ACS Central SciencePub Date : 2025-04-09DOI: 10.1021/acscentsci.5c0055710.1021/acscentsci.5c00557
Payal Dhar,
{"title":"A Conversation with Sambuddha Misra","authors":"Payal Dhar, ","doi":"10.1021/acscentsci.5c0055710.1021/acscentsci.5c00557","DOIUrl":"https://doi.org/10.1021/acscentsci.5c00557https://doi.org/10.1021/acscentsci.5c00557","url":null,"abstract":"<p >The oceanographer found that lead levels doubled in the western Indian Ocean between 1989 and 2013.</p>","PeriodicalId":10,"journal":{"name":"ACS Central Science","volume":"11 4","pages":"498–499 498–499"},"PeriodicalIF":12.7,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acscentsci.5c00557","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143858607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ACS Central SciencePub Date : 2025-04-09eCollection Date: 2025-04-23DOI: 10.1021/acscentsci.5c00557
Payal Dhar
{"title":"A Conversation with Sambuddha Misra.","authors":"Payal Dhar","doi":"10.1021/acscentsci.5c00557","DOIUrl":"https://doi.org/10.1021/acscentsci.5c00557","url":null,"abstract":"","PeriodicalId":10,"journal":{"name":"ACS Central Science","volume":"11 4","pages":"498-499"},"PeriodicalIF":12.7,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12036539/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143951071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ACS Central SciencePub Date : 2025-04-09DOI: 10.1021/acscentsci.4c0216410.1021/acscentsci.4c02164
Kosmas V. Kepesidis, Philip Jacob, Wolfgang Schweinberger, Marinus Huber, Nico Feiler, Frank Fleischmann, Michael Trubetskov, Liudmila Voronina, Jacqueline Aschauer, Tarek Eissa, Lea Gigou, Patrik Karandušovsky, Ioachim Pupeza, Alexander Weigel, Abdallah Azzeer, Christian G. Stief, Michael Chaloupka, Niels Reinmuth, Jürgen Behr, Thomas Kolben, Nadia Harbeck, Maximilian Reiser, Ferenc Krausz and Mihaela Žigman*,
{"title":"Electric-Field Molecular Fingerprinting to Probe Cancer","authors":"Kosmas V. Kepesidis, Philip Jacob, Wolfgang Schweinberger, Marinus Huber, Nico Feiler, Frank Fleischmann, Michael Trubetskov, Liudmila Voronina, Jacqueline Aschauer, Tarek Eissa, Lea Gigou, Patrik Karandušovsky, Ioachim Pupeza, Alexander Weigel, Abdallah Azzeer, Christian G. Stief, Michael Chaloupka, Niels Reinmuth, Jürgen Behr, Thomas Kolben, Nadia Harbeck, Maximilian Reiser, Ferenc Krausz and Mihaela Žigman*, ","doi":"10.1021/acscentsci.4c0216410.1021/acscentsci.4c02164","DOIUrl":"https://doi.org/10.1021/acscentsci.4c02164https://doi.org/10.1021/acscentsci.4c02164","url":null,"abstract":"<p >Human biofluids serve as indicators of various physiological states, and recent advances in molecular profiling technologies hold great potential for enhancing clinical diagnostics. Leveraging recent developments in laser-based electric-field molecular fingerprinting, we assess its potential for <i>in vitro</i> diagnostics. In a proof-of-concept clinical study involving 2533 participants, we conducted randomized measurement campaigns to spectroscopically profile bulk venous blood plasma across lung, prostate, breast, and bladder cancer. Employing machine learning, we detected infrared signatures specific to therapy-naı̈ve cancer states, distinguishing them from matched control individuals with a cross-validation ROC AUC of 0.88 for lung cancer and values ranging from 0.68 to 0.69 for the other three cancer entities. In an independent held-out test data set, designed to reflect different experimental conditions from those used during model training, we achieved a lung cancer detection ROC AUC of 0.81. Our study demonstrates that electric-field molecular fingerprinting is a robust technological framework broadly applicable to disease phenotyping under real-world conditions.</p><p >Laser-based infrared molecular fingerprinting detects cancer, demonstrating its potential for clinical disease diagnostics.</p>","PeriodicalId":10,"journal":{"name":"ACS Central Science","volume":"11 4","pages":"560–573 560–573"},"PeriodicalIF":12.7,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acscentsci.4c02164","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143858519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ACS Central SciencePub Date : 2025-04-09DOI: 10.1021/acscentsci.5c0055610.1021/acscentsci.5c00556
Marcos Dantus,
{"title":"Detecting the Feeble Electromagnetic Emissions from Cancer Biomarkers","authors":"Marcos Dantus, ","doi":"10.1021/acscentsci.5c0055610.1021/acscentsci.5c00556","DOIUrl":"https://doi.org/10.1021/acscentsci.5c00556https://doi.org/10.1021/acscentsci.5c00556","url":null,"abstract":"<p >Zigman and colleagues use electric-field molecular fingerprinting and machine learning on blood plasma to detect and differentiate major cancers with high precision.</p>","PeriodicalId":10,"journal":{"name":"ACS Central Science","volume":"11 4","pages":"505–507 505–507"},"PeriodicalIF":12.7,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acscentsci.5c00556","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143858608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ACS Central SciencePub Date : 2025-04-09eCollection Date: 2025-04-23DOI: 10.1021/acscentsci.5c00556
Marcos Dantus
{"title":"Detecting the Feeble Electromagnetic Emissions from Cancer Biomarkers.","authors":"Marcos Dantus","doi":"10.1021/acscentsci.5c00556","DOIUrl":"https://doi.org/10.1021/acscentsci.5c00556","url":null,"abstract":"","PeriodicalId":10,"journal":{"name":"ACS Central Science","volume":"11 4","pages":"505-507"},"PeriodicalIF":12.7,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12022907/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143952495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ACS Central SciencePub Date : 2025-04-09eCollection Date: 2025-04-23DOI: 10.1021/acscentsci.4c02164
Kosmas V Kepesidis, Philip Jacob, Wolfgang Schweinberger, Marinus Huber, Nico Feiler, Frank Fleischmann, Michael Trubetskov, Liudmila Voronina, Jacqueline Aschauer, Tarek Eissa, Lea Gigou, Patrik Karandušovsky, Ioachim Pupeza, Alexander Weigel, Abdallah Azzeer, Christian G Stief, Michael Chaloupka, Niels Reinmuth, Jürgen Behr, Thomas Kolben, Nadia Harbeck, Maximilian Reiser, Ferenc Krausz, Mihaela Žigman
{"title":"Electric-Field Molecular Fingerprinting to Probe Cancer.","authors":"Kosmas V Kepesidis, Philip Jacob, Wolfgang Schweinberger, Marinus Huber, Nico Feiler, Frank Fleischmann, Michael Trubetskov, Liudmila Voronina, Jacqueline Aschauer, Tarek Eissa, Lea Gigou, Patrik Karandušovsky, Ioachim Pupeza, Alexander Weigel, Abdallah Azzeer, Christian G Stief, Michael Chaloupka, Niels Reinmuth, Jürgen Behr, Thomas Kolben, Nadia Harbeck, Maximilian Reiser, Ferenc Krausz, Mihaela Žigman","doi":"10.1021/acscentsci.4c02164","DOIUrl":"https://doi.org/10.1021/acscentsci.4c02164","url":null,"abstract":"<p><p>Human biofluids serve as indicators of various physiological states, and recent advances in molecular profiling technologies hold great potential for enhancing clinical diagnostics. Leveraging recent developments in laser-based electric-field molecular fingerprinting, we assess its potential for <i>in vitro</i> diagnostics. In a proof-of-concept clinical study involving 2533 participants, we conducted randomized measurement campaigns to spectroscopically profile bulk venous blood plasma across lung, prostate, breast, and bladder cancer. Employing machine learning, we detected infrared signatures specific to therapy-naïve cancer states, distinguishing them from matched control individuals with a cross-validation ROC AUC of 0.88 for lung cancer and values ranging from 0.68 to 0.69 for the other three cancer entities. In an independent held-out test data set, designed to reflect different experimental conditions from those used during model training, we achieved a lung cancer detection ROC AUC of 0.81. Our study demonstrates that electric-field molecular fingerprinting is a robust technological framework broadly applicable to disease phenotyping under real-world conditions.</p>","PeriodicalId":10,"journal":{"name":"ACS Central Science","volume":"11 4","pages":"560-573"},"PeriodicalIF":12.7,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12022918/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143950703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ACS Central SciencePub Date : 2025-04-08eCollection Date: 2025-04-23DOI: 10.1021/acscentsci.5c00558
Jonathan Feakins
{"title":"Oceanographers Comb Waters for Genetic Warnings of a Coastal Neurotoxin.","authors":"Jonathan Feakins","doi":"10.1021/acscentsci.5c00558","DOIUrl":"https://doi.org/10.1021/acscentsci.5c00558","url":null,"abstract":"","PeriodicalId":10,"journal":{"name":"ACS Central Science","volume":"11 4","pages":"500-504"},"PeriodicalIF":12.7,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12036538/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143950962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ACS Central SciencePub Date : 2025-04-08DOI: 10.1021/acscentsci.5c0055810.1021/acscentsci.5c00558
Jonathan Feakins,
{"title":"Oceanographers Comb Waters for Genetic Warnings of a Coastal Neurotoxin","authors":"Jonathan Feakins, ","doi":"10.1021/acscentsci.5c0055810.1021/acscentsci.5c00558","DOIUrl":"https://doi.org/10.1021/acscentsci.5c00558https://doi.org/10.1021/acscentsci.5c00558","url":null,"abstract":"<p >To catch toxic algal blooms before they take over ecosystems, researchers are analyzing the vast body of environmental DNA, loose genetic material, in the ocean.</p>","PeriodicalId":10,"journal":{"name":"ACS Central Science","volume":"11 4","pages":"500–504 500–504"},"PeriodicalIF":12.7,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acscentsci.5c00558","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143858703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ACS Central SciencePub Date : 2025-04-07DOI: 10.1021/acscentsci.5c0054610.1021/acscentsci.5c00546
McKenna Loop Yao, and , Wenjun Zhang,
{"title":"Where Molecules Meet Mucus: Mutanofactins in the Oral Microbiome","authors":"McKenna Loop Yao, and , Wenjun Zhang, ","doi":"10.1021/acscentsci.5c0054610.1021/acscentsci.5c00546","DOIUrl":"https://doi.org/10.1021/acscentsci.5c00546https://doi.org/10.1021/acscentsci.5c00546","url":null,"abstract":"<p >Fully synthesized mutanofactins modulate biofilms in select oral species and alter mucins, revealing broader roles for oral specialized metabolism.</p>","PeriodicalId":10,"journal":{"name":"ACS Central Science","volume":"11 4","pages":"508–510 508–510"},"PeriodicalIF":12.7,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acscentsci.5c00546","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143858395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}