Dermatologic Therapy最新文献_第7页

The Effect of an Er:YAG Laser Combined with a 755 nm Picosecond Laser on Tattoo Removal in a Rat Model Er:YAG 激光器与 755 nm 皮秒激光器结合使用对大鼠模型去除纹身的影响

IF 3.6 4区医学

Dermatologic Therapy Pub Date : 2024-02-21 DOI: 10.1155/2024/4509910

Tianyu E., Chen Bi, Xiaopeng Liu, Li Lin, Yongqian Cao

{"title":"The Effect of an Er:YAG Laser Combined with a 755 nm Picosecond Laser on Tattoo Removal in a Rat Model","authors":"Tianyu E., Chen Bi, Xiaopeng Liu, Li Lin, Yongqian Cao","doi":"10.1155/2024/4509910","DOIUrl":"10.1155/2024/4509910","url":null,"abstract":"Laser tattoo removal is an effective technique, but multiple rounds of treatment are required to eliminate tattoos, which can be a challenge for patients who do not have the time. Additionally, there is relatively limited research on the mechanisms of laser tattoo removal, necessitating further in-depth studies. This study aimed to investigate the efficacy of an Er:YAG laser combined with a 755-picosecond laser for tattoo removal and the changes in skin diffuse reflection, pigment particle size, macrophage recruitment, and inflammatory factor levels during combined laser treatment. Our experiments used three sets of lasers—an Er:YAG laser, a 755 nm picosecond laser, and an Er:YAG laser combined with a 755 nm picosecond laser—for tattoo removal. The effects of tattoo removal at different time points were evaluated. Moreover, the mechanisms were explored using HE staining, immunohistochemistry, diffuse reflectance measurements, in vitro gel tests, mass spectrometry, and ELISA experiments. The combined treatment was more effective for tattoo removal in rats. The combined laser treatment effectively reduced diffuse reflection from the skin, thereby increasing the effective laser power, reducing the size of the pigment particles, allowing for easier removal of the pigment, and increasing the recruitment of dermal macrophages and the release of inflammatory factors, thus increasing the rate of tattoo removal in vivo.","PeriodicalId":11045,"journal":{"name":"Dermatologic Therapy","volume":"2024 1","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140444036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Characteristics of Basal Cell Carcinomas of the Scrotum: An Institutional Retrospective Review 阴囊基底细胞癌的临床特征：机构回顾性研究

IF 3.6 4区医学

Dermatologic Therapy Pub Date : 2024-01-19 DOI: 10.1155/2024/8871278

Qiuyan Duan, Yangfeng Lou, Longfei Yang, Peng Zhou

{"title":"Clinical Characteristics of Basal Cell Carcinomas of the Scrotum: An Institutional Retrospective Review","authors":"Qiuyan Duan, Yangfeng Lou, Longfei Yang, Peng Zhou","doi":"10.1155/2024/8871278","DOIUrl":"10.1155/2024/8871278","url":null,"abstract":"Objective. To analyse the clinical and pathologic features, discuss therapeutic strategies, and possibly cause and identify prognostic factors of scrotal basal cell carcinoma (BCC) in Chinese patients. Materials and Methods. Between January 2012 and December 2022, 12 patients with scrotal BCC were diagnosed and treated at our institution. A review was conducted based on the clinical characteristics, pathology slides, and tissues of these patients. Results. The median patient age was 69.26 ± 11.23 years. The skin lesions presented as red papules, blue-grey polypoid nodules, erythematous patches, brownish plaques, and so on. All patients were treated using wide excision, but the margins varied from 0.5 cm to 2 cm. HPV infection was checked in all lesions, with 4 out of 12 testing positive for P16 and 1 for HPV16 DNA. We found mottled positive expression of P16 in the cytoplasm and membrane. One patient developed left inguinal lymph node metastasis and was successfully treated using bilateral inguinal lymphadenectomy. The rest recovered well without relapse. Conclusions. BCC of the scrotum is rare, but long-term surveillance is recommended for BCC patients, and whether genital HPV infection is a noteworthy feature for these patients remains under investigation.","PeriodicalId":11045,"journal":{"name":"Dermatologic Therapy","volume":"2024 1","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139613021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Characteristics, Treatment, and Prognosis of Amoxicillin-Induced AGEP/ALEP 阿莫西林诱发的 AGEP/ALEP 的临床特征、治疗和预后

IF 3.6 4区医学

Dermatologic Therapy Pub Date : 2024-01-13 DOI: 10.1155/2024/3885057

Haibo Lei, Zhiqiang Fan, Yang He, Wei Sun, Zuojun Li, Chunjiang Wang

{"title":"Clinical Characteristics, Treatment, and Prognosis of Amoxicillin-Induced AGEP/ALEP","authors":"Haibo Lei, Zhiqiang Fan, Yang He, Wei Sun, Zuojun Li, Chunjiang Wang","doi":"10.1155/2024/3885057","DOIUrl":"10.1155/2024/3885057","url":null,"abstract":"Background. Amoxicillin was associated with acute generalized exanthematous pustulosis (AGEP), and the clinical characteristics were not clear. The purpose of this study was to explore the clinical characteristics of amoxicillin-induced AGEP and to provide a basis for prevention and treatment. Methods. Case reports and case series of amoxicillin-induced AGEP were collected for retrospective analysis by searching the Chinese and English databases from inception to January 31, 2023. Results. A total of 46 patients were included with a median age of 40 years (range 1.4, 87). The onset time of AGEP ranged from 6 hours to 28 days, with a median of 2.5 days. Fever occurred in 32 patients (69.6%), and pruritus occurred in 13 patients (28.3%). Ten patients (21.7%) had mucous membrane involvement and systemic involvement, respectively. Twenty-two patients had elevated neutrophils, with a median of 12850/mm3 (range 7880, 29140). Skin biopsy mainly showed subcorneal pustules (22 cases, 47.8%), spongy pustules (14 cases, 30.4%), and inflammatory cell infiltration (26 cases, 56.5%). Skin lesions disappeared in a median of 10 days (range 2, 42) after discontinuation of amoxicillin and administration of topical steroids (26 cases, 56.5%) as well as systemic corticosteroids (13 cases, 28.3%). Conclusions. AGEP is a rare complication of amoxicillin and is self-limiting. Clinicians should correctly identify AGEP and should avoid represcribing amoxicillin. Clinicians should correctly identify AGEP and avoid represcribing amoxicillin, which can prevent unnecessary treatment measures.","PeriodicalId":11045,"journal":{"name":"Dermatologic Therapy","volume":"2024 1","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139531048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tofacitinib for the Treatment of Refractory Progressive Vitiligo: A Retrospective Case Series 托法替尼治疗难治性进展期白癜风：回顾性病例系列

IF 3.6 4区医学

Dermatologic Therapy Pub Date : 2024-01-11 DOI: 10.1155/2024/9944826

Xiu-kun Sun, An-qi Sheng, Ai-e Xu

引用次数: 0

The Relationship between Eating Styles and the Severity of Psoriasis: A Cross-Sectional Study in Thailand 饮食方式与银屑病严重程度之间的关系：泰国横断面研究

IF 3.6 4区医学

Dermatologic Therapy Pub Date : 2024-01-09 DOI: 10.1155/2024/6677244

Wanjarus Roongpisuthipong, Theerawut Klangjareonchai

{"title":"The Relationship between Eating Styles and the Severity of Psoriasis: A Cross-Sectional Study in Thailand","authors":"Wanjarus Roongpisuthipong, Theerawut Klangjareonchai","doi":"10.1155/2024/6677244","DOIUrl":"10.1155/2024/6677244","url":null,"abstract":"Background. Psoriasis, a persistent inflammatory condition, is linked to several concurrent health issues. Among these, obesity stands out as a significant contributing factor, significantly influencing the development and seriousness of psoriasis. Furthermore, behavioral elements such as eating styles could potentially contribute to the activity of the disease. Objective. To investigate the relationships between eating styles and the clinical severity of psoriasis. Materials and Methods. A cross-sectional study among 158 chronic plaque psoriasis patients was conducted. Sociodemographic data and clinical presentation of psoriasis including risk factors and treatment, eating, stress, and sleep data were obtained from questionnaires. Psoriasis disease severity, weight, and height measurements, including bioelectrical impedance analysis were assessed. A multivariate logistic regression analysis was employed to assess eating patterns and identify notable factors linked to the severity of the disease. Results. After adjusting for the potential confounder, the emotional eating style was significantly associated with an increase in risk of psoriasis severity when compared to the restrained eating style (odds ratio, 3.9; 95% confidence interval, 1.52–9.81). Body mass index, body fat mass, eating attitude, alcohol consumption, nail involvement, psoriasis treatment, smoking status, duration of sleep, and stress status were not significant risk factors for disease severity. Conclusions. There is a significant correlation between emotional eating style and the severity of chronic plaque-type psoriasis in Asian patients. Further exploration into utilizing cognitive-behavioral therapy to address emotional eating styles as part of psoriasis management is warranted.","PeriodicalId":11045,"journal":{"name":"Dermatologic Therapy","volume":"2024 1","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139443871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Systemic Tofacitinib Treatment in Pediatric Patients with Resistant Alopecia Areata 托法替尼治疗小儿难治性脱发患者

IF 3.6 4区医学

Dermatologic Therapy Pub Date : 2024-01-05 DOI: 10.1155/2024/8336879

Eda Öksüm Solak, Murat Borlu

引用次数: 0

The Characteristics of COVID-19 Symptoms and Skin Manifestations among Nonhospitalized COVID-19 Patients with Psoriasis during the Omicron Pandemic in China: A Single-Center Survey-Based Study 中国Omicron大流行期间非住院COVID-19银屑病患者的COVID-19症状和皮肤表现特征：基于单中心调查的研究

IF 3.6 4区医学

Dermatologic Therapy Pub Date : 2023-12-26 DOI: 10.1155/2023/1559937

Yue Xiao, Xiwen Zhang, Xun Feng, Jingya Gao, Furong Li, Wenyao Mi, Mingqi Wang, Yuanxia Gu, Yiyi Wang, Wen Wang, W. Li

{"title":"The Characteristics of COVID-19 Symptoms and Skin Manifestations among Nonhospitalized COVID-19 Patients with Psoriasis during the Omicron Pandemic in China: A Single-Center Survey-Based Study","authors":"Yue Xiao, Xiwen Zhang, Xun Feng, Jingya Gao, Furong Li, Wenyao Mi, Mingqi Wang, Yuanxia Gu, Yiyi Wang, Wen Wang, W. Li","doi":"10.1155/2023/1559937","DOIUrl":"https://doi.org/10.1155/2023/1559937","url":null,"abstract":"Background. The global impact of coronavirus 2019 (COVID-19) has raised concerns about the management of psoriasis patients, especially among those using biologics. Methods. We conducted a survey-based research among Omicron-infected (confirmed, probable, and suspected ones) psoriasis patients in the department of dermatology, West China Hospital, Sichuan University, from January 9th to January 22nd, 2023. We collected demographic and clinical information (psoriasis- and COVID-19-related) and conducted statistics analysis. Results. Of the 240 patients enrolled, they were classified by the psoriatic treatment, as biologics (n = 138), nonbiological systematic treatment (n = 52), and topical treatment or without pharmacological treatment (n = 50). This study showed the characteristics of Omicron-related symptoms and cutaneous signs in patients. We observed that patients who received topical treatment or without pharmacological treatment had a lower risk of presenting with COVID-19 symptoms in the fully adjusted logistic model (OR = 0.40, 95% CI: 0.18–0.90, and P=0.025). Moreover, in the model for skin manifestations, nonbiological systematic treatment (OR = 2.15, 95% CI: 1.08–4.27, and P=0.029) and high BMI (OR = 1.10, 95% CI: 1.00–1.20, and P=0.042) were correlative factors. Conclusions. Our data suggested that differential psoriatic treatment might be a correlative factor in developing symptomatic or asymptomatic Omicron infection and presenting cutaneous signs.","PeriodicalId":11045,"journal":{"name":"Dermatologic Therapy","volume":"10 5","pages":""},"PeriodicalIF":3.6,"publicationDate":"2023-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139157540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treatment Resistance to TNF-α Inhibitors in Patients with Psoriasis 银屑病患者对 TNF-α 抑制剂的耐药性

IF 3.6 4区医学

Dermatologic Therapy Pub Date : 2023-12-21 DOI: 10.1155/2023/7399468

Amirmansoor Gholami, Ahmad Vafaeian, M. Daneshpazhooh, I. Etesami, K. Balighi, Delnavaz Jan, A. Salehi Farid, Ali Vafaei, H. Mahmoudi

{"title":"Treatment Resistance to TNF-α Inhibitors in Patients with Psoriasis","authors":"Amirmansoor Gholami, Ahmad Vafaeian, M. Daneshpazhooh, I. Etesami, K. Balighi, Delnavaz Jan, A. Salehi Farid, Ali Vafaei, H. Mahmoudi","doi":"10.1155/2023/7399468","DOIUrl":"https://doi.org/10.1155/2023/7399468","url":null,"abstract":"Background. Treatment resistance to biologic treatment at specific sites in the body is a challenging issue. However, there is insufficient evidence for factors affecting the resistance of these areas to biological therapies. Methods. In this study, patients with moderate-to-severetreatment-resistant psoriasis who were biologic naïve and referred to Razi hospital were included. The relationship between treatment resistance in different areas and demographic and clinical variables was investigated. Results. A total of 131 biologic-naïve patients with psoriasis treated with anti-TNF-α were included in this study. The most common resistant sites included the scalp, anterior lower legs, and elbows. Also, hand- and toe-nail involvements were considerable. BMI, gender, smoking, PASI score, the duration of the disease, the time distance between diagnosis and treatment, and treatment regiments were found to affect the incidence of resistance to treatment in multiple areas, while age, the incidence of recalcitrant disease and/or psoriatic arthritis, and the duration of current treatment did not have effects. Conclusion. The most common refractory sites were the scalp, anterior lower legs, and elbows. This study should be followed up with larger samples containing a variety of biological treatments in order to evaluate the results.","PeriodicalId":11045,"journal":{"name":"Dermatologic Therapy","volume":"42 26","pages":""},"PeriodicalIF":3.6,"publicationDate":"2023-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138949977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mogamulizumab Multimodality Therapy with Systemic Retinoids, Interferon, or Extracorporeal Photopheresis for Advanced Cutaneous T-Cell Lymphoma 治疗晚期皮肤 T 细胞淋巴瘤的莫干单抗多模式疗法与全身性类视黄醇、干扰素或体外射光疗法

IF 3.6 4区医学

Dermatologic Therapy Pub Date : 2023-12-19 DOI: 10.1155/2023/7625926

David M. Weiner, Supriya Rastogi, Daniel J. Lewis, Leah Cohen, Sara Choi, C. Vittorio, P. Haun, Sara S. Samimi, J. Villaseñor‐Park, R. Bhansali, E. Chong, D. Landsburg, S. Nasta, S. J. Schuster, J. Svoboda, Ellen J. Kim, Alain H. Rook, Stefan K. Barta

{"title":"Mogamulizumab Multimodality Therapy with Systemic Retinoids, Interferon, or Extracorporeal Photopheresis for Advanced Cutaneous T-Cell Lymphoma","authors":"David M. Weiner, Supriya Rastogi, Daniel J. Lewis, Leah Cohen, Sara Choi, C. Vittorio, P. Haun, Sara S. Samimi, J. Villaseñor‐Park, R. Bhansali, E. Chong, D. Landsburg, S. Nasta, S. J. Schuster, J. Svoboda, Ellen J. Kim, Alain H. Rook, Stefan K. Barta","doi":"10.1155/2023/7625926","DOIUrl":"https://doi.org/10.1155/2023/7625926","url":null,"abstract":"Mogamulizumab is a novel monoclonal antibody designed to target CC chemokine receptor 4 (CCR4), which is expressed by tumor cells in cutaneous T-cell lymphoma (CTCL). In clinical trials, mogamulizumab monotherapy has demonstrated efficacy in reducing tumor burden in advanced CTCL, particularly in the peripheral blood. In clinical practice at our center, mogamulizumab has been combined with other agents such as systemic interferon, systemic retinoids, and extracorporeal photopheresis for an enhanced synergistic effect. There is limited published research on mogamulizumab combination therapy. This study evaluates the clinical efficacy of mogamulizumab in combination with systemic interferon, retinoids, and/or extracorporeal photopheresis for therapy of CTCL. Nineteen patients on this regimen at our academic center were identified. Treatment response rates, progression-free survival, duration of response, and adverse effects were characterized by retrospective chart review. All patients on this regimen at our center had an initial partial or complete response. Moreover, responses were durable, and the regimen was well-tolerated with few grade 3 adverse effects. These results demonstrate the utility of a multimodality approach to the therapy of CTCL with mogamulizumab and warrant further confirmation.","PeriodicalId":11045,"journal":{"name":"Dermatologic Therapy","volume":"113 13","pages":""},"PeriodicalIF":3.6,"publicationDate":"2023-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138959724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gasdermin C (GSDMC) is Overexpressed in Psoriatic Tissue and Elevated in Psoriatic Serum: A Potential Marker of Cell Proliferation and Local Hypoxia in Psoriasis? Gasdermin C (GSDMC) 在银屑病组织中过度表达，并在银屑病血清中升高：银屑病细胞增殖和局部缺氧的潜在标记物？

IF 3.6 4区医学

Dermatologic Therapy Pub Date : 2023-12-16 DOI: 10.1155/2023/7813287

Julia Nowowiejska, A. Baran, J. Hermanowicz, A. Pryczynicz, B. Sieklucka, Dariusz Pawlak, I. Flisiak

{"title":"Gasdermin C (GSDMC) is Overexpressed in Psoriatic Tissue and Elevated in Psoriatic Serum: A Potential Marker of Cell Proliferation and Local Hypoxia in Psoriasis?","authors":"Julia Nowowiejska, A. Baran, J. Hermanowicz, A. Pryczynicz, B. Sieklucka, Dariusz Pawlak, I. Flisiak","doi":"10.1155/2023/7813287","DOIUrl":"https://doi.org/10.1155/2023/7813287","url":null,"abstract":"Psoriasis is an important disease in dermatological practice and, despite many studies, its pathogenesis is still not fully understood. Gasdermin C (GSDMC; melanoma-derived leucine zipper-containing extranuclear factor, MLZE) is a member of the gasdermin protein family. The study enrolled 60 patients with active plaque-type psoriasis and 30 volunteers without dermatoses. GSDMC concentration was assessed in serum and urine samples of all participants using ELISA. GSDMC tissue expression was assessed by immunohistochemistry. The GSDMC concentration was significantly higher in serum of patients than in controls (\u0000 \u0000 p\u0000 <\u0000 0.001\u0000 \u0000 ). A urinary GSDMC/creatinine ratio was significantly lower in patients than in controls (\u0000 \u0000 p\u0000 <\u0000 0.05\u0000 \u0000 ). Psoriatic lesions exhibited a significantly higher expression of GSDMC than nonlesional patients’ skin or controls’ skin (\u0000 \u0000 p\u0000 <\u0000 0.001\u0000 \u0000 , \u0000 \u0000 p\u0000 <\u0000 0.01\u0000 \u0000 , respectively). There was a positive correlation between the GSDMC serum concentration and the age of patients (R = 0.31, \u0000 \u0000 p\u0000 =\u0000 0.015\u0000 \u0000 ) and a negative correlation between GSDMC and RBC (R = −0.37; \u0000 \u0000 p\u0000 =\u0000 0.0038\u0000 \u0000 ), HGB (R = −0.26; \u0000 \u0000 p\u0000 =\u0000 0.047\u0000 \u0000 ), and urea concentration (R = −0.36; \u0000 \u0000 p\u0000 =\u0000 0.04\u0000 \u0000 ). Our study shows the potential involvement of GSDMC in psoriasis. An increased serum GSDMC and a decreased urinary GSDMC/creatinine ratio could be considered noninvasive psoriasis biomarkers, especially of local hypoxia or cell proliferation.","PeriodicalId":11045,"journal":{"name":"Dermatologic Therapy","volume":"23 1","pages":""},"PeriodicalIF":3.6,"publicationDate":"2023-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138966860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0