Current Opinion in HIV and AIDS最新文献_第9页

Clinical implementation of long-acting antiretroviral treatment in high-income countries: challenges and advantages 高收入国家长效抗逆转录病毒治疗的临床实施:挑战与优势

IF 4.1 3区医学

Current Opinion in HIV and AIDS Pub Date : 2022-04-18 DOI: 10.1097/COH.0000000000000730

L. Waters, Alex Sparrowhawk

{"title":"Clinical implementation of long-acting antiretroviral treatment in high-income countries: challenges and advantages","authors":"L. Waters, Alex Sparrowhawk","doi":"10.1097/COH.0000000000000730","DOIUrl":"https://doi.org/10.1097/COH.0000000000000730","url":null,"abstract":"Purpose of review Long-acting antiretroviral therapy (LA-ART) brings a paradigm shift to HIV care with injectable cabotegravir/rilpivirine (IM-CAB/RPV) in current or imminent use in several countries. This brings the usual opportunities and challenges of a new therapy, plus requirements to adapt services to reliably deliver injections and ensure patients understand advantages and limitations. We summarise key considerations for implementation in high-income countries. Recent findings Monthly IM-CAB/RPV is noninferior to oral ART and monthly IM-CAB/RPV to 1-monthly in carefully selected virally suppressed people. The numerically higher virological failure rate on two-monthly IM-CAB/RPV warrants close attention and careful monitoring. Implementation projects report positive experiences for patients and staff, but also barriers. Data is needed in younger people, pregnancy/breastfeeding, and in those with detectable viraemia secondary to suboptimal adherence. Summary We highlight a paucity of real-world data and key unanswered questions. Existing data on injection techniques may have implications for training; monitoring of outcomes is crucial to ensure clinical trial results are replicated in real-life. Better understanding of treatment failure, and individualised therapy, is crucial, and it is important to repeat patient preference surveys as new data emerges to ensure decisions are based on the most recent evidence of benefit vs risk.","PeriodicalId":10949,"journal":{"name":"Current Opinion in HIV and AIDS","volume":"17 1","pages":"121 - 126"},"PeriodicalIF":4.1,"publicationDate":"2022-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61654524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Editorial introductions. 编辑介绍。

IF 4.1 3区医学

Current Opinion in HIV and AIDS Pub Date : 2022-03-01 DOI: 10.1097/COH.0000000000000719

引用次数: 0

Adapting digital health interventions for the evolving HIV landscape: examples to support prevention and treatment research. 适应不断变化的艾滋病毒形势的数字卫生干预措施:支持预防和治疗研究的实例。

IF 4.1 3区医学

Current Opinion in HIV and AIDS Pub Date : 2022-03-01 DOI: 10.1097/COH.0000000000000721

Henna Budhwani, B Matthew Kiszla, Lisa B Hightow-Weidman

{"title":"Adapting digital health interventions for the evolving HIV landscape: examples to support prevention and treatment research.","authors":"Henna Budhwani, B Matthew Kiszla, Lisa B Hightow-Weidman","doi":"10.1097/COH.0000000000000721","DOIUrl":"https://doi.org/10.1097/COH.0000000000000721","url":null,"abstract":"Purpose of review Although many HIV prevention and/or treatment digital health interventions (DHIs) have shown feasibility and acceptability, fewer have indicated efficacy, and only a subset have been adapted for new contexts. Adaptation is a key element of pragmatic implementation science research. Adaptation is cost effective and time efficient compared with new development. Leveraging adaptation can lead to accelerated scale-up and enhanced public health impact. Considering the value of adaptation, the purpose of this piece is to present examples of DHI to DHI adaptation sequences to inform future HIV prevention and/or treatment research. Recent findings From an examination of recent academic articles (01 November 2016 to 31 October 2021), we identified adaptation sequences that included an original DHI with at least two adaptations. Four models are presented herein; examples consist of adapted DHIs for new population, health outcome, geography, or a combination thereof. Summary Adaptation is a promising scientific approach to expeditiously respond to the evolving HIV landscape. We present examples of DHI adaptations alongside considerations for each type of adaptation; we also present adaptation challenges with responsive strategies. We suggest when conducted with attention to rigor (leveraging adaptation frameworks, community engagement, and tailoring content), adaptation is a powerful tool to pragmatically address the HIV epidemic.","PeriodicalId":10949,"journal":{"name":"Current Opinion in HIV and AIDS","volume":"17 2","pages":"112-118"},"PeriodicalIF":4.1,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9833493/pdf/nihms-1859688.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10141324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Context, COVID-19 and comorbidities: exploring emergent directions in syndemics and HIV research. 背景、COVID-19 和合并症：探索综合症和艾滋病研究的新方向。

IF 4.1 3区医学

Current Opinion in HIV and AIDS Pub Date : 2022-03-01 DOI: 10.1097/COH.0000000000000722

Carmen H Logie, Madelaine Coelho, Brandon Kohrt, Alexander C Tsai, Emily Mendenhall

{"title":"Context, COVID-19 and comorbidities: exploring emergent directions in syndemics and HIV research.","authors":"Carmen H Logie, Madelaine Coelho, Brandon Kohrt, Alexander C Tsai, Emily Mendenhall","doi":"10.1097/COH.0000000000000722","DOIUrl":"10.1097/COH.0000000000000722","url":null,"abstract":"Purpose of review: The purpose of this review is to identify themes across articles that aimed to explore HIV-related syndemics in 2020 and 2021 and to discuss their implications for research on syndemics.Recent findings: We identified 189 articles on syndemics between 2020 and 2021. Key themes across studies included COVID-19; mental health and psychosocial challenges; substance use; socio-structural factors; protective factors; and methodological approaches. COVID-19's implications for HIV syndemic research were discussed. Mental health and substance use research largely examined linkages with sexual practices or reduced HIV care retention. Researchers examined associations between socio-structural variables (e.g. poverty) and elevated HIV exposure, reduced HIV testing and poorer health. Concepts of water insecurity and 'ecosyndemics' were also raised, as was the importance of attending to noncommunicable diseases and comorbidities. Most studies did not assess interactions between health conditions, signalling the need for methodological grounding in the foundational concepts of syndemic theory.Summary: Most studies recommended that HIV prevention and care research attend to the interplay between poor mental health, substance use and multidimensional violence. Increased attention to structural factors, particularly exacerbated poverty in the COVID-19 pandemic, is required. Research can identify protective factors to harness to advance HIV prevention and care.","PeriodicalId":10949,"journal":{"name":"Current Opinion in HIV and AIDS","volume":"17 2","pages":"46-54"},"PeriodicalIF":4.1,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11045292/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10194693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Behavioral and social interventions to promote optimal HIV prevention and care continua outcomes in the United States. 在美国采取行为和社会干预措施，促进实现最佳的艾滋病毒预防和护理效果。

IF 4.1 3区医学

Current Opinion in HIV and AIDS Pub Date : 2022-03-01 DOI: 10.1097/COH.0000000000000717

Kristi E Gamarel, Wesley M King, Don Operario

{"title":"Behavioral and social interventions to promote optimal HIV prevention and care continua outcomes in the United States.","authors":"Kristi E Gamarel, Wesley M King, Don Operario","doi":"10.1097/COH.0000000000000717","DOIUrl":"10.1097/COH.0000000000000717","url":null,"abstract":"Purpose of review: This review reports on trends in behavioral and social intervention research in the United States published over the past year (2020-2021) investigating HIV prevention and care outcomes, organized by the level of intervention focus - individual, dyadic, and organizational.Recent findings: Researchers have continued to develop and evaluate behavioral and social interventions to reduce HIV acquisition risk and disease progression. With few exceptions, social and behavioral interventions have primarily focused on individuals as the unit of behavior change. Interventions operating at the individual-, dyadic-, and organizational-level have made strides to reduce HIV transmission risk and disease progressing by addressing mental health, substance use, stigma, peer and romantic relationships, and, to some extent, structural vulnerabilities.Summary: Social and behavioral interventions continue to be critical in addressing HIV inequities in the United States. An important gap in the literature is the need for multilevel interventions designed and implemented within existing community-based organizations and local healthcare settings. We call on researchers to continue to attend to the structural, environmental, and economic vulnerabilities that shape HIV inequities in the development of multilevel approaches necessary to realize the full potential of existing and emerging HIV prevention and care strategies.","PeriodicalId":10949,"journal":{"name":"Current Opinion in HIV and AIDS","volume":"17 2","pages":"65-71"},"PeriodicalIF":4.1,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8885930/pdf/nihms-1772557.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10194694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From surviving to thriving: the current status of the behavioral, social, and psychological issues of aging with HIV. 从生存到繁荣:老年艾滋病患者的行为、社会和心理问题的现状。

IF 4.1 3区医学

Current Opinion in HIV and AIDS Pub Date : 2022-03-01 DOI: 10.1097/COH.0000000000000725

Erik L Ruiz, Karah Y Greene, Jerome T Galea, Brandon Brown

引用次数: 6

Beyond criminalization: reconsidering HIV criminalization in an era of reform. 超越刑事化:改革时代对艾滋病刑事化的重新思考。

IF 4.1 3区医学

Current Opinion in HIV and AIDS Pub Date : 2022-03-01 DOI: 10.1097/COH.0000000000000715

Trevor Hoppe, Alexander McClelland, Kenneth Pass

{"title":"Beyond criminalization: reconsidering HIV criminalization in an era of reform.","authors":"Trevor Hoppe, Alexander McClelland, Kenneth Pass","doi":"10.1097/COH.0000000000000715","DOIUrl":"https://doi.org/10.1097/COH.0000000000000715","url":null,"abstract":"Purpose of review: This paper reviews recent studies examining the application of human immunodeficiency virus (HIV)-specific criminal laws in North America (particularly the United States and Canada). In the wake of the development of new biomedical prevention strategies, many states in the United States (US) have recently begun to reform or repeal their HIV-specific laws. These findings can help inform efforts to 'modernize' HIV laws (or, to revise in ways that reflect recent scientific advances in HIV treatment and prevention).Recent findings: Recent studies suggest that HIV-specific laws disproportionately impact Black men, white women, and Black women. The media sensationally covers criminal trials under these laws, especially when they involve Black defendants who they often describe in racialized terms as predators. Activists contest these laws and raise concerns about new phylogenetic HIV surveillance techniques that have the potential to be harnessed for law enforcement purposes.Summary: These findings collectively raise urgent concerns for the continued use of HIV-specific criminal laws. These policies disproportionately impact marginalized groups - particularly Black men. Media coverage of these cases often helps to spread misinformation and stigmatizing rhetoric about people living with HIV and promulgate racist stereotypes. Although well-intentioned, new phylogenetic HIV surveillance technologies have the potential to exacerbate these issues if law enforcement is able to gain access to these public health tools.","PeriodicalId":10949,"journal":{"name":"Current Opinion in HIV and AIDS","volume":"17 2","pages":"100-105"},"PeriodicalIF":4.1,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10141321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Moving toward equity: fostering transdisciplinary research between the social and behavioral sciences and implementation science to end the HIV epidemic. 迈向公平:促进社会和行为科学与执行科学之间的跨学科研究，以结束艾滋病毒的流行。

IF 4.1 3区医学

Current Opinion in HIV and AIDS Pub Date : 2022-03-01 DOI: 10.1097/COH.0000000000000726

Maria Pyra, Darnell Motley, Alida Bouris

{"title":"Moving toward equity: fostering transdisciplinary research between the social and behavioral sciences and implementation science to end the HIV epidemic.","authors":"Maria Pyra, Darnell Motley, Alida Bouris","doi":"10.1097/COH.0000000000000726","DOIUrl":"https://doi.org/10.1097/COH.0000000000000726","url":null,"abstract":"Purpose of review: Since the beginning of the HIV epidemic, social and behavioral scientists have developed interventions to stem the spread of the virus. The dissemination of these interventions has traditionally been a lengthy process; however, implementation science (IS) offers a route toward hastening delivery of effective interventions. A transdisciplinary approach, wherein IS informs and is informed by social and behavioral sciences (SBS) as well as community participation, offers a strategy for more efficiently moving toward health equity and ending the HIV epidemic.Recent findings: There has been considerable growth in HIV research utilizing IS theories, methods and frameworks. Many of these studies have been multi or interdisciplinary in nature, demonstrating the ways that IS and SBS can strengthen one another. We also find areas for continued progress toward transdisciplinarity.Summary: We review literature from 2020 to 2021, exploring the ways IS and SBS have been used in tandem to develop, evaluate and disseminate HIV interventions. We highlight the interplay between disciplines and make a case for moving toward transdisciplinarity, which would yield new, integrated frameworks that can improve prevention and treatment efforts, moving us closer to achieving health equity.","PeriodicalId":10949,"journal":{"name":"Current Opinion in HIV and AIDS","volume":"17 2","pages":"89-99"},"PeriodicalIF":4.1,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10139202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Ending the HIV epidemic for all, not just some: structural racism as a fundamental but overlooked social-structural determinant of the US HIV epidemic. 终结所有人(而不仅仅是一部分人)的艾滋病毒流行:结构性种族主义是美国艾滋病毒流行的一个基本但被忽视的社会结构决定因素。

IF 4.1 3区医学

Current Opinion in HIV and AIDS Pub Date : 2022-03-01 DOI: 10.1097/COH.0000000000000724

Lisa Bowleg, Arianne N Malekzadeh, Mary Mbaba, Cheriko A Boone

{"title":"Ending the HIV epidemic for all, not just some: structural racism as a fundamental but overlooked social-structural determinant of the US HIV epidemic.","authors":"Lisa Bowleg, Arianne N Malekzadeh, Mary Mbaba, Cheriko A Boone","doi":"10.1097/COH.0000000000000724","DOIUrl":"https://doi.org/10.1097/COH.0000000000000724","url":null,"abstract":"Purpose of review: We review the recent theoretical and empirical literature on structural racism, social determinants of health frameworks within the context of HIV prevention and treatment, and criticism of the national responses to the US epidemic.Recent findings: In line with growing mainstream attention to the role of structural racism and health inequities, recent editorials and studies cite ending structural racism as an essential step to ending the US HIV epidemic. Recent studies demonstrate that barriers rooted in structural racism such as incarceration, housing instability, police discrimination, neighborhood disadvantage, health service utilization and community violence, and poor or no access to social services, transportation, and childcare, are barriers to HIV prevention. Recent articles also criticize national responses to HIV such as the ending the HIV epidemic (EHE) and National HIV/AIDS Strategy plans for failing to address structural racism and prioritize community engagement in EHE efforts.Summary: Collectively, the articles in this review highlight a growing consensus that the US has no real chance of EHE for all, absent a meaningful and measurable commitment to addressing structural racism and intersectional discrimination as core determinants of HIV, and without more equitable engagement with community-based organizations and communities disproportionately affected by HIV.","PeriodicalId":10949,"journal":{"name":"Current Opinion in HIV and AIDS","volume":"17 2","pages":"40-45"},"PeriodicalIF":4.1,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9109814/pdf/nihms-1785770.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10194696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 26

Editorial: Critical social and behavioral sciences perspectives on ending the HIV epidemic. 社论:关于结束艾滋病毒流行的关键社会和行为科学观点。

IF 4.1 3区医学

Current Opinion in HIV and AIDS Pub Date : 2022-03-01 DOI: 10.1097/COH.0000000000000716

Judith D Auerbach, Karine Dubé

引用次数: 0