Dermatologic Therapy最新文献_第9页

MicroRNAs as Potential Biomarkers for the Diagnosis, Treatment, and Prognosis of Sexually Transmitted Diseases: Recent Advances and Future Directions 作为性传播疾病诊断、治疗和预后潜在生物标记物的微RNA：最新进展与未来方向

IF 3.6 4区医学

Dermatologic Therapy Pub Date : 2024-03-18 DOI: 10.1155/2024/7835561

Shiyang Li, Ming Wang, Meihua He, Yi Xu, Changxia Li, Yue Huang, Xiaohua Tao

{"title":"MicroRNAs as Potential Biomarkers for the Diagnosis, Treatment, and Prognosis of Sexually Transmitted Diseases: Recent Advances and Future Directions","authors":"Shiyang Li, Ming Wang, Meihua He, Yi Xu, Changxia Li, Yue Huang, Xiaohua Tao","doi":"10.1155/2024/7835561","DOIUrl":"10.1155/2024/7835561","url":null,"abstract":"Sexually transmitted diseases (STDs), including condyloma acuminatum (CA), syphilis, gonorrhea, genital Chlamydia trachomatis (CT), and acquired immune deficiency syndrome (AIDS)/human immunodeficiency virus (HIV) infection, are a group of diseases primarily transmitted through sexual contact, similar behaviors, and indirect contact. These diseases exert a profound impact on both the physical and mental health of patients and impose a substantial socioeconomic burden. Nonetheless, there is a lack of satisfactory treatment options and preventive strategies currently. Research has revealed aberrant expression patterns of microRNAs (miRNAs) in the tissues and blood of individuals with STDs, which are involved in the regulation of essential cellular processes, including proliferation, differentiation, and apoptosis. Consequently, miRNAs hold promise as crucial biomarkers for early diagnosis, disease assessment, prognosis, and potential therapeutic targets for STDs. This systematic review presents pertinent research on miRNAs in the context of STDs to establish a theoretical foundation for clinical diagnosis and treatment strategies.","PeriodicalId":11045,"journal":{"name":"Dermatologic Therapy","volume":"2024 1","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140232395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regulating the Wnt/β-catenin Signaling Pathway Promotes Repigmentation in Vitiligo Using Fire Needle Therapy 利用火针疗法调节 Wnt/β-catenin 信号通路促进白癜风患者的色素再形成

IF 3.6 4区医学

Dermatologic Therapy Pub Date : 2024-03-11 DOI: 10.1155/2024/8522969

Yan-Li Xu, Guang-Mei Sun, Jin-Mei Zhang, Yu-Han Ma, Guang-Zhi Li, Lu Zhang, Fang Cheng, Bao-Xiang Zhang

{"title":"Regulating the Wnt/β-catenin Signaling Pathway Promotes Repigmentation in Vitiligo Using Fire Needle Therapy","authors":"Yan-Li Xu, Guang-Mei Sun, Jin-Mei Zhang, Yu-Han Ma, Guang-Zhi Li, Lu Zhang, Fang Cheng, Bao-Xiang Zhang","doi":"10.1155/2024/8522969","DOIUrl":"10.1155/2024/8522969","url":null,"abstract":"Background. Vitiligo is a dermatological disorder characterized by the depletion of melanocytes. The key to its treatment lies in the promotion of melanin regeneration. The Wnt/β-catenin signalling pathway assumes a pivotal role in this regenerative process. Fire needle therapy (FNT), a traditional Chinese medical technique, has emerged as a promising intervention. Methods. We analyzed gene expression associated with the Wnt/β-catenin signalling pathway in both normal skin and the lesions of patients with vitiligo in the Gene Expression Omnibus database (GEO database). Furthermore, we evaluated the gene expression of this pathway and assessed the effects of FNT on pigmentation and its influence on the Wnt/β-catenin signalling pathway in a vitiligo mouse model. Results. Compared to that of the normal skin, the mRNA levels of WNT10A, WNT10B, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5B, WNT7B, and LEF1 displayed significant decreases in the lesions of patients with vitiligo. Moreover, vitiligo mouse skin lesions improved following FNT, and the number of melanocytes and melanin levels increased. In addition, posttreatment, genes associated with the Wnt/β-catenin signalling pathway were revealed to be upregulated. Conclusion. FNT may play an important role in promoting pigmentation in vitiligo through modulation of the Wnt/β-catenin signalling pathway. This adds to the growing body of literature supporting the use of FNT to treat vitiligo. This, in turn, may inform clinical practice and improve patient outcomes.","PeriodicalId":11045,"journal":{"name":"Dermatologic Therapy","volume":"2024 1","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140254329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Features, Diagnosis, Treatment, and Prognosis of Heparin-Induced Bullous Hemorrhagic Dermatosis 肝素诱发的大疱出血性皮肤病的临床特征、诊断、治疗和预后

IF 3.6 4区医学

Dermatologic Therapy Pub Date : 2024-03-04 DOI: 10.1155/2024/1372188

Ronghui Li, Liping Peng, Jian Zhang, Hanqing Zeng, Zuojun Li, Chunjiang Wang

{"title":"Clinical Features, Diagnosis, Treatment, and Prognosis of Heparin-Induced Bullous Hemorrhagic Dermatosis","authors":"Ronghui Li, Liping Peng, Jian Zhang, Hanqing Zeng, Zuojun Li, Chunjiang Wang","doi":"10.1155/2024/1372188","DOIUrl":"10.1155/2024/1372188","url":null,"abstract":"Background. Heparin-induced bullous hemorrhagic dermatosis (HBHD) is a rare cutaneous adverse effect of heparin and has unclear clinical features. We explored the clinical features of HBHD to provide evidence for the safe use of heparin. Methods. We collected HBHD-related case reports for a retrospective analysis by searching the Chinese and English databases from inception to December 31, 2022. Results. Seventy-two patients, including 51 males (70.8%), were included, and they had a median age of 71.5 years (range: 21, 94). Low-molecular-weight heparin was used in 62 patients (86.1%), and unfractionated heparin was used in 10 patients (13.9%). The median time for HBHD to appear was 7 days (range: 0.25, 270). Lesions appeared far from the injection site, and the extremities (57 patients, 79.2%) were the most frequently involved site. The blisters were mainly located in the intraepidermal (34 patients, 47.2%), subcorneal (10 patients, 13.9%), and subepidermal (9 patients, 12.5%) regions. Thirty-seven patients (51.4%) had no obvious dermal inflammatory infiltration, and 20 patients (27.8%) had lymphocytic inflammatory infiltration. Sixty-seven patients (93.1%) recovered from their skin lesions after the discontinuation of heparin or despite continuing heparin and at a median treatment time of 14 days (range: 2, 141). Conclusion. HBHD is a rare self-limiting disease that occurs far from the injection site. Clinicians should be aware of BHD during the administration of heparin. Heparin can be discontinued or continued depending on the patient’s condition.","PeriodicalId":11045,"journal":{"name":"Dermatologic Therapy","volume":"2024 1","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140266586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effect of an Er:YAG Laser Combined with a 755 nm Picosecond Laser on Tattoo Removal in a Rat Model Er:YAG 激光器与 755 nm 皮秒激光器结合使用对大鼠模型去除纹身的影响

IF 3.6 4区医学

Dermatologic Therapy Pub Date : 2024-02-21 DOI: 10.1155/2024/4509910

Tianyu E., Chen Bi, Xiaopeng Liu, Li Lin, Yongqian Cao

{"title":"The Effect of an Er:YAG Laser Combined with a 755 nm Picosecond Laser on Tattoo Removal in a Rat Model","authors":"Tianyu E., Chen Bi, Xiaopeng Liu, Li Lin, Yongqian Cao","doi":"10.1155/2024/4509910","DOIUrl":"10.1155/2024/4509910","url":null,"abstract":"Laser tattoo removal is an effective technique, but multiple rounds of treatment are required to eliminate tattoos, which can be a challenge for patients who do not have the time. Additionally, there is relatively limited research on the mechanisms of laser tattoo removal, necessitating further in-depth studies. This study aimed to investigate the efficacy of an Er:YAG laser combined with a 755-picosecond laser for tattoo removal and the changes in skin diffuse reflection, pigment particle size, macrophage recruitment, and inflammatory factor levels during combined laser treatment. Our experiments used three sets of lasers—an Er:YAG laser, a 755 nm picosecond laser, and an Er:YAG laser combined with a 755 nm picosecond laser—for tattoo removal. The effects of tattoo removal at different time points were evaluated. Moreover, the mechanisms were explored using HE staining, immunohistochemistry, diffuse reflectance measurements, in vitro gel tests, mass spectrometry, and ELISA experiments. The combined treatment was more effective for tattoo removal in rats. The combined laser treatment effectively reduced diffuse reflection from the skin, thereby increasing the effective laser power, reducing the size of the pigment particles, allowing for easier removal of the pigment, and increasing the recruitment of dermal macrophages and the release of inflammatory factors, thus increasing the rate of tattoo removal in vivo.","PeriodicalId":11045,"journal":{"name":"Dermatologic Therapy","volume":"2024 1","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140444036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Characteristics of Basal Cell Carcinomas of the Scrotum: An Institutional Retrospective Review 阴囊基底细胞癌的临床特征：机构回顾性研究

IF 3.6 4区医学

Dermatologic Therapy Pub Date : 2024-01-19 DOI: 10.1155/2024/8871278

Qiuyan Duan, Yangfeng Lou, Longfei Yang, Peng Zhou

{"title":"Clinical Characteristics of Basal Cell Carcinomas of the Scrotum: An Institutional Retrospective Review","authors":"Qiuyan Duan, Yangfeng Lou, Longfei Yang, Peng Zhou","doi":"10.1155/2024/8871278","DOIUrl":"10.1155/2024/8871278","url":null,"abstract":"Objective. To analyse the clinical and pathologic features, discuss therapeutic strategies, and possibly cause and identify prognostic factors of scrotal basal cell carcinoma (BCC) in Chinese patients. Materials and Methods. Between January 2012 and December 2022, 12 patients with scrotal BCC were diagnosed and treated at our institution. A review was conducted based on the clinical characteristics, pathology slides, and tissues of these patients. Results. The median patient age was 69.26 ± 11.23 years. The skin lesions presented as red papules, blue-grey polypoid nodules, erythematous patches, brownish plaques, and so on. All patients were treated using wide excision, but the margins varied from 0.5 cm to 2 cm. HPV infection was checked in all lesions, with 4 out of 12 testing positive for P16 and 1 for HPV16 DNA. We found mottled positive expression of P16 in the cytoplasm and membrane. One patient developed left inguinal lymph node metastasis and was successfully treated using bilateral inguinal lymphadenectomy. The rest recovered well without relapse. Conclusions. BCC of the scrotum is rare, but long-term surveillance is recommended for BCC patients, and whether genital HPV infection is a noteworthy feature for these patients remains under investigation.","PeriodicalId":11045,"journal":{"name":"Dermatologic Therapy","volume":"2024 1","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139613021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Characteristics, Treatment, and Prognosis of Amoxicillin-Induced AGEP/ALEP 阿莫西林诱发的 AGEP/ALEP 的临床特征、治疗和预后

IF 3.6 4区医学

Dermatologic Therapy Pub Date : 2024-01-13 DOI: 10.1155/2024/3885057

Haibo Lei, Zhiqiang Fan, Yang He, Wei Sun, Zuojun Li, Chunjiang Wang

{"title":"Clinical Characteristics, Treatment, and Prognosis of Amoxicillin-Induced AGEP/ALEP","authors":"Haibo Lei, Zhiqiang Fan, Yang He, Wei Sun, Zuojun Li, Chunjiang Wang","doi":"10.1155/2024/3885057","DOIUrl":"10.1155/2024/3885057","url":null,"abstract":"Background. Amoxicillin was associated with acute generalized exanthematous pustulosis (AGEP), and the clinical characteristics were not clear. The purpose of this study was to explore the clinical characteristics of amoxicillin-induced AGEP and to provide a basis for prevention and treatment. Methods. Case reports and case series of amoxicillin-induced AGEP were collected for retrospective analysis by searching the Chinese and English databases from inception to January 31, 2023. Results. A total of 46 patients were included with a median age of 40 years (range 1.4, 87). The onset time of AGEP ranged from 6 hours to 28 days, with a median of 2.5 days. Fever occurred in 32 patients (69.6%), and pruritus occurred in 13 patients (28.3%). Ten patients (21.7%) had mucous membrane involvement and systemic involvement, respectively. Twenty-two patients had elevated neutrophils, with a median of 12850/mm3 (range 7880, 29140). Skin biopsy mainly showed subcorneal pustules (22 cases, 47.8%), spongy pustules (14 cases, 30.4%), and inflammatory cell infiltration (26 cases, 56.5%). Skin lesions disappeared in a median of 10 days (range 2, 42) after discontinuation of amoxicillin and administration of topical steroids (26 cases, 56.5%) as well as systemic corticosteroids (13 cases, 28.3%). Conclusions. AGEP is a rare complication of amoxicillin and is self-limiting. Clinicians should correctly identify AGEP and should avoid represcribing amoxicillin. Clinicians should correctly identify AGEP and avoid represcribing amoxicillin, which can prevent unnecessary treatment measures.","PeriodicalId":11045,"journal":{"name":"Dermatologic Therapy","volume":"2024 1","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139531048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tofacitinib for the Treatment of Refractory Progressive Vitiligo: A Retrospective Case Series 托法替尼治疗难治性进展期白癜风：回顾性病例系列

IF 3.6 4区医学

Dermatologic Therapy Pub Date : 2024-01-11 DOI: 10.1155/2024/9944826

Xiu-kun Sun, An-qi Sheng, Ai-e Xu

引用次数: 0

The Relationship between Eating Styles and the Severity of Psoriasis: A Cross-Sectional Study in Thailand 饮食方式与银屑病严重程度之间的关系：泰国横断面研究

IF 3.6 4区医学

Dermatologic Therapy Pub Date : 2024-01-09 DOI: 10.1155/2024/6677244

Wanjarus Roongpisuthipong, Theerawut Klangjareonchai

{"title":"The Relationship between Eating Styles and the Severity of Psoriasis: A Cross-Sectional Study in Thailand","authors":"Wanjarus Roongpisuthipong, Theerawut Klangjareonchai","doi":"10.1155/2024/6677244","DOIUrl":"10.1155/2024/6677244","url":null,"abstract":"Background. Psoriasis, a persistent inflammatory condition, is linked to several concurrent health issues. Among these, obesity stands out as a significant contributing factor, significantly influencing the development and seriousness of psoriasis. Furthermore, behavioral elements such as eating styles could potentially contribute to the activity of the disease. Objective. To investigate the relationships between eating styles and the clinical severity of psoriasis. Materials and Methods. A cross-sectional study among 158 chronic plaque psoriasis patients was conducted. Sociodemographic data and clinical presentation of psoriasis including risk factors and treatment, eating, stress, and sleep data were obtained from questionnaires. Psoriasis disease severity, weight, and height measurements, including bioelectrical impedance analysis were assessed. A multivariate logistic regression analysis was employed to assess eating patterns and identify notable factors linked to the severity of the disease. Results. After adjusting for the potential confounder, the emotional eating style was significantly associated with an increase in risk of psoriasis severity when compared to the restrained eating style (odds ratio, 3.9; 95% confidence interval, 1.52–9.81). Body mass index, body fat mass, eating attitude, alcohol consumption, nail involvement, psoriasis treatment, smoking status, duration of sleep, and stress status were not significant risk factors for disease severity. Conclusions. There is a significant correlation between emotional eating style and the severity of chronic plaque-type psoriasis in Asian patients. Further exploration into utilizing cognitive-behavioral therapy to address emotional eating styles as part of psoriasis management is warranted.","PeriodicalId":11045,"journal":{"name":"Dermatologic Therapy","volume":"2024 1","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139443871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Systemic Tofacitinib Treatment in Pediatric Patients with Resistant Alopecia Areata 托法替尼治疗小儿难治性脱发患者

IF 3.6 4区医学

Dermatologic Therapy Pub Date : 2024-01-05 DOI: 10.1155/2024/8336879

Eda Öksüm Solak, Murat Borlu

引用次数: 0

The Characteristics of COVID-19 Symptoms and Skin Manifestations among Nonhospitalized COVID-19 Patients with Psoriasis during the Omicron Pandemic in China: A Single-Center Survey-Based Study 中国Omicron大流行期间非住院COVID-19银屑病患者的COVID-19症状和皮肤表现特征：基于单中心调查的研究

IF 3.7 4区医学

Dermatologic Therapy Pub Date : 2023-12-26 DOI: 10.1155/2023/1559937

Yue Xiao, Xiwen Zhang, Xun Feng, Jingya Gao, Furong Li, Wenyao Mi, Mingqi Wang, Yuanxia Gu, Yiyi Wang, Wen Wang, Wei Li

{"title":"The Characteristics of COVID-19 Symptoms and Skin Manifestations among Nonhospitalized COVID-19 Patients with Psoriasis during the Omicron Pandemic in China: A Single-Center Survey-Based Study","authors":"Yue Xiao, Xiwen Zhang, Xun Feng, Jingya Gao, Furong Li, Wenyao Mi, Mingqi Wang, Yuanxia Gu, Yiyi Wang, Wen Wang, Wei Li","doi":"10.1155/2023/1559937","DOIUrl":"10.1155/2023/1559937","url":null,"abstract":"<div>\u0000 Background. The global impact of coronavirus 2019 (COVID-19) has raised concerns about the management of psoriasis patients, especially among those using biologics. Methods. We conducted a survey-based research among Omicron-infected (confirmed, probable, and suspected ones) psoriasis patients in the department of dermatology, West China Hospital, Sichuan University, from January 9th to January 22nd, 2023. We collected demographic and clinical information (psoriasis- and COVID-19-related) and conducted statistics analysis. Results. Of the 240 patients enrolled, they were classified by the psoriatic treatment, as biologics (n = 138), nonbiological systematic treatment (n = 52), and topical treatment or without pharmacological treatment (n = 50). This study showed the characteristics of Omicron-related symptoms and cutaneous signs in patients. We observed that patients who received topical treatment or without pharmacological treatment had a lower risk of presenting with COVID-19 symptoms in the fully adjusted logistic model (OR = 0.40, 95% CI: 0.18–0.90, and P = 0.025). Moreover, in the model for skin manifestations, nonbiological systematic treatment (OR = 2.15, 95% CI: 1.08–4.27, and P = 0.029) and high BMI (OR = 1.10, 95% CI: 1.00–1.20, and P = 0.042) were correlative factors. Conclusions. Our data suggested that differential psoriatic treatment might be a correlative factor in developing symptomatic or asymptomatic Omicron infection and presenting cutaneous signs.\u0000 </div>","PeriodicalId":11045,"journal":{"name":"Dermatologic Therapy","volume":"2023 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2023-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2023/1559937","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139157540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0