Cutaneous and Ocular Toxicology最新文献_第8页

Corneal endothelial density and morphology in long-term soft contact lens users in Japan: a retrospective cross-sectional study of 17,732 eyes. 日本长期佩戴软性隐形眼镜者的角膜内皮密度和形态：一项对 17732 只眼睛进行的回顾性横断面研究。

IF 1.6 4区医学

Cutaneous and Ocular Toxicology Pub Date : 2024-12-01 Epub Date: 2024-10-01 DOI: 10.1080/15569527.2024.2408685

Takashi Ono, Tomoko Kaida, Shizuka Higashi, Yosai Mori, Ryohei Nejima, Takuya Iwasaki, Fumie Kagaya, Takashi Miyai, Kazunori Miyata

{"title":"Corneal endothelial density and morphology in long-term soft contact lens users in Japan: a retrospective cross-sectional study of 17,732 eyes.","authors":"Takashi Ono, Tomoko Kaida, Shizuka Higashi, Yosai Mori, Ryohei Nejima, Takuya Iwasaki, Fumie Kagaya, Takashi Miyai, Kazunori Miyata","doi":"10.1080/15569527.2024.2408685","DOIUrl":"10.1080/15569527.2024.2408685","url":null,"abstract":"Purpose: There is a lack of long-term and large-scale studies on the adverse effects of soft contact lenses (SCLs) on the corneal endothelia of Asian populations. Here, we aimed to examine the effects of long-term SCL use on corneal endothelial density and morphology.Materials and methods: This retrospective study involved consecutive patients at the Miyata Eye Hospital (Miyazaki, Japan), who had used SCLs for more than 1 year. Patients with ophthalmological disorders without refractive errors were excluded. The period of SCL use, SCL type, corneal endothelial cell density (ECD), appearance rate of hexagonal cells (HEX), and coefficient of variation of cells (CV) were analyzed.Results: In total, 17,732 eyes of 8866 patients were included in the analysis (age, 26.0 ± 8.8 years). The mean period of SCL use was 6.3 ± 5.4 years. Multivariate regression analysis revealed that ECD and HEX were significantly negatively correlated with the period of SCL use, age, and sex (p < 0.001 for all). The CV was significantly positively correlated with the period of use (p < 0.001), sex (p = 0.002), and age (p < 0.001).Conclusions: Corneal ECD, HEX, and CV were significantly associated with the period of SCL use in long-term users. It is essential to regularly check the corneal endothelium in patients with a history of long-term SCL use.","PeriodicalId":11023,"journal":{"name":"Cutaneous and Ocular Toxicology","volume":" ","pages":"335-340"},"PeriodicalIF":1.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142343345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of the efficacy and safety of lacrimal gland botulinum toxin injection in functional versus non-functional epiphora 比较泪腺肉毒毒素注射治疗功能性与非功能性眼睑外翻的疗效和安全性

IF 1.6 4区医学

Cutaneous and Ocular Toxicology Pub Date : 2024-09-17 DOI: 10.1080/15569527.2024.2402402

Meryem Altin Ekin

引用次数: 0

A national analysis of systemic adverse events of beta-blockers used for glaucoma therapy. 对用于青光眼治疗的β-受体阻滞剂全身不良反应的全国性分析。

IF 1.6 4区医学

Cutaneous and Ocular Toxicology Pub Date : 2024-09-12 DOI: 10.1080/15569527.2024.2402408

Owais M Aftab,Hamza Khan,Roshun Sangani,Albert S Khouri

{"title":"A national analysis of systemic adverse events of beta-blockers used for glaucoma therapy.","authors":"Owais M Aftab,Hamza Khan,Roshun Sangani,Albert S Khouri","doi":"10.1080/15569527.2024.2402408","DOIUrl":"https://doi.org/10.1080/15569527.2024.2402408","url":null,"abstract":"PURPOSETo evaluate systemic complications for timolol, carteolol, levobunolol, and/or betaxalol by using an FDA Federal Adverse Event Reporting System (FAERS).METHODSWe evaluated FAERS for adverse events associated with β-blocker use for glaucoma. All reported symptoms were reviewed to identify systemic adverse events and to detect safety signals, defined as information on a new or known side effect that may be caused by a medicine. We used the proportional reporting ratio (PRR), reporting odds ratio (ROR), empirical Bayes geometric mean (EBGM), and information component (IC) as a part of a disproportionality analysis comparing the frequency of β-blocker symptoms with all other adverse event reports. We considered a signal to be detected when all four disproportionality analysis metrics were positive.RESULTSWe found 10,500,309 total adverse event reports from the FAERS database 2004-2022Q3, which included 8,793 case reports with a primary suspect of a β-blocker use for glaucoma. 1,838 unique adverse symptoms were reported were associated with β-blocker. Regarding outcomes, there were 165 (1.88%) reports of disability, 671 (7.63%) reports of hospitalisation, and 1,934 (21.99%) reports of some other unspecified complication. Regarding adverse events, the most reported general, cardiac, and respiratory symptoms were respectively dizziness (n = 281), bradycardia (n = 145), and dyspnoea (n = 195). 256 (2.91%) cases of death were reported. We found significant signals on bradycardia (n = 145), complete atrioventricular block (n = 38), and bronchospasm (n = 23). No allergic, endocrine, constitutional, or gastrointestinal symptoms generated positive signals.CONCLUSIONβ-blocker use in glaucoma therapy can be rarely associated with serious systemic and life-threatening complications.","PeriodicalId":11023,"journal":{"name":"Cutaneous and Ocular Toxicology","volume":"33 1","pages":"1-6"},"PeriodicalIF":1.6,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142198824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect Of Pentavalent Antimony Compounds On The İnflammatory, Hematological and Biochemical Parameters İn Patients With Cutaneous Leishmaniasis 五价锑化合物对皮肤利什曼病患者的炎症、血液学和生化指标的影响

IF 1.6 4区医学

Cutaneous and Ocular Toxicology Pub Date : 2024-09-09 DOI: 10.1080/15569527.2024.2402411

Kadir Kaya

引用次数: 0

The Effect of Adrenaline and Trypan Blue Used During Cataract Surgery on Anatomical and Functional Outcomes in Pseudoexfoliation Syndrome Patients. 白内障手术中使用肾上腺素和胰蓝对假性角膜外翻综合征患者解剖和功能结果的影响

IF 1.6 4区医学

Cutaneous and Ocular Toxicology Pub Date : 2024-09-09 DOI: 10.1080/15569527.2024.2402405

Ömer Özer,Levent Doĝan,Zeki Baysal

{"title":"The Effect of Adrenaline and Trypan Blue Used During Cataract Surgery on Anatomical and Functional Outcomes in Pseudoexfoliation Syndrome Patients.","authors":"Ömer Özer,Levent Doĝan,Zeki Baysal","doi":"10.1080/15569527.2024.2402405","DOIUrl":"https://doi.org/10.1080/15569527.2024.2402405","url":null,"abstract":"PURPOSETo evaluate the effect of the intracameral adrenaline and trypan blue used during cataract surgery on corneal endothelial parameters in pseudoexfoliation syndrome (PEX) patients.METHODSThe patients were divided into four groups according to intraoperative use of agents during cataract surgery: intracameral adrenaline (1/10,000, 0.1 ml) (group 1), trypan blue (0.6 mg/ml, 0.1 ml) (group 2), combination of adrenaline and trypan blue (group 3) and none (group 4).RESULTSPreoperative ECD, CV, HEX and CCT parameters were similar between the groups. A mean loss of 12.7% in ECD was observed at the postoperative third months compared to the preoperative. In group 3, ECD was found to be lower in the postoperative third months compared to the preoperative (p = 0.014). In the other groups, no statistically significant difference was found in preoperative and postoperative comparisons.CONCLUSIONIn conclusion, the utilization of intracameral adrenaline or trypan blue did not cause a significant difference in corneal endothelium in PEX patients. However, their combined use may have a negative effect on endothelial cell density. In a cataract surgery performed in the presence of PEX, the increased likelihood of endothelial damage should be taken into consideration, and appropriate precautions should be taken preoperatively and intraoperatively.","PeriodicalId":11023,"journal":{"name":"Cutaneous and Ocular Toxicology","volume":"4 1","pages":"1-11"},"PeriodicalIF":1.6,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142225483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The relationship between TNF-α, IL-1, IL-12, IL-17, IL-23, IL-36 expression and treatment response in psoriasis histopathologically and immunohistochemically. 银屑病组织病理学和免疫组化中 TNF-α、IL-1、IL-12、IL-17、IL-23、IL-36 表达与治疗反应的关系

IF 1.6 4区医学

Cutaneous and Ocular Toxicology Pub Date : 2024-09-01 Epub Date: 2024-07-25 DOI: 10.1080/15569527.2024.2380310

Selami Aykut Temiz, Recep Dursun, Sıddıka Fındık, Arzu Ataseven, Begüm Işık, İlkay Özer

{"title":"The relationship between TNF-α, IL-1, IL-12, IL-17, IL-23, IL-36 expression and treatment response in psoriasis histopathologically and immunohistochemically.","authors":"Selami Aykut Temiz, Recep Dursun, Sıddıka Fındık, Arzu Ataseven, Begüm Işık, İlkay Özer","doi":"10.1080/15569527.2024.2380310","DOIUrl":"10.1080/15569527.2024.2380310","url":null,"abstract":"Aim: There is no marker that can predict whether there is resistance to treatment in patients with psoriasis. In this study, we investigated the relationship between the staining rates of TNF-α, IL-1, IL-12, IL-17, IL-23, and IL-36 markers immunohistochemically from cutaneous biopsy and the treatment success.Methods: The patients who were followed up in the dermatology clinic with the diagnosis of plaque-type psoriasis vulgaris and received biological treatment and previously had cutaneous biopsy were included in the study. The cutaneous biopsies of the cases that met the conditions were re-sectioned and subjected to immunohistochemical examination for TNF-α, IL-1, IL-12, IL-17, IL-23, and IL-36.Results: Comparing the staining scores with psoriasis area severity index (PASI); A statistically significant positive correlation was found between PASI and TNF-α staining score (p = 0.034). A statistically significant positive correlation was found between PASI and IL-17 staining score (p = 0.004). When the staining scores and PASI response rates of psoriasis treatment were evaluated in terms of correlation; there was a positive correlation between TNF-α, IL-17, and IL-23 immunohistochemical staining rates and PASI response rates.Conclusions: In line with the data obtained from our study, we think that making immunohistochemical scoring before the biological treatment decision in psoriasis patients will be beneficial in treatment selection. In this respect, our study may open a new era in the selection of biological treatments for psoriasis.","PeriodicalId":11023,"journal":{"name":"Cutaneous and Ocular Toxicology","volume":" ","pages":"182-189"},"PeriodicalIF":1.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141632950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ophthalmic adverse effects of miltefosine in the treatment of leishmaniasis: a systematic review. 治疗利什曼病的米替福新对眼部的不良影响：系统综述。

IF 1.6 4区医学

Cutaneous and Ocular Toxicology Pub Date : 2024-09-01 Epub Date: 2024-07-18 DOI: 10.1080/15569527.2024.2380311

Biplab Pal, Tambe Daniel Atem, Sweta Kumari, Krishna Murti, Rishikesh Kumar, Krishna Pandey, Niyamat Ali Siddiqui, Sameer Dhingra, Vaibhav Chaudhary

{"title":"Ophthalmic adverse effects of miltefosine in the treatment of leishmaniasis: a systematic review.","authors":"Biplab Pal, Tambe Daniel Atem, Sweta Kumari, Krishna Murti, Rishikesh Kumar, Krishna Pandey, Niyamat Ali Siddiqui, Sameer Dhingra, Vaibhav Chaudhary","doi":"10.1080/15569527.2024.2380311","DOIUrl":"10.1080/15569527.2024.2380311","url":null,"abstract":"Objective: Miltefosine stands as the sole oral medication approved for the treatment of leishmaniasis. The appearance of severe ophthalmic toxicities induced by miltefosine in the context of leishmaniasis treatment is a matter of significant concern. The main objective of this study is to present a comprehensive summary of the ophthalmic adverse effects associated with miltefosine when used in the treatment of leishmaniasis.Methods: A systematic search was performed on PubMed, ScienceDirect, Embase, Scopus, and Google Scholar, covering articles from inception up to June 2023, without language restrictions, to identify relevant studies documenting ocular toxicity following miltefosine treatment for leishmaniasis.Results: A total of eight studies involving 31 leishmaniasis patients who developed ocular toxicities while undergoing miltefosine treatment were included in the analysis. These studies were conducted in various regions, with five originating from India, two from Bangladesh, and one from Nepal. Patients presented a spectrum of ophthalmic complications, including uveitis, keratitis, scleritis, and Mooren's ulcer. Commonly reported symptoms included pain, redness, excessive tearing, partial vision impairment, permanent blindness, light sensitivity, and the appearance of white spots on the eye. On average, patients received miltefosine treatment for a duration of 47 days before experiencing the onset of ocular problems. It is important to note that the risk of ocular toxicities increases with prolonged use of miltefosine.Conclusions: Therefore, to mitigate the potential for irreversible damage to the eyes, it is imperative that all individuals undergoing miltefosine therapy undergo regular eye examinations.","PeriodicalId":11023,"journal":{"name":"Cutaneous and Ocular Toxicology","volume":" ","pages":"190-197"},"PeriodicalIF":1.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141632948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of systemic isotretinoin treatment on the tear film, meibomian glands, and corneal endothelium. 全身性异维A酸治疗对泪膜、睑板腺和角膜内皮的影响。

IF 1.6 4区医学

Cutaneous and Ocular Toxicology Pub Date : 2024-09-01 Epub Date: 2024-06-14 DOI: 10.1080/15569527.2024.2366856

Kamile Demir, Feyzahan Uzun

{"title":"The impact of systemic isotretinoin treatment on the tear film, meibomian glands, and corneal endothelium.","authors":"Kamile Demir, Feyzahan Uzun","doi":"10.1080/15569527.2024.2366856","DOIUrl":"10.1080/15569527.2024.2366856","url":null,"abstract":"Purpose: The study aims to investigate changes in tear function, meibomian glands and corneal endothelium in patients receiving systemic isotretinoin therapy.Materials and methods: This prospective study included 38 eyes from 38 patients (23 females and 15 males) treated with systemic isotretinoin (0.5-1 mg/kg/day) following the diagnosis of acne vulgaris. All patients underwent a comprehensive ophthalmologic examination at baseline, 1st month, and third month of treatment. Subjective complaints were assessed using the Ocular Surface Disease Index (OSDI). Tear functions were evaluated through non-invasive tear break up time (NIBUT) and Schirmer I test. Meibomian gland (MG) changes were examined using meibography. Corneal parameters, including endothelial cell density (ECD), coefficient of variation (CV), the number of cells with a hexagonal shape (6A), average cell area (AVG), and central corneal thickness (CCT) were assessed using non-contact specular microscopy.Results: The mean age of the patients was 19.29 ± 2.83 years. Ocular surface-related discomfort, measured with OSDI scores, significantly worsened at the third month measurements compared to the pre-treatment values (p < 0.001). In the 1st month of treatment, there was a significant decrease in NIBUT (p < 0.05). No statistically significant difference was found in the Schirmer test results at each visit. According to the 1st and third-month analysis, there was a significant increase in MG loss compared to the pre-treatment period (p < 0.001). ECD, CV, 6 A, AVG measurements at the first and third months showed a significant change compared to the pre-treatment values (p < 0.001). No significant difference was observed in the CCT measurements during the treatment.Conclusion: Systemic isotretinoin disrupted tear stability, caused MG loss, deterioration in corneal endothelium, and led to symptomatic complaints in patients.","PeriodicalId":11023,"journal":{"name":"Cutaneous and Ocular Toxicology","volume":" ","pages":"176-181"},"PeriodicalIF":1.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141317101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of low-dose methotrexate on erectile dysfunction, sex hormone profile and spermiogram in male patients with psoriasis: a prospective study. 小剂量甲氨蝶呤对男性银屑病患者勃起功能障碍、性激素谱和精子图的影响：一项前瞻性研究。

IF 1.6 4区医学

Cutaneous and Ocular Toxicology Pub Date : 2024-09-01 Epub Date: 2024-06-03 DOI: 10.1080/15569527.2024.2360736

Hatice Atas, Tuğcan Yüksek, Ahmet Nihat Karakoyunlu, Selda Pelin Kartal, Gamze Taş Aygar

{"title":"The impact of low-dose methotrexate on erectile dysfunction, sex hormone profile and spermiogram in male patients with psoriasis: a prospective study.","authors":"Hatice Atas, Tuğcan Yüksek, Ahmet Nihat Karakoyunlu, Selda Pelin Kartal, Gamze Taş Aygar","doi":"10.1080/15569527.2024.2360736","DOIUrl":"10.1080/15569527.2024.2360736","url":null,"abstract":"Purpose: Psoriasis, affecting approximately 2% of the world's population, often necessitates systemic treatments, with methotrexate (MTX) as a cornerstone therapy. Despite documented systemic side effects of MTX, concerns about its impact on male reproductive health persist. We aim to investigate low-dose MTX effect on hormonal, cellular and functional ability of male reproductive system.Materials and methods: Our prospective study on 40 male psoriasis patients receiving low-dose MTX (<15mg/week) comprehensively investigates its effects on erectile function, sex hormones, and spermiogram parameters.Results: After six months of MTX treatment, a significant decline in erectile function (p < 0.001) decreased total testosterone levels (p = 0.03) were observed. No significant reduction in sperm count was noted after six months of MTX treatment.Conclusions: Our study highlights a significant decline in erectile function following low-dose MTX therapy, warranting further investigation into this potential side effect. While reassuring for sperm quantity and quality, the findings emphasise the necessity for larger cohorts and longer follow-up times to validate results and comprehend the complex interactions between MTX and male sexual health.","PeriodicalId":11023,"journal":{"name":"Cutaneous and Ocular Toxicology","volume":" ","pages":"161-166"},"PeriodicalIF":1.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141175101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of three different mydriatic eye drops on retinal vessel diameters. 三种不同的眼药水对视网膜血管直径的影响

IF 1.6 4区医学

Cutaneous and Ocular Toxicology Pub Date : 2024-09-01 Epub Date: 2024-07-18 DOI: 10.1080/15569527.2024.2380318

Osman Sayin, Hasan Altinkaynak

{"title":"The effect of three different mydriatic eye drops on retinal vessel diameters.","authors":"Osman Sayin, Hasan Altinkaynak","doi":"10.1080/15569527.2024.2380318","DOIUrl":"10.1080/15569527.2024.2380318","url":null,"abstract":"Purpose: To investigate the effects of topically applied 1% tropicamide, 2.5% phenylephrine and 1% cyclopentolate on retinal vessel calliper (VC) using optical coherence tomography (OCT).Methods: Patients who came to the ophthalmology clinic for routine examination and whose OCT films were taken before dilatation and after 30 min of last dilatation drop were included in the study. 90 ophthalmologically healthy subjects were divided into 3 groups of 30 subject each according to the application of the drops as follows: Tropicamide group (Group 1), Phenylephrine group (Group 2), Cyclopentolate group (Group 3). The right eyes of the subjects were dilated with drops and the left eyes were taken as the control group. VC of retinal artery and vein passing through an area one-half to one-disc diameter from the optic disc margin were measured from OCT films. The mean of the sum of superior retinal artery (SRA) and inferior retinal artery (IRA) VC and the mean of the sum of superior retinal vein (SRV) and inferior retinal vein (IRV) VC before and after the drop were compared.Results: There was no statistically significant change in the mean sum of SRA and IRA VC and the mean sum of SRV and IRV VC before and after dilatation drops in all three groups.Conclusion: Dilatation drops have no statistically significant effect on retinal artery and vein VC.","PeriodicalId":11023,"journal":{"name":"Cutaneous and Ocular Toxicology","volume":" ","pages":"198-203"},"PeriodicalIF":1.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141632949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0