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Enfortumab vedotin-induced bullous dermatitis. 黄黄素诱导的大疱性皮炎。
Dermatology online journal Pub Date : 2025-06-15 DOI: 10.5070/D331365370
Robin Wang, Kristen Fernandez, Brandon Zelman, Jodi Speiser, Madhu Dahiya, David Eilers
{"title":"Enfortumab vedotin-induced bullous dermatitis.","authors":"Robin Wang, Kristen Fernandez, Brandon Zelman, Jodi Speiser, Madhu Dahiya, David Eilers","doi":"10.5070/D331365370","DOIUrl":"https://doi.org/10.5070/D331365370","url":null,"abstract":"<p><p>Enfortumab vedotin is a first-in-class antibody-drug conjugate used in the treatment of locally advanced or metastatic urothelial carcinoma. A range of cutaneous adverse events has been reported with enfortumab vedotin use. Nectin-4, a transmembrane protein overexpressed by urothelial carcinoma cells, is the intended target of enfortumab vedotin. However, as nectin-4 is also expressed by epidermal keratinocytes, sweat glands, and hair follicles, it is believed that cutaneous toxicity is mediated though off-target delivery of enfortumab vedotin. We present a patient with metastatic urothelial carcinoma who developed a grade 3 bullous dermatitis after his second treatment cycle of enfortumab vedotin and pembrolizumab therapy. Histopathologic findings showed intraepidermal blisters with prominent dyskeratotic and necrotic keratinocytes. Temporary withholding of enfortumab vedotin and pembrolizumab and treatment with potent topical corticosteroids led to significant improvement and enfortumab vedotin (with pembrolizumab) was resumed at a reduced dosage of enfortumab vedotin without recurrence. We present this case to highlight the clinical manifestations, histopathologic findings, and management of enfortumab vedotin-induced cutaneous toxicity.</p>","PeriodicalId":11040,"journal":{"name":"Dermatology online journal","volume":"31 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Improvement of pruritus associated with erythrocytosis in transmasculine patients undergoing gender-affirming therapy with phlebotomy: a report of two patients. 跨男性患者接受性别确认治疗加静脉切开术后与红细胞增多相关的瘙痒症的改善：两例患者的报告。
Dermatology online journal Pub Date : 2025-06-15 DOI: 10.5070/D331365362
Jayden Galamgam, Erin Baroni, Steven Tsai, Carol E Cheng
{"title":"Improvement of pruritus associated with erythrocytosis in transmasculine patients undergoing gender-affirming therapy with phlebotomy: a report of two patients.","authors":"Jayden Galamgam, Erin Baroni, Steven Tsai, Carol E Cheng","doi":"10.5070/D331365362","DOIUrl":"https://doi.org/10.5070/D331365362","url":null,"abstract":"<p><p>Gender-affirming hormone therapy with testosterone may be a component in the treatment plan for transmasculine individuals. Secondary erythrocytosis induced by testosterone therapy and its subsequent complications, such as pruritus, have been reported in the literature in cisgender men. This report presents two transmasculine patients who developed generalized pruritus shortly after initiating testosterone therapy for gender-affirming care. Both patients exhibited elevated hemoglobin and hematocrit levels indicative of testosterone-induced erythrocytosis. Despite treatments, including topical corticosteroids, antihistamines, gabapentin, and benzodiazepines, their symptoms persisted. Symptomatic relief was achieved through therapeutic phlebotomy. The occurrence of polycythemia vera-like pruritus underscores a significant but less commonly recognized side effect of testosterone therapy. Balancing effective gender-affirming care and patient goals with the management of associated side effects is essential for optimizing patient outcomes.</p>","PeriodicalId":11040,"journal":{"name":"Dermatology online journal","volume":"31 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Article processing charges in dermatology journals: a bibliometric analysis. 皮肤病学期刊文章处理费：文献计量学分析。
Dermatology online journal Pub Date : 2025-06-15 DOI: 10.5070/D331365374
Kevin Yang, Kavita Kantamneni, Lauren Cs Kole
{"title":"Article processing charges in dermatology journals: a bibliometric analysis.","authors":"Kevin Yang, Kavita Kantamneni, Lauren Cs Kole","doi":"10.5070/D331365374","DOIUrl":"https://doi.org/10.5070/D331365374","url":null,"abstract":"","PeriodicalId":11040,"journal":{"name":"Dermatology online journal","volume":"31 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Atypical presentation of axillary web syndrome following punch biopsy: case report and literature review. 针刺活检后腋窝蹼综合征的不典型表现：病例报告和文献复习。
Dermatology online journal Pub Date : 2025-06-15 DOI: 10.5070/D331365361
Liora Rahmani, Miriam R Lieberman, Tatyana Groysman, Meryl Rosen
{"title":"Atypical presentation of axillary web syndrome following punch biopsy: case report and literature review.","authors":"Liora Rahmani, Miriam R Lieberman, Tatyana Groysman, Meryl Rosen","doi":"10.5070/D331365361","DOIUrl":"https://doi.org/10.5070/D331365361","url":null,"abstract":"<p><p>Axillary web syndrome, or cording, presents as fibrotic bands that develop beneath the skin, causing pain and restricted shoulder movement. Axillary web syndrome typically arises as a complication following axillary surgery for breast cancer. We present a unique case of a 38-year-old woman with no history of malignancy, breast surgery, or trauma, who developed AWS following a punch biopsy after initially presenting with a subcutaneous nodule in the right axilla. This case highlights the need for increased exploration of the pathogenesis of axillary web syndrome, suggesting a potentially higher incidence of axillary web syndrome than currently reported owing to its self-limiting nature. In addition, the case demonstrates the importance of dermatological awareness of this condition, as its presentation is not limited to breast cancer patients who have undergone major axillary and breast procedures.</p>","PeriodicalId":11040,"journal":{"name":"Dermatology online journal","volume":"31 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unilateral discoid lupus erythematosus: two atypical cases with distinct presentations. 单侧盘状红斑狼疮：两例表现明显的非典型病例。
Dermatology online journal Pub Date : 2025-06-15 DOI: 10.5070/D331365364
P Anthony Halim, Luddwi Achmad Rizky, Eyleny Meisyah Fitri, Endi Novianto, Maria Angela Putri Maharani, Sondang P Sirait, Windy Keumala Budianti
{"title":"Unilateral discoid lupus erythematosus: two atypical cases with distinct presentations.","authors":"P Anthony Halim, Luddwi Achmad Rizky, Eyleny Meisyah Fitri, Endi Novianto, Maria Angela Putri Maharani, Sondang P Sirait, Windy Keumala Budianti","doi":"10.5070/D331365364","DOIUrl":"https://doi.org/10.5070/D331365364","url":null,"abstract":"<p><p>Discoid lupus erythematosus can present in various atypical forms, posing significant diagnostic challenges as it can mimic other infectious or neoplastic dermatoses. Herein, we detail two cases of strictly unilateral, multifocal discoid lupus erythematosus and compare them with previously reported cases. This report contributes to the limited literature on this unusual presentation, particularly in individuals with skin of color.</p>","PeriodicalId":11040,"journal":{"name":"Dermatology online journal","volume":"31 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Purpura fulminans secondary to toxic shock syndrome induced by Group A Streptococcal bacteremia in an adult patient. 成人A群链球菌菌血症致中毒性休克综合征继发暴发性紫癜1例。
Dermatology online journal Pub Date : 2025-06-15 DOI: 10.5070/D331365368
Bredesen Hartmann, Kortni Kemper, Brittany Blaise
{"title":"Purpura fulminans secondary to toxic shock syndrome induced by Group A Streptococcal bacteremia in an adult patient.","authors":"Bredesen Hartmann, Kortni Kemper, Brittany Blaise","doi":"10.5070/D331365368","DOIUrl":"https://doi.org/10.5070/D331365368","url":null,"abstract":"<p><p>Purpura fulminans is a rare life-threatening presentation of disseminated intravascular congestion that presents with widespread purpura and skin necrosis secondary to considerable tissue thrombosis. It usually occurs in pediatric patients and can have various causes with acute infection being the most common. Common infectious triggers include Neisseria and Streptococcus pneumoniae as well as varicella. Our report describes a generally healthy adult patient who developed purpura fulminans in the setting of Group A Streptococcus bacteremia. Group A Streptococcus is a rare cause of purpura fulminans in adult patients with only a few documented cases reported in the literature.</p>","PeriodicalId":11040,"journal":{"name":"Dermatology online journal","volume":"31 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Asymptomatic telangiectatic macules on the trunk and proximal extremities. 躯干和四肢近端无症状毛细血管扩张斑。
Dermatology online journal Pub Date : 2025-06-15 DOI: 10.5070/D331365372
Christine Li, Elana Putterman, Kaitlyn Yim, April Deng, Nikki A Levin
{"title":"Asymptomatic telangiectatic macules on the trunk and proximal extremities.","authors":"Christine Li, Elana Putterman, Kaitlyn Yim, April Deng, Nikki A Levin","doi":"10.5070/D331365372","DOIUrl":"https://doi.org/10.5070/D331365372","url":null,"abstract":"<p><p>Cutaneous collagenous vasculopathy is a rare microangiopathy that presents with asymptomatic telangiectasias and distinct histopathological features, including hyaline material deposition in vessel walls. Diagnosis requires biopsy and differentiation from other telangiectatic disorders. Current treatment options are limited, but increased awareness may improve recognition and management of this rare condition. Herein, we describe an unusual presentation of cutaneous collagenous vasculopathy as asymptomatic, pink, mat-like telangiectatic macules on the trunk and proximal extremities of a 62-year-old woman. Histopathologic evaluation revealed dilated superficial dermal vessels with hyaline thickening of the vessel walls, consistent with a diagnosis of cutaneous collagenous vasculopathy.</p>","PeriodicalId":11040,"journal":{"name":"Dermatology online journal","volume":"31 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An evolving supraclavicular plaque: diagnostic challenges in dermatofibrosarcoma protuberans with atrophic and myxoid features. 发展中的锁骨上斑块：具有萎缩性和黏液样特征的隆突性皮肤纤维肉瘤的诊断挑战。
Dermatology online journal Pub Date : 2025-06-15 DOI: 10.5070/D331365359
Maha Kazmi, Ayan Kusari, Anna Haemel, Philip E LeBoit, Siegrid S Yu
{"title":"An evolving supraclavicular plaque: diagnostic challenges in dermatofibrosarcoma protuberans with atrophic and myxoid features.","authors":"Maha Kazmi, Ayan Kusari, Anna Haemel, Philip E LeBoit, Siegrid S Yu","doi":"10.5070/D331365359","DOIUrl":"https://doi.org/10.5070/D331365359","url":null,"abstract":"<p><p>Dermatofibrosarcoma protuberans is an uncommon locally aggressive mesenchymal neoplasm that classically presents with a proliferation of monomorphic spindled cells with thin nuclei and scant cytoplasm. We report a man in his twenties who presented for an unrelated skin concern and was incidentally noted to have a large, atrophic scar-like depression of the left supraclavicular neck and shoulder. The plaque was photographed and the patient was instructed to follow-up in one year, and careful photo comparison revealed the lesion had subtly enlarged and darkened in color. Accordingly, a punch biopsy revealed features of myxoid dermatofibrosarcoma protuberans, a dermal proliferation of spindled cells with mucinous degeneration and more cellular areas with extensive nuclear palisading resembling the Verocay bodies of a neurofibroma. Clinicians should be aware of the broad clinicopathologic spectrum of DFSP to ensure timely diagnosis and effective treatment. Myxoid dermatofibrosarcoma protuberans is a rare and clinically challenging diagnosis, as the mucinous areas can impart a bluish hue. Dermatofibrosarcoma protuberans can also be atrophic, with the loss of the normal dermal thickness corresponding to a clinical appearance easily mistaken for anetoderma or atrophic scar. Palisaded nuclei resembling the Verocay bodies of schwannoma are sometimes seen and can further obfuscate the diagnosis.</p>","PeriodicalId":11040,"journal":{"name":"Dermatology online journal","volume":"31 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Facial sinus tract mimicking cutaneous cyst or scar: unveiling a dental infection. 面部窦道模拟皮肤囊肿或疤痕：揭示牙齿感染。
Dermatology online journal Pub Date : 2025-06-15 DOI: 10.5070/D331365371
Ariel Orlando F Castellano, Maria Eduarda Tf Alves, Flavio Rf Alves
{"title":"Facial sinus tract mimicking cutaneous cyst or scar: unveiling a dental infection.","authors":"Ariel Orlando F Castellano, Maria Eduarda Tf Alves, Flavio Rf Alves","doi":"10.5070/D331365371","DOIUrl":"https://doi.org/10.5070/D331365371","url":null,"abstract":"<p><p>A 39-year-old man with an unrecognized facial sinus tract under his chin initially presented with an innocuous lesion resembling an acne pimple. The patient's journey began with dermatologic intervention, involving systemic and topical antibiotics. Upon treatment failure, referral to a general dentist revealed a carious lesion on the lower right lateral incisor, prompting further investigation. A subsequent referral to an endodontic specialist led to the diagnosis of a chronic periapical abscess, and an endodontic intervention was initiated. Despite the persistence of intracanal purulent exudate, a strategic application of pure calcium hydroxide was implemented, followed by a temporary seal. A two-year follow-up demonstrated complete healing of the periapical lesion and resolution of the extraoral cutaneous sinus tract. The report showcases the intricate diagnostic journey, meticulous endodontic intervention, and successful management of an extraoral cutaneous sinus tract mimicking scar or cyst, emphasizing the importance of a correct diagnosis to avoid ineffective treatment.</p>","PeriodicalId":11040,"journal":{"name":"Dermatology online journal","volume":"31 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Effect of anchoring on patients' likeliness to take an injection treatment for hidradenitis suppurativa. 锚定对化脓性汗腺炎患者注射治疗可能性的影响。
Dermatology online journal Pub Date : 2025-06-15 DOI: 10.5070/D331365373
Aaron D Smith, Catherine E Lyons, Katie Lovell, Diem-Phuong D Dao, Steven R Feldman
{"title":"The Effect of anchoring on patients' likeliness to take an injection treatment for hidradenitis suppurativa.","authors":"Aaron D Smith, Catherine E Lyons, Katie Lovell, Diem-Phuong D Dao, Steven R Feldman","doi":"10.5070/D331365373","DOIUrl":"https://doi.org/10.5070/D331365373","url":null,"abstract":"","PeriodicalId":11040,"journal":{"name":"Dermatology online journal","volume":"31 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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