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Oleamidopropyl dimethylamine. 油酰胺丙基二甲胺。
Dermatosen in Beruf und Umwelt. Occupation and environment Pub Date : 1989-05-01
A C de Groot
{"title":"Oleamidopropyl dimethylamine.","authors":"A C de Groot","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The cationic emulsifier oleamidopropyl dimethylamine has been responsible for many cases of cosmetic sensitisation in The Netherlands. Of 119 patients with proven cosmetic-related allergic contact dermatitis, 13 (11%) were allergic to oleamidopropyl dimethylamine. The clinical data of 12 patients, all sensitised by one particular baby body lotion containing 0.3% of the emulsifier, are presented. The cross-reaction pattern of oleamidopropyl dimethylamine was investigated by patch testing 13 patients allergic to the emulsifier with a series of related amideamine type emulsifiers. Most cross-reactions were observed to ricinoleamidopropyl dimethylamine lactate and tallowamidopropyl dimethylamine (11 patients, 85%). 9 patients (of 12 tested: 75%) reacted to lauramidopropyl dimethylamine and 6 (46%) to myristamidopropyl dimethylamine. It is concluded that the presence of oleamidopropyl dimethylamine in a concentration of 0.3% in stay-on cosmetics, especially when applied to damaged skin and/or the periorbital area, bears a definite risk of the induction and elicitation of contact allergic reactions.</p>","PeriodicalId":11073,"journal":{"name":"Dermatosen in Beruf und Umwelt. Occupation and environment","volume":"37 3","pages":"101-5"},"PeriodicalIF":0.0,"publicationDate":"1989-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13883742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
pH influence of surfactant-induced skin irritation. A non-invasive, multiparametric study with sodium laurylsulfate. pH值对表面活性剂诱导皮肤刺激的影响。一项使用十二烷基硫酸钠的无创多参数研究。
Dermatosen in Beruf und Umwelt. Occupation and environment Pub Date : 1989-05-01
J L Antoine, J L Contreras, D J Van Neste
{"title":"pH influence of surfactant-induced skin irritation. A non-invasive, multiparametric study with sodium laurylsulfate.","authors":"J L Antoine,&nbsp;J L Contreras,&nbsp;D J Van Neste","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Even though various experimental methods have been proposed for in vitro testing of detergents such as LSL (sodium laurylsulfate) no absolutely relevant clinical information can be inferred from them as to the irritancy of a given compound. In particular the relative importance of pH needs further assessment. This study reports on in vivo evaluation of skin function changes under given experimental conditions with SLS applied at 3 different pH values. There is a dramatic increase of transepidermal water loss (TEWL), i.e. a substantial reduction in the barrier function of the skin, when SLS is applied under occlusion for 48 H. The alkaline control solution (NaOH pH 9) induced low-grade, but significant TEWL increases, as compared to the other controls (distilled water pH 7; HCl pH 5), which had no influence on TEWL. The changes obtained with the controls were much lower than those observed with SLS. The barrier-function changes induced by the surfactant SLS could, however, promote transepidermal passage of acid and/or alkaline molecules, hence increasing toxic damage of the skin; yet no such effects could be observed, indicating that the main effects are due to detergency. Assessment of cutaneous blood flow values (CBFV) by laser Doppler velocimetry showed increased values after SLS. When pH-adjusted SLS solutions were compared, there was neither a difference in relation to pH nor did the control solutions induce any significant CBFV change. This study reveals that TEWL and CBFV are probably the most reliable methods to investigate acute irritancy by SLS. Accordingly, pH cannot be considered as a major contributive factor of irritancy when SLS solutions are applied under occlusion (48 h).(ABSTRACT TRUNCATED AT 250 WORDS)</p>","PeriodicalId":11073,"journal":{"name":"Dermatosen in Beruf und Umwelt. Occupation and environment","volume":"37 3","pages":"96-100"},"PeriodicalIF":0.0,"publicationDate":"1989-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13883744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Occupational dermatoses in Poland]. [波兰职业性皮肤病]。
Dermatosen in Beruf und Umwelt. Occupation and environment Pub Date : 1989-05-01
L Grzegorczyk
{"title":"[Occupational dermatoses in Poland].","authors":"L Grzegorczyk","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The work-related dermatological situation in Poland is presented based upon all cases of occupationally derived illnesses and supported by the statistical data, from the period 1985-1986.</p>","PeriodicalId":11073,"journal":{"name":"Dermatosen in Beruf und Umwelt. Occupation and environment","volume":"37 3","pages":"93-5"},"PeriodicalIF":0.0,"publicationDate":"1989-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13671540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Antiperspirants and deodorants--ingredients and evaluation]. [止汗剂和除臭剂——成分和评价]。
Dermatosen in Beruf und Umwelt. Occupation and environment Pub Date : 1989-03-01
V A Lukacs, H C Korting
{"title":"[Antiperspirants and deodorants--ingredients and evaluation].","authors":"V A Lukacs,&nbsp;H C Korting","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Antitranspirants and deodorants gain more and more interest. Aluminium chlorohydrate and aluminium zirkonium tetrachlorohydrate glycine complex are the most frequently used active ingredients in commercial antitranspirants today. Aluminium chloride and propantheline bromide, the anticholinergic substance, are important alternatives although less common. Active ingredients of deodorants are mainly perfumes or bactericidal/bacteriostatic substances, such as triclosan. In addition, there are substances which are meant to bind offending smells (e.g. zinc ricinoleate) or to influence the skin surface pH (e.g. triethyl citrate). As in the cosmetics industry in general, both safety and efficacy of a product are major parameters in the experimental and clinical evaluation. Establishment of efficacy is based on olfactory tests in model situations as well as on the detection of associated effects (e.g. influence on cutaneous microflora).</p>","PeriodicalId":11073,"journal":{"name":"Dermatosen in Beruf und Umwelt. Occupation and environment","volume":"37 2","pages":"53-7"},"PeriodicalIF":0.0,"publicationDate":"1989-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13796908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A standard method for repeated recording of skin blood flow using laser Doppler flowmetry. 一种使用激光多普勒血流仪重复记录皮肤血流的标准方法。
Dermatosen in Beruf und Umwelt. Occupation and environment Pub Date : 1989-03-01
E M de Boer, P D Bezemer, D P Bruynzeel
{"title":"A standard method for repeated recording of skin blood flow using laser Doppler flowmetry.","authors":"E M de Boer,&nbsp;P D Bezemer,&nbsp;D P Bruynzeel","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We investigated the simple method of non-invasive Laser Doppler Flowmetry (LDF), and its use as a reproducible standard method for measuring skin blood flow. Microcirculatory blood flow shows both considerable temporal as well as regional variation. The study of reactive changes in skin blood flow, e.g. in irritancy tests, requires repeated measurements. The normal variation of skin blood flow was studied on the forearms of healthy volunteers. Males showed higher values than females. Differences between left and right arms, and recordings in the morning and the afternoon were not significant. Differences between lateral and medial aspects were borderline significant; and significant differences were measured between proximal and distal test sites. To improve the reproducibility of the measurements, a probeholder was designed with a considerably larger test area than that of the original probeholder. Fixation at both ends of the probeholder allows for repeated measurements without affecting skin blood flow. Recommendations are given for repeated testing by LDF.</p>","PeriodicalId":11073,"journal":{"name":"Dermatosen in Beruf und Umwelt. Occupation and environment","volume":"37 2","pages":"58-62"},"PeriodicalIF":0.0,"publicationDate":"1989-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13796910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
["The standard epicutaneous test"]. [“标准表皮试验”]。
Dermatosen in Beruf und Umwelt. Occupation and environment Pub Date : 1989-03-01
W Aberer
{"title":"[\"The standard epicutaneous test\"].","authors":"W Aberer","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":11073,"journal":{"name":"Dermatosen in Beruf und Umwelt. Occupation and environment","volume":"37 2","pages":"67"},"PeriodicalIF":0.0,"publicationDate":"1989-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13862297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Evaluating skin tolerance. Study of skin cleansing agents in modifications of the Duhring chamber test]. 评估皮肤耐受性。杜林试验中皮肤清洗剂的改良研究[j]。
Dermatosen in Beruf und Umwelt. Occupation and environment Pub Date : 1989-03-01
J Kresken, J Eckert, S W Wassilew
{"title":"[Evaluating skin tolerance. Study of skin cleansing agents in modifications of the Duhring chamber test].","authors":"J Kresken,&nbsp;J Eckert,&nbsp;S W Wassilew","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Towards Elucidation of the Problems of Skin-compatibility Testing/An investigation of hand-cleansing products using a modified Duhring chamber test The irritant potential of commercially available liquid syndets was investigated in a repetitive Duhring chamber test using a modified test procedure. Instead of regularly testing over a period of five days, the test was conducted only as long as it took for the first signs of irritation to appear. Among those products tested, substantial differences were found with respect to irritation and possible application time, and, as a result, to skin compatibility. Some of them produced skin irritation with the same intensity and just as quickly as the control substance, sodium lauryl sulfate (0.5%). These differences are not observed in a simple 24-hour epicutaneous test. For this reason, the latter, as opposed to the repetitive Duhring chamber test, appears to be unsuitable for comparative skin compatibility studies of syndets. The skin compatibility of special hand cleaners containing solvents was also investigated in a modified Duhring chamber test. In addition to the modification introduced above for the liquid syndets, here the maximum cumulative application time was reduced from 48 to 30 h. In this manner different degrees of skin compatibility to various special hand cleaners can be ascertained and taken into account when developing new products.</p>","PeriodicalId":11073,"journal":{"name":"Dermatosen in Beruf und Umwelt. Occupation and environment","volume":"37 2","pages":"63-6"},"PeriodicalIF":0.0,"publicationDate":"1989-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13862295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Contact allergy to colour developing agents. Analysis of test preparations, bulk chemicals and tank solutions by high-performance liquid chromatography. 接触性对显色剂过敏。用高效液相色谱法分析试验制剂、散装化学品和储罐溶液。
Dermatosen in Beruf und Umwelt. Occupation and environment Pub Date : 1989-03-01
J Sollenberg, C Lidén, L Hansén, A Arvidson
{"title":"Contact allergy to colour developing agents. Analysis of test preparations, bulk chemicals and tank solutions by high-performance liquid chromatography.","authors":"J Sollenberg,&nbsp;C Lidén,&nbsp;L Hansén,&nbsp;A Arvidson","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Colour developing agents which are derivatives of p-phenylenediamine can cause contact allergy. This study was done to perform if the observed simultaneous test reactions between different colour developing agents could be explained by common contaminants, reaction products or impurities. High-performance liquid chromatography (HPLC) was used for the separation of p-phenylenediamine, 1,4-benzoquinone, hydroquinone, Metol and the colour developing agents CD-2, CD-3 and CD-4. The stability in water solutions and in petrolatum mixtures was examined for the last three substances. Samples of test preparations drawn at different stages of guinea pig maximization tests (GPMT) with colour developing agents were analysed, as well as patch test preparations for clinical use and tank solutions from developer machines. No contaminants or reaction products in common were shown in the bulk chemicals, tank solutions or test preparations of CD-2, CD-3 and CD-4. These findings and the GPMT studies imply that the simultaneous test reactions reflect cross-sensitization. The colour developing agents were stable in petrolatum mixtures, but unstable in water solutions. Therefore, fresh solutions for intradermal induction and petrolatum mixtures for topical induction and challenge were used in the final GPMT's.</p>","PeriodicalId":11073,"journal":{"name":"Dermatosen in Beruf und Umwelt. Occupation and environment","volume":"37 2","pages":"47-52"},"PeriodicalIF":0.0,"publicationDate":"1989-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13862293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Contact allergy to a new preservative]. [接触性过敏对一种新的防腐剂]。
Dermatosen in Beruf und Umwelt. Occupation and environment Pub Date : 1989-03-01
H Senff, M Exner, J Görtz, M Goos
{"title":"[Contact allergy to a new preservative].","authors":"H Senff,&nbsp;M Exner,&nbsp;J Görtz,&nbsp;M Goos","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A 43 year old woman with no previous skin disease developed contact eczema on the face and neck after application of a lotion used for \"smoothing wrinkels\", available as a non-prescription item. Patch testing of the product and of one of its ingredients, Euxyl K 400, revealed strong positive reactions. Upon testing of the individual components of the preservative Euxyl K 400, the substance 1,2-dibromo-2,4-dicyanobutane showed a positive reaction even in the concentration of 0.004%. Due to the increasing use of Euxyl K 400 inclusion of the preservative in the patch test battery should be considered.</p>","PeriodicalId":11073,"journal":{"name":"Dermatosen in Beruf und Umwelt. Occupation and environment","volume":"37 2","pages":"45-6"},"PeriodicalIF":0.0,"publicationDate":"1989-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13862292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cosmetic allergy to the UV-absorber bornelone. 化妆品对紫外线吸收剂冰片酮过敏。
Dermatosen in Beruf und Umwelt. Occupation and environment Pub Date : 1989-01-01
A C de Groot, J W Weyland
{"title":"Cosmetic allergy to the UV-absorber bornelone.","authors":"A C de Groot,&nbsp;J W Weyland","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Two cases of contact allergy to the UV-absorber bornelone in cosmetic products are presented. The literature on (photo)contact allergy to sunscreens is reviewed.</p>","PeriodicalId":11073,"journal":{"name":"Dermatosen in Beruf und Umwelt. Occupation and environment","volume":"37 1","pages":"13-5"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13861045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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