Current Traditional Medicine最新文献

{"title":"The Antiviral Potential of Zingiber officinale (Ginger): A Comprehensive Literature Review","authors":"Mohammad Amin Amini fard, Mahsa Asadi Anar, Gisou Erabi, Farhad Nikzad, Mehran Ghasemi, Mahdi Seyfi-Ghale-Jogh, Fateme Javaherchian, ladan baghban, Amir Jafari, Sepehr Olangian-Tehrani, Sepehr Nanbakhsh, Niloofar Deravi, Zohreh Tutunchian, Tina Mansourian, Fariba Arbab Mojeni, Alaleh Alizadeh, Farzad Sheikhzadeh, Parisa alsadat Dadkhah, Fatemeh Chichagi","doi":"10.2174/0122150838250624230926043708","DOIUrl":"https://doi.org/10.2174/0122150838250624230926043708","url":null,"abstract":"Abstract:: Herbal medicine has gained massive popularity among researchers worldwide. The leading causes of this rapid development are lower side effects, lower prices, and higher availability of plant extracts compared to synthetic drugs. Ginger (Zingiber officinale), from the Zingiberaceae family, is one of the most commonly used and popular plants utilized as a dietary spice, herbal medicine, and food preservative. Its biologically active components, such as shogaol, paradol, zingerone, and especially gingerol, can be highly effective for the treatment of several illnesses through various anti-inflammatory, anti-neoplastic, anti-emetic, anti-oxidant, antihyperlipidemic and anti-hyperglycaemic activities. Ginger can also be used as an antiviral agent. Numerous studies have been conducted to investigate the antiviral efficacy of ginger on several viruses; for instance, severe acute respiratory syndrome 2 (SARS-COV-2), influenza, dengue, hepatitis, herpes, Human Papilloma Virus (HPV), Human Immunodeficiency Virus (HIV), Epstein- Barr Virus (EBV), Chikungunya virus and so on. This review summarizes the efficacy of ginger in preventing or treating several viral diseases and its mechanism of action, emphasizing coronavirus disease 2019 (COVID-19) due to the current high burden of disease worldwide.","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134945072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review of Ethnopharmacological Uses, Phytochemistry and Pharmacological Attributes of Mesua ferrea Linn.","authors":"Sayukta Vijay Pahurkar, Ajaykumar Rikhabchand Surana, Pratiksha Ramesh Pawar","doi":"10.2174/0122150838249162230922034813","DOIUrl":"https://doi.org/10.2174/0122150838249162230922034813","url":null,"abstract":"Abstract: Ethnopharmacological relevance: Mesua ferrea Linn. belonging to family Guttiferae. The plant widely grows in the hills and is planted in gardens in many parts of India. It is cultivated as an ornamental plant because of its graceful shape, pink to red hanging leaves and enormous wonderful, fragrant white blossoms. The current review summarizes different significant, fundamental and medicinal properties of this Indian therapeutic herb. It is known to be an evergreen tree 20-30 m in height. Along with its elaborate utilization, entire plant has different therapeutic values in the conventional system of drugs. The main aim of this review is to provide a brief overview of the pharmacological, phytochemical, pharmacognostic, ethanomedical and toxicological studies of M. ferrea. A comprehensive review of the literature was conducted using multiple search sites such as PubMed, Google Scholar, Springer, and Science Direct, Scopus, Web of Science, SciFinder, etc. Other literary sources include Wikipedia, ethnobotanical books, and botanical journals. Numerous phytochemicals have been discovered and isolated from Mesua ferrea plant parts which include xanthones, terpenoids, sterol, β-amyrin, β-sitosterol, mesuaferrol, mesuaferrin-A, mesuaferrin B, caloxanthone C,1,8-dihydro-3-methoxy-6- methylanthraquinone, friedelin, fats, flavanoids and betulinic acid. All of the documented pharmacological activities, such as antioxidant and antibacterial activity, antiarthritic, antiinflammatory, antivenom, antiulcerogenic, anticonvulsant, wound healing, depressant, analgesic are due to the presence of certain phytochemical substances. This review mainly targets the botanical aspects of Mesua ferrea along with their phytochemical constituents, ethnomedicinal use, different pharmacological activity, and future possibilities. Mesua ferrea is very important in the traditional Indian system. More research is needed to uncover important features of Mesua ferrea in medical practice.","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135546201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Survey of the Fruit of Capparis spinosa Extracts Effects on the Expressional Profile of Essential Self-renewal Genes in MCF7 Cell Line","authors":"Faezeh Askarian Marji, Ameneh Javid, Mojgan Noroozi Karimabad, Seyedeh Atekeh Torabizadeh, Mohammad Reza Mirzaei","doi":"10.2174/0122150838258062230920091457","DOIUrl":"https://doi.org/10.2174/0122150838258062230920091457","url":null,"abstract":"Background: Several drugs have been proposed for the treatment of breast cancer, but none has fully treated the disease so far. Methods: MCF7 cells were cultured in RPMI-1640 medium, consisting of different concentrations of aqueous-alcoholic extract of the fruit of Capparis spinosa (0.125, 0.25, 0.5, 1, 1.5, 2, 2.5, and 5 mg/mL) for 48 and 72 hours. MTT assay was used to determine the cell proliferation inhibition (IC50). The percentage of apoptotic cells was determined by flow cytometry analysis using Annexin V/PI apoptosis detection kit. RT-PCR method was carried out to assess the fold changes of OCT4, NANOG, and SOX2 genes. Two-way ANOVA (tukeys) and t-test (repeated measure) were used for the statistical analysis of obtained data MTT assay and RT-PCR method, respectively. p < 0.05 was considered significant. Results: Our results have shown that cell death was induced by increasing fruit of Capparis spinosa extract concentration. IC50 was observed at 48 h culture period with 4.81 mg/mL, and 72 h with 2.72 mg/mL fruit extract, respectively. Flow cytometry results exhibited an obviously significant augmentation in apoptotic MF7 cells. According to RT-PCR findings on the fruit of Capparis spinosa extract-treated cells, the mean expression of OCT4, NANOG, and SOX2 genes decreased after 48 and 72 h of incubation with IC50 concentration compared to controls. Conclusion: The fruit of the Capparis spinosa species was able to decrease the expression of self-renewal genes in the MCF7 cell line. Therefore, the fruit of Capparis spinosa extract can be considered a promising candidate for the management of human breast cancer after clinical trials.","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135546439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ganoderma lucidum, a Potential Revolutionary Macro Fungus in the Field of Medicine","authors":"Isha Rani, Mehak Gupta, Samarth Sharma, Dr. Gagandeep Kaur, Pankaj Sharma","doi":"10.2174/0122150838264220230926002018","DOIUrl":"https://doi.org/10.2174/0122150838264220230926002018","url":null,"abstract":"Abstract:: Ganoderma lucidum is a traditional Asian medication used in China, Korea, and Japan. It is a well-known medicinal fungus that is regarded as the elixir of life. Polysaccharides, proteins, enzymes, sterols, fatty acids, vitamins, minerals, and peptides are some of the 400 physiologically active substances. Anti-inflammatory, anti-ulcer, anti-diabetic, antiandrogenic, anti-aging, anti-fibrotic, antioxidant, hepatoprotective, sleep-promoting, anticarcinogenic, chemo and radioprotective, immunomodulation, estrogenic, and antibacterial properties are just a few of the numerous reported pharmacological effects. This review will help us to examine the role that this macro fungus holds in various therapeutic applications and how it can be a significant influence in the field of medicine.","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135546672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lycopene: A Powerful Nutraceutical with Diversified Health Benefits","authors":"Disha Arora, Sahibpreet Singh, Jyoti Singh","doi":"10.2174/0122150838253252230920114357","DOIUrl":"https://doi.org/10.2174/0122150838253252230920114357","url":null,"abstract":"Abstract: Lycopene, a tetraterpene of eight isoprene units belongs to the family of carotenoids, abundantly found in tomatoes and its derivative products. It is non provitamin A carotenoid which is associated with powerful antioxidant action that may trap reactive oxygen species resulting in an increase in the overall antioxidant potential or a reduction in the oxidative damage to proteins, lipids, and DNA, thereby decreasing the oxidative stress. Due to this, the addition of lycopene to the diet is considered to be important. It is used as a food colorant owing to its strong color and non-toxic nature. Recent literature reports have highlighted the significance of lycopene in health. It exhibits many health benefits in ameliorating cancer, inflammation, diabetes mellitus, cardiovascular complications, Parkinson’s disease, Alzheimer’s disease, and hepatic, skin, and bone diseases. In this review, we have summarized the information regarding sources, chemistry, extraction techniques, and health benefits of lycopene.","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":"302 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135546435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Updated Account of Multifaceted Medicinal Values of Garlic: A Systematic Review","authors":"Sutanu Maji, Pragya Anand, Yusuf Akhter","doi":"10.2174/0122150838254577230926114153","DOIUrl":"https://doi.org/10.2174/0122150838254577230926114153","url":null,"abstract":"Background: Garlic (Allium sativum L.), one of the most important medicinal plants and spices, has many neuroprotective medicinal properties. Garlic has been mentioned in Indian medical traditions and Chinese literature as a remedy for infectious and other non-communicable diseases. Raw garlic and its derivatives have been used to treat a variety of ailments. Objectives: In this article, we attempted to summarize the numerous characteristics of specific sulfur-containing garlic components that have been observed thus far, to have a variety of medicinal aspects. Methods: Non-overlapping literature sources from recent years were searched and extracted using databases such as Dimensions, Google Scholar, and PubMed. We have summarized the concluding outputs collectively from the systematic literature search. Second, the catalytic site of the alliinase enzyme was identified to be formed by Y165, N207, D225, Y228, and K251 amino acid residues. We investigated the interaction of active site residues with the alliinase enzyme's natural substrate further, and the catalytic mechanism was deduced using molecular docking. Results: Several studies on various garlic products and their numerous derivatives are currently being conducted and vividly reported. These studies have found that it has antitumor activity as well as the ability to treat digestive issues and ulcers. Additionally, several potential antibacterial, antiviral, anticoagulant, etc. characteristics were reported by garlic components. Conclusion: In conclusion, the review focuses on the successful research on numerous novel garlic components and their derivatives, which may be useful in next-generation therapeutic approaches. In addition, it advises the use of garlic in moderation rather than carelessly.","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135546436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pneumonia Review based on Pathogenic Factors","authors":"Cheng Lin, Baibai Ye, Chen Ping, Linfu Li","doi":"10.2174/0122150838255055230919074231","DOIUrl":"https://doi.org/10.2174/0122150838255055230919074231","url":null,"abstract":"Abstract: Pneumonia is defined as an inflammation of the lung parenchyma, and is caused by different factors resulting in varied manifestations and sequelae. Pneumonia has a great impact on an individual well-being and quality of life, and has brought a heavy economic burden to society. Pneumonia can be classified based on etiologies, lesion sites, coverage, acquisition ways, disease duration, pathological essence, and so on. Based on the classification of etiologies, this article briefly reviewed pneumonia from pathogenic characteristics, pathogenic mechanisms, epidemiology, diagnosis and Chinese medicine treatment. It is found that pneumonia is mainly caused by pathogens via various mechanisms, often outbreaks in winter and early spring, especially in areas with poor medical conditions, and is inclined to the immunocompromised individuals, such as children under 5 years of age and the elderly, its diagnosis basis are mainly clinical features and chest CT. Up to now, almost all types of pneumonia can be accurately diagnosed and effectively improved by different traditional medicines, especially Chinese medicines, while the fast diagnosis technology which is specific to its corresponding pathogen remains urgently to be developed.","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":"2021 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135546583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The progress on the Chemical Constituents and Biological Activities of Dendrobium Officinalis Caulis","authors":"Fujunrui Jiang, Jianping Yong, Shaoji Lu, Ruiwen Huang, Jiancheng Chen, Danian Tian, canzhong lu","doi":"10.2174/0122150838254907230920054721","DOIUrl":"https://doi.org/10.2174/0122150838254907230920054721","url":null,"abstract":"Dendrobium Officinalis Caulis is a kind of Traditional Chinese Medicine, which has a long history of use and has been widely concerned by Chinese and foreign scholars. Much work on the chemical constituents (including polysaccharide, stilbene compound, flavonoids, alkaloids, volatile oil amino acids, etc.) together with their biological activities (including anti-oxidation, anti-tumor, enhance the body's immunity, anti-fatigue, regulate the digestive system, improve diabetes and so on) has been achieved. In this paper, we comprehensively reviewed the recent progress of its constitutents and biological activities, to provide the good reference for the researchers.","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135647383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medicinal Herbs for the Treatment of Peptic Ulcers","authors":"Divyansh Tiwari, Aftab Alam, Shivang Dhoundiyal, Shaweta Sharma, Shikha Yadav","doi":"10.2174/0122150838262681230920054706","DOIUrl":"https://doi.org/10.2174/0122150838262681230920054706","url":null,"abstract":"Abstract: Peptic ulcers are common gastrointestinal disorders characterized by the erosion of the stomach lining, duodenum, or esophagus. Conventional treatments, such as proton pump inhibitors and antibiotics for Helicobacter pylori eradication, have been the mainstay of therapy. However, the emergence of drug resistance and potential side effects have led to the exploration of alternative and complementary approaches, including medicinal herbs. This comprehensive review examines the potential use of medicinal herbs in the management of peptic ulcers. Ten herbal remedies, including Liquorice, Slippery Elm, Marshmallow Root, Aloe Vera, Chamomile, Ginger, Turmeric, Meadowsweet, Fenugreek, and Cabbage, are analyzed for their therapeutic properties and scientific research findings. These herbs have demonstrated anti-inflammatory, antimicrobial, and mucoprotective effects that may support ulcer healing and symptom relief. Herbal formulations, such as teas, capsules, tablets, and extracts, offer convenient delivery methods for patients seeking herbal remedies. However, safety considerations and potential herb-drug interactions must be carefully monitored. Integrating herbal remedies with conventional treatments presents a comprehensive approach to peptic ulcer management. By combining these therapies, patients may experience enhanced therapeutic outcomes and improved quality of life. Dietary recommendations also play a crucial role, with the inclusion of soothing and beneficial foods, while avoiding trigger foods that may exacerbate symptoms. As the evidence base grows, collaborative efforts between traditional herbal medicine practitioners and mainstream medical professionals are vital to ensure safe and effective integration.","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":"66 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135647186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Descriptive Analysis of the Nutraceutical Constituents, Extraction Techniques, and Possible Health Benefits of Tamarind","authors":"Pranay Wal, Biplab Debnath, Dhrubajyoti Sarkar, Neha Verma, Shruti Rathore, Ankita Wal","doi":"10.2174/2215083810666230918142027","DOIUrl":"https://doi.org/10.2174/2215083810666230918142027","url":null,"abstract":"Background: Tamarind is a multifunctional tree, with nearly every portion having significant nutritional or therapeutic use. The fruit, which produces acidic pulp, is the most valuable and often utilized portion. Objective: The aim of this paper is to discuss the distribution, habitat, chemical constituents and extraction techniques of tamarind. Method: This study reviews the chemical constituents, health benefits and extraction techniques of tamarind. Databases such as PubMed, Scopus, Science Direct, and Google Scholar were used to search articles from 1990 to 2022. The key search terms included tamarind, phytoconstituents extraction and anti-nutritional factor. Research studies also included similar plant parts extracted from similar solvents which were considered in this review. Results: According to our observations, Tamarindus indica is a crucial plant with significant pharmacological properties. It is extensively used as a conventional medicine to treat a variety of disorders; however, its active ingredients require further investigation for future drug development and pharmacological activity. Tamarind contains a diverse range of bioactive compounds, including polyphenols, flavonoids, alkaloids, vitamins, and minerals, which have been associated with various health-promoting properties. The study examines different extraction methods used to isolate tamarind's bioactive constituents, such as solvent extraction, supercritical fluid extraction (SFE), and microwave-assisted extraction (MAE). Furthermore, the research highlights the potential health benefits of tamarind, including antioxidant activity, anti-inflammatory effects, gastrointestinal support, cardiovascular benefits, and antimicrobial properties. Discussion: Tamarind includes citric acid, linoleic acid, volatile oils, vitamin C, potassium, Camp sterol, -amyrin, Tannins, saponins, and glycosides as a result of this. It has several pharmacological properties such as reducing swelling, preventing oxidation, hypolipidemic, weight loss, antibacterial, hepatoprotective, anthelmintic, and painkiller properties. These properties will assist to generate interest in Tamarind and develop novel preparations with more medicinal and commercial potential. The findings indicate that tamarind holds significant promise as a natural resource for developing functional foods, nutraceuticals, and pharmaceuticals with potential positive impacts on human health.","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135207242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}