Current Opinion in HIV and AIDS最新文献_第8页

Behavioral and social interventions to promote optimal HIV prevention and care continua outcomes in the United States. 在美国采取行为和社会干预措施，促进实现最佳的艾滋病毒预防和护理效果。

IF 4.1 3区医学

Current Opinion in HIV and AIDS Pub Date : 2022-03-01 DOI: 10.1097/COH.0000000000000717

Kristi E Gamarel, Wesley M King, Don Operario

{"title":"Behavioral and social interventions to promote optimal HIV prevention and care continua outcomes in the United States.","authors":"Kristi E Gamarel, Wesley M King, Don Operario","doi":"10.1097/COH.0000000000000717","DOIUrl":"10.1097/COH.0000000000000717","url":null,"abstract":"Purpose of review: This review reports on trends in behavioral and social intervention research in the United States published over the past year (2020-2021) investigating HIV prevention and care outcomes, organized by the level of intervention focus - individual, dyadic, and organizational.Recent findings: Researchers have continued to develop and evaluate behavioral and social interventions to reduce HIV acquisition risk and disease progression. With few exceptions, social and behavioral interventions have primarily focused on individuals as the unit of behavior change. Interventions operating at the individual-, dyadic-, and organizational-level have made strides to reduce HIV transmission risk and disease progressing by addressing mental health, substance use, stigma, peer and romantic relationships, and, to some extent, structural vulnerabilities.Summary: Social and behavioral interventions continue to be critical in addressing HIV inequities in the United States. An important gap in the literature is the need for multilevel interventions designed and implemented within existing community-based organizations and local healthcare settings. We call on researchers to continue to attend to the structural, environmental, and economic vulnerabilities that shape HIV inequities in the development of multilevel approaches necessary to realize the full potential of existing and emerging HIV prevention and care strategies.","PeriodicalId":10949,"journal":{"name":"Current Opinion in HIV and AIDS","volume":"17 2","pages":"65-71"},"PeriodicalIF":4.1,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8885930/pdf/nihms-1772557.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10194694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From surviving to thriving: the current status of the behavioral, social, and psychological issues of aging with HIV. 从生存到繁荣:老年艾滋病患者的行为、社会和心理问题的现状。

IF 4.1 3区医学

Current Opinion in HIV and AIDS Pub Date : 2022-03-01 DOI: 10.1097/COH.0000000000000725

Erik L Ruiz, Karah Y Greene, Jerome T Galea, Brandon Brown

引用次数: 6

Beyond criminalization: reconsidering HIV criminalization in an era of reform. 超越刑事化:改革时代对艾滋病刑事化的重新思考。

IF 4.1 3区医学

Current Opinion in HIV and AIDS Pub Date : 2022-03-01 DOI: 10.1097/COH.0000000000000715

Trevor Hoppe, Alexander McClelland, Kenneth Pass

{"title":"Beyond criminalization: reconsidering HIV criminalization in an era of reform.","authors":"Trevor Hoppe, Alexander McClelland, Kenneth Pass","doi":"10.1097/COH.0000000000000715","DOIUrl":"https://doi.org/10.1097/COH.0000000000000715","url":null,"abstract":"Purpose of review: This paper reviews recent studies examining the application of human immunodeficiency virus (HIV)-specific criminal laws in North America (particularly the United States and Canada). In the wake of the development of new biomedical prevention strategies, many states in the United States (US) have recently begun to reform or repeal their HIV-specific laws. These findings can help inform efforts to 'modernize' HIV laws (or, to revise in ways that reflect recent scientific advances in HIV treatment and prevention).Recent findings: Recent studies suggest that HIV-specific laws disproportionately impact Black men, white women, and Black women. The media sensationally covers criminal trials under these laws, especially when they involve Black defendants who they often describe in racialized terms as predators. Activists contest these laws and raise concerns about new phylogenetic HIV surveillance techniques that have the potential to be harnessed for law enforcement purposes.Summary: These findings collectively raise urgent concerns for the continued use of HIV-specific criminal laws. These policies disproportionately impact marginalized groups - particularly Black men. Media coverage of these cases often helps to spread misinformation and stigmatizing rhetoric about people living with HIV and promulgate racist stereotypes. Although well-intentioned, new phylogenetic HIV surveillance technologies have the potential to exacerbate these issues if law enforcement is able to gain access to these public health tools.","PeriodicalId":10949,"journal":{"name":"Current Opinion in HIV and AIDS","volume":"17 2","pages":"100-105"},"PeriodicalIF":4.1,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10141321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Moving toward equity: fostering transdisciplinary research between the social and behavioral sciences and implementation science to end the HIV epidemic. 迈向公平:促进社会和行为科学与执行科学之间的跨学科研究，以结束艾滋病毒的流行。

IF 4.1 3区医学

Current Opinion in HIV and AIDS Pub Date : 2022-03-01 DOI: 10.1097/COH.0000000000000726

Maria Pyra, Darnell Motley, Alida Bouris

{"title":"Moving toward equity: fostering transdisciplinary research between the social and behavioral sciences and implementation science to end the HIV epidemic.","authors":"Maria Pyra, Darnell Motley, Alida Bouris","doi":"10.1097/COH.0000000000000726","DOIUrl":"https://doi.org/10.1097/COH.0000000000000726","url":null,"abstract":"Purpose of review: Since the beginning of the HIV epidemic, social and behavioral scientists have developed interventions to stem the spread of the virus. The dissemination of these interventions has traditionally been a lengthy process; however, implementation science (IS) offers a route toward hastening delivery of effective interventions. A transdisciplinary approach, wherein IS informs and is informed by social and behavioral sciences (SBS) as well as community participation, offers a strategy for more efficiently moving toward health equity and ending the HIV epidemic.Recent findings: There has been considerable growth in HIV research utilizing IS theories, methods and frameworks. Many of these studies have been multi or interdisciplinary in nature, demonstrating the ways that IS and SBS can strengthen one another. We also find areas for continued progress toward transdisciplinarity.Summary: We review literature from 2020 to 2021, exploring the ways IS and SBS have been used in tandem to develop, evaluate and disseminate HIV interventions. We highlight the interplay between disciplines and make a case for moving toward transdisciplinarity, which would yield new, integrated frameworks that can improve prevention and treatment efforts, moving us closer to achieving health equity.","PeriodicalId":10949,"journal":{"name":"Current Opinion in HIV and AIDS","volume":"17 2","pages":"89-99"},"PeriodicalIF":4.1,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10139202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Ending the HIV epidemic for all, not just some: structural racism as a fundamental but overlooked social-structural determinant of the US HIV epidemic. 终结所有人(而不仅仅是一部分人)的艾滋病毒流行:结构性种族主义是美国艾滋病毒流行的一个基本但被忽视的社会结构决定因素。

IF 4.1 3区医学

Current Opinion in HIV and AIDS Pub Date : 2022-03-01 DOI: 10.1097/COH.0000000000000724

Lisa Bowleg, Arianne N Malekzadeh, Mary Mbaba, Cheriko A Boone

{"title":"Ending the HIV epidemic for all, not just some: structural racism as a fundamental but overlooked social-structural determinant of the US HIV epidemic.","authors":"Lisa Bowleg, Arianne N Malekzadeh, Mary Mbaba, Cheriko A Boone","doi":"10.1097/COH.0000000000000724","DOIUrl":"https://doi.org/10.1097/COH.0000000000000724","url":null,"abstract":"Purpose of review: We review the recent theoretical and empirical literature on structural racism, social determinants of health frameworks within the context of HIV prevention and treatment, and criticism of the national responses to the US epidemic.Recent findings: In line with growing mainstream attention to the role of structural racism and health inequities, recent editorials and studies cite ending structural racism as an essential step to ending the US HIV epidemic. Recent studies demonstrate that barriers rooted in structural racism such as incarceration, housing instability, police discrimination, neighborhood disadvantage, health service utilization and community violence, and poor or no access to social services, transportation, and childcare, are barriers to HIV prevention. Recent articles also criticize national responses to HIV such as the ending the HIV epidemic (EHE) and National HIV/AIDS Strategy plans for failing to address structural racism and prioritize community engagement in EHE efforts.Summary: Collectively, the articles in this review highlight a growing consensus that the US has no real chance of EHE for all, absent a meaningful and measurable commitment to addressing structural racism and intersectional discrimination as core determinants of HIV, and without more equitable engagement with community-based organizations and communities disproportionately affected by HIV.","PeriodicalId":10949,"journal":{"name":"Current Opinion in HIV and AIDS","volume":"17 2","pages":"40-45"},"PeriodicalIF":4.1,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9109814/pdf/nihms-1785770.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10194696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 26

Editorial: Critical social and behavioral sciences perspectives on ending the HIV epidemic. 社论:关于结束艾滋病毒流行的关键社会和行为科学观点。

IF 4.1 3区医学

Current Opinion in HIV and AIDS Pub Date : 2022-03-01 DOI: 10.1097/COH.0000000000000716

Judith D Auerbach, Karine Dubé

引用次数: 0

The innovative use of qualitative and mixed methods research to advance improvements along the HIV prevention and care continua. 创新地使用定性和混合方法研究，以推进艾滋病毒预防和护理方面的改进。

IF 4.1 3区医学

Current Opinion in HIV and AIDS Pub Date : 2022-03-01 DOI: 10.1097/COH.0000000000000720

Emily A Arnold, Chadwick K Campbell, Kimberly A Koester

{"title":"The innovative use of qualitative and mixed methods research to advance improvements along the HIV prevention and care continua.","authors":"Emily A Arnold, Chadwick K Campbell, Kimberly A Koester","doi":"10.1097/COH.0000000000000720","DOIUrl":"https://doi.org/10.1097/COH.0000000000000720","url":null,"abstract":"Purpose of review: Despite enormous advances in prevention and care modalities, HIV continues to burden populations around the globe and is largely driven by social and behavioral processes. Mixed methods and qualitative research endeavors are best suited to uncovering and making sense of these dynamics, producing unique and actionable findings to alleviate the burden of HIV. We reviewed the global literature published on PubMed from 2020 to 2021 to identify studies that produced new insights into the social and behavioral dynamics that drive the HIV epidemic, focusing on mixed methods or purely qualitative study designs.Recent findings: Mixed methods and qualitative studies have revealed important nuances in the social and behavioral dynamics associated with the HIV prevention and care continua, from preexposure prophylaxis uptake and adherence to engagement in HIV care and treatment, and have important implications for attaining goals for controlling the epidemic.Summary: Articles reviewed contribute to advancing our understanding of complex social dynamics, structural level factors such as healthcare systems and policy, as well as the research endeavor itself and the need to diversify and sustain research to truly represent the perspectives of those most impacted by HIV. Numerous studies represent the unique ability of qualitative and mixed methods research to expand our understanding of and empathy for individuals living with and affected by HIV, offering new insights to help alleviate the burden of HIV.","PeriodicalId":10949,"journal":{"name":"Current Opinion in HIV and AIDS","volume":"17 2","pages":"106-111"},"PeriodicalIF":4.1,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10194690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Promise, perils and cautious optimism: the next frontier in long-acting modalities for the treatment and prevention of HIV. 希望、危险和谨慎乐观:治疗和预防艾滋病毒长效模式的下一个前沿。

IF 4.1 3区医学

Current Opinion in HIV and AIDS Pub Date : 2022-03-01 DOI: 10.1097/COH.0000000000000723

Morgan M Philbin, Amaya Perez-Brumer

{"title":"Promise, perils and cautious optimism: the next frontier in long-acting modalities for the treatment and prevention of HIV.","authors":"Morgan M Philbin, Amaya Perez-Brumer","doi":"10.1097/COH.0000000000000723","DOIUrl":"https://doi.org/10.1097/COH.0000000000000723","url":null,"abstract":"Purpose of review: This paper provides a critical review of recent therapeutic advances in long-acting (LA) modalities for human immunodeficiency virus (HIV) treatment and prevention.Recent findings: LA injectable antiretroviral therapy (ART) has been approved in the United States, Canada and Europe; the United States also has approved LA injectable preexposure prophylaxis (PrEP) and the World Health Organization has recommended the vaginal PrEP ring. Current LA PrEP modalities in clinical trials include injections, films, rings, and implants; LA ART modalities in trials include subcutaneous injections and long-term oral pills. Although LA modalities hold incredible promise, global availability is inhibited by long-standing multilevel perils including declining multilateral funding, patent protections and lack of political will. Once available, access and uptake are limited by factors such as insurance coverage, clinic access, labor markets, stigma, and structural racism and sexism. These must be addressed to facilitate equitable access for all.Summary: There have been tremendous recent advances in the efficacy of LA ART and PrEP modalities, providing renewed hope that 'ending the HIV epidemic' is within reach. However, pervasive socio-structural inequities limit the promise of LA modalities, highlighting the need for cautious optimism in light of the embedded inequities in the trajectory of research, development, and population-level implementation.","PeriodicalId":10949,"journal":{"name":"Current Opinion in HIV and AIDS","volume":"17 2","pages":"72-88"},"PeriodicalIF":4.1,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b6/19/cohiv-17-72.PMC8915989.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10141319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Doravirine: its role in HIV treatment. 多拉韦林:它在艾滋病治疗中的作用。

IF 4.1 3区医学

Current Opinion in HIV and AIDS Pub Date : 2022-01-01 DOI: 10.1097/COH.0000000000000709

Alexander J Stockdale, Saye Khoo

{"title":"Doravirine: its role in HIV treatment.","authors":"Alexander J Stockdale, Saye Khoo","doi":"10.1097/COH.0000000000000709","DOIUrl":"https://doi.org/10.1097/COH.0000000000000709","url":null,"abstract":"Purpose of review: We reviewed evidence concerning the novel nonnucleoside reverse transcriptase inhibitor doravirine, aiming to identify situations where it may be selected in preference to integrase inhibitors.Recent findings: Doravirine is licenced for the treatment of HIV-1 in North America and Europe. In two multicentre randomized controlled trials, noninferiority with comparator drugs efavirenz and darunavir/ritonavir was observed at 96 weeks. Doravirine is associated with a lower incidence of neuropsychiatric side effects relative to efavirenz, and favourable lipid changes relative to darunavir over 96 weeks. A lower incidence of weight gain, relative to indirect comparisons with integrase inhibitors, was observed. Doravirine has a high genetic barrier to resistance with retained activity in the presence of single NNRTI mutations K103N, Y181C and G190A. Primary drug resistance is infrequent and may be higher in South Africa relative to European populations. Doravirine may be used in renal or hepatic impairment and has a low potential for drug-drug interactions.Summary: Doravirine is a well tolerated and effective agent in ART-naive patients. Direct comparison with integrase inhibitors, and evidence on the outcomes of treatment with doravirine in the presence of prior NNRTI experience are required to better elucidate which patients will benefit most from doravirine therapy.","PeriodicalId":10949,"journal":{"name":"Current Opinion in HIV and AIDS","volume":"17 1","pages":"4-14"},"PeriodicalIF":4.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10138346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Editorial introductions. 编辑介绍。

IF 4.1 3区医学

Current Opinion in HIV and AIDS Pub Date : 2022-01-01 DOI: 10.1097/COH.0000000000000714

引用次数: 0