Remnant cholesterol predicts the development of type 2 diabetes in patients with nonalcoholic fatty liver disease.

IF 3.9 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Diabetology & Metabolic Syndrome Pub Date : 2025-07-18 DOI:10.1186/s13098-025-01828-z

Liping Yang, Hangkai Huang, Zejun Wang, Chengfu Xu

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引用次数: 0

Abstract

Background: The predictive value of serum remnant cholesterol in cardiovascular disease has been widely recognized. This value has also been explored in metabolic disorders such as type 2 diabetes mellitus and nonalcoholic fatty liver disease (NAFLD). However, whether remnant cholesterol can predict the risk of incident diabetes in NAFLD patients remains unclear.

Methods: This study included adults who underwent health examinations from 2004 to 2015. NAFLD was diagnosed via abdominal ultrasonography with the exclusion of other causes of chronic liver disease. Cox proportional hazards regression analyses were performed to investigate the associations between baseline remnant cholesterol and diabetes risk in NAFLD patients and NAFLD-free participants.

Results: A total of 15,464 participants were included in this study, and 2,741 adults had NAFLD. During the 93,537 person-years of follow-up, 233 cases and 150 cases of incident diabetes were recorded among NAFLD patients and NAFLD-free individuals, respectively. Compared with the first quartile, the fourth quartile of remnant cholesterol was positively associated with the risk of diabetes in NAFLD patients (HR: 1.68, 95% CI: 1.13 - 2.51; P < 0.001). However, this association was not significant in NAFLD-free individuals.

Conclusions: High remnant cholesterol was associated with an increased risk of incident diabetes in NAFLD patients but not in NAFLD-free individuals.

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残余胆固醇预测非酒精性脂肪肝患者2型糖尿病的发展

背景：血清残余胆固醇对心血管疾病的预测价值已得到广泛认可。在代谢性疾病如2型糖尿病和非酒精性脂肪性肝病（NAFLD）中也探讨了这一价值。然而，残留胆固醇是否能预测NAFLD患者发生糖尿病的风险仍不清楚。方法：本研究纳入2004年至2015年接受健康检查的成年人。在排除其他慢性肝病原因的情况下，通过腹部超声诊断NAFLD。采用Cox比例风险回归分析来调查NAFLD患者和非NAFLD参与者的基线残余胆固醇与糖尿病风险之间的关系。结果：本研究共纳入15464名参与者，其中2741名成人患有NAFLD。在93537人年的随访中，NAFLD患者和非NAFLD患者分别记录了233例和150例糖尿病。与第一个四分位数相比，第四个四分位数的残余胆固醇与NAFLD患者的糖尿病风险呈正相关(HR: 1.68, 95% CI: 1.13 - 2.51；结论：高残余胆固醇与NAFLD患者发生糖尿病的风险增加有关，但与非NAFLD个体无关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetology & Metabolic Syndrome ENDOCRINOLOGY & METABOLISM-

CiteScore

6.20

自引率

0.00%

发文量

170

审稿时长

7.5 months

期刊介绍： Diabetology & Metabolic Syndrome publishes articles on all aspects of the pathophysiology of diabetes and metabolic syndrome. By publishing original material exploring any area of laboratory, animal or clinical research into diabetes and metabolic syndrome, the journal offers a high-visibility forum for new insights and discussions into the issues of importance to the relevant community.