Current Opinion in Neurology最新文献

Update on statin-associated myopathy symptoms in the view of new clinical management strategies. 从新的临床管理策略来看，他汀类药物相关肌病症状的最新进展

IF 4.1 2区医学

Current Opinion in Neurology Pub Date : 2025-06-13 DOI: 10.1097/WCO.0000000000001405

Olimpia Musumeci, Selene Francesca Anna Drago

{"title":"Update on statin-associated myopathy symptoms in the view of new clinical management strategies.","authors":"Olimpia Musumeci, Selene Francesca Anna Drago","doi":"10.1097/WCO.0000000000001405","DOIUrl":"https://doi.org/10.1097/WCO.0000000000001405","url":null,"abstract":"Purpose of review: Purpose of this review is to highlight the recent findings in terms of clinical aspects, pathogenic mechanisms and managements of statin associated muscle symptoms (SAMS), and focusing on the use of novel therapeutic alternatives in clinical practice.Recent findings: While extensive research has been conducted on SAMS, the precise mechanisms remain unclear. Recent findings continue to explore various aspects, including potential risk factors, diagnostic approaches, and management strategies. Managing SAMS involves a careful assessment to confirm the diagnosis, a stepwise approach to treatment that may include dose adjustments, switching statins, considering alternate-day dosing, and exploring nonstatin therapies, all while prioritizing patient well being and cardiovascular risk reduction through shared decision-making and ongoing monitoring. In recent years, the therapeutic landscape has expanded with the introduction of several novel lipid-lowering agents, providing valuable alternatives for both statin-tolerant and statin-intolerant patients but their use in clinical practice is still limited because of high costs, regulatory limitations and type of administration.Summary: Given the increasing use of both traditional and emerging lipid-lowering therapies, a clear understanding of their comparative safety, particularly regarding musculoskeletal adverse effects, is essential for guiding clinical decision-making.","PeriodicalId":11059,"journal":{"name":"Current Opinion in Neurology","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biomarkers in inflammatory neuropathies: where are we? 炎症性神经病变的生物标志物：进展如何？

IF 4.1 2区医学

Current Opinion in Neurology Pub Date : 2025-06-13 DOI: 10.1097/WCO.0000000000001406

Milou R Michael, Luuk Wieske, Filip Eftimov

{"title":"Biomarkers in inflammatory neuropathies: where are we?","authors":"Milou R Michael, Luuk Wieske, Filip Eftimov","doi":"10.1097/WCO.0000000000001406","DOIUrl":"https://doi.org/10.1097/WCO.0000000000001406","url":null,"abstract":"Purpose of review: This review provides an overview of recent advances in fluid-based biomarker research in inflammatory neuropathies, with a particular focus on disease activity monitoring. It explores challenges along the biomarker pipeline and outlines the stage of development of emerging disease activity biomarkers.Recent findings: Numerous biomarkers have recently been investigated for diagnostic, prognostic and monitoring purposes. Neurofilament light chain has been studied furthest but its clinical utility is limited in most patients. Other recent work has identified new biomarkers reflecting nerve damage, including peripherin, periaxin and Contactin-1. Additionally, potential immunological markers of disease activity have been explored, some more generic (such as chemokines) and others highly disease specific (such as autoantibody titers). Additional candidates have emerged through unbiased high-throughput discovery studies.Summary: Current fluid-based biomarkers can be grouped into nerve damage or immunological biomarkers. Most have not proceeded beyond discovery and validation stages, except for Neurofilament Light Chain. Biomarker development is challenging due to the inherent rarity and heterogeneity of inflammatory neuropathies, and, in the case of disease activity biomarkers, a lack of reference standard.","PeriodicalId":11059,"journal":{"name":"Current Opinion in Neurology","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emerging neuroinfectious diseases: public health implications. 新出现的神经传染病：公共卫生影响。

IF 4.1 2区医学

Current Opinion in Neurology Pub Date : 2025-06-12 DOI: 10.1097/WCO.0000000000001401

Carla Y Kim, Kathryn B Holroyd, Kiran T Thakur

{"title":"Emerging neuroinfectious diseases: public health implications.","authors":"Carla Y Kim, Kathryn B Holroyd, Kiran T Thakur","doi":"10.1097/WCO.0000000000001401","DOIUrl":"https://doi.org/10.1097/WCO.0000000000001401","url":null,"abstract":"Purpose of review: Direct neurological consequences from emerging and re-emerging infectious diseases such as poliomyelitis, West Nile virus and Zika virus, and those with indirect neurological effects such as COVID-19 and Influenza, are major contributors to the profound impact of infectious diseases on global human health. Here, we highlight select infections of the nervous system of public health significance and discuss some of the key factors of emergence. We focus on vector-borne infections including Oropouche virus and West Nile virus, those transmitted by other nonvector animal species including Nipah and Hendra virus, and vaccine preventable infections including neurological effects of Measles virus.Recent findings: Currently, the emergence of Oropouche virus, Avian Influenza, and the re-emergence of Measles outbreaks across Europe and America, are examples of current emerging infectious disease outbreaks. As pathogens spread to new areas, we will continue to see a rise in populations at risk of severe neurological effects. The recent resurgence of measles virus cases exemplifies the importance of strong vaccination programs and preventive public health measures to mitigate the impact of preventable re-emerging infections in vulnerable populations.Summary: Neuroinfectious diseases will continue to drive significant morbidity and mortality on global populations as risk factors remain high, and global public health initiatives are hampered by inadequate governmental support.","PeriodicalId":11059,"journal":{"name":"Current Opinion in Neurology","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nerve ultrasound in the diagnosis of inflammatory neuropathies. 神经超声在炎性神经病中的诊断价值。

IF 4.1 2区医学

Current Opinion in Neurology Pub Date : 2025-06-12 DOI: 10.1097/WCO.0000000000001407

Luca Leonardi, Eros Cerantola, Alessandro Salvalaggio

{"title":"Nerve ultrasound in the diagnosis of inflammatory neuropathies.","authors":"Luca Leonardi, Eros Cerantola, Alessandro Salvalaggio","doi":"10.1097/WCO.0000000000001407","DOIUrl":"https://doi.org/10.1097/WCO.0000000000001407","url":null,"abstract":"Purpose of review: This review synthesizes the recent advances in the application of nerve ultrasound (US) to inflammatory neuropathies, including chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), multifocal motor neuropathy (MMN), Guillain-Barré syndrome (GBS), neuralgic amyotrophy (NA), Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal gammopathy, Skin changes syndrome (POEMS), and anti-MAG neuropathy. The aim is to clarify nerve US clinical utility and guide its use in clinical practice.Recent findings: Nerve US supports differential diagnosis through characteristic sonographic patterns. In CIDP, it aids in identifying atypical forms, predicting treatment response, and may have a role in follow-up. In MMN, nerve US shows diagnostic value. In GBS, it can help differentiate acute-onset CIDP. In NA, alterations can be detected within hours from the onset. Anti-MAG antibody neuropathy lacks well characterized US features. In POEMS and vasculitis, data are scarce and conflicting.Summary: Nerve US is an established tool for diagnosing neuropathies, as it is noninvasive, accessible, reproducible, and complements electrophysiology. Its role is established in CIDP and its variants, while evidence supports its utility in MMN and the differential diagnosis of neuropathies with an inflammatory-like clinical presentation. In NA, nerve US may outperform neurophysiology. It appears less useful in GBS, POEMS, and anti-MAG neuropathy.","PeriodicalId":11059,"journal":{"name":"Current Opinion in Neurology","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Myofibrillar myopathy: towards a mechanism-based definition as a Z-disk-opathy. 肌原纤维肌病：迈向基于机制的z盘病定义。

IF 4.1 2区医学

Current Opinion in Neurology Pub Date : 2025-06-10 DOI: 10.1097/WCO.0000000000001397

Michio Inoue, Conrad C Weihl

{"title":"Myofibrillar myopathy: towards a mechanism-based definition as a Z-disk-opathy.","authors":"Michio Inoue, Conrad C Weihl","doi":"10.1097/WCO.0000000000001397","DOIUrl":"https://doi.org/10.1097/WCO.0000000000001397","url":null,"abstract":"Purpose of review: Myofibrillar myopathies (MFMs) are traditionally defined by histopathology, but recent genetic discoveries have broadened the spectrum of causative genes beyond Z-disk components. This review aims to address the resulting terminological inconsistency by proposing a refined, mechanism-based definition of MFM centered on its identity as a \"Z-disk-opathy.\" This re-evaluation is timely and relevant for improving diagnostic clarity and guiding future research.Recent findings: The literature increasingly reports MFM-like pathology in conditions caused by mutations in genes not directly encoding Z-disk structural proteins or their interacting chaperones. This review highlights the pathogenic mechanisms distinguishing true MFMs, which involve disruption of Z-disk protein structure or Z-disk protein homeostasis, from \"myopathies with MFM pathology\" that share histological features but stem from different molecular etiologies. Key themes include the dominant nature of mutations in Z-disk structural proteins and the critical role of chaperone dysfunction in MFM pathogenesis.Summary: A refined definition classifying MFM as a \"Z-disk-opathy\" offers a clearer framework for diagnosis and mechanistic understanding. This distinction has significant implications for clinical practice, facilitating more accurate diagnosis, and for research, by supporting the development of targeted therapeutic strategies aimed at either restoring Z-disk proteostasis or mitigating the effects of aberrant protein accumulation.","PeriodicalId":11059,"journal":{"name":"Current Opinion in Neurology","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current understanding of skeletal muscle repeat expansion disorders. 目前对骨骼肌重复扩张障碍的认识。

IF 4.1 2区医学

Current Opinion in Neurology Pub Date : 2025-06-10 DOI: 10.1097/WCO.0000000000001394

Manon Boivin, Gianina Ravenscroft

{"title":"Current understanding of skeletal muscle repeat expansion disorders.","authors":"Manon Boivin, Gianina Ravenscroft","doi":"10.1097/WCO.0000000000001394","DOIUrl":"https://doi.org/10.1097/WCO.0000000000001394","url":null,"abstract":"Purpose of review: Here, we summarize the current knowledge about the genetics and proposed mechanisms of disease underlying skeletal muscle short tandem repeat (STR) expansion disorders.Recent findings: The human genome contains up to 2 million STRs (also known as microsatellites), which are highly variable repetitions of two to six nucleotide-long DNA motifs. These elements, present in both coding and noncoding sequences, are highly instable, and their polymorphic variations have important roles in genes regulation and human phenotypic trait diversity. Importantly, expansion over a threshold size of a subset of these STR is the cause of approximately 60 neurological diseases, including some major muscle disorders such as myotonic dystrophy, oculopharyngodistal myopathy (OPDM) and oculopharyngeal muscular dystrophy. The discovery and characterisation of a number of these STR expansion disorders, in particular for OPDM, has been enabled in recent years by advanced genomic technologies.Summary: Many recently described STR expansion disorders are now recognized and genetic testing of patients is possible on a research basis, clinical testing for these newly described repeat loci is not yet readily available and is complicated by the reduced penetrance seen in some families, rendering clinical interpretation more difficult. The phenotypic spectrums associated with these STR expansion disorders are also evolving as unbiased sequencing approaches identified expansions at known loci in individuals with phenotypes that are quite different to those in which the STR expansions were first characterized. The pathomechanisms associated with these newer STR expansion disorders is still poorly understood, however there is evidence of both RNA toxicity and polyGly toxicity. Additional STR expansions underlying skeletal muscle diseases are likely to be identified in coming years and may shed further light onto the complex genetics, epigenetics and disease mechanisms underlying these disorders.","PeriodicalId":11059,"journal":{"name":"Current Opinion in Neurology","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enzyme replacement therapies in adults with Pompe disease: from trials to real-world data. 成人庞贝病的酶替代疗法：从试验到实际数据。

IF 4.1 2区医学

Current Opinion in Neurology Pub Date : 2025-06-06 DOI: 10.1097/WCO.0000000000001385

Nadine A M E van der Beek, Lianne H Potters, Benedikt Schoser

{"title":"Enzyme replacement therapies in adults with Pompe disease: from trials to real-world data.","authors":"Nadine A M E van der Beek, Lianne H Potters, Benedikt Schoser","doi":"10.1097/WCO.0000000000001385","DOIUrl":"https://doi.org/10.1097/WCO.0000000000001385","url":null,"abstract":"Purpose of review: To review the clinical trial results and emerging real-world data of two new enzyme replacement therapies (ERTs) for late-onset Pompe disease and to compare these effects in the context of what has been achieved over the last two decades in advancing care for Pompe disease.Recent findings: Randomized controlled trials (RCTs) of avalglucosidase alfa and cipaglucosidase alfa plus miglustat have demonstrated that both treatments are at least as efficacious as alglucosidase alfa and possess a comparable safety profile. Several post hoc analyses of the trial data have shown that these newer ERTs result in a greater percentage of patients achieving meaningful improvements and larger reductions in biomarker levels. The first real-world data on switching from alglucosidase alfa to avalglucosidase alfa has shown that the switch is safe and may alter individual disease trajectories.Summary: The advent of two next-generation enzyme replacement therapies marks a new era in treating patients diagnosed with Pompe disease. Clinical trials and early real-world data suggest that they may be superior to alglucosidase alfa, the standard of care for the past 20 years, although head-to-head comparisons between all three treatments are lacking. More data will become available over the next 5 years, leading to better guidelines for starting, stopping and switching therapies based on a more personalized assessment of outcomes.","PeriodicalId":11059,"journal":{"name":"Current Opinion in Neurology","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of climate change on neuroinfectious diseases. 气候变化对神经传染病的影响。

IF 4.1 2区医学

Current Opinion in Neurology Pub Date : 2025-06-06 DOI: 10.1097/WCO.0000000000001398

Simeona Jacinto

{"title":"The impact of climate change on neuroinfectious diseases.","authors":"Simeona Jacinto","doi":"10.1097/WCO.0000000000001398","DOIUrl":"https://doi.org/10.1097/WCO.0000000000001398","url":null,"abstract":"Purpose of review: COP28 Health Day demonstrated the growing global attention to climate health. The purpose of this article is to review the impact of climate change on the emergence of neuro-infectious diseases.Recent findings: Climate change influences meteorological shifts and extreme weather events which may have significant and complex effects on the emergence of neuroinfectious diseases. Particularly concerning is increasing vector borne, water borne and food borne diseases. Climate associated factors contribute to the high incidence of bacterial meningitis in the African Meningitis Belt, and expansion of viral and fungal meningitis in other regions. Increased risks to those living with HIV is a public health concern. The most vulnerable communities, especially in low and middle-income countries, will be particularly impacted.Summary: The complex effects of climate change on the emergence of neuroinfectious diseases result from consequences on ecologies, populations and health systems. The growing health burden must be addressed with a multifaceted approach to establishing climate resilient healthcare systems.","PeriodicalId":11059,"journal":{"name":"Current Opinion in Neurology","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances in the genetics of Parkinson's disease in underrepresented populations. 在代表性不足的人群中帕金森病遗传学的最新进展。

IF 4.1 2区医学

Current Opinion in Neurology Pub Date : 2025-06-06 DOI: 10.1097/WCO.0000000000001391

Gabriel Alves Marconi, Daniel Teixeira-Dos-Santos, Artur Francisco Schumacher Schuh

{"title":"Recent advances in the genetics of Parkinson's disease in underrepresented populations.","authors":"Gabriel Alves Marconi, Daniel Teixeira-Dos-Santos, Artur Francisco Schumacher Schuh","doi":"10.1097/WCO.0000000000001391","DOIUrl":"https://doi.org/10.1097/WCO.0000000000001391","url":null,"abstract":"Purpose of review: The aim of this study is to highlight recent key developments in Parkinson's disease genetics research in underrepresented populations, point out gaps related to ethnic and geographical diversity, and suggest future directions for increasing representation in genetics.Recent findings: Genome-wide association studies (GWAS) involving non-European ancestries have identified population-specific risk variants, even with relatively small sample sizes compared to European GWAS. Polygenic risk scores derived from European cohorts often fail to generalize to non-European populations. Additionally, the prevalence of variants in Parkinson's disease genes, such as LRRK2 and GBA1, varies across populations. Monogenic studies in regions like African and Latin America face significant challenges, including limited research infrastructure and underrepresentation in genetic studies, hindering a comprehensive understanding of Parkinson's disease's genetic diversity.Summary: Expanding Parkinson's disease genetics research to include diverse populations is essential to enhance disease understanding, uncover novel therapeutic targets, and ensure equitable access to precision medicine. Addressing participation barriers in underrepresented regions and investing in infrastructure development is essential for future progress.","PeriodicalId":11059,"journal":{"name":"Current Opinion in Neurology","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inclusion body myositis - what are new lines of pathogenesis and therapy? 包涵体肌炎的发病机制和治疗有哪些新进展？

IF 4.1 2区医学

Current Opinion in Neurology Pub Date : 2025-06-06 DOI: 10.1097/WCO.0000000000001393

Karsten Krause, Tobias Ruck, Felix Kleefeld

{"title":"Inclusion body myositis - what are new lines of pathogenesis and therapy?","authors":"Karsten Krause, Tobias Ruck, Felix Kleefeld","doi":"10.1097/WCO.0000000000001393","DOIUrl":"https://doi.org/10.1097/WCO.0000000000001393","url":null,"abstract":"Purpose of review: Although inclusion body myositis (IBM) is considered a rare disease, it is the most prevalent inflammatory myopathy in adults over 50 years of age. Its complex pathophysiological background includes inflammatory and degenerative features, but it remains poorly understood. As a result, no effective therapy is currently available. In this review, we provide an update on the relevant contemporary literature addressing the clinical and pathophysiological aspects of IBM.Recent findings: Recent studies have investigated drugs for IBM, including the immunosuppressant sirolimus, but haven't shown satisfactory results. Some advancements have been made in investigating IBM pathophysiology: a cell culture model recapitulating key disease features has been established. Multiple studies have used RNA sequencing to elucidate disease-specific pathways, including selective type 2 fiber vulnerability. The importance of TDP-43 deposition and subsequent mis-splicing as a disease mechanism has been demonstrated. Further studies have shown the value of patient-reported outcome measures (PROM) and quantitative MRI as investigation tools. Research has also investigated and demonstrated the complex genetic susceptibility related to IBM.Summary: In conclusion, significant discoveries have been made in the past year that enhance our clinical and pathophysiological insights into IBM. Due to the persistent lack of effective therapeutic options, additional research is essential - not only to investigate potential treatments but also to reveal the disease's underlying mechanisms.","PeriodicalId":11059,"journal":{"name":"Current Opinion in Neurology","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0