Cutaneous and Ocular Toxicology最新文献_第8页

Topical application of sh-oligopeptide-1 and clinical trials with cosmetic preparations: risk or fraud? sh-oligopeptide-1的局部应用和化妆品制剂的临床试验：风险还是欺诈？

IF 1.6 4区医学

Cutaneous and Ocular Toxicology Pub Date : 2023-12-01 Epub Date: 2023-07-14 DOI: 10.1080/15569527.2023.2234020

Pedro A Martínez-Carpio

{"title":"Topical application of sh-oligopeptide-1 and clinical trials with cosmetic preparations: risk or fraud?","authors":"Pedro A Martínez-Carpio","doi":"10.1080/15569527.2023.2234020","DOIUrl":"10.1080/15569527.2023.2234020","url":null,"abstract":"Background: sh-oligopeptide-1 is a cosmetic that is considered to be the bioequivalent of the Epidermal Growth Factor (EGF).Objective: The systematic search and selection of the information available on sh-oligopeptide-1, and field research on laboratories manufacturing cosmetics and the legal regulation of their products.Methods: Specialised search in Medline and Google Scholar (March 2023). A total of 22 references were obtained and 12 articles were selected for analysis, 7 of which were included in Medline. 9 articles correspond to clinical trials that use sh-oligopeptide-1 as equivalent to a functional recombinant human EGF (hr-EGF). The manufacturers are investigated and they are requested to provide scientific information.Results: Using an inactive ingredient, clinical trials are published with favourable results in order to treat diabetics and cancer patients. These trials do not follow medical standards. Active EGF is not a cosmetic, rather it is a potent unauthorised drug. Likewise, sh-oligopeptide-1 is not a functional EGF, and it is not authorised for medical treatments. Topical hr-EGF is not authorised as a medication in any concentration, except for clinical trials. However, sh-EGF (sh-oligopeptide-1) is authorised as a cosmetic in several different concentrations for generalised use, with unknown long-term risks.Conclusion: Clinical studies on sh-oligopeptide-1 have no scientific basis, as the preclinical bioactivity of this molecule has not been proven.","PeriodicalId":11023,"journal":{"name":"Cutaneous and Ocular Toxicology","volume":" ","pages":"190-197"},"PeriodicalIF":1.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10137107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of choroidal thickness and choroidal vascular index in patients using combined oral contraceptive pills. 联合口服避孕药患者的脉络膜厚度和脉络膜血管指数的评估。

IF 1.6 4区医学

Cutaneous and Ocular Toxicology Pub Date : 2023-12-01 Epub Date: 2023-07-18 DOI: 10.1080/15569527.2023.2235429

Mehmet Icoz, Sema Yuzbasioglu

{"title":"Evaluation of choroidal thickness and choroidal vascular index in patients using combined oral contraceptive pills.","authors":"Mehmet Icoz, Sema Yuzbasioglu","doi":"10.1080/15569527.2023.2235429","DOIUrl":"10.1080/15569527.2023.2235429","url":null,"abstract":"Purpose: To evaluate the choroidal thickness and choroidal vascular index (CVI) in healthy women using the combined oral contraceptive pill (COCp).Methods: This prospective study included 30 women using COCp (3 mg drospirenone/0.03 mg ethinylestradiol) for contraception for at least 1 year and 30 healthy women who did not use COCp. Intraocular pressure (IOP), axial length (AL) and body mass index (BMI) values of all participants were recorded. Subfoveal choroidal thickness (SCT) and choroidal thickness at 1500 micron distance in nasal and temporal regions (NCT, TCT) were measured through optical coherence tomography (OCT) images. Luminal, stromal and total choroidal area values were evaluated by binarization method. The ratio of the luminal choroidal area to the total choroidal area was determined as the CVI value.Results: There was no statistically significant difference in IOP and AL values between the two groups at no significant difference in age and BMI index (p > 0.05, for all). SCT, NCT and TCT values were no significant difference in the two groups (p > 0.05, for all). Luminal and stromal choroidal area values were found to be lower in the group using COCp (p = 0.01, p = 0.02 respectively). The CVI value was 62.1 ± 3.6% in the COCp group and 65.6 ± 4.3% in the control group. There was a significant difference between the two groups in terms of CVI value (p = 0.002).Conclusion: To our knowledge, this is the first study to evaluate CVI in women using COCp, and CVI was found to be lower in individuals using COCp. Therefore, CVI can be used in the follow-up of possible ocular pathologies that may develop in individuals using COCp.","PeriodicalId":11023,"journal":{"name":"Cutaneous and Ocular Toxicology","volume":" ","pages":"232-236"},"PeriodicalIF":1.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9818974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The effect of baseline intraocular pressure and anterior segment parameters on intraocular pressure after intravitreal bevacizumab injection. 玻璃体内注射贝伐单抗后基线眼压和眼前节参数对眼压的影响。

IF 1.6 4区医学

Cutaneous and Ocular Toxicology Pub Date : 2023-12-01 Epub Date: 2023-08-07 DOI: 10.1080/15569527.2023.2243505

Zeynep Özer Özcan, Gizem Gürbostan Soysal, Nesime Setge Tıskaoğlu, Mustafa Berhuni

{"title":"The effect of baseline intraocular pressure and anterior segment parameters on intraocular pressure after intravitreal bevacizumab injection.","authors":"Zeynep Özer Özcan, Gizem Gürbostan Soysal, Nesime Setge Tıskaoğlu, Mustafa Berhuni","doi":"10.1080/15569527.2023.2243505","DOIUrl":"10.1080/15569527.2023.2243505","url":null,"abstract":"Purpose: We aimed to compare the predictive effect of pre-injection intraocular pressure (IOP) and anterior segment parameters on post-injection IOP values after intravitreal bevacizumab injection for neovascular age-related macular degeneration (NVAMD) in phakic and pseudophakic patient groups.Material and methods: This retrospective cross-sectional study included 65 eyes of 65 treatment-naive NVAMD patients. Patients were divided into two groups according to their lens status (35 phakic and 30 pseudophakic patients). Pre-injection IOP, anterior segment parameters measured with PENTACAM, and post-injection IOP values measured at the 5th minute were recorded. Univariate and multivariate regression analyses were used to recognise the predictive effect of pre-injection IOP and anterior segment parameters on post-injection IOP for each group.Results: Multivariate regression analyses showed that the decrease in anterior chamber depth (ACD), and the increase in pre-injection IOP were significantly correlated with higher post-injection IOP in the phakic patient group (p = 0.019 and 0.031; respectively). No correlation was found in the pseudophakic patient group.Conclusion: Pre-injection ACD and IOP values may be predictive of higher post-injection IOP in phakic patients. Preoperative assessment of these parameters could be beneficial in patients at risk of glaucoma.","PeriodicalId":11023,"journal":{"name":"Cutaneous and Ocular Toxicology","volume":" ","pages":"248-252"},"PeriodicalIF":1.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9945542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Time to treat the climate and nature crisis as one indivisible global health emergency. 是时候将气候和自然危机视为一个不可分割的全球卫生紧急事件了。

IF 1.6 4区医学

Cutaneous and Ocular Toxicology Pub Date : 2023-11-06 DOI: 10.1080/15569527.2023.2276593

Kamran Abbasi, Parveen Ali, Virginia Barbour, Thomas Benfield, Kirsten Bibbins-Domingo, Gregory E Erhabor, Stephen Hancocks, Richard Horton, Laurie Laybourn-Langton, Robert Mash, Peush Sahni, Wadeia Mohammad Sharief, Paul Yonga, Chris Zielinski

引用次数: 0

Effects of fluorescein on corneal endothelial morphology after fundus fluorescein angiography in patients with diabetic macular edema. 荧光素对糖尿病性黄斑水肿患者眼底荧光素血管造影后角膜内皮形态的影响。

IF 1.6 4区医学

Cutaneous and Ocular Toxicology Pub Date : 2023-09-01 DOI: 10.1080/15569527.2023.2215346

Utku Limon, Işılay Özsoy Saygın, Tuğba Aydoğan Gezginaslan, Erdinç Bozkurt, Sinan Bulut, Betül Ilkay Sezgin Akçay

{"title":"Effects of fluorescein on corneal endothelial morphology after fundus fluorescein angiography in patients with diabetic macular edema.","authors":"Utku Limon, Işılay Özsoy Saygın, Tuğba Aydoğan Gezginaslan, Erdinç Bozkurt, Sinan Bulut, Betül Ilkay Sezgin Akçay","doi":"10.1080/15569527.2023.2215346","DOIUrl":"https://doi.org/10.1080/15569527.2023.2215346","url":null,"abstract":"Purpose: To evaluate the effects of fluorescein dye on corneal endothelial morphology (CEM) after fundus fluorescein angiography (FFA) in patients with diabetic macular edema (DME).Methods: In this retrospective study, patients were divided into two groups, nonproliferative diabetic retinopathy (Group-1, NPDR) and proliferative diabetic retinopathy (Group-2, PDR). CEM properties including endothelial cell density (ECD), coefficient of variation of cell area (CV), average cell area (AVG), percentage of hexagonal cells (HEX), and central corneal thickness (CCT) were measured before FFA and at week 1 and month 1 after FFA were collected from patients' charts.Results: The study consisted of 48 patient's 48 eyes in Group-1 and 50 patient's 50 eyes in Group-2. In both groups, the mean ECD, CV, AVG, HEX, and CCT measurements at week 1 and month 1 after FFA did not differ statistically from the mean measurements before FFA (p > 0.05). The mean ECD measurements in Group-1 were higher than that in Group-2 and showed statistically significant differences among the groups (p < 0.01 for all). In the Pearson correlation analysis in Group-1, there was no statistically significant relationship between best-corrected visual acuity (BCVA) and (intraocular pressure) IOP values and ECD, AVG, CV, HEX, and CCT measurements (except central macular thickness [CMT] and HEX) before FFA, at week 1 and month 1 after FFA (p > 0.05). In Group-2 there was no statistically significant relationship between BCVA, IOP, and CMT measurements and ECD, AVG, CV, HEX, and CCT measurements before FFA, at week 1 and month 1 after FFA (p > 0.05).Conclusions: There is no significant change in CEM after FFA in patients with NPDR and PDR with DME.","PeriodicalId":11023,"journal":{"name":"Cutaneous and Ocular Toxicology","volume":"42 3","pages":"91-96"},"PeriodicalIF":1.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9959547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Toxicity of simultaneous intrastromal and intracameral injection of voriconazole on corneal endothelium in a rabbit model. 同时眼内和眼内注射伏立康唑对兔角膜内皮的毒性作用。

IF 1.6 4区医学

Cutaneous and Ocular Toxicology Pub Date : 2023-09-01 DOI: 10.1080/15569527.2023.2226714

Ji Young Moon, Wool Suh, Roo Min Jun, Kyung Eun Han

{"title":"Toxicity of simultaneous intrastromal and intracameral injection of voriconazole on corneal endothelium in a rabbit model.","authors":"Ji Young Moon, Wool Suh, Roo Min Jun, Kyung Eun Han","doi":"10.1080/15569527.2023.2226714","DOIUrl":"https://doi.org/10.1080/15569527.2023.2226714","url":null,"abstract":"Purpose: To investigate the toxicity of repeated simultaneous intrastromal and intracameral injections of voriconazole in corneal endothelial cells in a rabbit model.Methods: Thirty-six eyes of 18 New Zealand white rabbits (six eyes per group) were divided into 6 groups according to the concentration of voriconazole (Group A, 0%; Group B, 0.05%; Group C, 0.1%; Group D, 0.25%; Group E, 0.5%; Group F, 1%). A combination of intrastromal and intracameral voriconazole injections were administrated to the eyes of each group three times on days 0, 3, and 7. Corneal clouding grades and central corneal thickness (CCT) were examined on days 0, 3, 7, 10, and 14. The endothelial cell counts (ECC) were measured on days 0 and 14. Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) were performed on day 14.Results: Group F (1%) showed more severe corneal clouding than the other groups (Groups A-E) from day 7 (p < 0.05, respectively). There were no significant differences in CCT and ECC among the six groups at any time point (p > 0.05, respectively). SEM revealed blurring of the cell border and loss of microvilli at concentrations ≥0.25% (Groups D-F). TEM revealed microstructural changes in endothelial cells at concentrations ≥0.1% (Groups C-F), and multiple vacuoles were observed at a concentration of 1% voriconazole (Group F).Conclusions: Repeated simultaneous intrastromal and intracameral voriconazole injections at a concentration of 0.1% or higher induced microstructural endothelial damage in rabbit corneal endothelial cells.","PeriodicalId":11023,"journal":{"name":"Cutaneous and Ocular Toxicology","volume":"42 3","pages":"144-150"},"PeriodicalIF":1.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10011428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Short time effect of sodium fluorescein on chorodial vascularity index. 荧光素钠对脉络膜血管指数的短期影响。

IF 1.6 4区医学

Cutaneous and Ocular Toxicology Pub Date : 2023-09-01 DOI: 10.1080/15569527.2023.2227894

Selim Cevher, Mehmet Barış Üçer, Mustafa Duran

{"title":"Short time effect of sodium fluorescein on chorodial vascularity index.","authors":"Selim Cevher, Mehmet Barış Üçer, Mustafa Duran","doi":"10.1080/15569527.2023.2227894","DOIUrl":"https://doi.org/10.1080/15569527.2023.2227894","url":null,"abstract":"Purpose: This study aimed to investigate the effect of sodium fluorescein on the choroidal vascularity index (CVI).Materials and methods: In this cross-sectional study, a total of 27 eyes of 27 mild nonproliferative diabetic retinopathy patients (without maculopathy and any systemic disease) who performed fluorescein angiography (FA) procedure were included. Choroidal parameters such as choroidal thickness (CT), total choroidal area (TCA), luminal area (LA), stromal area (SA), LA/SA, and CVI were examined with the optical coherence tomography and binarization technique at baseline and 5th, 15th, and 30th minutes after FA. The values of the parameters before and after the procedure were compared.Results: At baseline, the mean values of the TCA, LA, SA, LA/SA, and CVI were 0.44 ± 0.14mm2, 0.29 ± 0.09 mm2, 0.15 ± 0.05 mm2, 1.87 ± 0.19. Five minutes later to FA, the mean values of the TCA, LA, SA, LA/SA, and CVI were 0.43 ± 0.13 mm2, 0.28 ± 0.08 mm2, 0.15 ± 0.05 mm2, 1.82 ± 0.20, and 0.64 ± 0.03, respectively. There was a significant decrease in LA and CVI values 5 minutes after FA (p:0.002 and p:0.021, respectively). On the other hand, the mean, nasal, subfoveal, and temporal CT were 279.22 ± 93.40 μm, 289.78 ± 91.17 μm, 267.44 ± 95.71 μm before FA and 270.33 ± 90.34 μm, 279.67 ± 90.01 μm, 261.82 ± 95.82 μm 5 minutes after FA (p = 0.960, p = 0.952, and p = 0.991, respectively). Although there was a reduction in the value of CT, there was not a statistically significant difference between before and after FA.Conclusions: This study shows that there was a significant decrease in LA and CVI values 5 minutes after FA in patients with mild nonproliferative diabetic retinopathy.","PeriodicalId":11023,"journal":{"name":"Cutaneous and Ocular Toxicology","volume":"42 3","pages":"168-173"},"PeriodicalIF":1.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9957224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Toxicological evaluation of a nonlethal riot control combinational formulation upon dermal application using animal models. 一种非致死性防暴组合制剂在动物模型皮肤应用上的毒理学评价。

IF 1.6 4区医学

Cutaneous and Ocular Toxicology Pub Date : 2023-09-01 DOI: 10.1080/15569527.2023.2220393

Sanghita Das, Achintya Saha, Amartya Banerjee, Danswrang Goyary, Sanjeev Karmakar, Sanjai Kumar Dwivedi, Pronobesh Chattopadhyay

{"title":"Toxicological evaluation of a nonlethal riot control combinational formulation upon dermal application using animal models.","authors":"Sanghita Das, Achintya Saha, Amartya Banerjee, Danswrang Goyary, Sanjeev Karmakar, Sanjai Kumar Dwivedi, Pronobesh Chattopadhyay","doi":"10.1080/15569527.2023.2220393","DOIUrl":"https://doi.org/10.1080/15569527.2023.2220393","url":null,"abstract":"Numerous adverse effects on human health have been reported in epidemiological studies of oleoresin capsicum (OC) and other riot control agents (RCAs). Importantly, the daunting risk of such RCAs can be neutralized by optimizing the desired concentration of such agents for mob dispersal. Hence, a nonlethal riot control combinational formulation (NCF) was prepared for dispersing rioters without imparting fatal outcomes. However, for desired utilization of NCF, it is essential to recognize its extent of potential toxicity. Therefore, the current investigation evaluated the dermal toxicity of NCF using experimental animals in compliance with the OECD guidelines. Additionally, few essential metal ions were analyzed and found non -significantly different in the test rats as compared to control rats. Moreover, abnormal dermal morphology and lesions ultrastructural tissue defects were not noticed as evinced by different studies like ultrasonography, histology, and scanning electron microscopy (SEM) respectively. Further, Doppler ultrasonography exhibited non-significantly different blood flow velocity in both groups, whereas miles test demonstrated a significantly increased Evans blue concentration in test rats compared to the control rats, which might be due to an initial increase in blood flow via an instant action of the NCF at the cutaneous sensory nerve endings. However, our results demonstrated NCF can produce initial skin irritating and sensitizing effects in guinea pigs and rabbits without the antecedence of acute toxicity (≤2000 mg/kg) in Wistar rats.","PeriodicalId":11023,"journal":{"name":"Cutaneous and Ocular Toxicology","volume":"42 3","pages":"118-130"},"PeriodicalIF":1.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9948456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating the effects of dermal exposure to in-vivo animal models on the riot-control properties of a powder formulation of Tragia involucrata leaf hair lining. 研究皮肤接触活体动物模型对天花花叶毛衬里粉末配方抗暴性能的影响。

IF 1.6 4区医学

Cutaneous and Ocular Toxicology Pub Date : 2023-09-01 DOI: 10.1080/15569527.2023.2227255

Trishna Mani Nath, Sanghita Das, Zothanpuia, Pronobesh Chattopadhyay

{"title":"Investigating the effects of dermal exposure to in-vivo animal models on the riot-control properties of a powder formulation of Tragia involucrata leaf hair lining.","authors":"Trishna Mani Nath, Sanghita Das, Zothanpuia, Pronobesh Chattopadhyay","doi":"10.1080/15569527.2023.2227255","DOIUrl":"https://doi.org/10.1080/15569527.2023.2227255","url":null,"abstract":"Purpose: Riot control agents (RCAs) such as CS, CN, CR, PAVA, and OC, etc., are already in use and has produced numerous health risks, including skin burns, dermatitis, gastrointestinal issues, impairment of respiratory variables, conjunctivitis, etc., and even prolonged and repeated exposure may cause death. Therefore, there is a demand and need for non-lethal, non-toxic RCAs that can effectively control riots without resulting in fatal outcomes. This study was carried out to evaluate the health risks related to a novel formulation made from isolated Tragia involucrata leaf hair lining, that can be used as the best suitable non-lethal RCAs.Methods: According to the OECD guidelines, studies on acute dermal toxicity, dermal irritation/corrosion, and skin sensitisation were carried out. Wistar rats were used in an acute dermal toxicity study, and the results indicated no mortality, morbidity, or abnormal food-and-water intake, biochemical parameters, or histopathological examination findings. A study on dermal irritation in Rabbits produced moderate erythema and the effect was instantaneous and resolved within 72 hrs of post-exposure. A skin sensitisation test was conducted on Guinea pig.Results: The results showed that the formulation had moderate skin-sensitizing properties after the application of the challenge dose. Patchy erythema was seen, and it went away 30 hrs after the gauze patch was removed.Conclusion: The preclinical results did not produce any indication of severe toxicity which supports it to be used as a natural RCAs in the future.","PeriodicalId":11023,"journal":{"name":"Cutaneous and Ocular Toxicology","volume":"42 3","pages":"151-161"},"PeriodicalIF":1.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9948999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Systemic isotretinoin therapy and central macular and choroidal thicknesses in acne vulgaris: is there any association? 寻常痤疮的全身异维甲酸治疗与中央黄斑和脉络膜厚度:有任何关联吗?

IF 1.6 4区医学

Cutaneous and Ocular Toxicology Pub Date : 2023-09-01 DOI: 10.1080/15569527.2023.2227895

Alireza Dehghani, Saeed Kargar, Gita Faghihi, Neda Adibi, Pegah Noorshargh, Shakiba Dehghani, Mohsen Pourazizi, Bahareh Abtahi-Naeini

{"title":"Systemic isotretinoin therapy and central macular and choroidal thicknesses in acne vulgaris: is there any association?","authors":"Alireza Dehghani, Saeed Kargar, Gita Faghihi, Neda Adibi, Pegah Noorshargh, Shakiba Dehghani, Mohsen Pourazizi, Bahareh Abtahi-Naeini","doi":"10.1080/15569527.2023.2227895","DOIUrl":"https://doi.org/10.1080/15569527.2023.2227895","url":null,"abstract":"Purpose: To investigate the effect of oral isotretinoin therapy on central macular thickness (CMT) thickness and choroidal thickness (CT) using optical coherence tomography (OCT).Methods: CT and CMT thickness of 43 eyes were evaluated at baseline, the third, and sixth month of isotretinoin therapy by spectral-domain OCT. For assessment of CT, OCT measurements were obtained at the fovea with six additional measurements at adjacent locations (at 500-1000 µm temporal to the fovea and 500-1000 µm nasal to the fovea).Results: Forty-three eyes from 43 patients with acne vulgaris, including 33 females (76.7%), who had a mean age of 24.81 ± 6.60 years, completed the study. The mean CMT was 231.49 ± 19.52 at the baseline and significantly decreased to 229.0 ± 19.57 (p = 0.02) and 229.28 ± 18.83 after three and six months, respectively (p < 0.03). The change in the macular thicknesses measured at four quadrants and choroidal thicknesses were not statistically significant during the study (p > 0.05).Conclusion: The result of our study demonstrated choroidal thickness change is not significant in patients with acne vulgaris after systemic isotretinoin therapy during six months of follow-up. The decreased CMT amount was 2.2 microns; even if statistically significant, this amount is clinically insignificant.","PeriodicalId":11023,"journal":{"name":"Cutaneous and Ocular Toxicology","volume":"42 3","pages":"174-178"},"PeriodicalIF":1.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9957821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0