Current Chemistry Letters最新文献_第6页

Insecticidal thioureas: Preparation and biochemical impacts of some novel thiobenzamide derivatives as potential eco-friendly insecticidal against the cotton leafworm, Spodoptera littoralis (Boisd.) 杀虫硫脲:新型硫苯甲酰胺衍生物的制备及其对棉花叶虫生态友好型杀虫的生化影响

Current Chemistry Letters Pub Date : 2023-01-01 DOI: 10.5267/j.ccl.2023.5.006

Mohamed A Gad, M. Bakry, Eman A Shehata, Noha A. Dabour

{"title":"Insecticidal thioureas: Preparation and biochemical impacts of some novel thiobenzamide derivatives as potential eco-friendly insecticidal against the cotton leafworm, Spodoptera littoralis (Boisd.)","authors":"Mohamed A Gad, M. Bakry, Eman A Shehata, Noha A. Dabour","doi":"10.5267/j.ccl.2023.5.006","DOIUrl":"https://doi.org/10.5267/j.ccl.2023.5.006","url":null,"abstract":"The following work could bring new insights into the application of heterocyclic N, N′-substituted thiobenzamide derivatives as novel pesticides. Insect growth regulators such as chitin synthesis inhibitors seem promising because of their specific mode of action on insects and their lower toxicity against vertebrates than conventional insecticides. Thus, a novel series of thiobenzamide derivatives have been prepared in a pure state. The structure of these synthesized compounds which related to the most famous insect growth regulator insecticides, were confirmed by elemental and modern spectroscopic analyses (IR, UV, 1HNMR and 13CNMR). Toxicological and biochemical parameters of the synthesized compounds against the cotton leafworm, Spodoptera littoralis under laboratory conditions were also investigated. Regarding the determined LC50 value for compound 2,4-Dichloro-N-[(2-methoxyphenyl)carbamothioyl]- benzamide 14 showed the most potent toxic effects than the other synthetic target compounds, with LC50 46.84 ppm of 2nd instar larvae and LC50 148.05of the 4th instar larvae.","PeriodicalId":10942,"journal":{"name":"Current Chemistry Letters","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83531481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Synthetic approaches, modification ability and biological activity of 1,3,4-thiadiazole based [5+5] annelated heterosystems: Mini-review 1,3,4-噻二唑基[5+5]复合杂系统的合成方法、修饰能力和生物活性综述

Current Chemistry Letters Pub Date : 2023-01-01 DOI: 10.5267/j.ccl.2023.4.004

M. Lelyukh, M. Zhukrovska, Z. Komarenska, Vadym Flud, S. Harkov

引用次数: 0

Solid state synthesis, characterization and biological evaluation of silver doped nanosized metal oxides 银掺杂纳米金属氧化物的固态合成、表征及生物学评价

Current Chemistry Letters Pub Date : 2023-01-01 DOI: 10.5267/j.ccl.2023.3.011

G. Tanuja, Sangappa K Ganiger, Shashidhar Shashidhar, R.K. Preeti, Somanath Reddy Patil, Arunkumar Lagashetty

引用次数: 1

Synthesis and antioxidant activity evaluation of some new 4-thiomethyl functionalised 1,3-thiazoles 新型4-硫甲基功能化1,3-噻唑的合成及抗氧化活性评价

Current Chemistry Letters Pub Date : 2023-01-01 DOI: 10.5267/j.ccl.2023.6.002

I. Danyliuk, N. Kovalenko, V. Tolmachova, Olena Kovtun, L. Saliyeva, N. Slyvka, S. Holota, G. Kutrov, Magdalina D. Tsapko, M. Vovk

引用次数: 1

The study of using HZSM-5/silicate mesopores in the catalytic reaction of n-heptane isomerization HZSM-5/硅酸盐介孔催化正庚烷异构化反应的研究

Current Chemistry Letters Pub Date : 2023-01-01 DOI: 10.5267/j.ccl.2022.9.002

M. H. Peyrovi, B. Derakhshan, N. Parsafard

引用次数: 1

Synthesis of novel 2, 5-disubstituted tetrazole derivatives as potent biological agents 新型2,5 -二取代四唑衍生物强效生物制剂的合成

Current Chemistry Letters Pub Date : 2023-01-01 DOI: 10.5267/j.ccl.2022.11.006

G. V. Megha, Y. Bodke, H. Shanavaz

引用次数: 0

Virtual screening of novel pyridine derivatives as effective inhibitors of DNA gyrase (GyrA) of salmonella typhi 新型吡啶衍生物作为伤寒沙门氏菌DNA回转酶有效抑制剂的虚拟筛选

Current Chemistry Letters Pub Date : 2023-01-01 DOI: 10.5267/j.ccl.2022.10.002

J. Philip, A. Uzairu, G. Shallangwa, S. Uba

{"title":"Virtual screening of novel pyridine derivatives as effective inhibitors of DNA gyrase (GyrA) of salmonella typhi","authors":"J. Philip, A. Uzairu, G. Shallangwa, S. Uba","doi":"10.5267/j.ccl.2022.10.002","DOIUrl":"https://doi.org/10.5267/j.ccl.2022.10.002","url":null,"abstract":"In a bid to discovering novel antibiotics to combat growing trend of multi-drug resistance strains of Salmonella typhi, 48 new pyridine derivatives with significant inhibitory activities against the aforementioned bacterium were subjected to molecular docking against DNA gyrase protease of the bacterium, drug likeness evaluation and pharmacokinetics profiling. All the 48 leads displayed better binding affinity values when compared with Amoxicillin, Ciprofloxacin, Ceftriaxone, Ampicillin, and chloramphenicol, the standard antibiotics used herein for quality assurance. Furthermore, the majority of the compounds were, however, screened out due to their poor pharmacokinetics profiles and drug-likeness. Only five compounds emerged as the most promising leads and they include C4 with binding affinity of -8.0 kcal/mol, C8 (-8.6 kcal/mol), C9 (-8.1 kcal/mol), C26 (-8.3 kcal/mol), and C27 (-8.0 kcal/mol). These compounds not only displayed better binding affinity when compared with the reference antibiotics but also exhibit different modes of interactions with the target protease of the bacterium making them more potent and drug like. Toxicity evaluation of the leads also revealed that the compounds are neither tumorigenic nor mutagenic. In view of the excellent binding affinity, high pharmacokinetics profile and positive drug-likeness of the novel ligands, we recommend these promising compounds for in vitro and in vivo studies in order to discover novel antibiotics that could curb the dangerous trend of multiple drug resistance by Salmonella typhi.","PeriodicalId":10942,"journal":{"name":"Current Chemistry Letters","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86580707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

A review on Schiff base as colorimetric and fluorescence sensors for d-metal ions 席夫碱作为d-金属离子比色和荧光传感器的研究进展

Current Chemistry Letters Pub Date : 2023-01-01 DOI: 10.5267/j.ccl.2023.5.001

V. Inbaraj, Duraisamy Udhayakumari

引用次数: 1

3-Difluormethyl-5-carbomethoxy-2,4-pyrazole: Molecular mechanism of the formation and molecular docking study 3-二氟甲基-5-碳甲氧基-2,4-吡唑:分子形成机理及分子对接研究

Current Chemistry Letters Pub Date : 2023-01-01 DOI: 10.5267/j.ccl.2023.3.008

A. Barhoumi, Najia Ourhriss, M. E. Belghiti, M. Chafi, A. Syed, R. Eswaramoorthy, M. Verma, A. Zeroual, Karolina Zawadzińska, R. Jasiński

{"title":"3-Difluormethyl-5-carbomethoxy-2,4-pyrazole: Molecular mechanism of the formation and molecular docking study","authors":"A. Barhoumi, Najia Ourhriss, M. E. Belghiti, M. Chafi, A. Syed, R. Eswaramoorthy, M. Verma, A. Zeroual, Karolina Zawadzińska, R. Jasiński","doi":"10.5267/j.ccl.2023.3.008","DOIUrl":"https://doi.org/10.5267/j.ccl.2023.3.008","url":null,"abstract":"Application of the Molecular Electron Density Theory (MEDT) for the exploration of the [3+2] cycloaddition processes between methyl propynoate 1 and difluoromethyldiazomethane T-1, have been implemented using the DFT/B3LYP/6-311(d,p) level of theory. According to an examination of conceptual DFT indices, difluoromethyldiazomethane (T-1) participates in this reaction as a nucleophile, while methyl propynoate (1) should be considered as an electrophile. This cyclization is regiospecific, as evidenced by the activation and reaction energies, this agrees with the experiment's findings. It was discovered throughout ELF analysis that analyzed [3+2] cycloaddition is realised by a two-step mechanism. In addition, study of interactions of the products studied in this paper with the protein protease Covid-19 (PDB ID: 7R98) were carried out, by means of molecular docking study). The results indicate that the occurrence of the transfer of the proton to the nitrogen atom, increases the affinity of these products to the protein (CA32-F1 and CA32-F2).","PeriodicalId":10942,"journal":{"name":"Current Chemistry Letters","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78445750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Studying of the temperature influence on stability of fibrinogen macromolecules in aqueous solution: A literature mini-review 温度对水溶液中纤维蛋白原大分子稳定性影响的研究:文献综述

Current Chemistry Letters Pub Date : 2023-01-01 DOI: 10.5267/j.ccl.2022.8.004

Roman Nahatskyi

引用次数: 0