Diabetology & Metabolic Syndrome最新文献

{"title":"Plin5: A potential therapeutic target for type 2 diabetes mellitus.","authors":"Mengjuan Wei, Yan Wang, Yufei Zhang, Yun Qiao","doi":"10.1186/s13098-025-01680-1","DOIUrl":"10.1186/s13098-025-01680-1","url":null,"abstract":"<p><p>Type 2 diabetes mellitus (T2DM) is a kind of metabolic disease characterized by aberrant insulin secretion as a result of -cell loss or injury, or by impaired insulin sensitivity of peripheral tissues, which finally results in insulin resistance and a disturbance of glucose and lipid metabolism. Among them, lipid metabolism disorders lead to lipotoxicity through oxidative stress and inflammatory response, destroying the structure and function of tissues and cells. Abnormal lipid metabolism can lead to abnormal insulin signaling and disrupt glucose metabolism through a variety of pathways. Therefore, emphasizing lipid metabolism may be a crucial step in the prevention and treatment of T2DM. Plin5 is a lipid droplet surface protein, which can bi-directionally regulate lipid metabolism and plays an important role in lipolysis and fat synthesis. Plin5 can simultaneously decrease the buildup of free fatty acids in the cytoplasm, improve mitochondrial uptake of free fatty acids, speed up fatty acid oxidation through lipid drops-mitochondria interaction, and lessen lipotoxicity. In oxidative tissues like the heart, liver, and skeletal muscle, Plin5 is extensively expressed. And Plin5 is widely involved in β-cell apoptosis, insulin resistance, oxidative stress, inflammatory response and other pathological processes, which has important implications for exploring the pathogenesis of T2DM. In addition, recent studies have found that Plin5 is also closely related to T2DM and cancer, which provides a new perspective for exploring the relationship between T2DM and cancer.</p>","PeriodicalId":11106,"journal":{"name":"Diabetology & Metabolic Syndrome","volume":"17 1","pages":"114"},"PeriodicalIF":3.4,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11963521/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk analysis and mediation analysis of stress hyperglycemia ratio and all-cause mortality in patients with acute kidney injury.","authors":"Yue Shi, Hangyu Duan, Jing Liu, Xiujie Shi, Mingming Zhao, Yu Zhang","doi":"10.1186/s13098-025-01675-y","DOIUrl":"10.1186/s13098-025-01675-y","url":null,"abstract":"<p><strong>Background: </strong>Stress hyperglycemia ratio (SHR) has been associated with increased mortality from various cerebrovascular events and a higher incidence of acute kidney injury (AKI) in certain patient populations. However, the relationship between SHR and the mortality risk in patients with AKI has not been fully elucidated. Our study sought to comprehensively investigate the association and potential mediating effects between SHR and 28-day and 90-day mortality in patients with AKI.</p><p><strong>Methods: </strong>3703 patients with AKI were included in this study. Feature importance variables were screened by a random forest algorithm, and the independent association of SHR with mortality risk was determined by Kaplan ‒ Meier survival analysis with Cox regression analysis. Restricted cubic spline (RCS) was conducted to assess the non-linear relationship between SHR and mortality risk. Mediation analysis was deployed to investigate the indirect effect of SHR on respiratory failure (RF) -mediated mortality risk.</p><p><strong>Results: </strong>Among the patients with AKI included in this study, the 28-day mortality was 13.6% and the 90-day mortality was 18.7%. Fully adjusted Cox regression demonstrated that SHR was an independent risk factor for 28-day mortality (HR, 1.77 [95% CI 1.38-2.27], P < 0.001) and 90-day mortality (HR, 1.69 [95% CI 1.36-2.11], P < 0.001) in patients with AKI. RCS analysis revealed a linear relationship between SHR and outcome events. Additionally, the effect of SHR on 28-day and 90-day mortality risk were mediated by an increased RF risk in 6.62% and 6.54%, respectively.</p><p><strong>Conclusion: </strong>High SHR is an independent risk factor for 28-day and 90-day mortality in patients with AKI, and its effect is partly mediated by an increased risk of RF.</p>","PeriodicalId":11106,"journal":{"name":"Diabetology & Metabolic Syndrome","volume":"17 1","pages":"112"},"PeriodicalIF":3.4,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11963474/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Collagen glycosylation, hip structural analysis, and trabecular bone score in adolescents with type 1 diabetes: a cross-sectional study.","authors":"Sowmya Krishnan, Christopher E Aston, Jennifer Chadwick, Shelly Gulati, Huaiwen Wang, Susan B Sisson, Madhusmita Misra, Steven D Chernausek","doi":"10.1186/s13098-025-01677-w","DOIUrl":"10.1186/s13098-025-01677-w","url":null,"abstract":"<p><p>Both type 1 and type 2 diabetes mellitus (T1D and T2D) are associated with poor bone health and an increased risk of fracture in adults. However, there are limited data regarding the effects of diabetes on the growing skeleton, particularly during adolescence, the time of peak bone mineral accretion. The purpose of this study was to examine differences in markers of bone health and factors that influence bone health in White adolescents and young adults with well-controlled T1D (n = 17; Average A1C 7.45 ± 1.15%) and control participants without T1D (n = 13). Age across both groups was similar (17.41 ± 1.62 years for T1D vs. 17.46 ± 1.45 years for controls) as was BMI and height. Bone density was measured at the lumbar spine, whole body, and proximal femur sites using the GE HealthCare's Lunar iDXA (GE; v11-30.062) in all subjects. Hip structural analysis (HSA) was performed at the proximal femur and Trabecular Bone Score (TBS) was calculated from AP spine image using Trabecular Osteo Software from Medimaps. Markers of bone formation, resorption, serum sclerostin and urine pentosidine were measured in all subjects. No difference in total body bone mineral density (BMD), lumbar spine BMD, lumbar spine BMAD, dual femur BMD, HSA variables or TBS measures were noted between subjects with T1D and controls. However, duration of diabetes had a significant negative correlation (p: 0.035) with cross-sectional moment of inertia (a measure of resistance to bending forces) in subjects with T1D. IGF-1 levels were marginally lower in the group with T1D (p:0.06) and had a significant inverse relationship (r: -0.406, p:0.026) with mean hip axis angle; a known predictor of hip fractures. TBS score had a marginally significant negative correlation with urinary pentosidine (a marker for collagen glycosylation) across both groups after adjusting for age (r: -0.343, p: 0.07), suggesting increased collagen glycosylation has an adverse impact on bone microarchitecture. CLINICAL TRIAL NUMBER: Not applicable.</p>","PeriodicalId":11106,"journal":{"name":"Diabetology & Metabolic Syndrome","volume":"17 1","pages":"113"},"PeriodicalIF":3.4,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11963267/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of beinaglutide as an glucagon-like peptide-1 receptor agonists on cardiometabolic factors: a systematic review and meta-analysis.","authors":"Yan Xu, Periyannan Velu, Li Hu, Nathalia Sernizon Guimarães","doi":"10.1186/s13098-025-01633-8","DOIUrl":"10.1186/s13098-025-01633-8","url":null,"abstract":"<p><strong>Background: </strong>Considering the important role of cardiometabolic risk factors in different societies on increasing the burden of non-communicable diseases, in this study we will investigate the possible effects of Beinaglutide as an glucagon-like peptide-1 receptor agonists (GLP-1RAs) on these risk factors.</p><p><strong>Methods: </strong>In order to identify all randomized controlled trials that investigated the effects of Beinaglutide on cardiometabolic factors, a systematic search was conducted in the original databases using predefined keywords until July 2024. The pooled weighted mean difference and 95% confidence intervals were computed using the random-effects model.</p><p><strong>Results: </strong>A quantitative meta-analysis results from 7 studies with 872 participants showed that Beinaglutide has a significant lowering effect on weight (WMD: -3.74 kg; 95% CI: -5.03, -2.45), body mass index (BMI) (WMD:-1.64 kg/m²; 95% CI: -2.10, -1.17), waist circumference (WC) (WMD: -3.19 cm; 95% CI: -4.65 to -1.73), triglycerid (TG) levels (WMD: -0.14 mmol/l with; 95% CI: -0.25, -0.04), and systolic blood pressure (SBP) (WMD: -1.76 mm/Hg; 95% CI: -2.61, -0.91). Furthermore, the results obtain from subgroup analysis showed a greater effect of Beinaglutide on the reduction of weight and TG during the intervention of more than 12 weeks. In addition, body weight loss was greater in doses less than 0.4 mg compared to doses greater than or equal to 0.4 mg.</p><p><strong>Conclusions: </strong>The results of this meta-analysis show that Beinaglutide is effective in reducing factors related to obesity, TG as wll as SBP, especially with longer interventions and lower doses.</p>","PeriodicalId":11106,"journal":{"name":"Diabetology & Metabolic Syndrome","volume":"17 1","pages":"110"},"PeriodicalIF":3.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11959866/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of transdermal estrogens combined with Medroxyprogesterone Acetate on cardiovascular disease risk factors in postmenopausal women: a meta-analysis of randomized controlled trials.","authors":"Fan Zhou, Kousalya Prabahar, Jiao Shu","doi":"10.1186/s13098-025-01664-1","DOIUrl":"10.1186/s13098-025-01664-1","url":null,"abstract":"<p><strong>Background: </strong>To date, no meta-analysis has reported on the role of transdermal estrogens combined with Medroxyprogesterone Acetate (MPA) in relation to cardiovascular disease (CVD) risk factors in postmenopausal women. To fill this knowledge gap, a meta-analysis of randomized controlled trials (RCTs) was conducted to assess the effects of transdermal estrogens and MPA on CVD risk factors in postmenopausal women.</p><p><strong>Methods: </strong>A systematic literature search was conducted in major databases including PubMed/Medline, Web of Science, SCOPUS, and Embase, from inception to 12 February 2025. The combination of Medical Subject Headings (MeSH) and non-MeSH keywords was used.</p><p><strong>Results: </strong>A total of 14 trials were included in the meta-analysis. The combined eligible trials found that transdermal estrogens combined with MPA significantly decreased total cholesterol (TC) (WMD: -13.37 mg/dL, 95% CI: -21.54 to -5.21, p = 0.001), low density lipoprotein cholesterol (LDL-C) (WMD: -12.17 mg/dL, 95% CI: -23.26 to -1.08, p = 0.031), and apolipoprotein B (ApoB) (WMD: -7.26 mg/dL, 95% CI: -11.48 to -3.03, p = 0.001) compared to the control. No statistically significant associations were observed between transdermal estrogens combined with MPA on triglyceride (TG), high density lipoprotein cholesterol (HDL-C), lipoprotein(a) (Lp(a)), and apolipoprotein A1 (ApoAI).</p><p><strong>Conclusion: </strong>Based on the results of the current meta-analysis, transdermal estrogens combined with oral MPA administration had a beneficial effect on certain CVD risk factors in postmenopausal women, as evidenced by the significant reductions in TC, LDL-C, and ApoB.</p>","PeriodicalId":11106,"journal":{"name":"Diabetology & Metabolic Syndrome","volume":"17 1","pages":"111"},"PeriodicalIF":3.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11959720/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143762722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High levels of serum uric acid are associated with microvascular complications in patients with long-term diabetes.","authors":"Hanying Wang, Liping Gu, Yuhang Ma, Xindan Xing, Yuan Qu, Xin Shi, Xinyi Liu, Hancong Wan, Qian Zhu, Yingchen Shen, Chong Chen, Li Su, Yufan Wang, Kun Liu","doi":"10.1186/s13098-025-01656-1","DOIUrl":"10.1186/s13098-025-01656-1","url":null,"abstract":"<p><strong>Aims: </strong>To assess the association between serum uric acid (SUA) level and the prevalence of diabetic retinopathy (DR) and chronic kidney disease (CKD) in patients with long-term diabetes.</p><p><strong>Methods: </strong>A cross-sectional analysis was conducted involving diabetic patients from Shanghai General hospital during October 2018 and October 2021. Participants underwent measurements of SUA, renal function test and DR assessments via fundus photography. Multivariable ordinal logistic regression models assessed odd ratios (ORs) and 95% confidence intervals (95% CIs) for the progression of DR and CKD. Receiver operating characteristics (ROC) curves identified SUA thresholds, categorizing participants into low and high SUA groups.</p><p><strong>Results: </strong>Among the 1015 patients with diabetes, SUA levels were higher in individuals with advanced CKD stages (p < 0.001, compared with stage 1 CKD) and vision-threatening diabetic retinopathy (VTDR) (p = 0.019, compared with no diabetic retinopathy (NDR)). In multivariable models adjusted for potential confounders, higher SUA levels were associated with an increased risk of DR (OR: 1.002, 95% CI: 1.001-1.004) and CKD (OR: 1.008, 95% CI: 1.006-1.011). Notably, SUA levels exceeding 354.0 µmol/L (95% CI: 318.9-393.2) and 361.0 µmol/L (339.2-386.3) were associated with 1.571-fold (95% CI: 1.139-2.099, P = 0.006 for DR) and 1.395-fold (95% CI: 1.033-1.885, P = 0.030 for CKD) increased risks, respectively. Gender-specific analyses also demonstrated a positive correlation between higher SUA levels and the incidence of DR and CKD in both males and females.</p><p><strong>Conclusions: </strong>Elevated SUA levels are independently coincided with increased risks of DR and CKD, suggesting that SUA may serve as a potential risk marker for diabetic complications.</p>","PeriodicalId":11106,"journal":{"name":"Diabetology & Metabolic Syndrome","volume":"17 1","pages":"106"},"PeriodicalIF":3.4,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951721/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic effect of neutrophil percentage-to-albumin ratio (NPAR) on all-cause and cardiovascular mortality in diabetic kidney disease (DKD): NHANES 1999-2018.","authors":"Juntao Tan, Jinglong Du, Jiaxiu Liu, Wenlong Zhao, Yanbing Liu","doi":"10.1186/s13098-025-01674-z","DOIUrl":"10.1186/s13098-025-01674-z","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to evaluate the associations between neutrophil percentage-to-albumin ratio (NPAR) and both all-cause and cardiovascular mortality in diabetic kidney disease (DKD) patients.</p><p><strong>Methods: </strong>The data for this study were sourced from the National Health and Nutrition Examination Survey (NHANES) 1999-2018. Weighted logistic regression, Cox proportional hazards model, and Fine-Gray competing risk model were used to assess the association between NPAR and both all-cause and cardiovascular mortality in DKD patients.</p><p><strong>Results: </strong>A total of 2,699 participants were enrolled in this study. Cox regression analysis revealed that elevated NPAR levels were associated with a higher risk of all-cause mortality in all participants (HR: 2.17, 95%CI: 1.83-2.58). Meanwhile, a significant difference in cardiovascular mortality was observed in males (HR: 1.83, 95%CI: 1.42-2.38) but not in females. Finally, the adjusted Fine-Gray model identified NPAR as an independent predictor of cardiovascular mortality in males (SHR: 1.86 95%CI: 1.28-2.72) but not in females.</p><p><strong>Conclusions: </strong>In a nationally representative sample of DKD participants in the US, a significant association was detected between elevated NPAR and increased all-cause and cardiovascular mortality. In addition, gender differences in the relationship between NPAR and both all-cause and cardiovascular mortality were also observed.</p>","PeriodicalId":11106,"journal":{"name":"Diabetology & Metabolic Syndrome","volume":"17 1","pages":"105"},"PeriodicalIF":3.4,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951754/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetically predicted amino acids related to neural regulation mediate the association between diabetes mellitus and postherpetic neuralgia: a Mendelian randomization study.","authors":"Haoning Lan, Zhangran Ai, Songchao Xu, Huili Li, Zhong Feng, Ruijuan Guo, Yun Wang","doi":"10.1186/s13098-025-01672-1","DOIUrl":"10.1186/s13098-025-01672-1","url":null,"abstract":"<p><strong>Background: </strong>Postherpetic neuralgia (PHN) and diabetes mellitus frequently coexist in clinical settings; however, the causal relationship between them remains unclear. Moreover, the potential mediating role of amino acids related to neural regulation in this association has not been fully explored yet.</p><p><strong>Methods: </strong>Univariable Mendelian randomized (UVMR) was utilized to examine the causal relationship between various subtypes of diabetes mellitus and PHN, with the inverse variance weighted method as the main approach. Multivariable MR (MVMR) was conducted to assess the direct effect of diabetes mellitus, accounting for waist circumference, diabetic neuropathy/ulcers, and depression. Moreover, a two-step MR analysis was employed to investigate the mediating role of neurotransmitter-related amino acids in the association between diabetes mellitus and PHN.</p><p><strong>Results: </strong>A significant statistical correlation was found between type 2 diabetes mellitus (T2DM) and PHN (odds ratio, OR: 1.23, 95% confidence interval, CI: 1.01-1.49, P = 0.036), while in type 1 diabetes mellitus or pregnancy diabetes mellitus, no evidence of the association with PHN was observed. MVMR analyses demonstrated that the effect of T2DM on PHN remained significant after adjusting for waist circumference, diabetic neuropathy/ulcers, and depression. Further mediation analysis revealed that phenylalanine accounted for 49.2% (95% CI: 22.7- 75.6%) of the total effect of T2DM on PHN.</p><p><strong>Conclusion: </strong>The current study suggested that T2DM was associated with an increased risk of PHN, with phenylalanine playing a mediating role. These findings provided valuable insights for the screening and prevention of PHN in clinical practice.</p>","PeriodicalId":11106,"journal":{"name":"Diabetology & Metabolic Syndrome","volume":"17 1","pages":"104"},"PeriodicalIF":3.4,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951531/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of the stress hyperglycemia ratio for all-cause and cardiovascular mortality in population with cardiovascular-kidney-metabolic syndrome stages 0-4: evidence from a large cohort study.","authors":"Fan-Shun Guo, Jia-Hao Dou, Jun-Xiang Wang, Chen Guo, Rui-Yun Wu, Xue-Lu Sun, Yi-Wei Hu, Jin Wei","doi":"10.1186/s13098-025-01671-2","DOIUrl":"10.1186/s13098-025-01671-2","url":null,"abstract":"<p><strong>Background: </strong>The Cardiovascular-kidney-metabolic (CKM) syndrome is a health disorder caused by interactions between cardiovascular disease, kidney disease, and metabolism-related risk factors. The stress hyperglycemia ratio (SHR) has been shown to correlate with the prognosis of participants with diabetes mellitus, heart failure, and myocardial infarction. However, the predictive value of SHR in the CKM syndrome population is unclear and requires further exploration.</p><p><strong>Methods: </strong>This study analyzed 19,345 participants from the National Health and Nutrition Examination Survey (1999-2018). CKM syndrome was staged according to the American Heart Association (AHA) guidelines. SHR was calculated using fasting blood glucose (FBG) and glycated hemoglobin type A1c (HbA1c). Participants were grouped into four quartiles based on SHR. The primary and secondary outcomes were all-cause mortality and cardiovascular mortality, respectively. Kaplan-Meier survival curves and Cox proportional hazard regression models were used to evaluate the association between SHR and outcomes. Then, the potential nonlinear relationship was explored using restricted cubic spline (RCS) analysis. We also performed subgroup analyses to assess the effects of different variables.</p><p><strong>Results: </strong>A total of 2,736 all-cause deaths and 699 cardiovascular deaths were recorded during a median follow-up period of 115 months. Kaplan-Meier analysis revealed that participants in quartile 2 had the lowest risk for both all-cause and cardiovascular mortality (Log Rank P < 0.05). Multivariate Cox regression demonstrated the lowest all-cause mortality in the 2nd quartile (HR = 0.84, 95% CI = 0.73-0.97, P = 0.015) and the highest all-cause mortality in the 4th quartile (HR = 1.19, 95% CI = 1.03-1.37, P = 0.018), compared with the 1st quartile group of SHR. The RCS curve demonstrated a U-shape association of SHR with both all-cause and cardiovascular mortality, with the lowest points of 0.89 and 0.91, respectively.</p><p><strong>Conclusions: </strong>SHR is strongly correlated with prognosis in the CKM syndrome population, with high or low SHR increasing the risk of death. This index shows great potential for predicting the risk of death in this population.</p>","PeriodicalId":11106,"journal":{"name":"Diabetology & Metabolic Syndrome","volume":"17 1","pages":"109"},"PeriodicalIF":3.4,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951755/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fatty pancreas disease in newly diagnosed type 2 diabetes patients: a case-control study on relationships with glycemic control and exocrine function.","authors":"Tahsin Taner Karaevren, Refika Yorulmaz, Mahinur Cerit, Halit Nahit Şendur, Burak Kalafat, Gizem Yaz Aydın, Özlem Gülbahar, Mehmet Muhittin Yalçın, Ayhan Karakoç, Müjde Aktürk, Füsun Baloş Törüner, Alev Eroğlu Altınova, Taha Enes Çetin, Ethem Turgay Cerit","doi":"10.1186/s13098-025-01663-2","DOIUrl":"10.1186/s13098-025-01663-2","url":null,"abstract":"<p><strong>Background: </strong>Fatty pancreas disease (FPD) is characterized by abnormal fat accumulation in pancreatic tissue and is often associated with obesity, metabolic syndrome, and type 2 diabetes mellitus (T2DM). While its pathophysiology and impact on pancreatic functions have been explored, the interplay between FPD, glycemic control, and exocrine dysfunction in T2DM remains inadequately defined. This study aimed to evaluate the presence of FPD, the factors affecting it, and its relationship with endocrine and exocrine pancreatic functions in newly diagnosed T2DM.</p><p><strong>Methods: </strong>A total of 126 individuals were included in the study, comprising 63 newly diagnosed T2DM patients and 63 healthy controls matched for age, sex, body mass index and body fat distribution. Body composition, biochemical parameters (glucose, insulin, C-peptide, HbA1c), fecal elastase levels, and pancreatic/hepatic steatosis grades (evaluated using ultrasonography) were assessed.</p><p><strong>Results: </strong>Newly diagnosed T2DM patients presented significantly higher hepatic steatosis grades (p = 0.018) and lower fecal elastase levels (p < 0.001) compared to controls. Pancreatic exocrine insufficiency was more prevalent in the T2DM group (p < 0,001). A positive correlation was observed between the FPD grade, hepatic steatosis grade, and hepatic fat fraction. A negative and statistically significant correlation (p < 0.05) was observed between FPD grade and fecal elastase level (r = -0.264). HbA1c levels demonstrated a nonlinear (inverse U-shaped) relationship with FPD, peaking at 9.8% and declining thereafter, while showing a continuous negative relationship with fecal elastase levels. HbA1c predicted low fecal elastase (< 200 μg/g) with a cutoff value of 7.4%. Patients with HbA1c levels > 9.8% presented with reduced FPD alongside persistent exocrine insufficiency.</p><p><strong>Conclusions: </strong>Fatty pancreas disease is closely associated with hepatic steatosis, glycemic control, and exocrine pancreatic dysfunction in newly diagnosed T2DM patients. The interplay between FPD, glycemic control, and exocrine dysfunction highlights the need for comprehensive metabolic assessments in this population.</p>","PeriodicalId":11106,"journal":{"name":"Diabetology & Metabolic Syndrome","volume":"17 1","pages":"107"},"PeriodicalIF":3.4,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951613/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}