Current Hypertension Reports最新文献_第6页

Clinical Significance of Nocturnal Hypertension and Nighttime Blood Pressure Dipping in Hypertension. 夜间高血压与夜间血压下降在高血压中的临床意义。

IF 5.6 2区医学

Current Hypertension Reports Pub Date : 2024-02-01 Epub Date: 2023-10-31 DOI: 10.1007/s11906-023-01277-x

Panagiota Anyfanti, Anastasia Malliora, Agapi Chionidou, Konstantinos Mastrogiannis, Antonios Lazaridis, Eugenia Gkaliagkousi

{"title":"Clinical Significance of Nocturnal Hypertension and Nighttime Blood Pressure Dipping in Hypertension.","authors":"Panagiota Anyfanti, Anastasia Malliora, Agapi Chionidou, Konstantinos Mastrogiannis, Antonios Lazaridis, Eugenia Gkaliagkousi","doi":"10.1007/s11906-023-01277-x","DOIUrl":"10.1007/s11906-023-01277-x","url":null,"abstract":"Purpose of review: This narrative review article aims to discuss more recent evidence, current challenges, and future perspectives regarding the clinical importance of nocturnal hypertension and nighttime blood pressure dipping, with particular reference to diagnosis, prognostic value, and therapeutic approach.Recent findings: The importance of nighttime blood pressure and nighttime blood pressure dipping has been demonstrated in decades. Increased nighttime blood pressure has been acknowledged as an unfavorable clinical trait. However, more recent evidence suggests that the abolishment of normal circadian blood pressure rhythm is not always a solid predictor of adverse cardiovascular events and needs to be interpreted in the light of each patients' individual characteristics. Physicians treating hypertensive patients with adverse nighttime blood pressure profiles often face the dilemma of chronotherapy. This has been a blurred field for years, yet very recent evidence from appropriately designed studies attempts to shed light on this puzzling question. As 24-h ambulatory blood pressure monitoring is being increasingly recommended and applied in real-world practice for the diagnosis and monitoring of hypertension, information on nighttime blood pressure and nocturnal dipping profile is collected but is not always easy to interpret.","PeriodicalId":10963,"journal":{"name":"Current Hypertension Reports","volume":" ","pages":"69-80"},"PeriodicalIF":5.6,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71421566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Challenges in Conducting Clinical Trials for Preeclampsia. 开展子痫前期临床试验的挑战。

IF 5.6 2区医学

Current Hypertension Reports Pub Date : 2024-02-01 Epub Date: 2023-11-16 DOI: 10.1007/s11906-023-01276-y

T Caroline Bank, Diana Kline, Maged M Costantine

{"title":"Challenges in Conducting Clinical Trials for Preeclampsia.","authors":"T Caroline Bank, Diana Kline, Maged M Costantine","doi":"10.1007/s11906-023-01276-y","DOIUrl":"10.1007/s11906-023-01276-y","url":null,"abstract":"Purpose of review: To review recent data describing the challenges and innovations in therapeutic research focused on the prevention and treatment of preeclampsia.Recent findings: Pregnant individuals have traditionally been excluded from therapeutic research, resulting in a paucity of innovation in therapeutics for pregnancy-specific medical conditions, especially preeclampsia. With the increased awareness of maternal morbidity and mortality, there is significant interest among researchers to expand therapeutic research in pregnancy. Several medications, including aspirin, pravastatin, metformin, and esomeprazole, which are commonly used in non-pregnant populations, are now being investigated for preeclampsia prevention. However, given the historic precedent of exclusion, along with the regulatory, ethical, and feasibility concerns that accompany this population, the study of these and novel medications has been complicated by numerous challenges. While complex, and laden with challenges, there is great ongoing need for therapeutic research to address preeclampsia. Aspirin, pravastatin, metformin, and esomeprazole have all shown promise as potential therapeutic agents; however, their use remains to be optimized, and innovative therapeutics need to be developed.","PeriodicalId":10963,"journal":{"name":"Current Hypertension Reports","volume":" ","pages":"59-68"},"PeriodicalIF":5.6,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136396770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-Dipping Blood Pressure or Nocturnal Hypertension: Does One Matter More? 非浸入性血压和夜间高血压:哪个更重要?

IF 5.6 2区医学

Current Hypertension Reports Pub Date : 2024-01-01 Epub Date: 2023-11-13 DOI: 10.1007/s11906-023-01273-1

Amber Tang, Eugene Yang, Joseph E Ebinger

{"title":"Non-Dipping Blood Pressure or Nocturnal Hypertension: Does One Matter More?","authors":"Amber Tang, Eugene Yang, Joseph E Ebinger","doi":"10.1007/s11906-023-01273-1","DOIUrl":"10.1007/s11906-023-01273-1","url":null,"abstract":"Purpose of review: Nocturnal hypertension and non-dipping are both associated with increased cardiovascular risk; however, debate remains over which is a better prognosticator of cardiovascular outcomes. This review explores current literature on nocturnal hypertension and non-dipping to assess their relationship to cardiovascular disease and implications for clinical practice.Recent findings: While current data remain inconclusive, some suggest that nocturnal hypertension is a more reliable and clinically significant marker of cardiovascular risk than non-dipping status. Importantly, reducing nocturnal HTN and non-dipping through chronotherapy, specifically evening dosing of antihypertensives, has not been conclusively shown to provide long-term cardiovascular benefits. Recent data suggests that non-dipping, compared to nocturnal hypertension, may be falling out of favor as a prognostic indicator for adverse cardiovascular outcomes. However, additional information is needed to understand how aberrant nighttime blood pressure patterns modulate cardiovascular risk to guide clinical management.","PeriodicalId":10963,"journal":{"name":"Current Hypertension Reports","volume":" ","pages":"21-30"},"PeriodicalIF":5.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10796526/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89717252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pressure Building Against the Clock: The Impact of Circadian Misalignment on Blood Pressure. 昼夜节律失调对血压的影响。

IF 3.9 2区医学

Current Hypertension Reports Pub Date : 2024-01-01 Epub Date: 2023-10-14 DOI: 10.1007/s11906-023-01274-0

Brooke M Shafer, Sophia A Kogan, Andrew W McHill

{"title":"Pressure Building Against the Clock: The Impact of Circadian Misalignment on Blood Pressure.","authors":"Brooke M Shafer, Sophia A Kogan, Andrew W McHill","doi":"10.1007/s11906-023-01274-0","DOIUrl":"10.1007/s11906-023-01274-0","url":null,"abstract":"Purpose of review: Misalignment between the endogenous biological timing system and behavioral activities (i.e., sleep/wake, eating, activity) contributes to adverse cardiovascular health. In this review, we discuss the effects of recurring circadian misalignment on blood pressure regulation and the implications for hypertension development. Additionally, we highlight emerging therapeutic approaches designed to mitigate the negative cardiovascular consequences elicited by circadian disruption.Recent findings: Circadian misalignment elicited by work schedules that require individuals to be awake during the biological night (i.e., shift work) alters 24-h blood pressure rhythms. Mechanistically, circadian misalignment appears to alter blood pressure via changes in autonomic nervous system balance, variations to sodium retention, dysregulation of endothelial vasodilatory responsiveness, and activation of proinflammatory mechanisms. Recurring circadian misalignment produced by a mismatch in sleep timing on free days vs. work days (i.e., social jetlag) appears to have no direct effects on prevailing blood pressure levels in healthy adults; though, circadian disruptions resulting from social jetlag may increase the risk of hypertension through enhanced sympathetic activation and/or obesity. Furthermore, social jetlag assessment may be a useful metric in shift work populations where the magnitude of circadian misalignment may be greater than in the general population. Circadian misalignment promotes unfavorable changes to 24-h blood pressure rhythms, most notably in shift working populations. While light therapy, melatonin supplementation, and the timing of drug administration may improve cardiovascular outcomes, interventions designed to target the effects of circadian misalignment on blood pressure regulation are warranted.","PeriodicalId":10963,"journal":{"name":"Current Hypertension Reports","volume":" ","pages":"31-42"},"PeriodicalIF":3.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10916535/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41194263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Salty Subjects: Unpacking Racial Differences in Salt-Sensitive Hypertension. 盐敏感型高血压的种族差异。

IF 3.9 2区医学

Current Hypertension Reports Pub Date : 2024-01-01 Epub Date: 2023-10-25 DOI: 10.1007/s11906-023-01275-z

Soolim Jeong, Stacy D Hunter, Marc D Cook, Gregory J Grosicki, Austin T Robinson

{"title":"Salty Subjects: Unpacking Racial Differences in Salt-Sensitive Hypertension.","authors":"Soolim Jeong, Stacy D Hunter, Marc D Cook, Gregory J Grosicki, Austin T Robinson","doi":"10.1007/s11906-023-01275-z","DOIUrl":"10.1007/s11906-023-01275-z","url":null,"abstract":"Purpose of review: To review underlying mechanisms and environmental factors that may influence racial disparities in the development of salt-sensitive blood pressure.Recent findings: Our group and others have observed racial differences in diet and hydration, which may influence salt sensitivity. Dietary salt elicits negative alterations to the gut microbiota and immune system, which may increase hypertension risk, but little is known regarding potential racial differences in these physiological responses. Antioxidant supplementation and exercise offset vascular dysfunction following dietary salt, including in Black adults. Furthermore, recent work proposes the role of racial differences in exposure to social determinants of health, and differences in health behaviors that may influence risk of salt sensitivity. Physiological and environmental factors contribute to the mechanisms that manifest in racial differences in salt-sensitive blood pressure. Using this information, additional work is needed to develop strategies that can attenuate racial disparities in salt-sensitive blood pressure.","PeriodicalId":10963,"journal":{"name":"Current Hypertension Reports","volume":" ","pages":"43-58"},"PeriodicalIF":3.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11414742/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50157175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Angiotensin Receptor Blockers and Cognition: a Scoping Review. 血管紧张素受体阻滞剂与认知：范围界定综述。

IF 3.9 2区医学

Current Hypertension Reports Pub Date : 2024-01-01 Epub Date: 2023-09-21 DOI: 10.1007/s11906-023-01266-0

Zhen Zhou, Suzanne G Orchard, Mark R Nelson, Michelle A Fravel, Michael E Ernst

{"title":"Angiotensin Receptor Blockers and Cognition: a Scoping Review.","authors":"Zhen Zhou, Suzanne G Orchard, Mark R Nelson, Michelle A Fravel, Michael E Ernst","doi":"10.1007/s11906-023-01266-0","DOIUrl":"10.1007/s11906-023-01266-0","url":null,"abstract":"Purpose of review: To provide an overview of the association between angiotensin II receptor blocker (ARB) use and cognitive outcomes.Recent findings: ARBs have previously shown greater neuroprotection compared to other anti-hypertensive classes. The benefits are primarily attributed to the ARB's effect on modulating the renin-angiotensin system via inhibiting the Ang II/AT1R pathway and activating the Ang II/AT2R, Ang IV/AT4R, and Ang-(1-7)/MasR pathways. These interactions are associated with pleiotropic neurocognitive benefits, including reduced β-amyloid accumulation and abnormal hyperphosphorylation of tau, ameliorated brain hypo-fusion, reduced neuroinflammation and synaptic dysfunction, better neurotoxin clearing, and blood-brain barrier function restoration. While ACEis also inhibit AT1R, they simultaneously lower Ang II and block the Ang II/AT2R and Ang IV/AT4R pathways that counterbalance the potential benefits. ARBs may be considered an adjunctive approach for neuroprotection. This preliminary evidence, coupled with their underlying mechanistic pathways, emphasizes the need for future long-term randomized trials to yield more definitive results.","PeriodicalId":10963,"journal":{"name":"Current Hypertension Reports","volume":" ","pages":"1-19"},"PeriodicalIF":3.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10796582/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41114817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Update on the Use of Pulse Wave Velocity to Measure Age-Related Vascular Changes 使用脉搏波速度测量与年龄有关的血管变化的最新进展

IF 5.6 2区医学

Current Hypertension Reports Pub Date : 2023-12-30 DOI: 10.1007/s11906-023-01285-x

Andrea G. Marshall, Kit Neikirk, Jeremiah Afolabi, Naome Mwesigwa, Bryanna Shao, Annet Kirabo, Anilkumar K. Reddy, Antentor Hinton

{"title":"Update on the Use of Pulse Wave Velocity to Measure Age-Related Vascular Changes","authors":"Andrea G. Marshall, Kit Neikirk, Jeremiah Afolabi, Naome Mwesigwa, Bryanna Shao, Annet Kirabo, Anilkumar K. Reddy, Antentor Hinton","doi":"10.1007/s11906-023-01285-x","DOIUrl":"https://doi.org/10.1007/s11906-023-01285-x","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose of Review</h3>Pulse wave velocity (PWV) is an important and well-established measure of arterial stiffness that is strongly associated with aging. Age-related alterations in the elastic properties and integrity of arterial walls can lead to cardiovascular disease. PWV measurements play an important role in the early detection of these changes, as well as other cardiovascular disease risk factors, such as hypertension. This review provides a comprehensive summary of the current knowledge of the effects of aging on arterial stiffness, as measured by PWV.<h3 data-test=\"abstract-sub-heading\">Recent Findings</h3>This review highlights recent findings showing the applicability of PWV analysis for investigating heart failure, hypertension, and other cardiovascular diseases, as well as cerebrovascular diseases and Alzheimer’s disease. It also discusses the clinical implications of utilizing PWV to monitor treatment outcomes, various challenges in implementing PWV assessment in clinical practice, and the development of new technologies, including machine learning and artificial intelligence, which may improve the usefulness of PWV measurements in the future.<h3 data-test=\"abstract-sub-heading\">Summary</h3>Measuring arterial stiffness through PWV remains an important technique to study aging, especially as the technology continues to evolve. There is a clear need to leverage PWV to identify interventions that mitigate age-related increases in PWV, potentially improving CVD outcomes and promoting healthy vascular aging.","PeriodicalId":10963,"journal":{"name":"Current Hypertension Reports","volume":"14 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2023-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139070649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Blood Pressure Effects of SGLT2 Inhibitors: Mechanisms and Clinical Evidence in Different Populations. SGLT2抑制剂对血压的影响：不同人群的机制和临床证据。

IF 5.6 2区医学

Current Hypertension Reports Pub Date : 2023-12-01 Epub Date: 2023-11-10 DOI: 10.1007/s11906-023-01281-1

Bryony Beal, Aletta E Schutte, Brendon L Neuen

{"title":"Blood Pressure Effects of SGLT2 Inhibitors: Mechanisms and Clinical Evidence in Different Populations.","authors":"Bryony Beal, Aletta E Schutte, Brendon L Neuen","doi":"10.1007/s11906-023-01281-1","DOIUrl":"10.1007/s11906-023-01281-1","url":null,"abstract":"Purpose of review: Sodium glucose transporter 2 inhibitors (SGLT2 inhibitors) are increasingly prescribed due to their considerable benefits on clinical outcomes in people with diabetes, heart failure, and chronic kidney disease (CKD). Hypertension is a common comorbidity in each of these disease states, increasing risk of cardiovascular morbidity and mortality. We herein review the effects of SGLT2 inhibitors on blood pressure in different populations, proposed mechanisms of action, and the contribution of blood pressure lowering to end-organ protection.Recent findings: A recognised effect of SGLT2 inhibitors in recent clinical trials is blood pressure lowering, with multiple postulated mechanisms. This advantageous effect was first identified in populations with type 2 diabetes mellitus, prior to expansion of these trials to broader cohorts. On our review, we identified that the blood pressure lowering effect of SGLT2 inhibitors appears to be a dose-independent class-effect, with a magnitude of effect comparable to that seen with a low dose hydrochlorothiazide. There is considerable evidence demonstrating that this effect is observed across populations including those with type 2 diabetes mellitus, chronic kidney disease, and resistant hypertension.","PeriodicalId":10963,"journal":{"name":"Current Hypertension Reports","volume":" ","pages":"429-435"},"PeriodicalIF":5.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72013878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of Inflammatory Processes in the Brain-Body Relationship Underlying Hypertension. 炎症过程在高血压脑-体关系中的作用。

IF 5.6 2区医学

Current Hypertension Reports Pub Date : 2023-12-01 Epub Date: 2023-10-03 DOI: 10.1007/s11906-023-01268-y

Daniela Carnevale

{"title":"Role of Inflammatory Processes in the Brain-Body Relationship Underlying Hypertension.","authors":"Daniela Carnevale","doi":"10.1007/s11906-023-01268-y","DOIUrl":"10.1007/s11906-023-01268-y","url":null,"abstract":"Purpose of review: Essential hypertension is a huge health problem that significantly impacts worldwide population in terms of morbidity and mortality. Idiopathic in its nature, elevated blood pressure results from a complex interaction between polygenic components and environmental and lifestyle factors. The constant growth in the burden of hypertension is at odds with expectations, considering the availability of therapeutic strategies. Hence, there is an endless need to further investigate the complexity of factors contributing to blood pressure elevation.Recent findings: Recent data indicate that bidirectional interactions between the nervous system and the immune system alter inflammation in the brain and periphery, contributing to chronic hypertension. These findings indicate that the nervous system is both a direct driver of hypertension and also a target of feedback that often elevates blood pressure further. Similarly, the immune system is both target and driver of the blood pressure increases. The contributions of the feedback loops among these systems appear to play an important role in hypertension. Together, recent mechanistic studies strongly suggest that the interactions among the brain, immune system, and inflammation affect the participation of each system in the pathogenesis of hypertension, and thus, all of these systems must be considered in concert to gain a full appreciation of the development and potential treatments of hypertension.","PeriodicalId":10963,"journal":{"name":"Current Hypertension Reports","volume":" ","pages":"455-461"},"PeriodicalIF":5.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10698121/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41108091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microvascular Dysfunction in Obesity-Hypertension. 肥胖高血压患者的微血管功能障碍。

IF 5.6 2区医学

Current Hypertension Reports Pub Date : 2023-12-01 Epub Date: 2023-10-14 DOI: 10.1007/s11906-023-01272-2

Tammy Do, Ashley Van, Arash Ataei, Swati Sharma, Rajesh Mohandas

引用次数: 0