Current Opinion in Neurology最新文献_第10页

Vestibular migraine: an update. 前庭性偏头痛：最新进展。

IF 4.8 2区医学

Current Opinion in Neurology Pub Date : 2024-04-16 DOI: 10.1097/wco.0000000000001257

Maria D Villar-Martinez, Peter J Goadsby

引用次数: 0

Pregnancy and reproductive health in women with multiple sclerosis: an update. 多发性硬化症女性患者的妊娠和生殖健康：最新进展。

IF 4.8 2区医学

Current Opinion in Neurology Pub Date : 2024-04-09 DOI: 10.1097/wco.0000000000001275

Maria K Houtchens

引用次数: 0

Glymphatic system dysfunction in neurodegenerative diseases. 神经退行性疾病中的淋巴系统功能障碍。

IF 4.8 2区医学

Current Opinion in Neurology Pub Date : 2024-04-01 Epub Date: 2024-02-12 DOI: 10.1097/WCO.0000000000001252

Natalie Beschorner, Maiken Nedergaard

引用次数: 0

Recent advances in clinical electroencephalography. 临床脑电图的最新进展。

IF 4.8 2区医学

Current Opinion in Neurology Pub Date : 2024-04-01 Epub Date: 2024-01-17 DOI: 10.1097/WCO.0000000000001246

Birgit Frauscher, Andrea O Rossetti, Sándor Beniczky

{"title":"Recent advances in clinical electroencephalography.","authors":"Birgit Frauscher, Andrea O Rossetti, Sándor Beniczky","doi":"10.1097/WCO.0000000000001246","DOIUrl":"10.1097/WCO.0000000000001246","url":null,"abstract":"Purpose of review: Clinical electroencephalography (EEG) is a conservative medical field. This explains likely the significant gap between clinical practice and new research developments. This narrative review discusses possible causes of this discrepancy and how to circumvent them. More specifically, we summarize recent advances in three applications of clinical EEG: source imaging (ESI), high-frequency oscillations (HFOs) and EEG in critically ill patients.Recent findings: Recently published studies on ESI provide further evidence for the accuracy and clinical utility of this method in the multimodal presurgical evaluation of patients with drug-resistant focal epilepsy, and opened new possibilities for further improvement of the accuracy. HFOs have received much attention as a novel biomarker in epilepsy. However, recent studies questioned their clinical utility at the level of individual patients. We discuss the impediments, show up possible solutions and highlight the perspectives of future research in this field. EEG in the ICU has been one of the major driving forces in the development of clinical EEG. We review the achievements and the limitations in this field.Summary: This review will promote clinical implementation of recent advances in EEG, in the fields of ESI, HFOs and EEG in the intensive care.","PeriodicalId":11059,"journal":{"name":"Current Opinion in Neurology","volume":" ","pages":"134-140"},"PeriodicalIF":4.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139477529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An update on psychogenic nonepileptic seizures. 精神性非癫痫发作的最新进展。

IF 4.8 2区医学

Current Opinion in Neurology Pub Date : 2024-04-01 Epub Date: 2024-01-18 DOI: 10.1097/WCO.0000000000001245

Mithila Vijay, Markus Reuber

{"title":"An update on psychogenic nonepileptic seizures.","authors":"Mithila Vijay, Markus Reuber","doi":"10.1097/WCO.0000000000001245","DOIUrl":"10.1097/WCO.0000000000001245","url":null,"abstract":"Purpose of review: The understanding of psychogenic nonepileptic seizures (PNES) has advanced steadily over recent decades. This update summarizes new insights from the last three years.Recent findings: The process of diagnosing PNES has shifted from the exclusion of epilepsy to one based on the recognition of typical clinical features. While the diagnosis cannot rely on any single feature in isolation, a range of semiological features characterising PNES are now recognised and a number of studies hint at the potential for machine learning and AI to improve the diagnostic process. Advances in data processing and analysis may also help to make sense of the heterogeneity of PNES populations demonstrated by recent studies focussing on aetiology and patient subgroups. It is now clear that PNES are associated with high rates of mental and physical comorbidities and premature death, highlighting that they are only one manifestation of a complex disorder extending beyond the nervous system and the seizures themselves.Summary: PNES are now understood as a manifestation of dysfunction in interacting brain networks. This understanding provides an explanation for the psychopathological and semiological heterogeneity of PNES patient populations. New insights into medical comorbidities and increased rates of premature death call for more research into associated pathological processes outside the nervous system.","PeriodicalId":11059,"journal":{"name":"Current Opinion in Neurology","volume":" ","pages":"121-126"},"PeriodicalIF":4.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139484615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evidence based noninvasive presurgical evaluation for patients with drug resistant epilepsies. 对耐药性癫痫患者进行循证无创手术前评估。

IF 4.8 2区医学

Current Opinion in Neurology Pub Date : 2024-04-01 Epub Date: 2024-02-14 DOI: 10.1097/WCO.0000000000001253

Eugen Trinka, Matthias Koepp, Gudrun Kalss, Teia Kobulashvili

{"title":"Evidence based noninvasive presurgical evaluation for patients with drug resistant epilepsies.","authors":"Eugen Trinka, Matthias Koepp, Gudrun Kalss, Teia Kobulashvili","doi":"10.1097/WCO.0000000000001253","DOIUrl":"10.1097/WCO.0000000000001253","url":null,"abstract":"Purpose of review: To review the current practices and evidence for the diagnostic accuracy and the benefits of presurgical evaluation.Recent findings: Preoperative evaluation of patients with drug-resistant focal epilepsies and subsequent epilepsy surgery leads to a significant proportion of seizure-free patients. Even those who are not completely seizure free postoperatively often experience improved quality of life with better social integration. Systematic reviews and meta-analysis on the diagnostic accuracy are available for Video-electroencephalographic (EEG) monitoring, magnetic resonance imaging (MRI), electric and magnetic source imaging, and functional MRI for lateralization of language and memory. There are currently no evidence-based international guidelines for presurgical evaluation and epilepsy surgery.Summary: Presurgical evaluation is a complex multidisciplinary and multiprofessional clinical pathway. We rely on limited consensus-based recommendations regarding the required staffing or methodological expertise in epilepsy centers.","PeriodicalId":11059,"journal":{"name":"Current Opinion in Neurology","volume":" ","pages":"141-151"},"PeriodicalIF":4.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139706355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ambulatory seizure detection. 移动式癫痫发作检测。

IF 4.8 2区医学

Current Opinion in Neurology Pub Date : 2024-04-01 Epub Date: 2024-02-07 DOI: 10.1097/WCO.0000000000001248

Adriano Bernini, Jonathan Dan, Philippe Ryvlin

{"title":"Ambulatory seizure detection.","authors":"Adriano Bernini, Jonathan Dan, Philippe Ryvlin","doi":"10.1097/WCO.0000000000001248","DOIUrl":"10.1097/WCO.0000000000001248","url":null,"abstract":"Purpose of review: To review recent advances in the field of seizure detection in ambulatory patients with epilepsy.Recent findings: Recent studies have shown that wrist or arm wearable sensors, using 3D-accelerometry, electrodermal activity or photoplethysmography, in isolation or in combination, can reliably detect focal-to-bilateral and generalized tonic-clonic seizures (GTCS), with a sensitivity over 90%, and false alarm rates varying from 0.1 to 1.2 per day. A headband EEG has also demonstrated a high sensitivity for detecting and help monitoring generalized absence seizures. In contrast, no appropriate solution is yet available to detect focal seizures, though some promising findings were reported using ECG-based heart rate variability biomarkers and subcutaneous EEG.Summary: Several FDA and/or EU-certified solutions are available to detect GTCS and trigger an alarm with acceptable rates of false alarms. However, data are still missing regarding the impact of such intervention on patients' safety. Noninvasive solutions to reliably detect focal seizures in ambulatory patients, based on either EEG or non-EEG biosignals, remain to be developed. To this end, a number of challenges need to be addressed, including the performance, but also the transparency and interpretability of machine learning algorithms.","PeriodicalId":11059,"journal":{"name":"Current Opinion in Neurology","volume":" ","pages":"99-104"},"PeriodicalIF":4.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139702014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Update on modifiable risk factors for Alzheimer's disease and related dementias. 阿尔茨海默病及相关痴呆症可改变风险因素的最新进展。

IF 4.1 2区医学

Current Opinion in Neurology Pub Date : 2024-04-01 Epub Date: 2024-01-24 DOI: 10.1097/WCO.0000000000001243

Methasit Jaisa-Aad, Clara Muñoz-Castro, Alberto Serrano-Pozo

{"title":"Update on modifiable risk factors for Alzheimer's disease and related dementias.","authors":"Methasit Jaisa-Aad, Clara Muñoz-Castro, Alberto Serrano-Pozo","doi":"10.1097/WCO.0000000000001243","DOIUrl":"10.1097/WCO.0000000000001243","url":null,"abstract":"Purpose of review: All human beings undergo a lifelong cumulative exposure to potentially preventable adverse factors such as toxins, infections, traumatisms, and cardiovascular risk factors, collectively termed exposome. The interplay between the individual's genetics and exposome is thought to have a large impact in health outcomes such as cancer and cardiovascular disease. Likewise, a growing body of evidence is supporting the idea that preventable factors explain a sizable proportion of Alzheimer's disease and related dementia (ADRD) cases.Recent findings: Here, we will review the most recent epidemiological, experimental preclinical, and interventional clinical studies examining some of these potentially modifiable risk factors for ADRD. We will focus on new evidence regarding cardiovascular risk factors, air pollution, viral and other infectious agents, traumatic brain injury, and hearing loss.Summary: While greater and higher quality epidemiological and experimental evidence is needed to unequivocally confirm their causal link with ADRD and/or unravel the underlying mechanisms, these modifiable risk factors may represent a window of opportunity to reduce ADRD incidence and prevalence at the population level via health screenings, and education and health policies.","PeriodicalId":11059,"journal":{"name":"Current Opinion in Neurology","volume":" ","pages":"166-181"},"PeriodicalIF":4.1,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10932854/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139540875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances in Alzheimer disease genetics. 阿尔茨海默病遗传学的最新进展。

IF 4.8 2区医学

Current Opinion in Neurology Pub Date : 2024-04-01 Epub Date: 2024-01-19 DOI: 10.1097/WCO.0000000000001242

Gaël Nicolas

{"title":"Recent advances in Alzheimer disease genetics.","authors":"Gaël Nicolas","doi":"10.1097/WCO.0000000000001242","DOIUrl":"10.1097/WCO.0000000000001242","url":null,"abstract":"Purpose of review: Genetics studies provide important insights into Alzheimer disease (AD) etiology and mechanisms. Critical advances have been made recently, mainly thanks to the access to novel techniques and larger studies.Recent findings: In monogenic AD, progress has been made with a better understanding of the mechanisms associated with pathogenic variants and the input of clinical studies in presymptomatic individuals. In complex AD, increasing sample sizes in both DNA chip-based (genome-wide association studies, GWAS) and exome/genome sequencing case-control studies unveiled novel common and rare risk factors, while the understanding of their combined effect starts to suggest the existence of rare families with oligogenic inheritance of early-onset, nonmonogenic, AD.Summary: Most genetic risk factors with a known consequence designate the aggregation of the Aβ peptide as a core etiological factor in complex AD thus confirming that the research based on monogenic AD - where the amyloid cascade seems more straightforward - is relevant to complex AD as well. Novel mechanistic insights and risk factor studies unveiling novel factors and attempting to combine the effect of common and rare variants will offer promising perspectives for future AD prevention, at least regarding early-onset AD, and probably in case of later onset as well.","PeriodicalId":11059,"journal":{"name":"Current Opinion in Neurology","volume":" ","pages":"154-165"},"PeriodicalIF":4.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139484625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial: Epilepsy advances in 2023. 社论：2023 年的癫痫进展。

IF 4.8 2区医学

Current Opinion in Neurology Pub Date : 2024-04-01 Epub Date: 2024-03-07 DOI: 10.1097/WCO.0000000000001251

Philippe Ryvlin

引用次数: 0