Dermatologic Therapy最新文献

{"title":"Clinical Trial Eligibility in Real-World Alopecia Areata Patients Treated With Baricitinib","authors":"Daniel Muñoz-Barba,&nbsp;Miguel Limeres de la Rosa,&nbsp;Andrea Isabel Rodríguez-Sanna,&nbsp;Carmen García-Moronta,&nbsp;Manuel Sánchez-Díaz,&nbsp;Salvador Arias-Santiago","doi":"10.1155/dth/1358468","DOIUrl":"https://doi.org/10.1155/dth/1358468","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The eligibility criteria applied in baricitinib randomised clinical trials (RCTs) for alopecia areata (AA) may not fully capture the spectrum of patients encountered in routine clinical practice. The aim of this study was to determine the proportion of patients with AA treated with baricitinib in routine clinical practice who would have met RCT eligibility criteria.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A prospective, observational, single-centre study was conducted. Patients receiving baricitinib were classified according to whether they fulfilled BRAVE AA’s RCT eligibility criteria. Variables collected were compared between groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Forty-eight patients were included, with a mean age of 36.9 years and a female-to-male ratio of 2:1. Overall, only 20.8% of patients fulfilled RCT eligibility criteria, most commonly due to recent use of corticosteroids (62.5%), disease duration (43.8%) and baseline Severity of Alopecia Tool (SALT) score (29.17%). Noneligible patients more frequently had long-standing disease, whereas eligible patients exhibited higher baseline SALT score and more frequent eyebrow/eyelash involvement (<i>p</i> &lt; 0.05). Despite these baseline differences, exploratory analyses showed broadly overlapping efficacy and safety trends between groups during follow-up (<i>p</i> &gt; 0.10).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study shows that only a minority of real-world patients with AA treated with baricitinib would have met the eligibility criteria applied in RCT. Although exploratory analyses revealed broadly overlapping effectiveness and safety trends between eligible and noneligible patients, larger prospective studies are needed to determine whether broader eligibility criteria could improve the representativeness and generalisability of future clinical trials.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11045,"journal":{"name":"Dermatologic Therapy","volume":"2026 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/dth/1358468","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148784989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emergency Department Utilization in Patients With Chronic Spontaneous Urticaria Followed at a Tertiary Referral Center: A Retrospective Cross-Sectional Study","authors":"Nazlı Caf,&nbsp;Zafer Türkoğlu,&nbsp;Erişcan Melih Kırsoy,&nbsp;Seyfettin Mahir Koçak,&nbsp;Ayşe Nilhan Atsü,&nbsp;Hediye Eker,&nbsp;Defne Özkoca","doi":"10.1155/dth/9077043","DOIUrl":"https://doi.org/10.1155/dth/9077043","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Chronic spontaneous urticaria (CSU) frequently prompts emergency department (ED) visits, but few studies have characterized this utilization in a defined dermatology cohort under contemporary anti-IgE therapy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To quantify ED utilization, identify factors associated with prior ED visits, and describe the pattern of ED-initiated dermatology consultation in adult CSU patients at a tertiary referral center.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Retrospective cross-sectional analysis of 195 adult patients with physician-diagnosed CSU at a single tertiary dermatology clinic between June 1, 2025, and December 31, 2025. Three operational ED utilization rates were estimated. Patients with at least one prior ED visit were compared with patients without, and a multivariable logistic regression model was constructed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Median age was 43 years (Q1–Q3: 36–51); 66.2% were female; angioedema was reported in 24.1% and omalizumab prescribed in 97.9%. The ED served as the initial point of contact in 5.1% (95% confidence interval [CI]: 2.8%–9.2%); 45.1% (95% CI: 38.3%–52.1%) had any prior ED visit and 26.2% (95% CI: 20.5%–32.7%) had recurrent visits. Among ED users, antihistamines were administered in 93.2% and systemic corticosteroids in 59.1%, while ED-initiated dermatology consultation was documented in only 8.0% (95% CI: 3.9%–15.5%). In multivariable analysis, concomitant angioedema was independently associated with prior ED utilization (adjusted OR: 3.99, 95% CI: 1.93–8.69, <i>p</i> &lt; 0.001); identifiable trigger was inversely associated (adjusted OR: 0.36, 95% CI: 0.14–0.88, <i>p</i> = 0.025).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Even though omalizumab had been prescribed in 97.9% of the patients, almost half had attended the ED and consultation occurred in fewer than one in ten ED users. Concomitant angioedema independently predicts ED utilization, and ED encounters represent a missed integration point in CSU longitudinal care.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11045,"journal":{"name":"Dermatologic Therapy","volume":"2026 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/dth/9077043","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148784863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pattern Analysis of 6.78-MHz Monopolar and 1-MHz Mono-/Bipolar Radiofrequency-Induced Porcine and Rat Skin Reactions","authors":"Hyun-Jo Kim,&nbsp;Jin-Chul Ahn,&nbsp;Yea-Jin Lee,&nbsp;Jeongah Ko,&nbsp;Hye Sun Lee,&nbsp;Youngseung Koh,&nbsp;Min Choi,&nbsp;Youngju Kim,&nbsp;Sung Bin Cho","doi":"10.1155/dth/7975718","DOIUrl":"https://doi.org/10.1155/dth/7975718","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Radiofrequency (RF) treatment improves chronologically aged and photodamaged skin with rhytids. The patterns of RF-induced thermal tissue reactions can vary depending on the tissue resistance and treatment settings. In this study, we aimed to histologically and thermometrically evaluate the patterns of 6.78-MHz monopolar and 1-MHz mono-/bipolar RF-induced thermal tissue reactions in animal skin in vivo and ex vivo.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Various settings of 6.78-MHz monopolar RF at two different pulse mode characteristics (types S and H) were applied in vivo to minipigs, whereas various settings of 6.78-MHz monopolar RF or 1-MHz monopolar or bipolar RF were applied in vivo to rats. Subsequently, samples of the treated tissues were evaluated histologically. Ex vivo, porcine skin samples were treated with 6.78-MHz monopolar RF, and real-time noncontact infrared thermometry was used to monitor their surface and deep temperatures.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In the in vivo porcine skin study, 6.78-MHz monopolar RF treatments at both pulse characteristics generated similarly effective thermal tissue reactions in the entire dermis and the fibrous septa of subcutaneous fat. However, RF treatment at the type-S setting delivered RF energy preferentially through the fibrous septa of subcutaneous fat into the muscular fibrous layers. Meanwhile, RF treatment at the type-H setting induced volumetric thermal reactions in the mid- to deep dermis and the fibrous septa of the subcutaneous fat layer. Thirty days post-treatment, qualitatively increased numbers of thickened and elongated elastic fibers were noted in the lower reticular dermis and the fibrous septa of the subcutaneous fat layer across all experimental settings. RF treatments with three or five stacked passes using two pulse types resulted in different thermometric reactions in the surface and subcutaneous fat areas of ex vivo porcine skin. Additionally, the in vivo rat skin study revealed histopathologic differences based on experimental settings using 1-MHz RF.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Our histologic and thermometric pilot experiments demonstrated various patterns of RF-induced early and late thermal tissue reactions based on the treatment settings, including 6.78-MHz monopolar, 1-MHz monopolar, and 1-MHz bipolar RF delivery.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11045,"journal":{"name":"Dermatologic Therapy","volume":"2026 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/dth/7975718","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148784123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multimodal Ultrasound and Multispectral Imaging Combined With Investigator Global Assessment for Quantitative Evaluation of Rosacea: A Feasibility Study","authors":"Tiantian Ren,&nbsp;Baoyun Zhang,&nbsp;Aixia Wang,&nbsp;Li Wu,&nbsp;Si Chen,&nbsp;Xiao Luo,&nbsp;Weibo Cheng","doi":"10.1155/dth/4153163","DOIUrl":"https://doi.org/10.1155/dth/4153163","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Current assessment of rosacea relies on subjective visual scoring, which often fails to capture subtle changes predictive of treatment response or progression. Multimodal imaging may provide complementary quantitative structural, vascular, and biomechanical information to improve disease evaluation.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Objective&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;To evaluate the feasibility of multimodal ultrasound, including grayscale ultrasound (GSUS), shear wave elastography (SWE), and ultramicro angiography (UMA)—combined with multispectral skin imaging (MSI) and investigator global assessment (IGA) scores in detecting rosacea and monitoring treatment response.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Forty participants (20 rosacea and 20 healthy controls) were examined. IGA erythema and papule scores and all imaging parameters were obtained from identical facial sites before and after 4-week barrier-repair therapy. The epidermal thickness (ET), dermal thickness (DT), color pixel percentage (CPP), SWE elasticity values (E_mean, E_max, and E_min), and erythema indices (EAR and REI) were extracted from the images. Data between the two groups were compared using Student’s &lt;i&gt;t&lt;/i&gt;-test for normally distributed variables, the Mann–Whitney &lt;i&gt;U&lt;/i&gt; test for nonnormal variables, and the chi-square or Fisher’s exact test for categorical variables. Diagnostic performance was assessed by measuring the area under the curve of a receiver operator characteristic curve (ROC).&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Compared with healthy controls, patients with rosacea exhibited significant alterations in ultrasound parameters, including reduced ET and DT and increased CPP, alongside significant changes in erythema-related parameters on multispectral imaging. ROC analysis showed that ET and CPP may have potential value in distinguishing rosacea from healthy skin. Following treatment, ET and DT increased, while CPP and IGA scores decreased, whereas SWE parameters showed no significant change.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusion&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;MMUS combined with MSI and IGA enables quantitative assessment of structural, vascular, and erythema-related changes in rosacea. This multimodal imaging clinical approach may serve as an adjunctive objective tool for the evaluation and monitoring of rosacea.&lt;/p&gt;\u0000 \u0000 &lt;p&gt;&lt;b&gt;Trial Registration:&lt;/b&gt; Chinese Clinical Trial Registry (ChiCTR): ChiCTR2600128241&lt;/p&gt;\u0000 &lt;/s","PeriodicalId":11045,"journal":{"name":"Dermatologic Therapy","volume":"2026 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/dth/4153163","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148784333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in Scalp Condition Following the Use of a Moisturizer Containing Celastrol and Cichorium intybus Root Extract: A Prospective Clinical Trial Utilizing Artificial Intelligence–Based Scalp Assessment","authors":"Minsu Kim,&nbsp;Bo Ri Kim,&nbsp;Jee Yoon Park,&nbsp;Jae Moon Shin,&nbsp;Jung-Won Shin,&nbsp;Jung Im Na,&nbsp;Chang-Hun Huh","doi":"10.1155/dth/4887762","DOIUrl":"https://doi.org/10.1155/dth/4887762","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Scalp conditions such as dandruff and pruritus are common even among otherwise healthy individuals and have been associated with impaired skin barrier function and abnormal epidermal differentiation. Moisturizers containing celastrol and <i>Cichorium intybus</i> root extract have previously demonstrated clinical benefits in patients with psoriasis, a condition characterized by similar pathogenic abnormalities.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To evaluate changes in scalp condition following the use of a scalp moisturizer containing celastrol and <i>C</i>. <i>intybus</i> root extract and to assess the clinical utility of an artificial intelligence–based scalp assessment system (SPI-AI) in detecting treatment-related improvements.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This prospective clinical trial enrolled 23 participants with scalp conditions, including erythema, dryness, scaling, and dandruff, who applied the moisturizer once daily for 4 weeks. The primary outcome was the change in scalp condition, assessed using SPI-AI. Secondary outcomes included biophysical parameters (erythema index, stratum corneum hydration, and transepidermal water loss [TEWL]) and patient-reported symptoms assessed using the visual analog scale (VAS).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>At Week 4, the total SPI-AI score showed significant improvement (23.7 ± 4.5 to 20.5 ± 4.3, <i>p</i> = 0.005), with the erythema (9.5 ± 3.5 to 7.6 ± 2.9, <i>p</i> = 0.003) and folliculitis (4.0 ± 1.6 to 2.7 ± 1.1, <i>p</i> = 0.008) components exhibiting the most pronounced changes. In parallel, patient-reported symptoms improved significantly (5.9 ± 1.8 to 3.7 ± 1.7, <i>p</i> &lt; 0.001). Among the secondary outcomes, erythema index decreased significantly at Week 2 (139.3 ± 37.3 to 131.4 ± 40.4, <i>p</i> = 0.020), whereas no significant changes were observed in stratum corneum hydration or TEWL. Treatment compliance was high without serious adverse events reported.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>A scalp moisturizer containing celastrol and <i>C. intybus</i> root extract significantly improved scalp condition and exhibited a favorable safety profile. SPI-AI sensitively detected early changes in scalp condition in a clinical trial setting.</p>\u0000 \u0000 <p><b>Trial Registration:</b> ClinicalTrials.gov Identifier: NCT07459023</p>\u0000 </section>\u0000 </div>","PeriodicalId":11045,"journal":{"name":"Dermatologic Therapy","volume":"2026 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/dth/4887762","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148783645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research Progress in Photodynamic Therapy for Infectious Skin Diseases","authors":"Lingzhi Xu,&nbsp;Haochen Guo,&nbsp;Xin Yang,&nbsp;Rongya Yang,&nbsp;Zhikuan Xia","doi":"10.1155/dth/5794214","DOIUrl":"https://doi.org/10.1155/dth/5794214","url":null,"abstract":"<p>Photodynamic therapy (PDT) is a noninvasive therapeutic strategy that utilizes the synergistic interaction among a photosensitizer, light of a specific wavelength, and tissue oxygen to generate cytotoxic reactive oxygen species (ROS), thereby selectively destroying pathological tissues. Against the backdrop of increasingly severe global antibiotic resistance, PDT has demonstrated significant potential in the treatment of infectious skin diseases, owing to its unique multitarget mechanism of action and low propensity for inducing resistance. This review systematically elucidates the core antimicrobial mechanisms of PDT, summarizes its clinical advances in bacterial, fungal, and viral skin infections, and specifically discusses treatment strategies for special populations (such as children and pregnant women) and refractory cases. Finally, the article analyzes the current challenges in the clinical translation of PDT, including the lack of standardized treatment parameters and limited PS delivery efficiency, and offers perspectives on future directions, encompassing the development of novel PSs, the application of nanotechnology, and personalized treatment.</p>","PeriodicalId":11045,"journal":{"name":"Dermatologic Therapy","volume":"2026 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/dth/5794214","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148753381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Redrawing the Map in Prurigo Nodularis: From Conventional Approaches to Targeted Biologics","authors":"Göknur Kalkan","doi":"10.1155/dth/1342428","DOIUrl":"https://doi.org/10.1155/dth/1342428","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Prurigo nodularis (PN) is a chronic, neuroimmune-mediated dermatosis characterized by intense pruritus and nodular lesions that severely impair patient quality of life. The limitations of conventional therapies in providing more than symptomatic relief have necessitated novel approaches targeting the disease’s heterogeneous pathogenesis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This review evaluates current treatment algorithms and the potential future clinical frameworks tailored to the immunological and neuropathic endotypes of PN.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A comprehensive literature search was conducted across PubMed/MEDLINE, Scopus, and Google Scholar databases for English-language peer-reviewed articles, clinical trials, and guidelines published up to December 2025, focusing on targeted and conventional therapies for prurigo nodularis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In addition to approved biologics such as the IL-4/IL-13 pathway inhibitor dupilumab and the IL-31 receptor antagonist nemolizumab, this review discusses emerging options, including JAK inhibitors, mast cell–targeted therapies, and opioid modulators. Current evidence suggests that these targeted agents offer significant improvements in both pruritus and lesion resolution by addressing specific molecular drivers.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The management of PN is entering a transitional phase, with an emerging goal to evolve from uniform approaches toward future biomarker- and phenotype-based, disease-modifying, and personalized strategies. Defining these endotypes more precisely will be essential for optimizing potential therapeutic individualization and long-term clinical success.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11045,"journal":{"name":"Dermatologic Therapy","volume":"2026 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/dth/1342428","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148753379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modified Hematoporphyrin Monomethyl Ether Photodynamic Therapy for Large-Area Port-Wine Stains: A Self-Controlled Retrospective Study","authors":"Yunfeng Zhang,&nbsp;Dixin Wang,&nbsp;Long Wen,&nbsp;Linglin Zhang,&nbsp;Peiru Wang,&nbsp;Xiuli Wang","doi":"10.1155/dth/8896911","DOIUrl":"https://doi.org/10.1155/dth/8896911","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>HMME-PDT has been proven to be safe and effective for treating port-wine stains (PWS). However, due to the relatively high overall cost of a single session, particularly for patients with large-area PWS, some patients may forego treatment due to financial constraints. There is a need to explore new treatment methods for HMME-PDT for large-area PWS.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To investigate the safety and effectiveness of modified HMME-PDT, aiming to provide a more efficient treatment option for large-area PWS.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Patients with large-area PWS were treated with modified HMME-PDT. Modified HMME-PDT consists of two treatment stages, with the first stage being equivalent to the traditional HMME-PDT for partial lesions, continuously followed by the second stage in which the treatment device heads were moved to remaining untreated lesions for irradiation. Initially, all patients received an intravenous injection of 5 mg/kg HMME, and then the partial lesions of the patients were exposed to 532 nm LED green light after 10 min. The irradiation power density ranged between 80 and 100 mW/cm². Treatment parameters in the second stage remained consistent with the first stage. Efficacy was evaluated 2 months after treatment, and adverse reactions were recorded and compared.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 27 patients with large-area PWS were included in the study. In Stage 1, 1 patient (3.7%) achieved cured, 5 patients (18.6%) achieved good efficacy, 12 patients (44.4%) achieved alleviation, and 9 patients (33.3%) showed no effect, with a total effective rate of 66.7%. In the second stage treatment, 1 patient (3.7%) achieved cured, 6 patients (22.2%) achieved good efficacy, 9 patients (33.3%) achieved alleviation, and 11 patients (40.7%) showed no effect, with a total effective rate of 59.3%. No statistically significant difference in efficacy between the two stages was observed (<i>p</i> &gt; 0.05). The occurrence and severity of adverse reactions did not differ significantly (<i>p</i> &gt; 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Modified HMME-PDT can provide effective treatment for double the area in a single session for patients with large-area PWS, potentially reducing the cost and time per unit area.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11045,"journal":{"name":"Dermatologic Therapy","volume":"2026 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/dth/8896911","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148753127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atopic Dermatitis: Global Prevalence Trends and Dietary Relationship in Adults Aged 25 and Older","authors":"Kuangnan Song,&nbsp;Yao Liu,&nbsp;Shifeng Zhou,&nbsp;Ledong Sun","doi":"10.1155/dth/4937894","DOIUrl":"https://doi.org/10.1155/dth/4937894","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Recent research has revealed that adults make up a large share of atopic dermatitis (AD) cases and that moderate-to-severe AD is most common in this group. However, there are very few studies reporting on the association between dietary factors and AD in adults.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Objective&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;To explore changing trends in AD prevalence across countries and regions and the association between AD incidence rate and dietary factors among individuals aged 25 years and older from 1990 to 2021.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;We extracted incidence rates and disability-adjusted life year (DALY) estimates for AD, along with their 95% uncertainty intervals (UIs), from the Global Burden of Disease (GBD) study (1990–2021) to analyze disease burden and prevalence trends at the global, regional, and national levels. To assess the effects of dietary factors on AD, we used the age–period–cohort (APC) model to compare local and net drift effects of milk, red meat, sugar-sweetened beverages (SSBs), and fiber on the incidence of AD in France (the country with the highest incidence rate) and Congo (the country with the lowest incidence rate). Age-deviation analyses were then used to investigate the overall age-trend effect of diet on the incidence of AD in both countries.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;From 1990 to 2021, the global incidence and DALY rates of AD showed a slight decline, with an estimated annual percentage change (EAPC) of −0.04 (95% CI: −0.06, −0.03). The AD incidence rate remained higher in females than in males. AD incidence rates were significantly positively correlated with sociodemographic index (SDI) levels (&lt;i&gt;p&lt;/i&gt; &lt; 0.001). Decomposition analysis showed that age contributed more to incidence in high-than low-SDI regions (8.94% vs. −0.16%). Dietary analysis revealed that SSBs, milk, and red meat were positively associated with AD incidence (&lt;i&gt;r&lt;/i&gt; &gt; 0.5, &lt;i&gt;p&lt;/i&gt; &lt; 0.001), while fiber was negatively associated with AD incidence (&lt;i&gt;r&lt;/i&gt; = −0.297, &lt;i&gt;p&lt;/i&gt; &lt; 0.001). The APC model revealed that the net drift values for the three dietary factors—SSBs, milk, and red meat—in both France and Congo were statistically significant (&lt;i&gt;p&lt;/i&gt; &lt; 0.05), and the local and net drift curves exhibited significant differences. Age-deviation analysis further confirmed consistent age-related dietary influences on AD incidence in both countries (&lt;i&gt;p&lt;/i&gt; &lt; 0.001).&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclu","PeriodicalId":11045,"journal":{"name":"Dermatologic Therapy","volume":"2026 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/dth/4937894","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148752953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polidocanol Foam Sclerotherapy for Nodular Type V Port-Wine Birthmark: A Retrospective Study","authors":"Xiong Zhang,&nbsp;Ming Li,&nbsp;Hao He,&nbsp;Zheye Li,&nbsp;Chang Shu,&nbsp;Chenzi Yang","doi":"10.1155/dth/7303162","DOIUrl":"https://doi.org/10.1155/dth/7303162","url":null,"abstract":"<p>Type V nodular port-wine birthmarks (PWBs) are challenging to treat due to dilated vasculature and potential arteriovenous malformations, with conventional therapies such as pulsed dye laser often yielding limited results. Polidocanol foam sclerotherapy, though promising for vascular malformations, remains underexplored for PWB. This retrospective study evaluated the safety and efficacy of polidocanol foam sclerotherapy in patients with nodular Type V PWB at our institution. A total of 10 patients (3 male, 7 female; mean age: 41.1 ± 14.0 years) were treated with 1% or 3% polidocanol foam injections administered at monthly intervals. Efficacy was measured by nodule volume reduction, clinical improvement, and patient satisfaction. At 1-month follow-up, median nodule volume reduction was 77.5%, with a mean clinical improvement score of 3.1 ± 1.0 and a mean patient satisfaction score of 7.2 ± 1.7. No disease progression or major complications occurred during extended follow-up (mean duration: 13.4 ± 10.4 months), although one patient developed a hypertrophic scar. These results suggest that polidocanol foam sclerotherapy is a safe and effective option for managing Type V nodular PWB, with minimal adverse events and high patient satisfaction, warranting further investigation in larger, prospective studies.</p>","PeriodicalId":11045,"journal":{"name":"Dermatologic Therapy","volume":"2026 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/dth/7303162","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148752902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}