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A Conversation with Sambuddha Misra 与Sambuddha Misra的对话
IF 12.7 1区 化学
ACS Central Science Pub Date : 2025-04-09 DOI: 10.1021/acscentsci.5c0055710.1021/acscentsci.5c00557
Payal Dhar, 
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引用次数: 0
A Conversation with Sambuddha Misra. 与Sambuddha Misra的对话。
IF 12.7 1区 化学
ACS Central Science Pub Date : 2025-04-09 eCollection Date: 2025-04-23 DOI: 10.1021/acscentsci.5c00557
Payal Dhar
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引用次数: 0
Electric-Field Molecular Fingerprinting to Probe Cancer 电场分子指纹技术探测癌症
IF 12.7 1区 化学
ACS Central Science Pub Date : 2025-04-09 DOI: 10.1021/acscentsci.4c0216410.1021/acscentsci.4c02164
Kosmas V. Kepesidis, Philip Jacob, Wolfgang Schweinberger, Marinus Huber, Nico Feiler, Frank Fleischmann, Michael Trubetskov, Liudmila Voronina, Jacqueline Aschauer, Tarek Eissa, Lea Gigou, Patrik Karandušovsky, Ioachim Pupeza, Alexander Weigel, Abdallah Azzeer, Christian G. Stief, Michael Chaloupka, Niels Reinmuth, Jürgen Behr, Thomas Kolben, Nadia Harbeck, Maximilian Reiser, Ferenc Krausz and Mihaela Žigman*, 
{"title":"Electric-Field Molecular Fingerprinting to Probe Cancer","authors":"Kosmas V. Kepesidis,&nbsp;Philip Jacob,&nbsp;Wolfgang Schweinberger,&nbsp;Marinus Huber,&nbsp;Nico Feiler,&nbsp;Frank Fleischmann,&nbsp;Michael Trubetskov,&nbsp;Liudmila Voronina,&nbsp;Jacqueline Aschauer,&nbsp;Tarek Eissa,&nbsp;Lea Gigou,&nbsp;Patrik Karandušovsky,&nbsp;Ioachim Pupeza,&nbsp;Alexander Weigel,&nbsp;Abdallah Azzeer,&nbsp;Christian G. Stief,&nbsp;Michael Chaloupka,&nbsp;Niels Reinmuth,&nbsp;Jürgen Behr,&nbsp;Thomas Kolben,&nbsp;Nadia Harbeck,&nbsp;Maximilian Reiser,&nbsp;Ferenc Krausz and Mihaela Žigman*,&nbsp;","doi":"10.1021/acscentsci.4c0216410.1021/acscentsci.4c02164","DOIUrl":"https://doi.org/10.1021/acscentsci.4c02164https://doi.org/10.1021/acscentsci.4c02164","url":null,"abstract":"<p >Human biofluids serve as indicators of various physiological states, and recent advances in molecular profiling technologies hold great potential for enhancing clinical diagnostics. Leveraging recent developments in laser-based electric-field molecular fingerprinting, we assess its potential for <i>in vitro</i> diagnostics. In a proof-of-concept clinical study involving 2533 participants, we conducted randomized measurement campaigns to spectroscopically profile bulk venous blood plasma across lung, prostate, breast, and bladder cancer. Employing machine learning, we detected infrared signatures specific to therapy-naı̈ve cancer states, distinguishing them from matched control individuals with a cross-validation ROC AUC of 0.88 for lung cancer and values ranging from 0.68 to 0.69 for the other three cancer entities. In an independent held-out test data set, designed to reflect different experimental conditions from those used during model training, we achieved a lung cancer detection ROC AUC of 0.81. Our study demonstrates that electric-field molecular fingerprinting is a robust technological framework broadly applicable to disease phenotyping under real-world conditions.</p><p >Laser-based infrared molecular fingerprinting detects cancer, demonstrating its potential for clinical disease diagnostics.</p>","PeriodicalId":10,"journal":{"name":"ACS Central Science","volume":"11 4","pages":"560–573 560–573"},"PeriodicalIF":12.7,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acscentsci.4c02164","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143858519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Detecting the Feeble Electromagnetic Emissions from Cancer Biomarkers 检测癌症生物标志物的微弱电磁辐射
IF 12.7 1区 化学
ACS Central Science Pub Date : 2025-04-09 DOI: 10.1021/acscentsci.5c0055610.1021/acscentsci.5c00556
Marcos Dantus​, 
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引用次数: 0
Detecting the Feeble Electromagnetic Emissions from Cancer Biomarkers. 检测癌症生物标志物的微弱电磁辐射。
IF 12.7 1区 化学
ACS Central Science Pub Date : 2025-04-09 eCollection Date: 2025-04-23 DOI: 10.1021/acscentsci.5c00556
Marcos Dantus
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引用次数: 0
Electric-Field Molecular Fingerprinting to Probe Cancer. 电场分子指纹技术探测癌症。
IF 12.7 1区 化学
ACS Central Science Pub Date : 2025-04-09 eCollection Date: 2025-04-23 DOI: 10.1021/acscentsci.4c02164
Kosmas V Kepesidis, Philip Jacob, Wolfgang Schweinberger, Marinus Huber, Nico Feiler, Frank Fleischmann, Michael Trubetskov, Liudmila Voronina, Jacqueline Aschauer, Tarek Eissa, Lea Gigou, Patrik Karandušovsky, Ioachim Pupeza, Alexander Weigel, Abdallah Azzeer, Christian G Stief, Michael Chaloupka, Niels Reinmuth, Jürgen Behr, Thomas Kolben, Nadia Harbeck, Maximilian Reiser, Ferenc Krausz, Mihaela Žigman
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引用次数: 0
Oceanographers Comb Waters for Genetic Warnings of a Coastal Neurotoxin. 海洋学家梳理水域,寻找沿海神经毒素的遗传警告。
IF 12.7 1区 化学
ACS Central Science Pub Date : 2025-04-08 eCollection Date: 2025-04-23 DOI: 10.1021/acscentsci.5c00558
Jonathan Feakins
{"title":"Oceanographers Comb Waters for Genetic Warnings of a Coastal Neurotoxin.","authors":"Jonathan Feakins","doi":"10.1021/acscentsci.5c00558","DOIUrl":"https://doi.org/10.1021/acscentsci.5c00558","url":null,"abstract":"","PeriodicalId":10,"journal":{"name":"ACS Central Science","volume":"11 4","pages":"500-504"},"PeriodicalIF":12.7,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12036538/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143950962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Oceanographers Comb Waters for Genetic Warnings of a Coastal Neurotoxin 海洋学家梳理水域,寻找海岸神经毒素的基因警报
IF 12.7 1区 化学
ACS Central Science Pub Date : 2025-04-08 DOI: 10.1021/acscentsci.5c0055810.1021/acscentsci.5c00558
Jonathan Feakins, 
{"title":"Oceanographers Comb Waters for Genetic Warnings of a Coastal Neurotoxin","authors":"Jonathan Feakins,&nbsp;","doi":"10.1021/acscentsci.5c0055810.1021/acscentsci.5c00558","DOIUrl":"https://doi.org/10.1021/acscentsci.5c00558https://doi.org/10.1021/acscentsci.5c00558","url":null,"abstract":"<p >To catch toxic algal blooms before they take over ecosystems, researchers are analyzing the vast body of environmental DNA, loose genetic material, in the ocean.</p>","PeriodicalId":10,"journal":{"name":"ACS Central Science","volume":"11 4","pages":"500–504 500–504"},"PeriodicalIF":12.7,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acscentsci.5c00558","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143858703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Where Molecules Meet Mucus: Mutanofactins in the Oral Microbiome. 分子与黏液相遇的地方:口腔微生物群中的变异体因子。
IF 12.7 1区 化学
ACS Central Science Pub Date : 2025-04-07 eCollection Date: 2025-04-23 DOI: 10.1021/acscentsci.5c00546
McKenna Loop Yao, Wenjun Zhang
{"title":"Where Molecules Meet Mucus: Mutanofactins in the Oral Microbiome.","authors":"McKenna Loop Yao, Wenjun Zhang","doi":"10.1021/acscentsci.5c00546","DOIUrl":"https://doi.org/10.1021/acscentsci.5c00546","url":null,"abstract":"","PeriodicalId":10,"journal":{"name":"ACS Central Science","volume":"11 4","pages":"508-510"},"PeriodicalIF":12.7,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12022904/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143950682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Where Molecules Meet Mucus: Mutanofactins in the Oral Microbiome 分子与黏液相遇的地方:口腔微生物群中的变异体因子
IF 12.7 1区 化学
ACS Central Science Pub Date : 2025-04-07 DOI: 10.1021/acscentsci.5c0054610.1021/acscentsci.5c00546
McKenna Loop Yao,  and , Wenjun Zhang​​, 
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引用次数: 0
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