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Asymptomatic hepatotoxicity following exposure to oral terbinafine for onychomycosis treatment. 暴露于口服特比萘芬治疗甲癣后无症状肝毒性。
Dermatology online journal Pub Date : 2025-02-15 DOI: 10.5070/D331164965
Rachel C Hill, Shari R Lipner
{"title":"Asymptomatic hepatotoxicity following exposure to oral terbinafine for onychomycosis treatment.","authors":"Rachel C Hill, Shari R Lipner","doi":"10.5070/D331164965","DOIUrl":"https://doi.org/10.5070/D331164965","url":null,"abstract":"<p><p>Hepatotoxicity is a known but very rare side effect of oral terbinafine therapy. To our knowledge, there are no reported cases of patients with cleared hepatitis B infection prescribed oral terbinafine. We report an 82-year-old woman with previous hepatitis B exposure who experienced asymptomatic elevation of aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase levels following 28 days of therapy with 250mg of oral terbinafine daily for onychomycosis treatment. After drug discontinuation, her liver function tests returned to baseline about three months later, without permanent liver damage. Oral terbinafine therapy, although typically efficacious and well-tolerated for onychomycosis treatment, rarely causes hepatoxicity. Physician knowledge of this rare but important side effect is necessary to prevent morbidity and mortality resulting from continued therapy. Oral terbinafine therapy might not reactivate hepatitis B in patients with past infection.</p>","PeriodicalId":11040,"journal":{"name":"Dermatology online journal","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cutaneous nodules secondary to Mycobacterium avium complex in a patient with human immunodeficiency virus. 人类免疫缺陷病毒患者继发于鸟分枝杆菌复合体的皮肤结节。
Dermatology online journal Pub Date : 2024-12-16 DOI: 10.5070/D330664688
Jay Patel, Shannon Sayyadioskoie, Hanna Siatecka, Theodore Rosen
{"title":"Cutaneous nodules secondary to Mycobacterium avium complex in a patient with human immunodeficiency virus.","authors":"Jay Patel, Shannon Sayyadioskoie, Hanna Siatecka, Theodore Rosen","doi":"10.5070/D330664688","DOIUrl":"10.5070/D330664688","url":null,"abstract":"<p><p>We present a patient with human immunodeficiency virus who developed multiple painful lesions that previously in the past had speciated as Cryptococcus neoformans cutaneously, and in the lung. Despite induction therapy for presumed re-infection, the patient did not improve so a biopsy was performed and this was speciated as Mycobacterium avium complex, with final diagnosis being disseminated Mycobacterium avium complex. This case highlights the importance of considering a broad differential diagnosis for any new lesions regardless of prior culture data.</p>","PeriodicalId":11040,"journal":{"name":"Dermatology online journal","volume":"30 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lichen planus pigmentosus inversus presenting with clinical features mimicking acanthosis nigricans. 相反，色素性扁平苔藓表现出类似黑棘皮病的临床特征。
Dermatology online journal Pub Date : 2024-12-15 DOI: 10.5070/D330664690
Joohyung Youh, Hiroaki Iwata, Shinya Kitamura, Hideyuki Ujiie
{"title":"Lichen planus pigmentosus inversus presenting with clinical features mimicking acanthosis nigricans.","authors":"Joohyung Youh, Hiroaki Iwata, Shinya Kitamura, Hideyuki Ujiie","doi":"10.5070/D330664690","DOIUrl":"10.5070/D330664690","url":null,"abstract":"<p><p>Lichen planus pigmentosus (LPP) is recognized as a rare variant of lichen planus, characterized by dermal hyperpigmentation. Specifically, a particular intertriginous variant of LPP is known as lichen planus pigmentosus inversus (LPPI). In our case, the patient presented with symmetric, hyperpigmented dark brown patches mainly in axillary areas, closely resembling the features of acanthosis nigricans (AN). The differential diagnosis considered included LPPI, AN, post-inflammatory hyperpigmentation related to contact dermatitis, symmetrical drug-related intertriginous and flexural exanthema, fixed drug eruption, and erythema dyschromicum perstans (EDP). Histopathological examination revealed the absence of hyperkeratosis and papillomatosis, typically associated with AN. Dermoscopy revealed diffuse brownish hue along with dots and globules of inconsistent size, which suggests dermal pigmentary incontinence and the likelihood of LPPI. This case illustrates the challenge in differentiating LPPI from similar flexural hyperpigmentation disorders based on the comprehensive approach including thorough history taking, clinical manifestations, histopathological analysis, and dermoscopic examination.</p>","PeriodicalId":11040,"journal":{"name":"Dermatology online journal","volume":"30 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Personal protective equipment modification by health care workers owing to skin concerns during the COVID-19 pandemic: a multicenter cross-sectional study. COVID-19大流行期间卫生保健工作者因皮肤问题修改个人防护装备：一项多中心横断面研究
Dermatology online journal Pub Date : 2024-12-15 DOI: 10.5070/D330664701
Nicole Trepanowski, Haya S Raef, Sarina B Elmariah, Ari M Goldminz, Allison R Larson, Rachel Meltzer
{"title":"Personal protective equipment modification by health care workers owing to skin concerns during the COVID-19 pandemic: a multicenter cross-sectional study.","authors":"Nicole Trepanowski, Haya S Raef, Sarina B Elmariah, Ari M Goldminz, Allison R Larson, Rachel Meltzer","doi":"10.5070/D330664701","DOIUrl":"https://doi.org/10.5070/D330664701","url":null,"abstract":"","PeriodicalId":11040,"journal":{"name":"Dermatology online journal","volume":"30 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prescription trends of antipsychotic medications in dermatology among Medicare patients, 2013-2020. 2013-2020年医疗保险患者皮肤科抗精神病药物处方趋势
Dermatology online journal Pub Date : 2024-12-15 DOI: 10.5070/D330664699
Katie Roster, Katherine M Erickson, Alina Zufall, Frederick A Pereira
{"title":"Prescription trends of antipsychotic medications in dermatology among Medicare patients, 2013-2020.","authors":"Katie Roster, Katherine M Erickson, Alina Zufall, Frederick A Pereira","doi":"10.5070/D330664699","DOIUrl":"https://doi.org/10.5070/D330664699","url":null,"abstract":"","PeriodicalId":11040,"journal":{"name":"Dermatology online journal","volume":"30 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acquired reactive perforating collagenosis in skin of color. 有色皮肤获得性反应性穿孔性胶原病。
Dermatology online journal Pub Date : 2024-12-15 DOI: 10.5070/D330664686
Spencer P McClure, William Liakos, Edward W Seger, Maryam Abdo, Abigail Murray, Ryan Gillihan
{"title":"Acquired reactive perforating collagenosis in skin of color.","authors":"Spencer P McClure, William Liakos, Edward W Seger, Maryam Abdo, Abigail Murray, Ryan Gillihan","doi":"10.5070/D330664686","DOIUrl":"10.5070/D330664686","url":null,"abstract":"<p><p>Acquired reactive perforating collagenosis is an uncommon disorder that present as keratotic plugs on the skin owing to transepidermal perforation of dermal connective tissue. Etiology is unclear, although the condition has been associated with renal disease, diabetes, and HIV. It can frequently be misdiagnosed and lead to significant impact on quality of life, particularly in patients with skin of color. Herein, we present an skin of color patient with this condition who experienced severe pruritus over years before receiving a definitive diagnosis. Clobetasol improved her condition and quality of life over several months.</p>","PeriodicalId":11040,"journal":{"name":"Dermatology online journal","volume":"30 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Liquefactive subcutaneous fat necrosis of the newborn. 新生儿液化性皮下脂肪坏死。
Dermatology online journal Pub Date : 2024-12-15 DOI: 10.5070/D330664694
Negar Esfandiari, Hannah J Porter, Keith Morley
{"title":"Liquefactive subcutaneous fat necrosis of the newborn.","authors":"Negar Esfandiari, Hannah J Porter, Keith Morley","doi":"10.5070/D330664694","DOIUrl":"https://doi.org/10.5070/D330664694","url":null,"abstract":"<p><p>Subcutaneous fat necrosis of the newborn is a disease affecting neonates in the first weeks to months of life. It is characterized by dermal edema and underlying fat necrosis, typically presenting with firm, erythematous subcutaneous plaques and nodules, often located on the shoulders, back, buttocks, thighs, and extremities. We report an unusual presentation of liquefactive subcutaneous fat necrosis of the newborn in a two-week old term infant. The neonatal period was complicated by respiratory failure requiring intubation and severe encephalopathy. After completion of therapeutic hypothermia, the patient developed fluctuant and liquefactive nodules on her back. The neonate also had initial hypocalcemia that required treatment and then developed hypercalcemia, that resolved without intervention. The nodules and plaques on her back persisted into the first year of life and then gradually started to improve when she was 13 months old.</p>","PeriodicalId":11040,"journal":{"name":"Dermatology online journal","volume":"30 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Deoxycholic acid injections as a nonsurgical treatment for lipomas in adiposis dolorosa (Dercum disease). 去氧胆酸注射作为非手术治疗多脂性脂肪瘤。
Dermatology online journal Pub Date : 2024-12-15 DOI: 10.5070/D330664693
Ziv Schwartz, Kayla Brockmeyer, Neda Nikbakht
{"title":"Deoxycholic acid injections as a nonsurgical treatment for lipomas in adiposis dolorosa (Dercum disease).","authors":"Ziv Schwartz, Kayla Brockmeyer, Neda Nikbakht","doi":"10.5070/D330664693","DOIUrl":"https://doi.org/10.5070/D330664693","url":null,"abstract":"<p><p>Adiposis dolorosa (Dercum disease) is a rare condition characterized by diffuse and recurring painful lipomas on the trunk and extremities. Patients are typically middle-aged females with an elevated BMI presenting with chronic pain. Physical examination reveals soft subcutaneous nodules and masses, tender to palpation. The associated pain significantly impacts quality of life and requires therapeutic intervention. The most common treatment option is surgical excision. Alternative options should be considered for patients with numerous lipomas where surgical management is not practical or is not desired. Deoxycholic acid injections are a viable alternative non-surgical technique. We present a case of a 55-year-old woman who presented with a history of Dercum disease and worsening pain associated with multiple lipomas. The patient desired a non-surgical intervention. She was subsequently treated with three rounds of deoxycholic acid injections with reduction in pain and improved mobility. Intralesional deoxycholic acid injections are a safe and effective nonsurgical alternative for patients with multiple lipomas.</p>","PeriodicalId":11040,"journal":{"name":"Dermatology online journal","volume":"30 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Drug-induced subacute cutaneous lupus erythematous from cenobamate: case presentation and review of the literature. 药物致亚急性皮肤红斑狼疮：病例报告及文献复习。
Dermatology online journal Pub Date : 2024-12-15 DOI: 10.5070/D330664689
Safiyyah A Bhatti, Daniel Joffe, Timothy Webster, Jason B Lee
{"title":"Drug-induced subacute cutaneous lupus erythematous from cenobamate: case presentation and review of the literature.","authors":"Safiyyah A Bhatti, Daniel Joffe, Timothy Webster, Jason B Lee","doi":"10.5070/D330664689","DOIUrl":"https://doi.org/10.5070/D330664689","url":null,"abstract":"<p><p>A 68-year-old woman with a history of seizures on cenobamate presented with an itchy rash all over her body. The rash started about one month prior to her presentation to the dermatology clinic. The rash was initially treated with topical triamcinolone with improvement at one-month follow-up. However, four months later the rash flared and there was concern that cenobamate was the cause. Biopsy was performed showing vacuolar interface dermatitis with atrophy, suggestive of subacute lupus erythematosus. Blood work revealed positive antinuclear antibody, anti-ribonucleoprotein antibody, Sjogren Anti-SS-A and positive histone antibody. Given the worsening rash, positive labs, and cenobamate as the only changed drug several months before initial onset, she was diagnosed with drug-induced subacute cutaneous lupus erythematous and her cenobamate was discontinued. To the best of your knowledge, this is the first reported case of a medication in the carbamate family leading to drug induced subacute cutaneous lupus erythematosus.</p>","PeriodicalId":11040,"journal":{"name":"Dermatology online journal","volume":"30 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Severe disseminated paracoccidioidomycosis. 严重播散性副球孢子菌病。
Dermatology online journal Pub Date : 2024-12-15 DOI: 10.5070/D330664692
Ezequias B Martins, Halber Fm Alves, Remberto Mc Vilte, Luciana Pantaleao, Isadora Ocp Da Silva, Natalia Cz Silva, Laura C Ferreira, Karla Rom Ronchini, Thais O Vieira, Maria Vitoria M, Veronica Rb Leite, Patricia Yvonne M
{"title":"Severe disseminated paracoccidioidomycosis.","authors":"Ezequias B Martins, Halber Fm Alves, Remberto Mc Vilte, Luciana Pantaleao, Isadora Ocp Da Silva, Natalia Cz Silva, Laura C Ferreira, Karla Rom Ronchini, Thais O Vieira, Maria Vitoria M, Veronica Rb Leite, Patricia Yvonne M","doi":"10.5070/D330664692","DOIUrl":"https://doi.org/10.5070/D330664692","url":null,"abstract":"<p><p>Paracoccidioidomycosis is a systemic fungal disease with a highly variable distribution, endemic to Central and South America with the highest prevalence in Brazil, Argentina, and Colombia. The chronic presentation of the disease is commonly observed in adult men and they manifest with pulmonary and mucocutaneous lesions. We report a fatal case of disseminated paracoccidioidomycosis in a 68-year-old immunocompetent man, with pulmonary, skin, mucosal, and cerebral involvement. Mucocutaneous lesions were decisive for the etiological diagnosis.</p>","PeriodicalId":11040,"journal":{"name":"Dermatology online journal","volume":"30 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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