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Recurrent aseptic abscesses resulting in superficial pyoderma gangrenosum-like ulcers in a patient with granulomatosis with polyangiitis. 一例肉芽肿病合并多血管炎的患者复发性无菌性脓肿导致浅表脓皮坏疽样溃疡。
Dermatology online journal Pub Date : 2024-10-15 DOI: 10.5070/D330564432
Toshiyuki Yamamoto
{"title":"Recurrent aseptic abscesses resulting in superficial pyoderma gangrenosum-like ulcers in a patient with granulomatosis with polyangiitis.","authors":"Toshiyuki Yamamoto","doi":"10.5070/D330564432","DOIUrl":"https://doi.org/10.5070/D330564432","url":null,"abstract":"<p><p>Patients with granulomatosis with polyangiitis occasionally present with cutaneous manifestations, which are important clues for the early diagnosis. Although pyoderma gangrenosum-like ulcers are rarely observed, a unique case with unusual clinical features is presented herein. A 75-year-old woman with positive proteinase 3-antineutrophil cytoplasmic antibody (PR3-ANCA) repeatedly developed aseptic abscesses on the abdomen, buttock, lower legs, and forearms. Histopathological features of biopsy taken from ulcers showed necrotizing granulomatous inflammation with multinucleated giant cells without leukocytoclastic vasculitis. The present case was initially diagnosed as limited granulomatosis with polyangiitis without renal and lung involvement. However, two years later, she died of cerebral hemorrhage.</p>","PeriodicalId":11040,"journal":{"name":"Dermatology online journal","volume":"30 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142834266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lactation anaphylaxis: report of a rare case with recurrent postpartum anaphylaxis. 哺乳期过敏性休克:报告一例罕见的产后过敏性休克复发病例。
Dermatology online journal Pub Date : 2024-10-15 DOI: 10.5070/D330564435
Yasutoshi Hida, Shunsuke Takahagi, Ayaka Iwawaki, Kaori Ishii, Kayo Myogo
{"title":"Lactation anaphylaxis: report of a rare case with recurrent postpartum anaphylaxis.","authors":"Yasutoshi Hida, Shunsuke Takahagi, Ayaka Iwawaki, Kaori Ishii, Kayo Myogo","doi":"10.5070/D330564435","DOIUrl":"10.5070/D330564435","url":null,"abstract":"<p><p>Lactation anaphylaxis is extremely rare and has been scarcely reported in the literature. Breast feeding and/or milk expression immediately induces life-threatening anaphylactic reactions, including generalized urticaria, angioedema, respiratory symptoms, and hypotension. Six English-language case reports have described the clinical course in detail. The present report describes a case involving a 24-year-old woman with no history of allergic reactions or anaphylaxis who experienced anaphylactic reactions three times immediately after milk expression. Lactation anaphylaxis was suspected when a detailed medical history revealed lactation-related recurrent anaphylactic symptoms. The authors prescribed bromocriptine to stop lactation and switched her to formula feeding, which resulted in no further anaphylactic episodes. Based on a review of the relevant literature, this report describes the characteristics of lactation anaphylaxis and possible management strategies. The pathogenesis of lactation anaphylaxis has been inferred from various experimental results.</p>","PeriodicalId":11040,"journal":{"name":"Dermatology online journal","volume":"30 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142834066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cutaneous ulcers in sarcoidosis. 结节病的皮肤溃疡。
Dermatology online journal Pub Date : 2024-08-15 DOI: 10.5070/D330464113
Hanadi Alsatti, Atheel Balkhy, Bashaer H Almahdi, Amal H Abualola
{"title":"Cutaneous ulcers in sarcoidosis.","authors":"Hanadi Alsatti, Atheel Balkhy, Bashaer H Almahdi, Amal H Abualola","doi":"10.5070/D330464113","DOIUrl":"10.5070/D330464113","url":null,"abstract":"<p><p>Sarcoidosis is a disease characterized by immunological granuloma formation in various organs. Cutaneous manifestations occur in about 25% of patients with rare cases showing ulcerative sarcoidosis, that can be debilitating if not treated promptly. This article presents a patient with isolated ulcerative sarcoidosis and reviews existing literature. A 44-year-old woman presented with a non-healing ulcer on her right gluteal area. A skin biopsy confirmed sarcoidosis with non-necrotizing granulomas. Systemic involvement of sarcoidosis was ruled out. Treatment involved topical corticosteroids and intralesional corticosteroid injections, resulting in complete healing. This case emphasizes the importance of considering ulcerative sarcoidosis in non-healing wounds and the efficacy of corticosteroid treatment.</p>","PeriodicalId":11040,"journal":{"name":"Dermatology online journal","volume":"30 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diffuse face and ear hypertrichosis caused by 5% topical minoxidil in an adult woman with spontaneous resolution. 5%外用米诺地尔引起的弥漫性面部和耳朵多毛症,1例成年女性,自发性消退。
Dermatology online journal Pub Date : 2024-08-15 DOI: 10.5070/D330464117
Fares A Alkhayal, Ali A Alkinani
{"title":"Diffuse face and ear hypertrichosis caused by 5% topical minoxidil in an adult woman with spontaneous resolution.","authors":"Fares A Alkhayal, Ali A Alkinani","doi":"10.5070/D330464117","DOIUrl":"10.5070/D330464117","url":null,"abstract":"<p><p>Minoxidil is a vasodilator medication known for its ability to promote hair growth. Although it was first introduced as an oral drug to treat hypertension, minoxidil was observed to have the important side-effect of increasing hair growth. This led to the development of a topical formulation as a 2% concentration solution for the treatment of female androgenic alopecia (AGA) and 5% for treating male AGA, which is considered as a first line U.S. Food and Drug Administration (FDA)-approved treatment for AGA in addition to oral 5-alpha-reductase inhibitor (finasteride). The mechanism by which minoxidil promotes hair growth is not fully understood but can be related to increasing blood flow owing to its vasodilator effects. Androgenic alopecia is characterized by the gradual conversion of terminal hairs into vellus hairs. Alterations in the hair cycle include reduced duration of the anagen phase and increased duration of the telogen phase, resulting in shorter hairs and eventual balding. Side effects of topical minoxidil include irritant and allergic contact dermatitis, pruritus, and facial hypertrichosis, which are more often seen with the use of 5% solutions rather than 2%. Herein, we report a 24-year-old woman who developed severe ear and face hypertrichosis after using a topical 5% minoxidil solution. She later had spontaneous resolution of her hypertrichosis three months after stopping it.</p>","PeriodicalId":11040,"journal":{"name":"Dermatology online journal","volume":"30 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nivolumab-induced hidradenitis suppurativa: a case report. 尼沃鲁单抗致化脓性汗腺炎1例。
Dermatology online journal Pub Date : 2024-08-15 DOI: 10.5070/D330464106
Olivia Lamberg, Karan Pandher, Natalie H Matthews
{"title":"Nivolumab-induced hidradenitis suppurativa: a case report.","authors":"Olivia Lamberg, Karan Pandher, Natalie H Matthews","doi":"10.5070/D330464106","DOIUrl":"https://doi.org/10.5070/D330464106","url":null,"abstract":"<p><p>We present a 44-year-old man with metastatic clear cell renal cell cancer undergoing treatment with nivolumab immunotherapy. Three months post-initiation, he developed symmetric recurrent nodules and boils in intertriginous areas, diagnosed as stage II hidradenitis suppurativa of the groin and gluteal cleft. The progressive course, lesion symmetry and location, worsening with nivolumab infusions, and biopsy findings supported the diagnosis. Hidradenitis suppurativa pathogenesis involves immune dysregulation marked by elevated IL17 and neutrophil-dominated inflammation [1]. Immune checkpoint inhibitors, including anti-PD1 agents like nivolumab, are linked to immune-related adverse events related to widespread T cell activation, potentially increasing IL17 signaling associated with HS [2,3]. Clinicians should be aware of, and observant for anti-PD1-induced HS, a rare immune-related adverse event, in patients undergoing immune checkpoint inhibitor therapy.</p>","PeriodicalId":11040,"journal":{"name":"Dermatology online journal","volume":"30 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A rapidly-growing friable nodule on the cheek. 脸颊上迅速生长的易碎的结节。
Dermatology online journal Pub Date : 2024-08-15 DOI: 10.5070/D330464116
Melissa C Leeolou, Peter A Young, Iesha L Ticknor, Jinping Lai, Ricardo T Paniagua, Robert L Burns
{"title":"A rapidly-growing friable nodule on the cheek.","authors":"Melissa C Leeolou, Peter A Young, Iesha L Ticknor, Jinping Lai, Ricardo T Paniagua, Robert L Burns","doi":"10.5070/D330464116","DOIUrl":"https://doi.org/10.5070/D330464116","url":null,"abstract":"<p><p>Atypical fibroxanthoma and pleomorphic dermal sarcoma are on a spectrum of cutaneous tumors that present as ulcerated lesions in older adults. We present an 84-year-old man with pleomorphic dermal sarcoma, initially presenting as a bleeding lesion of the cheek that progressed to an eroded nodule.</p>","PeriodicalId":11040,"journal":{"name":"Dermatology online journal","volume":"30 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Annular secondary syphilis with HIV coinfection that resembles other dermatoses. 环状继发性梅毒与HIV合并感染,类似于其他皮肤病。
Dermatology online journal Pub Date : 2024-08-15 DOI: 10.5070/D330464109
Nabila Kirtti Pradipta, Devi Artami Susetiati, Hafidzah Nurmastuti, Retno Danarti, Satiti Retno Pudjiati
{"title":"Annular secondary syphilis with HIV coinfection that resembles other dermatoses.","authors":"Nabila Kirtti Pradipta, Devi Artami Susetiati, Hafidzah Nurmastuti, Retno Danarti, Satiti Retno Pudjiati","doi":"10.5070/D330464109","DOIUrl":"https://doi.org/10.5070/D330464109","url":null,"abstract":"<p><p>Syphilis is a sexually transmitted infection with manifestations that can mimic other diseases, leading to misdiagnosis. Annular syphilis is a rare atypical secondary syphilitic lesion that seldomly involves the face. Human immunodeficiency virus (HIV) coinfection can increasingly lead to atypical manifestations of syphilis and complicate the diagnosis. Herein, we describe a 29-year-old man with a diagnosis of annular secondary syphilis and HIV coinfection. He had clinical manifestations of annular erythematous papules and plaques with white scales at the edges, distributed and scattered on the face, neck, and upper back. The skin lesions went undetected on several visits and were misdiagnosed owing to similarities with other dermatoses. Serological examination showed positive Treponema pallidum particle agglutination assay and venereal disease research laboratory test titer 1/512, confirming syphilis infection. Results from the histopathological examination supported the diagnosis of secondary syphilis. Positive anti-HIV rapid test results indicated concurrent HIV infection. He was treated for syphilis and given antiretroviral therapy, and showed a good response as demonstrated by improvement of the lesions and serological titers. This case highlights the importance of recognizing the possibility of annular secondary syphilis and HIV coinfection which can have atypical manifestations.</p>","PeriodicalId":11040,"journal":{"name":"Dermatology online journal","volume":"30 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Supravenous and perivenous distribution of a benign pigmented purpuric eruption. 良性色素紫癜疹的静脉上及静脉周围分布。
Dermatology online journal Pub Date : 2024-08-15 DOI: 10.5070/D330464123
Yoshihiro Matsudate
{"title":"Supravenous and perivenous distribution of a benign pigmented purpuric eruption.","authors":"Yoshihiro Matsudate","doi":"10.5070/D330464123","DOIUrl":"https://doi.org/10.5070/D330464123","url":null,"abstract":"","PeriodicalId":11040,"journal":{"name":"Dermatology online journal","volume":"30 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Updates in the prevention of glucocorticoid-induced adverse effects. 预防糖皮质激素引起的不良反应的最新进展。
Dermatology online journal Pub Date : 2024-08-15 DOI: 10.5070/D330464122
Callie Cunningham, Allison Limmer, Dario Kivelevitch
{"title":"Updates in the prevention of glucocorticoid-induced adverse effects.","authors":"Callie Cunningham, Allison Limmer, Dario Kivelevitch","doi":"10.5070/D330464122","DOIUrl":"https://doi.org/10.5070/D330464122","url":null,"abstract":"","PeriodicalId":11040,"journal":{"name":"Dermatology online journal","volume":"30 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Folliculotropic and syringotropic mycosis fungoides mimicking basal cell carcinoma. 仿基底细胞癌的嗜滤泡性和嗜筒性真菌病。
Dermatology online journal Pub Date : 2024-08-15 DOI: 10.5070/D330464115
Claudia Quarshie, Brittney DeClerck, Jenny C Hu
{"title":"Folliculotropic and syringotropic mycosis fungoides mimicking basal cell carcinoma.","authors":"Claudia Quarshie, Brittney DeClerck, Jenny C Hu","doi":"10.5070/D330464115","DOIUrl":"https://doi.org/10.5070/D330464115","url":null,"abstract":"<p><p>Mycosis fungoides (MF) is characterized by a clonal proliferation of skin-homing mature T cells with special predilection for involving the epidermis. Folliculotropic and syringotropic MF typically present with erythematous papules, patches, and plaques, with punctate accentuation that is folliculocentric in the former. We report a 67-year-old woman, with an extensive history of allergic contact dermatitis, who was referred to the Mohs surgery clinic with a large pink plaque extending from the nasal bridge to the right upper medial cheek concerning for basal cell carcinoma. An outside punch biopsy showed benign basaloid follicular neoplasm. The patient was found to also have indurated erythematous plaques of the bilateral upper arms and erythematous scaly patches of bilateral arms and legs, abdomen, lateral trunk, buttocks, and groin. Owing to concern for possible cutaneous lymphoma, punch biopsies were performed which revealed the diagnosis of folliculotropic and syringotropic MF. Of note, folliculotropic and syringotropic MF are often, but not uniformly, characterized by a more aggressive disease course. This case highlights the importance of a high index of suspicion and awareness of all clinical and histopathologic pitfalls to avoid misdiagnosis of MF.</p>","PeriodicalId":11040,"journal":{"name":"Dermatology online journal","volume":"30 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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