inflammatory response induced by pyroptosis may adversely affect wound healing, making this phenomenon a focus of research. This study employed bioinformatics methods to systematically analyze the role of pyroptosis-related genes (PRGs) in the healing process of diabetic foot ulcers. Based on public datasets GSE147890 and GSE80178, we performed differential expression analysis, random forest, and LASSO regression to screen for key genes, and constructed and evaluated a multivariate logistic regression diagnostic model. We analyzed the GEO datasets GSE147890 and GSE80178, identifying 1336 and 2727 differentially expressed genes (DEGs), respectively. The intersection analysis with PRGs revealed 9 pyroptosis-related differentially expressed genes (PRDEGs). Functional enrichment analysis associated these genes with pathways such as I-kappaB kinase/nuclear factor-kappaB (IKK/NF-κB) signaling and mitophagy. Six key PRDEGs (FSTL1, PINK1, HDAC3, ULK1, CPTP, and NOD2) were selected, and a diagnostic model was constructed using random forest and LASSO regression. The accuracy of the model was assessed through multivariate logistic regression, calibration curve analysis, decision curve analysis (DCA), and receiver operating characteristic (ROC) curve analysis. The model demonstrated excellent diagnostic performance, with an area under the curve (AUC) of 1.000 in both the training and validation sets. This study highlights the importance of PRGs in diabetic wound healing (DWH). Our findings not only elucidate the mechanisms of action of PRGs in diabetic wound healing but also provide a theoretical basis for the development of clinical early diagnosis and individualized treatment strategies, holding significant clinical application potential. Future research should validate these findings in larger populations and explore therapeutic interventions targeting these pathways to improve DWH outcomes.</p>","PeriodicalId":11106,"journal":{"name":"Diabetology & Metabolic Syndrome","volume":"17 1","pages":"306"},"PeriodicalIF":3.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12315281/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144764749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploration of the potential therapeutic benefits of naringenin against diabetic retinopathy through a National comprehensive cross-sectional study and in vitro experiments.","authors":"Yuan Chen, Yihong Cao, Weigen Zhu, Zhengru Huang","doi":"10.1186/s13098-025-01879-2","DOIUrl":"10.1186/s13098-025-01879-2","url":null,"abstract":"<p><strong>Background: </strong>Diabetic retinopathy (DR) is a severe, vision-threatening complication of diabetes. Despite the implementation of various preventive measures, controlling and preventing DR remains a significant challenge. This study investigates the association between naringenin (NAR) intake and the risk of DR.</p><p><strong>Methods: </strong>Data were collected from the National Health and Nutrition Examination Survey (NHANES), and binary logistic regression analysis was used to examine the relationship between NAR consumption and DR after adjusting for multiple confounding variables. Additionally, biological experiments, such as CCK8, Western blot and Flow cytometry analysis, were conducted to elucidate the potential mechanisms underlying NAR's protective effects.</p><p><strong>Results: </strong>The results revealed that higher NAR consumption was associated with a reduced risk of DR, particularly in subgroups with diabetes duration exceeding 10 years. In vitro experiments revealed that high-glucose (HG) conditions significantly decreased the viability of human retinal microvascular endothelial cells (HRMECs). However, NAR administration mitigated these adverse effects. Western blot analysis showed that HG conditions markedly increased the expression of cleaved-Caspase-3 and Bax while decreasing Bcl-2 expression; these changes were reversed by NAR treatment. Flow cytometry analysis further confirmed that NAR significantly alleviated the increased apoptosis rate of HRMECs under HG conditions.</p><p><strong>Conclusion: </strong>In conclusion, NAR intake may benefit DR prevention by protecting retinal vascular endothelial cells from hyperglycemia-induced injury.</p>","PeriodicalId":11106,"journal":{"name":"Diabetology & Metabolic Syndrome","volume":"17 1","pages":"304"},"PeriodicalIF":3.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12315193/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144764748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interaction between the non-alcoholic fatty liver disease fibrosis score and vitamin D deficiency on left ventricular hypertrophy and impaired diastolic function in patients with type 2 diabetes mellitus.","authors":"Yun-Ming Li, Jia-Yi Huang, Ran Guo, Shi-Ming Li, Cong Chen, Min Wu, Run Wang, Ming-Ya Liu, Kai-Hang Yiu","doi":"10.1186/s13098-025-01808-3","DOIUrl":"10.1186/s13098-025-01808-3","url":null,"abstract":"<p><strong>Aims: </strong>The present study aimed to evaluate the effect of Non-Alcoholic Fatty Liver Disease Fibrosis Score (NFS), vitamin D deficiency, and their interaction on the Left Ventricle (LV) structure and diastolic function in type 2 diabetes mellitus (T2DM) patients.</p><p><strong>Methods: </strong>A total of 595 T2DM patients were recruited and stratified according to NFS grades (low, intermediate, and high) and the level of serum 25(OH)D (with and without vitamin D deficiency). Parameters of LV structure and diastolic dysfunction were measured by echocardiography. The association between NFS and LV structure and diastolic function was assessed using multivariable linear regression models stratified by vitamin D levels.</p><p><strong>Results: </strong>Left ventricular hypertrophy (LVH) was more prevalent in patients with high NFS compared to those with low and intermediate NFS (41.0 vs 14.0% and 9.0%, P < 0.001). The average E/e' was higher in patients with intermediate and high NFS, as compared to those with low NFS. Within the high NFS group, patients with vitamin D deficiency exhibited significantly higher left ventricular mass index (LVMI) and average E/e' compared to those without vitamin D deficiency. An interaction between vitamin D and NFS groups was found on both LVMI (P for interaction = 0.008) and average E/e' (P for interaction = 0.001).</p><p><strong>Conclusions: </strong>NFS and vitamin D deficiency are associated with an increased risk of LVH and impaired diastolic function in patients with T2DM. Notably, the impact of vitamin D deficiency on these parameters is more pronounced in individuals with a high NFS score.</p>","PeriodicalId":11106,"journal":{"name":"Diabetology & Metabolic Syndrome","volume":"17 1","pages":"307"},"PeriodicalIF":3.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12315323/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144764750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating BCKAs are closely associated with adipose tissue insulin resistance in type 2 diabetes.","authors":"Jie Gao, Mai Re YanMu Rouzi, Haofan Yang, Wenhao Zheng, Liang Wang, Tao Lei, Jun Lu","doi":"10.1186/s13098-025-01860-z","DOIUrl":"10.1186/s13098-025-01860-z","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to examine the association between branched-chain amino acids/branched-chain α-keto acids (BCAAs/BCKAs) and adipose tissue insulin resistance (Adipo-IR) in patients with type 2 diabetes mellitus (T2DM).</p><p><strong>Methods: </strong>A total of 506 patients with T2DM were included in this cross-sectional study. Participants were categorized into two groups based on Adipo-IR levels (non-Adipo-IR: Adipo-IR<7.68; Adipo-IR: Adipo-IR ≥ 7.68). Serum BCAA/BCKA concentrations were measured using ELISA kits. Correlations between BCAAs/BCKAs and Adipo-IR or HOMA-IR were evaluated using Spearman correlation analysis. Binary logistic regression was used to examine the associations of BCKAs with both indices of insulin resistance.</p><p><strong>Results: </strong>Median serum BCKA levels were significantly higher in the Adipo-IR group than in the non-Adipo-IR (128.27 vs. 121.16, p < 0.001), while there was no significant difference in median serum BCAA levels between the two groups (2.54 vs. 2.52, p = 0.714). BCKAs were positively correlated with both Adipo-IR and HOMA-IR (both p < 0.01), and the association with Adipo-IR was stronger. Binary logistic regression analysis revealed that BCKAs were associated with Adipo-IR regardless of adjustment for influencing factors, with increasing odds ratios across BCKAs quartiles (p for trend < 0.01). However, after adjusting for covariates, the association between BCKAs and HOMA-IR was no longer significant.</p><p><strong>Conclusions: </strong>Serum BCKA levels were elevated in T2DM patients with Adipo-IR and were more strongly correlated with Adipo-IR than HOMA-IR. BCKAs may serve as sensitive biomarkers for Adipo-IR. Consequently, we would promote their clinical usage in the early screening of individuals with obesity, insulin resistance and a high risk of T2DM.</p>","PeriodicalId":11106,"journal":{"name":"Diabetology & Metabolic Syndrome","volume":"17 1","pages":"308"},"PeriodicalIF":3.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12315228/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144764747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep disorders impact hormonal regulation: unravelling the relationship among sleep disorders, hormones and metabolic diseases.","authors":"Yang Jiao, Claudette Butoyi, Qian Zhang, Swailla Amina Araújo Intchasso Adotey, Mengxue Chen, Wen Shen, Dong Wang, Guoyue Yuan, Jue Jia","doi":"10.1186/s13098-025-01871-w","DOIUrl":"10.1186/s13098-025-01871-w","url":null,"abstract":"<p><p>Sleep plays a crucial biological role, and mounting evidence suggests that sleep disorders negatively impact health. In contemporary society, sleep disorders, such as sleep deprivation, insomnia, disrupted sleep-wake disorders, and circadian rhythm disorders, are widespread. Sleep disorders affect hormone production and secretion, which lead to endocrine changes, including impaired glucose tolerance, decreased insulin sensitivity, hepatic steatosis, and increased inflammatory responses, all of which accelerate the onset of various diseases. To support optimal metabolic and cardiovascular health, maintaining a consistent sleep schedule and practicing good sleep hygiene are essential.</p>","PeriodicalId":11106,"journal":{"name":"Diabetology & Metabolic Syndrome","volume":"17 1","pages":"305"},"PeriodicalIF":3.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12315459/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144764751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal effects of primary aldosteronism on inflammation and bone density: evidence from Mendelian randomization, animal, and clinical studies.","authors":"Zhiyu Zhang, Yun Du, Fei Zhang, Xiaoqi Li, Lei Rong, Heng Zhu, Jie Tan, Jing Huang","doi":"10.1186/s13098-025-01875-6","DOIUrl":"10.1186/s13098-025-01875-6","url":null,"abstract":"<p><strong>Background: </strong>Studies on the pro-inflammatory effects of primary aldosteronism (PA) in humans have largely relied on measurements of circulating inflammatory biomarkers and are mostly observational in nature, making it difficult to establish a causal relationship between PA and inflammatory responses. In addition, the association between PA and bone mineral density (BMD) remains controversial and warrants further investigation.</p><p><strong>Objective: </strong>This study aimed to evaluate the causal effects of PA on circulating inflammatory proteins and bone mineral density.</p><p><strong>Methods: </strong>We performed a Mendelian randomization (MR) analysis to assess the causal relationships between PA and 91 circulating inflammatory proteins, as well as BMD at four anatomical sites. The findings were further validated using a rat model and clinical data.</p><p><strong>Results: </strong>MR analysis revealed significant inverse causal associations between PA and the circulating levels of interleukin-10 receptor subunit beta (IL-10RB) and hepatocyte growth factor (HGF). These findings were further supported by the rat model results, in which serum IL-10RB (2.10 ± 1.18 ng/mL) and HGF (1120.95 ± 144.33 pg/mL) levels in the Aldo-salt group were significantly lower than those in both the Aldo-salt-Epl group (4.80 ± 1.40 ng/mL and 1434.74 ± 192.45 pg/mL, respectively) and the control group (5.07 ± 0.79 ng/mL and 1540.42 ± 316.32 pg/mL, respectively) (P < 0.05). Consistently, clinical data showed that patients with PA had significantly lower serum IL-10Rb and HGF levels compared to those with essential hypertension (EH) (1146.20 ± 178.23 vs. 1660.49 ± 238.44 pg/mL and 1082.93 ± 231.47 vs. 1935.18 ± 296.44 pg/mL, respectively; P < 0.001 for both). Notably, MR analysis did not identify any significant causal associations between PA and bone mineral density at the total body, forearm, femoral neck, or lumbar spine.</p><p><strong>Conclusion: </strong>This study is the first to demonstrate a causal relationship between PA and reduced circulating levels of IL-10RB and HGF, suggesting that PA may promote disease progression by impairing anti-inflammatory defenses and providing new insights for diagnostic and therapeutic strategies targeting inflammation-related pathways.</p>","PeriodicalId":11106,"journal":{"name":"Diabetology & Metabolic Syndrome","volume":"17 1","pages":"303"},"PeriodicalIF":3.9,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12308995/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between metabolic score of visceral fat and all-cause mortality among individuals with metabolic dysfunction-associated steatotic liver disease: a follow-up study based on NHANES III (1988-1994).","authors":"Guoqing Huang, Ping-Ping Zhang, Tieqiao Wang, Shixue Bao, Yushan Mao","doi":"10.1186/s13098-025-01864-9","DOIUrl":"10.1186/s13098-025-01864-9","url":null,"abstract":"<p><strong>Background: </strong>Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease, seriously threatening the public health. However, the specific role of metabolic score of visceral fat (METS-VF) as a prognostic marker in the MASLD population remains unclear. In this study, we explored the association and nonlinear relationship between METS-VF and all-cause mortality among MASLD population.</p><p><strong>Methods: </strong>This study included American adults aged over 20 years with MASLD who participated in the Third National Health and Nutrition Examination Survey (NHANES III, 1988-1994) in the United States. Kaplan-Meier curve was used to explore the relationship between different METS-VF levels and all-cause mortality. Multivariable Cox regression analysis was used to explore the independent linear relationship between METS-VF and all-cause mortality. In addition, Cox regression with restricted cubic spline functions and smooth curve fitting were used to evaluate potential nonlinear associations. An inflection point of METS-VF was determined using a two-piece Cox regression model.</p><p><strong>Results: </strong>During an average follow-up period of 23.15 years, there were 1,413 all-cause deaths and the cumulative all-cause mortality proportion was 46.6%. Kaplan-Meier curve revealed that high METS-VF significantly increased the mortality risk in the MASLD population. Multivariate Cox regression analysis revealed that METS-VF was independently associated with all-cause mortality (hazard ratio [HR]: 1.121; 95% confidence interval [CI]: 1.103-1.139; P < 0.001). Cox regression with restricted cubic spline functions and smooth curve fitting showed a J-shaped relationship between METS-VF and all-cause mortality, with an inflection point of 6.394. The HR was 1.068 (95% CI: 1.038-1.099, P < 0.001) before the inflection point and 1.143 (95% CI: 1.122-1.166, P < 0.001) after it.</p><p><strong>Conclusion: </strong>This study reveals that higher METS-VF levels are significantly associated with an increased risk of all-cause mortality in individuals with MASLD, characterized by a J-shaped non-linear relationship. This finding provides a new indicator for prognosis assessment in the MASLD population.</p>","PeriodicalId":11106,"journal":{"name":"Diabetology & Metabolic Syndrome","volume":"17 1","pages":"302"},"PeriodicalIF":3.9,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12309096/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between different dimensions of the C-reactive protein-triglyceride-glucose index and future cardiovascular disease risk in individuals with cardiovascular-kidney-metabolic syndrome stages 0-3: a nationwide cohort study.","authors":"Jintao Chen, Liying Yan, Lei He, Weixue Wang","doi":"10.1186/s13098-025-01882-7","DOIUrl":"10.1186/s13098-025-01882-7","url":null,"abstract":"<p><strong>Background: </strong>Cardiovascular-kidney-metabolic (CKM) syndrome highlights the complex interplay between metabolic disturbances, kidney disease, and cardiovascular conditions. In this process, inflammation and insulin resistance play pivotal roles. The C-reactive protein-triglyceride-glucose index (CTI), a novel biomarker of insulin resistance and inflammation, remains unestablished for predicting cardiovascular disease (CVD) risk in CKM syndrome stages 0-3.</p><p><strong>Methods: </strong>This study analyzed data from the China Health and Retirement Longitudinal Study. The outcome measure was self-reported CVD. The exposure measure, CTI, was calculated as: 0.412*Ln(C-reactive protein [mg/L]) + Ln[fasting triglycerides (mg/dL) * fasting glucose (mg/dL)/2]. Cumulative CTI was calculated as: (CTI 2012 + CTI 2015)/2 *Time (2015-2012). K-means clustering was used to categorize CTI fluctuations into four distinct clusters. Cox proportional hazards models were employed to examine the relationship between CTI and new-onset CVD risk in individuals across different CKM syndrome stages. The form of this relationship was further analyzed using restricted cubic splines. Additionally, the predictive ability was assessed using the receiver operating characteristic curve.</p><p><strong>Results: </strong>This study included 5111 individuals with CKM syndrome stages 0-3, with a mean age of 61.78 ± 8.68 years, of which 45.7%(2337) were male. During the follow-up period, 555 new cases of CVD were observed (10.9%). Our findings demonstrated a significant positive linear relationship between CTI and the risk of CVD in individuals with CKM syndrome stages 0-3. In model 3, each 1.0-SD increase in cumulative CTI was associated with a 21% increase in CVD risk (adjusted hazard ratio, aHR = 1.21 [95% CI: 1.10-1.33]). Similarly, each 1.0-SD increase in baseline CTI was associated with an 18% increase in CVD risk (aHR = 1.18 [95% CI: 1.07-1.30]). Additionally, Receiver operating characteristic analysis revealed that cumulative CTI had a better predictive performance for CVD risk compared to the cumulative TyG index (AUC: 0.596 vs 0.560, DeLong test p < 0.05).</p><p><strong>Conclusions: </strong>Higher CTI levels in individuals with CKM syndrome stages 0-3 are significantly associated with increased CVD risk. Longitudinal monitoring of CTI changes over time can help early identification of high CVD risk in this population, and its predictive value is significantly superior to that of the TyG index.</p>","PeriodicalId":11106,"journal":{"name":"Diabetology & Metabolic Syndrome","volume":"17 1","pages":"299"},"PeriodicalIF":3.9,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12306132/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144741591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}