ACS Central Science最新文献_第3页

IF 12.7 1区化学

ACS Central Science Pub Date : 2025-06-25

Markus Staudt, and , Jonathan C. T. Carlson*,

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IF 12.7 1区化学

ACS Central Science Pub Date : 2025-06-25

Yang Chen, Jiayan Chen and Shifa Zhu*,

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IF 12.7 1区化学

ACS Central Science Pub Date : 2025-06-25

F. Gomollón-Bel, and , J. García-Martínez,

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IF 12.7 1区化学

ACS Central Science Pub Date : 2025-06-25

Xin Jin, Susana Garcia and Berend Smit*,

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IF 12.7 1区化学

ACS Central Science Pub Date : 2025-06-25

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IF 12.7 1区化学

ACS Central Science Pub Date : 2025-06-25

Robert P. Sparks, William Lawless, Anna Kharitonova, Rainer Metcalf, Jamie Nunziata, Grace A. Binder, Sauradip Chaudhuri, Christine S.R. Gambino, Michelle Wilde, Linette S. Harding, Jaret J. Crews, Mansi Gopu, Emilia Dalamangas, Sarah Lawless, Mark Eschenfelder, Robert M. Green, Elizabeth X Nompleggi, Timothy H. Tran, Yan Yang, Donna V. Trask, Paul R. Thompson, Rekha Patel, Niketa A. Patel, Wesley H. Brooks, Guy Bradley, Mildred E. Acevedo-Duncan, Alan C. Mullen, James W. Leahy, Kenyon G. Daniel* and Wayne C. Guida*,

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IF 12.7 1区化学

ACS Central Science Pub Date : 2025-06-25

Hao Guo, Chunlei Dong, Qingquan Han, Hongyu Jiang, Hongji Sun, Xuemei Sun, Songlin Zhang* and Huisheng Peng*,

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IF 12.7 1区化学

ACS Central Science Pub Date : 2025-06-25

Junyoung Park, Juhee Hahm, Junhyeong Yim, Hyelim Lee, Hwan Min Hwang, Soyeon Lee, Ju-Young Park, Arun Velladurai, Jagadeesh Kumar Gangasani, Hana Cho, Hankum Park, Minju Lee, Jeehee Lee, Hyunuk Eom, Woon Ju Song, Sanghee Lee*, Eunha Kim* and Jongmin Park*,

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Discovery of Clonixeril as a Sub-Femtomolar Modulator of the Human STING Receptor. 克罗昔利作为人STING受体亚飞摩尔调制剂的发现。

IF 12.7 1区化学

ACS Central Science Pub Date : 2025-06-06 eCollection Date: 2025-06-25 DOI: 10.1021/acscentsci.4c01982

Robert P Sparks, William Lawless, Anna Kharitonova, Rainer Metcalf, Jamie Nunziata, Grace A Binder, Sauradip Chaudhuri, Christine S R Gambino, Michelle Wilde, Linette S Harding, Jaret J Crews, Mansi Gopu, Emilia Dalamangas, Sarah Lawless, Mark Eschenfelder, Robert M Green, Elizabeth X Nompleggi, Timothy H Tran, Yan Yang, Donna V Trask, Paul R Thompson, Rekha Patel, Niketa A Patel, Wesley H Brooks, Guy Bradley, Mildred E Acevedo-Duncan, Alan C Mullen, James W Leahy, Kenyon G Daniel, Wayne C Guida

{"title":"Discovery of Clonixeril as a Sub-Femtomolar Modulator of the Human STING Receptor.","authors":"Robert P Sparks, William Lawless, Anna Kharitonova, Rainer Metcalf, Jamie Nunziata, Grace A Binder, Sauradip Chaudhuri, Christine S R Gambino, Michelle Wilde, Linette S Harding, Jaret J Crews, Mansi Gopu, Emilia Dalamangas, Sarah Lawless, Mark Eschenfelder, Robert M Green, Elizabeth X Nompleggi, Timothy H Tran, Yan Yang, Donna V Trask, Paul R Thompson, Rekha Patel, Niketa A Patel, Wesley H Brooks, Guy Bradley, Mildred E Acevedo-Duncan, Alan C Mullen, James W Leahy, Kenyon G Daniel, Wayne C Guida","doi":"10.1021/acscentsci.4c01982","DOIUrl":"10.1021/acscentsci.4c01982","url":null,"abstract":"Stimulator of interferon genes (STING) is a transmembrane endoplasmic reticulum (ER) resident protein involved in innate immunity. STING activation occurs by binding of cyclic guanosine-(2'→5')-monophosphate-adenosine-(3'→5')-monophosphate (2',3'-cGAMP) to STING, which leads to downstream production of type 1 interferons (IFN-1). We generated molecular dynamics (MD) equilibrated agonist and antagonist models of human STING (hSTING) for computer-based screening and now report the discovery of clonixeril (CXL) as the most potent non-nucleotide hSTING modulator discovered to date. We demonstrate in vitro and in cellulo that CXL has two modes of interaction with hSTING, one with an EC50 above 1 nM and the other with an EC50 in the 1 fM-100 aM range (10-15-10-16 M). In cell-based experiments, when CXL is titrated below 1 nM, it displays inverse dose-dependent antagonistic behavior toward hSTING. We have substantiated that CXL displays this exceptionally strong inhibitory effect on hSTING mediated IFN-1 production using a THP-1 cell luciferase reporter for interferon regulatory factor 3 (IRF3). Further characterization of CXL was performed in HEK293 cells by using biophysical and biochemical techniques.","PeriodicalId":10,"journal":{"name":"ACS Central Science","volume":"11 6","pages":"994-1008"},"PeriodicalIF":12.7,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12203428/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144525287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Dual-Wavelength Simultaneous Patterning of Degradable Thermoset Supports for One-Pot Embedded 3D Printing. 一锅嵌入式3D打印可降解热固性支架的双波长同步图案。

IF 12.7 1区化学

ACS Central Science Pub Date : 2025-06-04 eCollection Date: 2025-06-25 DOI: 10.1021/acscentsci.5c00337

Isabel Arias Ponce, Bryan Moran, Craig J Hawker, Maxim Shusteff, Sijia Huang

{"title":"Dual-Wavelength Simultaneous Patterning of Degradable Thermoset Supports for One-Pot Embedded 3D Printing.","authors":"Isabel Arias Ponce, Bryan Moran, Craig J Hawker, Maxim Shusteff, Sijia Huang","doi":"10.1021/acscentsci.5c00337","DOIUrl":"10.1021/acscentsci.5c00337","url":null,"abstract":"Vat photopolymerization (VP) techniques have enabled the fabrication of complex geometries while balancing high precision and fast processing times. 3D printed objects are traditionally built layer-by-layer with newly cured layers being structurally supported by previous ones. Fabricating unsupported features such as overhangs and arches risks misalignment and sagging, limiting the range of accessible designs. To overcome this issue, support structures are fabricated along with the primary object as temporary scaffolds that provide stability and conserve print fidelity. For VP specifically, patterning dissolvable sacrificial supports is attractive to avoid manual removal after printing. In this study, we demonstrate a base-degradable thermoset to pattern print supports in a one-pot formulation along with the primary structural material. Efficient printing is enabled using a dual-wavelength negative imaging (DWNI) DLP printer that patterns the degradable thermoset with visible light and the permanent network with UV light, which are simultaneously projected using a single digital micromirror device (DMD). Printed objects undergo thermal postprocessing to enhance the final conversion of the primary material, after which thermoset supports are degraded in a basic, aqueous solution. This approach provides a robust method for the dual-wavelength patterning of sacrificial thermoset supports, broadening the range of accessible 3D printable materials and geometries.","PeriodicalId":10,"journal":{"name":"ACS Central Science","volume":"11 6","pages":"967-974"},"PeriodicalIF":12.7,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12203427/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144525288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0