Synthetic approaches, modification ability and biological activity of 1,3,4-thiadiazole based [5+5] annelated heterosystems: Mini-review

Q2 Chemistry

Current Chemistry Letters Pub Date : 2023-01-01 DOI:10.5267/j.ccl.2023.4.004

M. Lelyukh, M. Zhukrovska, Z. Komarenska, Vadym Flud, S. Harkov

引用次数: 0

Abstract

Condensed bicyclic systems with thiadiazole core being annelated to other five-membered heterocycles such as 1,3-thiazole, imidazole or 1,2,4-triazole occupy prominent place in medicinal chemistry because of their broad spectrum of pharmacological activities. The combination of several heterocycles into a bicyclic system commonly provides much more interest in the enhanced activity profile of its analogs than their parent separate constituents. In this review, we summarized the literature data about the main approaches for obtaining and possible directions of structural modification of the most common 1,3,4-thiadiazole containing [5+5] annelated heterosystems as promising objects for modern medicinal chemistry.

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1,3,4-噻二唑基[5+5]复合杂系统的合成方法、修饰能力和生物活性综述

以噻二唑为核心与其他五元杂环如1,3-噻唑、咪唑或1,2,4-三唑相连的缩合双环体系因其广泛的药理活性在药物化学中占有重要地位。几个杂环组合成一个双环系统通常提供了更多的兴趣，其类似物的增强活性谱比他们的亲本分离成分。本文综述了含[5+5]1,3,4-噻二唑的环结杂系统作为现代药物化学的研究对象，其主要的获得途径和可能的结构修饰方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Chemistry Letters Chemistry-Chemistry (all)

CiteScore

4.90

自引率

0.00%

发文量

审稿时长

20 weeks

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