Current Psychiatry Reports最新文献

{"title":"Disruption of DNA Repair as an Emerging Epigenetic Mechanism Underlying Autism Spectrum Disorder.","authors":"Benjamin Kelvington, Jaekyoon Kim, Sourav Banerjee, Hanna E Stevens, Kim Hei-Man Chow, Ted Abel","doi":"10.1007/s11920-026-01684-2","DOIUrl":"10.1007/s11920-026-01684-2","url":null,"abstract":"<p><strong>Purpose of review: </strong>To summarize recent advances in our conceptual understanding of the epigenetic mechanisms of DNA repair contributing to autism spectrum disorder (ASD).</p><p><strong>Recent findings: </strong>Large-scale genetic studies indicate that genes involved in DNA repair contribute to some cases of ASD, and smaller scale studies have reported increased DNA damage in peripheral tissues of both individuals with ASD and their parents. ASD-associated chromatin remodelers, thought to contribute to ASD by regulating gene expression, also facilitate DNA repair. Recent evidence has provided some mechanistic insight into the function of ASD-associated genes in the epigenetic regulation of DNA repair. Importantly, the disruption of DNA repair is a leading candidate to explain the emerging connection between ASD and neurodegenerative disease and may also provide insight into sex differences in ASD. Here, we highlight recent evidence that dysfunction of the DNA repair machinery is an overlooked mechanism underlying ASD, one which requires further systematic study for the benefit of individuals with ASD and their support systems.</p>","PeriodicalId":11057,"journal":{"name":"Current Psychiatry Reports","volume":"28 1","pages":""},"PeriodicalIF":7.5,"publicationDate":"2026-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13222229/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148101305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Lithium in Pregnancy and Lactation: An Individualized Approach.","authors":"Hannah K Betcher, Alexandra Vydysh, Brittany D Ellington, Crystal T Clark","doi":"10.1007/s11920-026-01674-4","DOIUrl":"10.1007/s11920-026-01674-4","url":null,"abstract":"<p><strong>Purpose of review: </strong>Bipolar disorder (BD) is a chronic illness that affects around 4% of the population, impacting women throughout their reproductive years. Times of hormonal change, such as peripartum, can be a particularly vulnerable period for individuals. There is a high risk of mood episodes during this time, and pharmacotherapy remains the primary treatment for individuals with BD. For many patients and clinicians, fears and misunderstandings around the use of lithium in pregnancy and lactation result in discontinuation of treatment or undertreatment. This review examines the data on lithium use in pregnancy and lactation, and focuses on optimizing management with an individualized approach.</p><p><strong>Recent findings: </strong>Lithium is a reasonable treatment option throughout peripartum including during lactation, although dose adjustments and additional monitoring may be necessary. Patients with mood disorders who achieve stability on lithium and are planning for pregnancy can continue lithium and maintain emotional wellness, with an individualized approach to dosing and monitoring.</p>","PeriodicalId":11057,"journal":{"name":"Current Psychiatry Reports","volume":"28 1","pages":""},"PeriodicalIF":7.5,"publicationDate":"2026-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148005137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psilocybin-Assisted Therapy for Adolescent Anorexia Nervosa: Clinical Considerations and Emerging Models of Care.","authors":"Jamarie A Geller, Rachel Pacilio, Amanda E Downey, Anya Ragnhildstveit, Marissa Raymond-Flesch, Stephanie Knatz-Peck, Natalie Gukasyan","doi":"10.1007/s11920-026-01679-z","DOIUrl":"10.1007/s11920-026-01679-z","url":null,"abstract":"<p><strong>Purpose of review: </strong>There is growing evidence that psychedelics and associated treatment modalities may offer therapeutic benefits across a range of psychiatric conditions. Anorexia nervosa (AN), a serious and often treatment-resistant illness associated with significant morbidity and mortality, is one such condition for which psilocybin-assisted therapy (PAT) may hold promise.</p><p><strong>Recent findings: </strong>To date, research on PAT for AN has focused primarily on adults, despite the fact that AN frequently begins in adolescence, and early age of onset portends poorer prognosis, including more severe AN, more lifetime psychiatric comorbidity, and greater life difficulties. Given these risks, an exploration of the theoretical potential of PAT for adolescent populations is warranted. Important considerations include biological implications, developmental stage, and consent. Adaptations to the current models of psilocybin-assisted therapy in studies of adults are proposed, and emerging models that address the unique challenges of these patients are discussed.</p>","PeriodicalId":11057,"journal":{"name":"Current Psychiatry Reports","volume":"28 1","pages":""},"PeriodicalIF":7.5,"publicationDate":"2026-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13171658/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147927606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digital Media Use and Psychosocial Health among Adolescent Boys and Young Men.","authors":"Jason M Nagata, Patrick Low, Eliot D Lee, Selena Yu, Alicia W Leong, Kevin Bao, Jennifer H Wong, Megan A Moreno, Jason M Lavender","doi":"10.1007/s11920-026-01681-5","DOIUrl":"10.1007/s11920-026-01681-5","url":null,"abstract":"<p><strong>Purpose of review: </strong>To synthesize recent literature highlighting how and why adolescent boys and young men may face unique media-related psychosocial health risks and potential benefits.</p><p><strong>Recent findings: </strong>Adolescent boys and young men appear to demonstrate distinct media use profiles, including higher engagement with video gaming, masculinity-oriented and appearance-focused social media content, online communities such as the manosphere, and, more recently, generative artificial intelligence tools. For adolescent boys and young men, gendered digital environments intersect with developmental processes related to identity formation, masculinity norms, social connection, and risk-taking, with important implications for mental health outcomes such as depression, anxiety, body dissatisfaction, muscle dysmorphia, disordered eating, aggression, and social isolation. Understanding these distinct media use profiles may allow clinicians, educators, and families to develop tailored approaches for screening, intervention, and prevention, supporting healthier development for adolescent boys and young men.</p>","PeriodicalId":11057,"journal":{"name":"Current Psychiatry Reports","volume":"28 1","pages":""},"PeriodicalIF":7.5,"publicationDate":"2026-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13171674/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147927505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Type of Providers Delivering Practice Elements Used in Child Mass Trauma Interventions: A Systematic Review.","authors":"Betty Pfefferbaum, Elana Newman, Pascal Nitiéma, Autumn Slaughter, Richard L Van Horn","doi":"10.1007/s11920-026-01680-6","DOIUrl":"10.1007/s11920-026-01680-6","url":null,"abstract":"<p><strong>Purpose of review: </strong>This review identified the relative frequency of use of various types of providers delivering practice elements in 130 child mass trauma interventions and compared the use of these providers across events, populations, and settings.</p><p><strong>Recent findings: </strong>Mental health professionals (MHPs) more frequently delivered cognitive, self-monitoring, exposure, and narrative elements than other providers while non-specialist providers (NSPs) and teachers and school personnel (TSPs) delivered support networking and social skills training more frequently. MHPs administered interventions to targeted populations more frequently, and TSPs administered interventions to universal populations more frequently. Only MHPs administered interventions at clinical facilities; NSPs delivered a majority of interventions at community sites. Understanding the specific practice elements delivered by providers with different backgrounds and training can inform efforts to enhance the reach and impact of mass trauma services. Future publications should report greater detail about providers and their training and about specific practice elements used.</p>","PeriodicalId":11057,"journal":{"name":"Current Psychiatry Reports","volume":"28 1","pages":""},"PeriodicalIF":7.5,"publicationDate":"2026-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147873724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use and Performance of Language-based Artificial Intelligence (AI) Models to Screen for Depressive Disorders.","authors":"Jorge Arias de la Torre, Roman Dahl, Jordi Alonso, Ioannis Bakolis, Lorena Botella-Juan, Alejandro Gonzalez-Diez, Mario F Juruena, Vicente Martín, Gonzalo Martinez-Alés, Daniel Munblit, Gemma Vilagut, Alex Dregan, Jose M Valderas","doi":"10.1007/s11920-026-01676-2","DOIUrl":"10.1007/s11920-026-01676-2","url":null,"abstract":"<p><p>PURPOSE OF REVIEW: This review summarised and assessed the current evidence on the use of language-based Artificial Intelligence (AI) models for the screening of depressive disorders in adults. RECENT FINDINGS: Most of the studies assessing the use of language-based AI models for the screening of depression were conducted in high-income countries, primarily in the US, and used heterogeneous datasets and populations, limiting generalizability. Most of the evidence was based on text data analysed using transformer models, followed by speech data through convolutional or recurrent neural networks (CNN and RNN models respectively). The evidence combining both modalities (text and speech) and models is limited. Considering the performance for the screening of depressive. disorders, the models tested achieved a performance comparable to standard instruments and cut-off scores, such as the 9-item version of the Patient Health Questionnaire (PHQ-9) with a cut-off of 10 or higher. A better understanding of the performance of language-based AI models in real-world settings is required. However, the evidence identified shows that they can be a relevant resource for this screening of depressive disorders and, consequently, for preventing them and reduce their prevalence, burden, and impact at all levels. </p>","PeriodicalId":11057,"journal":{"name":"Current Psychiatry Reports","volume":"28 1","pages":""},"PeriodicalIF":7.5,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13133213/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147765275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disorders of Gut-Brain Interaction in Eating Disorders: A Review of Management Approaches.","authors":"Sophie R Abber, Neha R Santucci, Helen Burton-Murray, Micaela Atkins","doi":"10.1007/s11920-026-01675-3","DOIUrl":"10.1007/s11920-026-01675-3","url":null,"abstract":"<p><p>PURPOSE OF REVIEW: Disorders of gut-brain interaction (DGBI; formerly known as functional gastrointestinal disorders) are chronic gastrointestinal conditions with no objective biomarker. DGBI such as irritable bowel syndrome and functional dyspepsia are common in eating disorders (EDs) and may maintain ED behaviors including restriction and purging, but DGBI symptoms are not explicitly addressed in standard ED treatments. This review aims to summarize pharmacological, behavioral, and nutritional support interventions for DGBI that may be beneficial in managing DGBI symptoms in individuals with EDs. RECENT FINDINGS: DGBI symptoms are common in EDs, including shape/weight-motivated EDs (e.g., anorexia nervosa) and in avoidant/restrictive food intake disorder. Theoretical work supports bi-directional risk. While evidence-based treatments for DGBI symptoms are available, there is limited research on treatment of DGBI within the context of an ED. Neuromodulator medications, brain-gut behavioral therapies (BGBTs), and nutritional support may help manage DGBI symptoms in EDs, but currently only retrospective chart reviews and case studies support this approach.  DGBI symptoms are frequently present in patients with EDs and could be an important maintaining factor for ED symptoms but further prospective research is needed. DGBI management techniques have not been well-studied in ED populations. Future research may consider adapting interventions for DGBI in ED populations.  </p>","PeriodicalId":11057,"journal":{"name":"Current Psychiatry Reports","volume":"28 1","pages":""},"PeriodicalIF":7.5,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13464233/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147765198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural Neuroimaging in Substance-Induced Psychosis.","authors":"Murad Atmaca, Muhammed Fatih Tabara","doi":"10.1007/s11920-026-01678-0","DOIUrl":"10.1007/s11920-026-01678-0","url":null,"abstract":"<p><p>PURPOSE OF REVIEW: This review evaluates structural neuroimaging research on substance-related psychosis to determine if these conditions share common neurobiological pathways with primary psychotic disorders, such as schizophrenia, or exhibit unique signatures. RECENT FINDINGS: Research indicates that methamphetamine, cannabis, and cocaine induce significant structural changes, including cortical thinning and grey matter loss. Methamphetamine-induced psychosis is associated with frontal lobe reductions and smaller hippocampal and amygdalar volumes. Cannabis use is linked to alterations in the cingulate cortex and cerebellar networks, particularly when use begins early in life. While many neuroimaging patterns overlap with schizophrenia substance-specific variations exist. For instance, methamphetamine users show more pronounced amygdalar reduction than those with primary psychosis. Generally, structural deficits are more severe and widespread in schizophrenia than in purely substance-induced cases. Substance-induced psychoses exhibit neuroanatomical signatures largely similar to primary psychoses, though distinct regional variations suggest partially divergent mechanisms. Future longitudinal and multimodal research is essential to identify definitive biomarkers for clinical differentiation. </p>","PeriodicalId":11057,"journal":{"name":"Current Psychiatry Reports","volume":"28 1","pages":""},"PeriodicalIF":7.5,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13132968/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147765297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Scoping Review of Interventions and Available Programs for Justice-Involved Women with Substance Use Disorders.","authors":"Sophia C Scott, Nicole A Barbaro, Emma H Lu, Kaitlin Shannon, Christine E Grella, Shelly F Greenfield","doi":"10.1007/s11920-026-01677-1","DOIUrl":"10.1007/s11920-026-01677-1","url":null,"abstract":"<p><p>PURPOSE OF REVIEW: This review scopes existing research examining substance use-related services for women in carceral settings. The paper focuses on gender-specific care and programs not specifically tailored for women that analyze results by gender. The paper also suggests recommendations for future research based on identified gaps in the literature. RECENT FINDINGS: Existing literature indicates that there has been a dramatic increase in the number of women in correctional settings over the past four decades. Compared to women in the general population, those in correctional settings have high rates of substance use disorders (SUDs) and upon release, experience elevated risk of returning to substance use, drug overdose, and re-incarceration. Incarcerated women also present with more severe substance use histories and co-occurring mental-health and trauma-related needs than incarcerated men, factors associated with higher return to substance use and overdose risk. While programs accessible to incarcerated women exist, there is limited literature comparing their distinct features. Evidence garnered from eight heterogeneous studies indicate that more intensive and gender-responsive programs, along with interventions that facilitate treatment linkage post-release, were associated with greater treatment engagement and reduced return to substance use. However, effects on recidivism and long-term individual outcomes were inconsistent and limited by methodological weaknesses. Future research should evaluate the barriers to integrated gender-responsive SUD treatment for women in carceral settings to inform the implementation of tailored services. </p>","PeriodicalId":11057,"journal":{"name":"Current Psychiatry Reports","volume":"28 1","pages":""},"PeriodicalIF":7.5,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147765248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Light Exposure as a Modifiable Determinant of Mental Health.","authors":"Manuel Spitschan, Johannes Zauner","doi":"10.1007/s11920-026-01671-7","DOIUrl":"10.1007/s11920-026-01671-7","url":null,"abstract":"<p><p>PURPOSE OF REVIEW: Light is a fundamental environmental signal that shapes human physiology, behaviour, and mental health. Beyond vision, light exposure regulates circadian rhythms, sleep, neuroendocrine function, arousal, and brain circuits implicated in emotional regulation. This review synthesizes recent evidence linking light exposure to mental health and argues that light should be conceptualized as a core, modifiable component of the mental health exposome – the cumulative, dynamic set of environmental influences shaping mental health across the lifespan. RECENT FINDINGS: Recent randomized controlled trials using light therapy, large-scale epidemiological studies, and neurophysiological investigations demonstrate that habitual patterns of daytime and nighttime light exposure are associated with a broad range of mental health outcomes. Higher daytime light exposure is generally associated with better mood and lower depressive symptomatology, whereas greater exposure to light at night is linked to increased risk of depression, anxiety, and sleep disturbance. Advances in wearable light measurement and digital phenotyping now enable precise characterization of individual light environments, supporting observational studies and improving dose verification in light-based interventions. Emerging neurobiological evidence further suggests that light can influence affective brain circuits through pathways that extend beyond sleep and circadian regulation. Together, converging evidence positions light exposure as a biologically potent and highly modifiable determinant of mental health operating across multiple temporal scales, from acute alerting effects to longer-term circadian and behavioural adaptation. Conceptual challenges remain, including bidirectionality between light exposure and mental health and limitations in causal inference. Nevertheless, improved measurement technologies and personalized, just-in-time intervention strategies open new opportunities for integrating light exposure into psychiatric research, prevention, and clinical practice. </p>","PeriodicalId":11057,"journal":{"name":"Current Psychiatry Reports","volume":"28 1","pages":""},"PeriodicalIF":7.5,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13124800/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147765195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}