Improvement of pruritus associated with erythrocytosis in transmasculine patients undergoing gender-affirming therapy with phlebotomy: a report of two patients.

Q3 Medicine
Jayden Galamgam, Erin Baroni, Steven Tsai, Carol E Cheng
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引用次数: 0

Abstract

Gender-affirming hormone therapy with testosterone may be a component in the treatment plan for transmasculine individuals. Secondary erythrocytosis induced by testosterone therapy and its subsequent complications, such as pruritus, have been reported in the literature in cisgender men. This report presents two transmasculine patients who developed generalized pruritus shortly after initiating testosterone therapy for gender-affirming care. Both patients exhibited elevated hemoglobin and hematocrit levels indicative of testosterone-induced erythrocytosis. Despite treatments, including topical corticosteroids, antihistamines, gabapentin, and benzodiazepines, their symptoms persisted. Symptomatic relief was achieved through therapeutic phlebotomy. The occurrence of polycythemia vera-like pruritus underscores a significant but less commonly recognized side effect of testosterone therapy. Balancing effective gender-affirming care and patient goals with the management of associated side effects is essential for optimizing patient outcomes.

跨男性患者接受性别确认治疗加静脉切开术后与红细胞增多相关的瘙痒症的改善:两例患者的报告。
使用睾酮的性别确认激素疗法可能是跨男性个体治疗计划中的一个组成部分。由睾酮治疗引起的继发性红细胞增多及其随后的并发症,如瘙痒,在顺性男性中已有文献报道。本报告介绍了两名跨性别患者,他们在开始进行性别确认护理的睾丸激素治疗后不久就出现了全身瘙痒。两例患者均表现出血红蛋白和红细胞压积水平升高,表明睾酮诱导的红细胞增多。尽管治疗,包括局部皮质类固醇、抗组胺药、加巴喷丁和苯二氮卓类药物,他们的症状持续存在。通过治疗性静脉切开术达到症状缓解。vera型红细胞增多症样瘙痒的发生强调了睾酮治疗的一个重要但不太常见的副作用。平衡有效的性别确认护理和患者目标以及相关副作用的管理对于优化患者结果至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Dermatology online journal
Dermatology online journal Medicine-Dermatology
CiteScore
1.70
自引率
0.00%
发文量
200
审稿时长
6 weeks
期刊介绍: An open-access, refereed publication intended to meet reference and education needs of the international dermatology community since 1995. Dermatology Online Journal is supported by the Department of Dermatology UC Davis, and by the Northern California Veterans Administration.
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