Current Reviews in Musculoskeletal Medicine最新文献

{"title":"Management of Ulnar Collateral Ligament Injuries of the Elbow.","authors":"Patrick M Ryan, Julia Beyer, Hayden Hartman, Humza Ismail, Mazin Alam, Steven F DeFroda","doi":"10.1007/s12178-026-10042-x","DOIUrl":"10.1007/s12178-026-10042-x","url":null,"abstract":"<p><strong>Purpose of review: </strong>Ulnar collateral ligament (UCL) injuries are increasingly prevalent among overhead throwing athletes, with reconstruction rates rising 193% from 2002 to 2011 and an annual 9% increase among adolescents. This review synthesizes current evidence on the anatomy, biomechanics, clinical evaluation, and management of UCL injuries, with a focus on comparative outcomes across nonsurgical and surgical treatment strategies.</p><p><strong>Key findings: </strong>Nonsurgical management achieves return to sport in 80-100% of non-throwing athletes, while outcomes in overhead throwers are highly dependent on tear location, with proximal tears yielding superior success rates (89.7%) compared to distal tears (41.2%). Platelet-rich plasma remains controversial. UCL reconstruction achieves 80-97% return to play at 12-14 months; however, return to pre-injury performance is less consistent (67-87%). Primary repair with internal brace augmentation offers comparable return-to-play rates (98%) with a faster recovery timeline (9.2 versus 13.4 months) in appropriately selected patients with acute avulsion injuries. Treatment decisions should be individualized based on injury characteristics, tear location, tissue quality, and patient competitive goals. The proposed treatment algorithm stratifies management by tear location to facilitate evidence-based decision-making and realistic preoperative counseling.</p>","PeriodicalId":10950,"journal":{"name":"Current Reviews in Musculoskeletal Medicine","volume":"19 1","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13263370/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148239107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rehabilitation Protocols Following Patellar Instability Surgery: A Structured Review of Published Recommendations and AI Generated Guidance.","authors":"Matias Vidra, Jonathan Sigal, Ilan Y Mitchnik, Oscar Carvajal Masis, Netanel Krugliak, Gil Rachevsky, Ran Atzmon, Ron Gilat","doi":"10.1007/s12178-026-10036-9","DOIUrl":"10.1007/s12178-026-10036-9","url":null,"abstract":"<p><strong>Purpose of review: </strong>To review postoperative rehabilitation protocols after surgery for patellar instability, including medial patellofemoral ligament reconstruction (MPFLR), tibial tubercle osteotomy (TTO), trochleoplasty, and combined procedures. A secondary aim was to compare published recommendations with guidance generated by selected artificial intelligence (AI) platforms.</p><p><strong>Recent findings: </strong>Sixty three protocol entries were included: 35 isolated MPFLR, 9 isolated TTO, 4 isolated trochleoplasty, and 15 combined procedures. Isolated MPFLR showed the most consistent rehabilitation pattern, favoring immediate weight bearing as tolerated (66%, p < 0.001), locked bracing for up to 6 weeks (63%, p < 0.001), and full ROM by 6 to 12 weeks (51%, p = 0.002). Isolated TTO protocols recommended delayed or non weight bearing (56%), locked brace duration greater than 6 weeks (67%), and full ROM by 6 to 12 weeks (44%), with no significant predominance (all p > 0.05). Trochleoplasty protocols were too few and heterogeneous. Combined procedures were mostly protective but variable overall. RTS criteria were mostly time, functional, and strength based (76%-89%), whereas psychological readiness (43%) and physician approval (22%) were infrequent. AI generated protocols broadly reproduced MPFLR rehabilitation principles but lacked procedure specific differentiation. Rehabilitation protocols following patellar instability surgery remain highly variable, particularly for non MPFLR procedures. Isolated MPFLR protocols generally follow a more structured and accelerated pathway, whereas rehabilitation after TTO, trochleoplasty, and combined procedures remains less clearly defined and more protective. RTS decisions rely mainly on time, strength, and functional based criteria, whereas psychological readiness remains underutilized. AI based tools may serve as supportive decision making aids but currently require integration with clinical judgment and procedure-specific expertise.</p>","PeriodicalId":10950,"journal":{"name":"Current Reviews in Musculoskeletal Medicine","volume":"19 1","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13247021/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148197587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management and Outcomes of Osteochondritis Dissecans of the Knee in the Pediatric and Adolescent Population.","authors":"Samuel I Rosenberg, Nikhil B Patel, Eileen A Crawford","doi":"10.1007/s12178-026-10040-z","DOIUrl":"10.1007/s12178-026-10040-z","url":null,"abstract":"<p><strong>Purpose of review: </strong>Osteochondritis dissecans (OCD) of the knee is a complex condition in pediatric and adolescent patients, and management relies heavily on lesion characteristics including size, stability, and fragmentation. The purpose of this review is to inform readers of the current understanding, treatment options, and outcomes of the disorder in pediatric and adolescent patients.</p><p><strong>Recent findings: </strong>While management of OCD of the knee is tailored highly to patient- and lesion-specific factors, broad management pathways are dictated first by lesion stability, and further by salvageability of unstable lesions. Lesion appearance on MRI and arthroscopy are critical in informing appropriate management. Stable lesions, especially in skeletally immature patients, should undergo 3-6 months of nonoperative management, with an initial 4-6 week period of nonweightbearing and avoidance of high impact or repetitive stress for a minimum of 3 months. Patients with stable lesions who fail nonoperative treatment are candidates for retro- or trans-articular drilling of the lesion to promote healing. Unstable lesions may be amenable to salvage approaches including arthroscopic or open fixation with metallic screws, bioabsorbable implants, autograft, and suture bridge constructs. When not salvageable, osteochondral autograft transfer, osteochondral allograft transplantation, or autologous chondrocyte implantation is recommended and pursued depending on lesion size and subchondral involvement. All techniques have good potential for success in healing, patient reported outcomes, and return to activity when applied in the appropriate circumstances. Significant heterogeneity exists in management and outcomes of OCD of the knee, largely attributed to the varying presentation and treatment modalities. Management pathway should be patient-specific, however there is a paucity of robust comparative trials within specific populations.</p>","PeriodicalId":10950,"journal":{"name":"Current Reviews in Musculoskeletal Medicine","volume":"19 1","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13241550/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148175488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rehabilitation of Arthrogenic Muscle Inhibition in Patients with Knee Osteoarthritis and after Knee Arthroplasty.","authors":"Georgios Kakavas, Claudia Sasse, Aleksandra Królikowska, Stephanie Wong, Roland Becker, Robert Prill","doi":"10.1007/s12178-026-10038-7","DOIUrl":"10.1007/s12178-026-10038-7","url":null,"abstract":"<p><strong>Purpose of review: </strong>Arthrogenic muscle inhibition (AMI) is a key neurophysiological mechanism that impairs voluntary quadriceps activation following total knee arthroplasty (TKA), potentially limiting functional recovery despite technically successful surgery. This review aims to synthesize current evidence on the neurophysiological mechanisms underlying AMI and to propose a mechanism-based rehabilitation framework targeting these inhibitory processes.</p><p><strong>Recent findings: </strong>Emerging evidence indicates that AMI is mediated by altered afferent input from the joint, leading to changes in spinal reflex excitability and supraspinal motor control. Mechanisms such as presynaptic inhibition, reduced α-motoneuron excitability, and impaired γ-loop function contribute to diminished quadriceps activation. In addition, recent studies suggest that AMI may manifest at the level of motor unit recruitment and firing behavior, reflecting persistent neuromuscular adaptations. These inhibitory processes are further influenced by joint effusion, pain, and pre-existing neuromotor deficits in patients with knee osteoarthritis. AMI represents a multilevel sensorimotor dysfunction that may act as a major limiting factor in postoperative recovery after TKA. A targeted rehabilitation approach addressing peripheral, spinal, and supraspinal mechanisms-including effusion control, neuromuscular electrical stimulation, blood flow restriction training, and sensorimotor retraining-may improve quadriceps activation and functional outcomes. Integrating neurophysiological principles into rehabilitation strategies may enhance recovery trajectories and should be a focus of future clinical research.</p>","PeriodicalId":10950,"journal":{"name":"Current Reviews in Musculoskeletal Medicine","volume":"19 1","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13241345/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148175528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meniscus Pathology in the Setting of Revision ACL Surgery: Unique Considerations.","authors":"Adam V Daniel, Sophia Mavrommatis, Aaron J Krych, Patrick A Smith","doi":"10.1007/s12178-026-10027-w","DOIUrl":"10.1007/s12178-026-10027-w","url":null,"abstract":"<p><strong>Purpose of review: </strong>Similar to primary anterior cruciate ligament reconstruction (ACLR), meniscal pathology is frequently encountered during revision ACLR (RACLR). In the revision setting, however, meniscal disease often presents a greater challenge because tissue quality may be compromised, particularly when prior meniscal treatment was performed at the index ACLR. This review highlights key considerations and treatment strategies for managing extensive, complex meniscal lesions in the setting of RACLR.</p><p><strong>Recent findings: </strong>Graft failure significantly increases the incidence of meniscal tears. Furthermore, graft insufficiency may result in extensive, complex, and sometimes, irreparable meniscal tears. Meniscal treatment strategies, and ultimately joint preservation, have been studied to restore appropriate knee anatomy and biomechanics. Furthermore, special considerations must be made to best treat a wide range of meniscal pathologies in the RACLR, especially in a suboptimal joint environment. Graft failure requiring revision ACL reconstruction is often accompanied by extensive, complex meniscal tearing. Meniscus-preserving strategies may help restore knee anatomy and biomechanics and, in turn, may slow the progression of osteoarthritis.</p>","PeriodicalId":10950,"journal":{"name":"Current Reviews in Musculoskeletal Medicine","volume":"19 1","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13234055/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148148903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Update on Pain Management in Pediatric Spine Surgery.","authors":"Sara N Kiani, Katherine Bach, Vivian Kwok, Ishaan Swarup","doi":"10.1007/s12178-026-10037-8","DOIUrl":"10.1007/s12178-026-10037-8","url":null,"abstract":"<p><strong>Purpose of review: </strong>This paper aims to provide an overview on current recommendations for perioperative pain control for pediatric spine surgery. Managing pediatric pain is important to decrease postoperative morbidity, improve early mobilization, and decrease narcotic analgesic use. We aimed to summarize the data on preoperative pain management, intraoperative pain management, and postoperative pain management pathways for pediatric spine surgery.</p><p><strong>Recent findings: </strong>Pre-operative mental health conditions have been shown to be associated with increased post-operative pain. Intravenous ketorolac and oral gabapentin use postoperatively can improve postoperative pain control and decrease opioid use. While patient-controlled anesthesia is currently widespread after pediatric spine surgery, there is increasing research on regional modalities for pain control, including erector spinae plane blocks, liposomal bupivacaine, epidural analgesia, and intrathecal morphine injections, which are associated with earlier mobilization and decreased narcotic use, with maintained or decreased pain scores. Multimodal pain control, as outlined in Enhanced Recovery After Surgery protocols, is necessary to achieve adequate pain control while decreasing narcotic usage and the associated side effects. Psychosocial factors can impact pain through anxiety and pain catastrophizing. There is increased emphasis on regional and neuraxial anesthesia modalities for pain control. Further research is needed directly comparing the effectiveness of these modalities and further exploring the effect of psychosocial factors on pain and methods to address this.</p>","PeriodicalId":10950,"journal":{"name":"Current Reviews in Musculoskeletal Medicine","volume":"19 1","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13222912/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148136753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rehabilitation and Return to Play Protocols Following Osteochondral Autograft and Allograft Transplantation for Knee Chondral Lesions in Athletic Populations.","authors":"S Ryan Pierson, Richard M Silverman, Brock Knapp, Robert H Brophy","doi":"10.1007/s12178-026-10033-y","DOIUrl":"10.1007/s12178-026-10033-y","url":null,"abstract":"<p><strong>Purpose of review: </strong>Osteochondral autograft transplantation (OATS) and osteochondral allograft transplantation (OCA) are established cartilage restoration procedures for symptomatic chondral and osteochondral defects of the knee in athletes. Postoperative rehabilitation is central to graft healing and incorporation, functional recovery, and safe return to play (RTP). This review synthesizes contemporary evidence on rehabilitation after OATS and OCA, including weight-bearing progression, bracing, range of motion, blood flow restriction training, and RTP criteria.</p><p><strong>Recent findings: </strong>Systematic reviews and survey studies report substantial variability in rehabilitation protocols, including weight-bearing timelines, bracing duration, continuous passive motion utilization, and RTP criteria. Few published protocols incorporate objective functional testing to guide RTP. Criteria-based frameworks that individualize progression by graft type, lesion location, and functional milestones are increasingly advocated, although supporting evidence remains limited. Blood flow restriction training may help preserve strength early after surgery, but data specific to OATS and OCA remain sparse. Return to play is commonly reported after both procedures, with earlier timelines more frequently reported after OATS than OCA. Rehabilitation after OATS and OCA requires balancing early graft protection with progressive restoration of motion, strength, and sport-specific capacity. Current evidence demonstrates wide protocol heterogeneity and continued reliance on time-based milestones, with underuse of objective RTP criteria. Standardized, criteria-driven pathways and multidisciplinary decision-making may improve consistency and optimize outcomes in athletic populations.</p>","PeriodicalId":10950,"journal":{"name":"Current Reviews in Musculoskeletal Medicine","volume":"19 1","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13197494/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147986789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Brief Overview and Update of Regenerative Medicine for the Treatment of Musculoskeletal Conditions.","authors":"Matthew Negaard, Michael Kelleher","doi":"10.1007/s12178-026-10030-1","DOIUrl":"10.1007/s12178-026-10030-1","url":null,"abstract":"","PeriodicalId":10950,"journal":{"name":"Current Reviews in Musculoskeletal Medicine","volume":"19 1","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13184063/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147962350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pain Management Strategies in Reverse Total Shoulder Arthroplasty.","authors":"Wyatt B David, Luke Sang, Ryan T Halvorson, Brian T Feeley","doi":"10.1007/s12178-026-10034-x","DOIUrl":"10.1007/s12178-026-10034-x","url":null,"abstract":"<p><strong>Purpose of review: </strong>Reverse total shoulder arthroplasty (rTSA) is a commonly utilized procedure for rotator cuff arthropathy, irreparable rotator cuff tears, and complex proximal humerus fractures. Although rTSA significantly improves long-term pain and function, postoperative pain remains common and is closely associated with increased opioid consumption, prolonged hospitalization, delayed recovery, and reduced patient satisfaction. Within the modern context of the opioid epidemic, optimizing pain control while minimizing narcotic usage is essential. This review summarizes recent evidence on pain management strategies for rTSAs, with emphasis on regional anesthesia techniques, multimodal analgesia, periarticular injections, Enhanced Recovery After Surgery (ERAS) protocols, and patient-specific factors influencing pain outcomes.</p><p><strong>Recent findings: </strong>Recent studies demonstrate that interscalene nerve blocks provide effective early postoperative analgesia and reduce opioid requirements, though complications such as phrenic nerve paralysis and rebound pain persist. Alternative regional techniques, including combined suprascapular and axillary nerve blocks, could offer comparable analgesia with reduced adverse risks in select patients. Multimodal analgesia protocols consistently decrease opioid consumption, improve early pain scores, and shorten hospital length of stay, although outcomes vary based on regimen composition. Periarticular injections further enhance analgesia when used alone or as adjuncts to regional anesthesia. ERAS protocols are associated with improved postoperative outcomes in hip and knee arthroplasty, but evidence of their application remains limited in rTSA. Patient-level factors, including preoperative opioid use, mental health conditions, and comorbidity burden, strongly predict postoperative pain and prolonged opioid dependence. Postoperative pain management after rTSA has evolved toward a multimodal, patient-centered approach integrating approaches such as regional anesthesia, non-opioid multimodal analgesia, and periarticular injections. Despite recent advances, optimal regional anesthetic techniques and the implementation of standardized ERAS protocols in rTSA remain areas of necessary future investigation.</p>","PeriodicalId":10950,"journal":{"name":"Current Reviews in Musculoskeletal Medicine","volume":"19 1","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13179405/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147947936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Factors for Failure of Meniscal Repair.","authors":"Nathan Graden, David Clark, Jacob D Mikula, Adam J Tagliero","doi":"10.1007/s12178-026-10032-z","DOIUrl":"10.1007/s12178-026-10032-z","url":null,"abstract":"<p><strong>Purpose of review: </strong>Meniscal preservation is a cornerstone of modern knee surgery given the meniscus's essential role in load transmission, joint stability, and cartilage protection. As indications for meniscal repair have expanded, understanding the factors associated with repair failure has become increasingly important. The purpose of this review is to synthesize contemporary evidence regarding risk factors for failure of meniscal repair, clarify how failure is defined and evaluated, and outline current strategies for management of failed repairs to guide clinical decision-making.</p><p><strong>Recent findings: </strong>Recent literature supports meniscal repair as a joint-preserving procedure with superior long-term outcomes compared with meniscectomy, though failure and reoperation remain clinically relevant concerns. Failure risk is influenced by a combination of patient-related factors, including smoking status, limb alignment, and medical comorbidities; tear characteristics such as vascular zone, tear pattern, chronicity, and meniscal laterality; and surgical variables including isolated repair versus concomitant ligament reconstruction, repair technique, and postoperative rehabilitation. Advances in repair devices, imaging, and biologic augmentation have improved healing potential, and growing evidence supports revision meniscal repair in select patients with favorable tissue quality and tear morphology. Meniscal repair failure is multifactorial and cannot be attributed to surgical technique alone. Successful outcomes depend on appropriate patient selection, careful assessment of tear biomechanics, selection of an optimal repair strategy, and individualized rehabilitation. Revision meniscal repair remains a viable option for preserving meniscal function in appropriately selected patients. Future research should prioritize standardized definitions of failure, comparative studies of repair techniques, and biologic strategies to further improve healing and long-term joint preservation.</p>","PeriodicalId":10950,"journal":{"name":"Current Reviews in Musculoskeletal Medicine","volume":"19 1","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13176444/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147940469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}