Diabetology & Metabolic Syndrome最新文献

{"title":"Prognostic value of atherogenic index of plasma on the all-cause and causes-specific mortality among patients with metabolic dysfunction-associated steatotic liver disease.","authors":"Guo Song, Heyu Chu, Yuting Liu, Xiaoli Liu, Rong Gu","doi":"10.1186/s13098-025-01800-x","DOIUrl":"10.1186/s13098-025-01800-x","url":null,"abstract":"<p><strong>Background: </strong>The atherogenic index of plasma (AIP) has been proposed as a potential predictor of prognosis for atherosclerosis and cardiovascular disease (CVD). However, its prognostic value in patients with metabolic dysfunction-associated steatotic liver disease (MASLD) remains unclear.</p><p><strong>Methods: </strong>This study included 4,062 participants with MASLD from the Third National Health and Nutrition Examination Survey (NHANES III). Kaplan-Meier curves, the Cox proportional hazards regression model, and restricted cubic splines (RCS) were used to assess the associations between the AIP and both all-cause and cause-specific mortality in patients with MASLD. Additionally, subgroup analyses and interaction test were conducted.</p><p><strong>Results: </strong>During a median follow-up of 311 months, a total of 1821 (44.83%) all-cause deaths, 606 (14.92%) CVD deaths and 313 (7.71%) diabetes deaths occurred. After adjusting for potential confounding factors, the hazard ratios (HR) for the highest tertile (AIP ≥ 0.30) compared to the lowest tertile (AIP < 0.01) were 1.41 (95% confidence interval [CI]: 1.17-1.68; P < 0.001) for all-cause mortality, 1.49 (95% CI: 1.07-2.09; P = 0.019) for CVD mortality, and 2.27 (95% CI: 1.28-4.01; P = 0.005) for diabetes mortality. Furthermore, subgroup analyses revealed that the highest tertile of AIP was associated with an increased risk of CVD mortality in MASLD patients with diabetes (HR = 2.46; 95% CI: 1.46-4.13; P < 0.001) or obesity/overweight (HR = 2.36; 95% CI: 1.41-3.95; P = 0.001).</p><p><strong>Conclusions: </strong>The elevated AIP is independently associated with all-cause mortality, as well as CVD and diabetes mortality in patients with MASLD. AIP can be used as a prognostic indicator for patients with MASLD.</p>","PeriodicalId":11106,"journal":{"name":"Diabetology & Metabolic Syndrome","volume":"17 1","pages":"212"},"PeriodicalIF":3.4,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12166619/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144293470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual-faced guardians: SGLT2 inhibitors' kidney protection and health challenges: a position statement by Kasralainy nephrology group (KANG).","authors":"Amin Roshdy Soliman, Mohamed Elkhatib, Sahier El-Khashab, Rasha Ahmed Darwish, Ahmed Fayed, Tarek S Abdelaziz, Hany Hammad, Rabab Mahmoud Ahmed, Hoda Abdelhamid Maamoun","doi":"10.1186/s13098-025-01790-w","DOIUrl":"10.1186/s13098-025-01790-w","url":null,"abstract":"<p><strong>Background: </strong>SGLT2 inhibitors represent a revolutionary drug class that delivers benefits exceeding those of diabetes management alone. Initially approved for type 2 diabetes management, research continually demonstrates their protective effects on kidney function across several nephrological conditions, including acute kidney injury (AKI), chronic kidney disease (CKD), dialysis-dependent kidney failure, anemia, metabolic bone disease, polycystic kidney disease (PKD), glomerulonephritis, and kidney transplantation.</p><p><strong>Purpose: </strong>This study aims to identify how SGLT2 inhibitors modify nephrological care by investigating their mechanisms of action, therapeutic outcomes, and potential applications in multiple kidney diseases. It summarizes clinical trial data alongside mechanistic insights to provide a comprehensive assessment of therapeutic outcomes beyond diabetes mellitus.</p><p><strong>Findings: </strong>Numerous clinical studies have demonstrated that SGLT2 inhibitors reduce kidney disease progression in patients with or without diabetes. These findings indicate that SGLT2 inhibitors provide kidney protection by enhancing tubuloglomerular feedback, improving renal blood flow, and reducing inflammation and ischemic tissue damage. They also provide cardiovascular benefits to dialysis patients while maintaining effective blood flow during dialysis. SGLT2 inhibitors should not be used in autosomal dominant polycystic kidney disease (ADPKD) outside clinical trials. The potential impact of SGLT2 inhibitors on bone mineral health, particularly regarding bone mineral density (BMD) reduction and fracture risk, requires careful consideration, especially in patients with pre-existing bone health concerns. Kidney transplant recipients benefit from SGLT2 inhibitors' protective effects on kidney health and assistance with diabetes management; however, further research is needed on drug compatibility with immunosuppressants and infection prevention.</p>","PeriodicalId":11106,"journal":{"name":"Diabetology & Metabolic Syndrome","volume":"17 1","pages":"214"},"PeriodicalIF":3.4,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12166609/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144293391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From muscle quality to metabolic health: investigating the association between muscle quality index and metabolic syndrome in adults.","authors":"Wen Chen, Debin Chen, Yizhou Zhuang, Liying Xu, Yaojie Wang, Youlan Chen, Yining Li, Jianhui Zhao","doi":"10.1186/s13098-025-01766-w","DOIUrl":"10.1186/s13098-025-01766-w","url":null,"abstract":"<p><strong>Objective: </strong>Metabolic syndrome (MetS) has a high prevalence in the United States (US); however, limited research comprehensively evaluates the relationship between muscle quality index (MQI) and MetS. This study aims to investigate the association between MQI and MetS.</p><p><strong>Methods: </strong>Adults aged 20-60 years from the 2011-2014 National Health and Nutrition Examination Survey were included. Handgrip strength (HGS) was measured using a dynamometer, and appendicular skeletal muscle mass (ASM) was assessed via dual-energy X-ray absorptiometry. MQI_total was calculated as the sum of HGS from both hands divided by ASM. Weighted multivariable logistic regression models and restricted cubic splines (RCS) were used to explore the association between MQI_total and MetS, and subgroup, interaction, and sensitivity analyses were conducted.</p><p><strong>Results: </strong>A total of 4,503 US residents were included in the study, with 1,165 diagnosed with MetS, yielding a prevalence of 25.9% (1,165/4,503). The weighted multivariable logistic regression model indicated that after adjusting for multiple covariates, MQI was negatively associated with the risk of MetS (odds ratio [OR] = 0.49, 95%CI: 0.32-0.73). Among the different components of MetS, MQI was negatively associated with elevated waist circumference (OR = 0.19, 95%CI: 0.12-0.28), elevated high-density lipoprotein cholesterol (OR = 0.66, 95%CI: 0.51-0.85), and elevated serum triglycerides (OR = 0.66, 95%CI: 0.51-0.85). RCS revealed a negative linear relationship between MQI and MetS (P < 0.001, P_non-linear = 0.98).</p><p><strong>Conclusion: </strong>Low MQI is associated with an increased risk of MetS, exhibiting a linear relationship. These findings suggest that improving muscle quality may be an effective strategy for the prevention of MetS.</p>","PeriodicalId":11106,"journal":{"name":"Diabetology & Metabolic Syndrome","volume":"17 1","pages":"213"},"PeriodicalIF":3.4,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12166612/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144293392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between baseline cardio-kidney-metabolic syndrome, its transition and cognitive impairment: result from CHARLS study.","authors":"Yuanyue Zhu, Xuejie Wang, Kan Wang, Yiming Dai, Weiguo Hu, Yufang Bi, Linhui Shen","doi":"10.1186/s13098-025-01779-5","DOIUrl":"10.1186/s13098-025-01779-5","url":null,"abstract":"<p><strong>Aims: </strong>Cardiovascular-Kidney-Metabolic (CKM) syndrome is an integrated context encompassing diabetes, obesity, cardiovascular, and chronic kidney diseases. The impact of CKM syndrome on cognitive impairment remained unclear.</p><p><strong>Methods: </strong>This longitudinal, observational study used data from the China Health and Retirement Longitudinal Study waves 1 and 4 (2011 to 2018). In total, 8,833 participants were included for the analysis between baseline CKM and cognitive impairment, and 4,230 were included for the analysis between CKM transition and cognitive impairment. Baseline CKM were classified into 5 consecutive stages according to the AHA statement, and transitions in CKM stages were classified as improved, stable, or progressed based on the difference in states between 2011 and 2015. Logistic regressions were used to explore the associations between CKM stages, transitions and the risk of subsequent cognitive impairment.</p><p><strong>Result: </strong>Compared with those in stage 0, the adjusted odds ratio [95% confidence intervals] (aOR [95% CI]) of incident cognitive impairment were 1.74 (1.00-3.18) for stage 1, 2.05 (1.17-3.81) for stage 2, 2.09 (1.27-3.66) for stage 3, and 3.91 (2.33-6.99) for stage 4, respectively. The odds ratios were higher among male and elder participants. In the transition analysis, the aOR (95% CI) was 0.44 (0.19-1.03) for improved group and 1.61 (1.01-2.59) for progressed group, compared with the those maintaining stable CKM stages.</p><p><strong>Conclusions: </strong>Higher CKM stages are associated with incrementally elevated risk of cognitive impairment. Additionally, the progression of CKM stages corresponded with greater hazards of cognitive impairment, while stage reversion might be associated with reduced risk.</p>","PeriodicalId":11106,"journal":{"name":"Diabetology & Metabolic Syndrome","volume":"17 1","pages":"211"},"PeriodicalIF":3.4,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12164072/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144293390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep habits, brain functional networks, and type 2 diabetes risk: cohort studies from North American and Asian populations and mediating Mendelian randomization analyses.","authors":"Faquan Hu, Qian Gong, Liyuan Xiong, Wei Zhao, Lingxiu Li, Yujiao Zheng","doi":"10.1186/s13098-025-01777-7","DOIUrl":"10.1186/s13098-025-01777-7","url":null,"abstract":"<p><strong>Background: </strong>Brain resting-state functional networks and sleep habits are associated with Type 2 diabetes mellitus (T2DM). However, the causal mediating effect between them remains largely unexplored.</p><p><strong>Methods: </strong>We analyzed data from 20,994 U.S. adults in the National Health and Nutrition Examination Survey (NHANES) and 8,652 Chinese adults from the China Health and Aging Longitudinal Study (CHARLS), focusing on sleep habits and the incidence of T2DM. Two-sample Mendelian randomization (MR) was employed to assess the causal relationships between sleep habits, resting-state functional magnetic resonance imaging (rs-fMRI), and T2DM. Furthermore, a mediation analysis was conducted to examine the role of rs-fMRI in moderating the association between sleep patterns and T2DM.</p><p><strong>Results: </strong>In the Chinese population, daytime naps lasting 0-0.25 h (β = 0.365) and more than 0.5 h (β = 0.039), along with nighttime sleep of less than 5 h (β = 0.049) and more than 9 h of sleep overall (β = 0.124) were linked to a higher risk of T2DM. Similarly, in the U.S. population, sleeping less than 5 h (β = 0.056), 5-6 h (β = 0.034), and more than 8 h (β = 0.052) also significantly increased the risk of T2DM. Moreover, sleeping in later than 1:00 a.m. or before 10:00 p.m. raises the chance of acquiring T2DM. A correlation between the incidence of T2DM and increased connectivity in the default mode network (DMN), visual network (VN), central executive network, (CEN), and motor networks (MN) was found by MR analysis. Additionally, mediation analysis revealed that sleep disorders, naps during the day, and daytime sleep affect T2DM morbidity via changing connectivity in the central executive, motor, and default mode networks.</p><p><strong>Conclusions: </strong>According to our research, changed brain functional network connectivity and sleep habits, significantly influence the risk of T2DM. This demonstrates the critical function that brain networks play in modulating the link between sleep patterns and the prevalence of T2DM.</p>","PeriodicalId":11106,"journal":{"name":"Diabetology & Metabolic Syndrome","volume":"17 1","pages":"210"},"PeriodicalIF":3.4,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12164148/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144293471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"I lost my syringes, my insulin, and my glucose test strips. I lost all my belongings\": a qualitative study on the perspective of elderly individuals with type 2 diabetes regarding the unprecedented flooding in southern Brazil.","authors":"Bianca Gomes Corrêa, Lucas Strassburger Matzenbacher, Laura Gomes Boabaid de Barros, Ana Gabriela Rodrigues Haussen, Mariana Kude Perrone, Vicenzo Gheno, Helena Toniazzi Uchôa, Marcell Machado Cipolat, Frederico Ludwig da Costa, Gabriela Heiden Telo","doi":"10.1186/s13098-024-01569-5","DOIUrl":"10.1186/s13098-024-01569-5","url":null,"abstract":"<p><strong>Aims: </strong>To qualitatively evaluate the impact of the unprecedented floods that hit Brazil in 2024 on homes, personal life, daily routine, mental health, and diabetes care among elderly with diabetes.</p><p><strong>Methods and results: </strong>This qualitative study included elderly individuals with type 2 diabetes. A structured interview was conducted to assess the impact of the floods on their lives. Inductive thematic content analysis with deductive coding was used to analyze the interview responses and present the overall findings. Fifty individuals (35 females and 15 males), with a mean age of 72.0 years, long diabetes duration, low socioeconomic level, and a high prevalence of psychiatric disorders were included. Thematic analysis revealed four major themes: (1) Emotional response; (2) Negative impact on health and self-care; (3) Material losses; (4) Feelings of community support and empathy. All participants reported negative impacts as a consequence of the disaster, affecting various aspects of their lives, including mental health, access to health care, medication shortages, barriers to diabetes management, and worsening of dietary and physical activity habits.</p><p><strong>Conclusion: </strong>The unprecedented climate disaster that hits Brazil in 2024 had a profound impact on elderly individuals with diabetes, affecting not only material belongings but also their mental well-being and access to healthcare. These findings highlight the urgent need for targeted interventions and support systems to address the vulnerabilities of elderly populations with chronic conditions during climate-related disasters. The long-term consequences of such crises must be further studied to better prepare for and mitigate their impact on vulnerable communities.</p>","PeriodicalId":11106,"journal":{"name":"Diabetology & Metabolic Syndrome","volume":"17 1","pages":"207"},"PeriodicalIF":3.4,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12160346/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation analysis between serum Klotho and cognitive function in diabetes individuals.","authors":"Li Gong, Qing Ge","doi":"10.1186/s13098-025-01789-3","DOIUrl":"10.1186/s13098-025-01789-3","url":null,"abstract":"<p><strong>Background: </strong>The relationship between Klotho, blood glucose levels, and cognitive function is well-established. However, limited data exist on the association between Klotho and cognitive function in diabetes individuals.</p><p><strong>Objective: </strong>To investigate the potential link between serum Klotho levels and cognitive function in diabetes individuals.</p><p><strong>Methods: </strong>Using data from the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2014, we employed generalized linear regression to assess the correlation between serum Klotho levels and cognitive function in diabetes individuals. Furthermore, a restricted cubic spline (RCS) analysis was conducted to explore the relationship, with stratified analyses by sex.</p><p><strong>Results: </strong>Our study included a total of 514 individuals. Serum Klotho levels were positively correlated with DSST cognitive test scores (β = 0.31, P < 0.05, P-non-linear = 0.041) and overall cognitive scores (β = 0.83, P < 0.01, P-non-linear = 0.8001) in diabetes individuals. Subsequent sex-stratified analysis revealed significant correlations, particularly in females, where an inverted U-shaped curve was observed between Klotho and DSST cognitive test scores, with a turning point at Ln(Klotho) of 6.766 pg/mL.</p><p><strong>Conclusion: </strong>Elevated serum Klotho levels in diabetes individuals were associated with higher cognitive function, with this association being particularly significant in females. This study provided new evidence regarding sex differences in the association between Klotho levels and cognitive function in diabetes individuals.</p>","PeriodicalId":11106,"journal":{"name":"Diabetology & Metabolic Syndrome","volume":"17 1","pages":"208"},"PeriodicalIF":3.4,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12160124/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between the triglyceride glucose index and long-term outcomes in patients with acute coronary syndrome and chronic kidney disease.","authors":"Feng Wang, Wendi Huang, Chonghao Shi, Yongfu Zhu, Weicheng Ni","doi":"10.1186/s13098-025-01775-9","DOIUrl":"10.1186/s13098-025-01775-9","url":null,"abstract":"<p><strong>Background: </strong>Despite the association between the triglyceride-glucose (TyG) index and major adverse cardiovascular events (MACE) has been reported, a notable research gap persists regarding its predictive value in patients with acute coronary syndrome (ACS) and chronic kidney disease (CKD). This study endeavors to bridge this gap by investigating the relationship between the TyG index and outcomes among this unique patient cohort.</p><p><strong>Methods: </strong>Patients having ACS with CKD were recruited from January 2013 to December 2021. Outcomes included all-cause mortality and MACE. The potential linear relationship was visualized by the restricted cubic spline (RCS) curve. Cox proportional hazards models were employed to rigorously examine the association between the TyG index and study outcomes. Furthermore, to assess the incremental value of the TyG index, we conducted analyses using C-statistics, the continuous net reclassification index (cNRI), and the integrated discrimination index (IDI).</p><p><strong>Results: </strong>A total of 1094 patients were included in the final analysis. Over a median follow-up period of 30.1 months (IQR: 16.5 to 40.0 months), we recorded 167 (15.3%) all-cause mortality events and 285 (26.1%) MACE. Additionally, each 1-unit increase of it was significantly associated with a 61% elevation in the risk of all-cause mortality (95% CI: 1.28-2.03, P < 0.001) and a 72% increase in the risk of MACE (95% CI: 1.45-2.05, P < 0.001). These associations between TyG index (as quantitative or categorical variables) and endpoints remained robust even after multivariable adjustment. RCS analysis showed linear relationships between TyG and endpoints (all P for non-linear > 0.05). Moreover, subgroup analysis revealed significant interactions of dialysis and renal function (P for interaction = 0.008 and 0.011, respectively) with all-cause mortality. Lastly, combining with the established risk score significantly enhanced the discrimination and reclassification performance of TyG, as evidenced by the C-statistic, cNRI, and IDI values (all P < 0.05).</p><p><strong>Conclusion: </strong>For patients with both ACS and CKD, TyG index is associated with both MACE and all-cause death. Prognostic classification is enhanced by the TyG index. The results collectively suggest that the TyG index serves as a reliable predictor of outcomes among patients with ACS and CKD, offering a novel metabolic perspective.</p>","PeriodicalId":11106,"journal":{"name":"Diabetology & Metabolic Syndrome","volume":"17 1","pages":"206"},"PeriodicalIF":3.4,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12153136/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144265551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal role of the plasma lipidome in the occurrence and progression of chronic kidney disease: a two-sample Mendelian randomization study.","authors":"Jiaming Su, Jiyuan Hu, Hongfang Liu, Yan Guo, Yang Shi, Yicheng Zheng, Zhaoxi Dong, Jiayou Liu, Zheyu Xu, Xinhui Yu, Jie Mei, Jing Peng, Lin Wang, Qingqing Liu","doi":"10.1186/s13098-025-01764-y","DOIUrl":"10.1186/s13098-025-01764-y","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to utilize Mendelian randomization (MR) techniques to determine causal relationships between the plasma lipidome and the occurrence and progression of chronic kidney disease (CKD).</p><p><strong>Methods: </strong>Summary statistics for 179 lipid species and six CKD-related phenotypes were retrieved from published large-scale genome-wide association studies. A bidirectional two-sample MR analysis was performed using the inverse-variance weighting (IVW) as the primary MR method. Cochrane's Q test, the MR‒Egger intercept analysis, and the MR-PRESSO were employed to evaluate heterogeneity and horizontal pleiotropy. The leave-one-out test was applied to ensure the stability of the MR findings, and Benjamini‒Hochberg (BH) correction was utilized to assess the robustness of causal links.</p><p><strong>Results: </strong>This study unveiled significant associations between 33 plasma lipid levels and various CKD-related outcomes by combining insights from both MR and sensitivity analyses. Various plasma lipid species were identified as having either positive or negative causal connections with kidney conditions, demonstrated by specific ranges of IVW-OR values (all P < 0.05). Following the BH correction, elevated sterol ester (27:1/18:2) levels (OR: 1.012 ~ 1.037, P < 0.05) and reduced phosphatidylcholine (16:1_20:4) levels (OR: 0.954 ~ 0.985, P < 0.05) consistently showed a strong causal relationship with increased urine albumin-creatinine ratio. These findings were robust across all sensitivity analyses.</p><p><strong>Conclusion: </strong>This study revealed potential causal associations between specific types of lipidome other than conventional lipids and the occurrence and progression of CKD. These insights pave the way for the development of early diagnostic and prophylactic CKD interventions.</p>","PeriodicalId":11106,"journal":{"name":"Diabetology & Metabolic Syndrome","volume":"17 1","pages":"205"},"PeriodicalIF":3.4,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12153193/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144265552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of elevated glucose levels on cardiac function in STEMI patients: glucose delta as a prognostic biomarker.","authors":"Bernardo F Garcia, Francisco A Fonseca, Maria C Izar, Gilberto Szarf, Attilio Galhardo, Ibraim M Pinto, Adriano M Caixeta, Adriano P Barbosa, Henrique T Bianco","doi":"10.1186/s13098-025-01738-0","DOIUrl":"10.1186/s13098-025-01738-0","url":null,"abstract":"<p><strong>Background: </strong>Elevated glucose levels have emerged as a significant prognostic factor following acute myocardial infarction (AMI).</p><p><strong>Objective: </strong>This study aimed to evaluate glycemic parameters associated with infarct size and left ventricular function.</p><p><strong>Research design and methods: </strong>A total of 244 patients with ST-segment elevation myocardial infarction (STEMI) treated using a pharmacoinvasive strategy were included. Glucose delta was calculated as the difference between mean glucose levels estimated from glycated hemoglobin (HbA1c) and serum glucose levels collected at hospital admission. Infarct size and left ventricular ejection fraction (LVEF) were assessed 30 days post-infarction using cardiac magnetic resonance (CMR) imaging.</p><p><strong>Results: </strong>Higher glucose delta values were significantly associated with reduced LVEF and larger infarct size, regardless of diabetes diagnosis. Differences in infarcted ventricular mass were noted between diabetic and non-diabetic patients above specific thresholds: (18.62 ± 11.0 g) vs. (16.24 ± 13.17 g), p = 0.019, with an effect size of 0.55. The receiver operating characteristic curve yielded an area under the curve (AUC) of 0.65 (95% CI 0.57-0.72).</p><p><strong>Conclusions: </strong>In STEMI patients undergoing pharmacoinvasive treatment, a higher glycemic delta was associated with greater infarct size and lower LVEF. This straightforward glycemic parameter provides valuable prognostic insight for both diabetic and non-diabetic populations.</p>","PeriodicalId":11106,"journal":{"name":"Diabetology & Metabolic Syndrome","volume":"17 1","pages":"203"},"PeriodicalIF":3.4,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12150584/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}