Diabetology & Metabolic Syndrome最新文献

{"title":"The value of growth differentiation factor 15 as a biomarker for peripheral artery disease in diabetes patients.","authors":"Wan-Chi Chuang, Chih-Hsun Chu, Cai-Sin Yao, Mei-Chih Wei, I-Lun Hsieh, Chia-Mei Liao","doi":"10.1186/s13098-025-01588-w","DOIUrl":"10.1186/s13098-025-01588-w","url":null,"abstract":"<p><strong>Background: </strong>Growth differentiation factor 15 (GDF15) is significantly correlated with glycolipid metabolic disorders. Increased GDF15 levels are associated with obesity, insulin resistance, and diabetes as well as a poorer diabetes progression and prognosis. This is a prospective cohort study investigated the association between circulating GDF15 and diabetic peripheral artery disease.</p><p><strong>Methods: </strong>A total of 174 diabetic patients aged 20-80 were enrolled. Plasma GDF15 levels were measured using ELISA. Peripheral Artery Disease (PAD) was evaluated with the Ankle brachial index (ABI) and the Cardio-ankle vascular index (CAVI).</p><p><strong>Results: </strong>We found that diabetic patients with higher serum GDF15 levels (mean: 2521.5 pg/mL) had a higher incidence of peripheral artery disease. Multivariate logistic regression analysis indicated that patients with high serum GDF15 levels were at an increased risk of developing peripheral artery disease. High GDF15 levels were associated with ABI < 0.9 (right and left mean 19.5% p = 0.80, OR:1.13; 95%CI: [0.44-2.90]). Increased age (p = 0.025 OR:1.02; 95% CI [0.13-0.87]), family history (p = 0.001 OR:1.37; 95%CI: [0.37-5.05]), heart failure (p = 0.002 OR:4.96; 95%CI: [1.76-13.97]), sodium-glucose linked transporter 2 (SGLT 2) inhibitor use (p = 0.026), estimated glomerular filtration rate (eGFR) (p = < 0.001), and uric acid (p = < 0.001) was also positively associated with high GDF15 levels. Urine albumin-to-creatinine ratio (UACR) (p = < 0.010) was associated with higher GDF15 levels after one year of follow up.</p><p><strong>Conclusions: </strong>Elevated GDF15 was significantly associated with worsening metabolic parameters and an increased risk of peripheral artery disease. Thus, it may be a stronger predictor of these outcomes in people with diabetes.</p>","PeriodicalId":11106,"journal":{"name":"Diabetology & Metabolic Syndrome","volume":"17 1","pages":"31"},"PeriodicalIF":3.4,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11755927/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143028093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abnormal insulin metabolism and decreased levels of mindfulness in type 2 diabetes mellitus.","authors":"Xue Zhang, Rui Huang, Jiaxin Li, Mingyue Yang, Daowen Zhang, Cancan Liu, Kuanlu Fan","doi":"10.1186/s13098-025-01594-y","DOIUrl":"10.1186/s13098-025-01594-y","url":null,"abstract":"<p><strong>Objective: </strong>Disorders of insulin metabolism are strongly associated with a variety of psychological problems. The aim of this study was to investigate the differences in mindfulness levels among type 2 diabetes mellitus (T2DM) patients categorized based on their insulin resistance and β-cell function.</p><p><strong>Methods: </strong>A total of 157 T2DM patients were included in this study and divided into four groups according to their levels of insulin resistance and β-cell function. The Five Facet Mindfulness Questionnaire (FFMQ) was employed to assess the mindfulness levels of the patients. Linear regression models were utilized to investigate the relationships between various T2DM categories and mindfulness levels and dimensions. Furthermore, subgroup analyses of key variables were conducted, and mediation analysis was performed to evaluate the sources of differences.</p><p><strong>Results: </strong>Significant differences were observed among the four groups in terms of total mindfulness scores and in the dimensions of \"Describing,\" \"Non-judging of Inner Experience,\" and \"Acting with Awareness\" (P < 0.05). Compared to the control group (low HOMA-IR/high HOMA-β), the high HOMA-IR/low HOMA-β group exhibited markedly lower scores in \"Non-judging of Inner Experience\" (P = 0.02) and \"Acting with Awareness\" (P < 0.001). The low HOMA-IR/low HOMA-β group demonstrated weaker performance in \"Non-judging of Inner Experience\" (P = 0.005) and \"Describing\" (P = 0.002).</p><p><strong>Conclusion: </strong>Significant differences in mindfulness levels were found to exist among T2DM patients with varying degrees of insulin resistance and β-cell function. Early-stage diabetes patients, particularly those with lower β-cell function or higher insulin resistance levels, may require additional psychological intervention support to enhance their mindfulness and overall well-being.</p>","PeriodicalId":11106,"journal":{"name":"Diabetology & Metabolic Syndrome","volume":"17 1","pages":"32"},"PeriodicalIF":3.4,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11755820/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143028099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anthropometric and metabolic parameters associated with visceral fat in non-obese type 2 diabetes individuals.","authors":"Ming Jiao, Jiaoli Chen, Xiaoling Wang, Wenyu Tao, Yunhua Feng, Huijun Yang, Haiying Yang, Shanshan Zhao, Ying Yang, Yiping Li","doi":"10.1186/s13098-025-01583-1","DOIUrl":"10.1186/s13098-025-01583-1","url":null,"abstract":"<p><strong>Background and aim: </strong>Visceral fat (VF) was proved to be a more precise predictor of atherosclerotic cardiovascular disease (ASCVD) risk in individuals with type 2 diabetes mellitus (T2DM) than body mass index (BMI) itself. Even when the BMI was normal, visceral fat area (VFA) ≥ 90 cm² could raise the ten-year risk of developing ASCVD. Therefore, it was worth evaluating the association of influencing factors with high VF in non-obese T2DM individuals.</p><p><strong>Methods: </strong>This study enrolled 1,409 T2DM participants with T2DM, of whom 538 had a normal BMI. Based on VFA, these subjects were divided into two groups: VF (+) (VFA ≥ 90cm²) (n = 110) and VF (-) (VFA < 90cm²) (n = 428). The measurement of VFA was conducted using an Omron VF measuring device. Anthropometric and metabolic parameters were detected. Novel insulin resistance indices, such as lipid accumulation product (LAP) was calculated. Factors associated with VF were screened using univariate analysis, multifactorial binary logistic regression models and chi-squared automatic interaction detector decision tree model.</p><p><strong>Results: </strong>The VF (+) OB (-) (BMI ≤ 23.9 kg/m²) prevalence were 7.8% in T2DM subjects (n = 1,409) and 20.4% in T2DM subjects with normal BMI (n = 538), respectively. In T2DM subjects with normal BMI, the logistic regression model suggested that neck circumference (NC) had an odds ratio (OR) of 1.891 (95% CI: 1.165-3.069, P = 0.010). The OR for VF gradually increased from the 1st to the 4th in LAP quartile (P < 0.05). LAP emerged as the root node, followed by NC in the decision tree model. Receiver operating characteristic curve (ROC) analysis demonstrated that the area under the curve (AUC) for NC in predicting high VF levels was 0.640 for males and 0.682 for females. Optimal NC cut-off points were 37.75 cm for males and 34.75 cm for females, respectively. Additionally, the AUC values of LAP in predicting high VF levels were 0.745 for males and 0.772 for females, with optimal LAP cut-off points of 22.64 and 26.45 for males and females, respectively.</p><p><strong>Conclusion: </strong>This study identified NC and LAP can be considered predictors of high VF in T2DM subjects with normal BMI.</p>","PeriodicalId":11106,"journal":{"name":"Diabetology & Metabolic Syndrome","volume":"17 1","pages":"28"},"PeriodicalIF":3.4,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11753141/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143022650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between stress hyperglycemia ratio and progression of non target coronary lesions: a retrospective cohort study.","authors":"Shiqi Liu, Ziyang Wu, Gaoliang Yan, Yong Qiao, Yuhan Qin, Dong Wang, Chengchun Tang","doi":"10.1186/s13098-024-01575-7","DOIUrl":"10.1186/s13098-024-01575-7","url":null,"abstract":"<p><strong>Background: </strong>Stress hyperglycemia ratio is a novel indicator of acute coronary synthesis (ACS), which is closely related to the severity and complications of ACS and other cardiovascular diseases. However, its relationship with the progression of non target coronary lesions remains unclear. The purpose of this paper is to explore the relationship between stress hyperglycemia ratio and the progression of non target coronary lesions.</p><p><strong>Methods: </strong>This study retrospectively enrolled patients diagnosed with acute coronary syndrome who underwent stent implantation and follow-up evaluations by coronary angiography at Zhongda Hospital between January 2019 and January 2024. Patients were classified into progression and non progression groups based on follow-up angiography findings. Logistic regression models, restricted cubic spline analysis, and machine learning algorithms (LightGBM, decision tree, and XGBoost) were utilized to analyse the relationship of stress hyperglycemia ratio and non target lesion progression.</p><p><strong>Results: </strong>A total of 1,234 ACS patients were included; 29.1% experienced non target lesions progression. Logistic regression analysis showed that stress hyperglycemia ratio (SHR) was a risk factor for non target disease progression (P < 0.001), and after adjusting for other variables, SHR was still independently associated with non target disease progression (OR = 2.12, 95% CI: 1.30-3.44, p = 0.003). RCS analysis revealed a near-linear relationship between SHR and nontarget lesions progression (P = 0.14). With the increase of SHR, the risk of non target lesions progression continued to increase, and the risk was significant when the SHR was greater than 0.96, but tended to be stable when the SHR was greater than 1.36 (p = 0.0047). A hybrid model combining logistic regression and XGBoost yielded the best predictive performance, with an AUC of 0.78 (95% CI: 0.72-0.85), incorporating SHR, number and stenosis severity of non target lesions (NTLs), hypertension and high-density lipoprotein cholesterol (HDL-c). Subgroup analysis showed that elevated SHR was a stronger predictor of NTL progression in non-diabetic patients (OR = 3.76, p = 0.007) compared with diabetic patients (OR = 1.69, p = 0.083).</p><p><strong>Conclusion: </strong>Stress hyperglycemia ratio is closely related to the progression of non target lesions. This study provides a novel insight for optimizing the long-term management of non target lesions after PCI.</p>","PeriodicalId":11106,"journal":{"name":"Diabetology & Metabolic Syndrome","volume":"17 1","pages":"27"},"PeriodicalIF":3.4,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11752666/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143022143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel indicator of microvascular complications in patients with type 2 diabetes mellitus and shortened erythrocyte lifespan: a multicenter cross-sectional analysis.","authors":"Yunqi Wu, Binshan Zhang, Xin Ma, Pei Yu, Saijun Zhou, Xinli Wang","doi":"10.1186/s13098-025-01591-1","DOIUrl":"10.1186/s13098-025-01591-1","url":null,"abstract":"<p><strong>Introduction: </strong>In this study, we assessed whether the ratio of glucose management index (GMI) to glycated albumin (GA) was linked to microvascular complications in patients with type 2 diabetes mellitus (T2DM) who also possessed a shortened erythrocyte lifespan.</p><p><strong>Methods: </strong>This study encompassed individuals from the Tianjin Diabetic Retinopathy Screening Cohort who completed continuous glucose monitoring and had an erythrocyte lifespan of under 90 days. Differences in GMI/GA were compared between the T2DM patients with or without microvascular complications, including diabetic kidney disease (DKD) and diabetic retinopathy (DR). The relationship between GMI/GA and microvascular complications (DKD and/or DR) was assessed by dividing GMI/GA into three groups based on tertiles.</p><p><strong>Results: </strong>Our study comprised 140 participants with T2DM (62 men and 78 women, with a median age of 67 years) with a median DM duration of 9.68 years, a mean glycated hemoglobin A1c (HbA1c) value of 7.10%, and a median GA value of 16.10%. As expected, the lower GMI/GA group exhibited higher HbA1c and GA (P < 0.001) with similar mean glucose levels (P = 0.099). GMI/GA values were significantly higher in participants without microvascular complications than in those with microvascular complications, including DKD and/or DR (P < 0.05). After adjusting for confounders, the lowest GMI/GA group (T1) had a 3.601-fold increased risk of microvascular complications (95% CI, 1.364-9.508, P = 0.010) and a 3.830-fold increased risk of DKD, specifically (95% CI, 1.364-12.222, P = 0.023) relative to the highest group (T3).</p><p><strong>Conclusion: </strong>GMI/GA serves as a novel risk indicator for microvascular complications in T2DM, independent of HbA1c.</p>","PeriodicalId":11106,"journal":{"name":"Diabetology & Metabolic Syndrome","volume":"17 1","pages":"26"},"PeriodicalIF":3.4,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11752720/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143022720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are standardized conditions needed for correct CGM data interpretation in subjects at early stages of glucose intolerance?","authors":"R Dimova, N Chakarova, T Tankova","doi":"10.1186/s13098-025-01579-x","DOIUrl":"10.1186/s13098-025-01579-x","url":null,"abstract":"<p><strong>Aim: </strong>The present study comparatively evaluated glucose variability (GV) parameters derived from both continuous glucose monitoring (CGM) performed under standard conditions for a 24-h period and under usual everyday conditions for a 14-day period in a high-risk population without diabetes.</p><p><strong>Methods and results: </strong>Seventy five subjects: 14 with normal glucose tolerance (NGT; mean age 43.6 ± 10.7 years; BMI 30.5 ± 6.9 kg/m²), 19 with high 1-h postload glucose > 8.6 mmol/l (1hrOGTT; mean age 45.6 ± 8.9 years; BMI 33.7 ± 6.9 kg/m²), and 42 with isolated impaired glucose tolerance (iIGT; mean age 47.6 ± 11.8 years; BMI 31.0 ± 6.5 kg/m²), were enrolled. An OGTT was performed. CGM was performed with blinded FreeStyleLibrePro for 24 h under standard conditions and for the rest of the 14-day period under usual everyday conditions. GV parameters derived from both periods were compared. There was a significant increase in GV with worsening of glucose tolerance from NGT, to 1hrOGTT and iIGT, independently of the conditions. Our findings showed moderate to strong correlations among GV indices between the studied periods in the cohort and in the 1hrOGTT and iIGT groups. However, a significant difference was found in some of the GV parameters between the analyzed periods.</p><p><strong>Conclusion: </strong>The trend in GV is independent of the conditions, under which CGM is performed, in subjects at early stages of glucose intolerance. Although its measurements to some extend differ in standard and everyday conditions, there is no need of standardized conditions for correct interpretation of GV indices in this population.</p>","PeriodicalId":11106,"journal":{"name":"Diabetology & Metabolic Syndrome","volume":"17 1","pages":"29"},"PeriodicalIF":3.4,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11899435/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143022659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the prevalence of gout among underrepresented low socioeconomic status type 2 diabetes populations.","authors":"Jessica Smith, Abey Martin, Jane Mundadan, Michael Roberts, Youssef Roman, Arturo Bravo-Nuevo, Farzaneh Daghigh","doi":"10.1186/s13098-025-01586-y","DOIUrl":"10.1186/s13098-025-01586-y","url":null,"abstract":"<p><strong>Background: </strong>Underserved and underrepresented populations often lack access to affordable, quality healthcare, educational resources, and nutritious foods, all of which contribute to increased risk of Type 2 Diabetes and gout. Type 2 Diabetes is a condition characterized by the denaturation of the insulin receptors, due to chronically high blood glucose levels, leading to impaired regulation of blood sugar. Gout is a chronic inflammatory disease affecting joints in the lower limbs, marked by elevated serum urate levels and the accumulation of uric acid crystals in synovial fluid, causing painful flare-ups that significantly impact quality of life.</p><p><strong>Methods: </strong>This multisite cross-sectional study was conducted in three low-income senior residential communities across the mid-Atlantic United States, including Philadelphia and Harrisburg, Pennsylvania, and Clinton, Maryland. A total of 88 consenting participants were surveyed on their health history and tested for hemoglobin A1c (HbA1c), blood glucose, and uric acid levels using finger-stick blood tests and commercially available devices. Inclusion criteria included individuals of any gender, aged 35-92, residing in these communities. Exclusion criteria were a personal history of cancer, organ transplantation, or current pregnancy. Educational materials were provided after discussing each participant's results.</p><p><strong>Results: </strong>There is an identifiable prevalence of gout among this population of low-income senior adults living with Type 2 Diabetes. Among the participants, 30.7% had serum urate levels indicative of hyperuricemia, exceeding the national average of 20.1% as reported by the National Health and Nutrition Examination Survey. Participants with high HbA1c had significantly higher uric acid levels compared to those with lower HbA1c levels, with diabetic levels of HbA1c accounting for approximately 40% of the variance in uric acid levels. Additionally, study participants who smoked cigarettes were more likely to have hyperuricemia than non-smokers.</p><p><strong>Conclusion: </strong>Preventive educational efforts focused on diet and lifestyle are critical to reducing the incidence of gout and Type 2 Diabetes in low-income elderly populations. Diabetic individuals are at a higher risk of developing hyperuricemia and gout compared to non-diabetics. Community-based educational health programs are necessary to make a measurable impact on these populations, prevent disease progression, and reduce the burden on healthcare systems.</p>","PeriodicalId":11106,"journal":{"name":"Diabetology & Metabolic Syndrome","volume":"17 1","pages":"25"},"PeriodicalIF":3.4,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11748529/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Burden of type 2 diabetes due to high body mass index in different SDI regions and projections of future trends: insights from the Global Burden of Disease 2021 study.","authors":"Yun-Fa Ding, An-Xia Deng, Teng-Fei Qi, Hao Yu, Liang-Ping Wu, Hong-Bing Zhang","doi":"10.1186/s13098-024-01554-y","DOIUrl":"10.1186/s13098-024-01554-y","url":null,"abstract":"<p><strong>Aim: </strong>The aim of our study was to assess the impact of high body mass index (BMI) on type 2 diabetes mellitus (T2DM) in different Socio-Demographic Development Index (SDI) regions using data from the Global Burden of Disease (GBD) 2021 study.</p><p><strong>Methods: </strong>Using data from the GBD study, the burden of disease for T2DM was measured by analyzing the age-standardized disability-adjusted life year rate (ASDR) and age-standardized mortality rate (ASMR) for type 2 diabetes due to high BMI and the associated estimated annual percentage change (EAPC). Decomposition analyses, frontier analyses, and predictive models were used to analyze changes and influencing factors for each metric.</p><p><strong>Results: </strong>The study revealed the significant global health burden of T2DM induced by high BMI, which EAPC of 1.82 with confidence intervals (CI) ranging from 1.78 to 1.87 for disability-adjusted life years (DALYs) and 0.85 with CIs ranging from 0.77 to 0.93 for mortality. The results of the analysis emphasized the geographic variability of T2DM disease burden associated with SDI Within the area covered by the study, a decreasing trend in ASMR for T2DM was observed in high SDI areas, with an EAPC value of - 1.07 and a confidence interval ranging from - 1.39 to - 0.76. At the same time, in the other SDI areas, the ASMR and ASDR for T2DM showed an increasing trend. In addition, the study noted that individuals in the 65- to 75-year-old age group accounted for a higher proportion of T2DM-related deaths and DALYs, with females affected at a greater rate than males. Projections for future trends indicate that the ASDR and ASMR for T2DM are expected to continue an upward trajectory over the next decade.</p><p><strong>Conclusion: </strong>This study investigates the variation in T2DM burden attributable to high BMI across regions with different SDI levels. The analysis reveals that, in high-SDI regions, the ASMR decreased from 1990 to 2021 and stabilized around 4.4 deaths per 100,000 people, while the ASDR increased, reaching approximately 416 cases per 100,000 people in 2021. Conversely, both ASDR and ASMR exhibited an upward trend in other SDI regions over the same period.</p>","PeriodicalId":11106,"journal":{"name":"Diabetology & Metabolic Syndrome","volume":"17 1","pages":"23"},"PeriodicalIF":3.4,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11748324/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction Note: Emerging insights into the role of IL-1 inhibitors and colchicine for inflammation control in type 2 diabetes.","authors":"Jianbin Guan, Haimiti Abudouaini, Kaiyuan Lin, Kaitan Yang","doi":"10.1186/s13098-025-01596-w","DOIUrl":"https://doi.org/10.1186/s13098-025-01596-w","url":null,"abstract":"","PeriodicalId":11106,"journal":{"name":"Diabetology & Metabolic Syndrome","volume":"17 1","pages":"21"},"PeriodicalIF":3.4,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11744967/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between various blood glucose variability-related indicators during early ICU admission and 28-day mortality in non-diabetic patients with sepsis.","authors":"Jingyan Zhou, Zhiheng Chen, Hao-Neng Huang, Chun-Quan Ou, Xin Li","doi":"10.1186/s13098-025-01580-4","DOIUrl":"10.1186/s13098-025-01580-4","url":null,"abstract":"<p><strong>Background: </strong>Various blood glucose (BG) variability-related indexes have been widely used to assess glycemic control and predict glycemic risks, but the association between BG variations and prognosis in non-diabetic patients with sepsis remains unclear.</p><p><strong>Methods: </strong>The single-center retrospective cohort study included 7,049 non-diabetic adults with sepsis who had at least 3 records of bedside capillary point of care BG testing during the first day after ICU admission from MIMIC-IV database (2008 to 2019). Coefficient of variation and standard deviation of glucose (i.e., Glu_CV and Glu_SD), M-value, J-index, high blood glucose index (HBGI), and low blood glucose index (LBGI) were used to describe glucose variability, quality of glycemic control, and glycemic risk of patients with sepsis. The dose-response relationship between BG variability-related indexes and mortality was explored using multivariate logistic regression with restricted cubic spline (RCS) function. If the dose-response curve presented a J-shape with a specific threshold value, a linear threshold function instead of RCS would be employed.</p><p><strong>Results: </strong>There is a J-shaped relationship between hospital mortality risk and glucose variability-related indexes in ICU patients with sepsis. The mortality risk remained relatively stable below the threshold of these indexes. However, over the threshold, the 28-day mortality risk increased by 2.82% (95% CI: 1.80-3.85%), 1.13% (95% CI: 0.66-1.60%), 1.96% (95% CI: 0.98-2.95%), 1.37% (95% CI: 0.57-2.16%), 11.19% (95% CI: 6.56-15.98%) and 39.04% (95% CI: 29.86-48.81%) for each unit increases in Glu_CV, Glu_SD, M-value, J-index, LBGI and HBGI, respectively. The effects of LBGI and HBGI on 7-day and 14-day mortality were more pronounced.</p><p><strong>Conclusions: </strong>High levels of Glu_CV, Glu_SD, M-value, J-index, HBGI, and LBGI on the first day of ICU admission were important risk markers of hospital mortality among non-diabetic patients with sepsis.</p>","PeriodicalId":11106,"journal":{"name":"Diabetology & Metabolic Syndrome","volume":"17 1","pages":"22"},"PeriodicalIF":3.4,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11744847/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}