Current Chemistry Letters最新文献

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Synthesis of 5-aryl/heterylidene substituted 2-imino-4-thiazolidinones possessing 1,3,4-thiadiazole moiety and their antitrypanosomal activity 具有1,3,4-噻二唑基团的5-芳基/杂基取代2-亚胺-4-噻唑烷酮的合成及其抗锥虫活性
Current Chemistry Letters Pub Date : 2023-01-01 DOI: 10.5267/j.ccl.2022.11.005
M. Lelyukh, Halyna Halevych, M. Zhukrovska, Olga n Semiion-Luchyshyn, M. Kalytovska
{"title":"Synthesis of 5-aryl/heterylidene substituted 2-imino-4-thiazolidinones possessing 1,3,4-thiadiazole moiety and their antitrypanosomal activity","authors":"M. Lelyukh, Halyna Halevych, M. Zhukrovska, Olga n Semiion-Luchyshyn, M. Kalytovska","doi":"10.5267/j.ccl.2022.11.005","DOIUrl":"https://doi.org/10.5267/j.ccl.2022.11.005","url":null,"abstract":"A novel 1,3,4-thiadiazole containing 2-iminothiazolidine-4-ones 4a-b were synthesized through the reaction of 2-chloro-N-(5-ethyl/allylsulfanyl-[1,3,4]thiadiazol-2-yl)-acetamides 1a-b with ammonium thiocyanate in dry acetone. Condensation of 4a-b with various carbonyl compounds according to the standard Knoevenagel procedure yielded the corresponding 5-arylidene- (5a-d), 5-heterylidene- (6a-c), 5-isatinylidene- (7a-b) and 5-(3-phenyl-2-propene-1-ylidene)- (8a-b) derivatives. All the newly synthesized compounds were confirmed by their elemental analysis and spectral data. Synthesized compounds 4a, 5a, 5b, 6a, 6c and 7a were screened for their in vitro antitrypanosomal activity against T. brucei gambience (Feo strain). The 5-ylidene substituted compounds with S-allyl group in position 5 of thiadiazole cycle (5a, 5b, 6a and 7a) displayed good to excellent antitrypanosomal potency with a range IC50 = 7.3-12.8 µM.","PeriodicalId":10942,"journal":{"name":"Current Chemistry Letters","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77116263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Thermal and morphological studies of chitosan and agar-agar blends 壳聚糖和琼脂共混物的热学和形态学研究
Current Chemistry Letters Pub Date : 2023-01-01 DOI: 10.5267/j.ccl.2022.12.002
M. Jayaprakash, S. Shashidhar, A. Lagashetty, S. Ganiger, T. Vishnuvardhan
{"title":"Thermal and morphological studies of chitosan and agar-agar blends","authors":"M. Jayaprakash, S. Shashidhar, A. Lagashetty, S. Ganiger, T. Vishnuvardhan","doi":"10.5267/j.ccl.2022.12.002","DOIUrl":"https://doi.org/10.5267/j.ccl.2022.12.002","url":null,"abstract":"Many researchers are attracted to Chitosan based blends due to its properties and potential applications in various fields. The advanced development of Chitosan blends integrates the science and technology of blended materials. The present experimentation is reporting the preparation of Chitosan and Agar-Agar blends (CCA) by chemical mixing of these materials at different compositions. The thermal studies of the prepared blends were studied by differential scanning colorimeter (DSC) and thermogravimetric analysis (TGA) tools. Thermal studies reveal that the lowest degradation temperatures of blends might be attributed to the partial miscibility of CAA blends at particular composition and miscibility due to single glass transition temperature (Tg) between Chitosan and Agar-agar. Bonding nature of sample blends were carried out by Fourier transform infrared (FT-IR) instrumentation. This study reveals the interaction between Chitosan and Agar-agar is partial miscibility. Morphological study reveals that a few aggregated particles, which suggest the partial miscibility of CAA blends. Homogeneity of blend compositions and specific intermolecular interactions of hydrogen bonding type is also observed.","PeriodicalId":10942,"journal":{"name":"Current Chemistry Letters","volume":"45 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72460127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effect of compaction pressure, sintering time, and temperature on the characterization of an aluminum/alumina composite with rising alumina proportions 研究了压实压力、烧结时间和温度对铝/氧化铝复合材料性能的影响
Current Chemistry Letters Pub Date : 2023-01-01 DOI: 10.5267/j.ccl.2022.12.008
A. Choudhury, J. Nanda, S. N. Das
{"title":"The effect of compaction pressure, sintering time, and temperature on the characterization of an aluminum/alumina composite with rising alumina proportions","authors":"A. Choudhury, J. Nanda, S. N. Das","doi":"10.5267/j.ccl.2022.12.008","DOIUrl":"https://doi.org/10.5267/j.ccl.2022.12.008","url":null,"abstract":"The purpose of this article is to investigate the effect of various process parameters such as compaction pressure, sintering temperature, and time on the physio-mechanical properties of a powder metallurgy-fabricated composite made of pure aluminium/alumina. Temperatures (580°C, 600°C, and 630°C), periods (1.5, 2, and 2.5 hr), compacting loads (30KN-65KN), and alumina percentages (2, 4, 6, and 8weight percent) are all considered. X-ray diffraction (XRD) and X-ray fluorescence spectroscopy (XRF) studies are carried out to determine the phases present and their proportions. Crystallite size study is performed using XRD data, and the Al+4 weight % alumina composite has the smallest size of any composite tested. For optimization, sintering density, porosity, and microhardness are calculated. Scanning electron microscopy (SEM) is used to analyse the different microstructures. At 600°C, 2 hr of operating time, and 4weight% alumina additions, the highest sintering density and microhardness are found.","PeriodicalId":10942,"journal":{"name":"Current Chemistry Letters","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89449569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Heterogeneous vanadium Schiff base complexes in catalytic oxidation reactions 非均相钒席夫碱配合物在催化氧化反应中的应用
Current Chemistry Letters Pub Date : 2023-01-01 DOI: 10.5267/j.ccl.2022.9.003
Christiana Abimbola Salubi
{"title":"Heterogeneous vanadium Schiff base complexes in catalytic oxidation reactions","authors":"Christiana Abimbola Salubi","doi":"10.5267/j.ccl.2022.9.003","DOIUrl":"https://doi.org/10.5267/j.ccl.2022.9.003","url":null,"abstract":"The chemistry of Schiff base has received remarkable attention in different applications, both organic synthesis and industries. Over the past few years many reports have been on the synthesis, characterization and application of vanadium Schiff base complexes. However, heterogeneous vanadium Schiff base catalysts are active for various oxidation reactions, making catalytic oxidation of hydrocarbons a great interest. This review summarizes the recent development of organic substrate oxidation with heterogeneous vanadium Schiff base catalysts.","PeriodicalId":10942,"journal":{"name":"Current Chemistry Letters","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74146461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Synthesis and anti-inflammatory activity of S-oxides of pyridinyloxy substituted imidazo[2,1-b][1,3]thiazines 吡啶基氧基取代咪唑[2,1-b][1,3]噻唑s -氧化物的合成及抗炎活性
Current Chemistry Letters Pub Date : 2023-01-01 DOI: 10.5267/j.ccl.2022.12.006
N. Slyvka, L. Saliyeva, S. Holota, M. Litvinchuk, S. Shishkina, M. Vovk
{"title":"Synthesis and anti-inflammatory activity of S-oxides of pyridinyloxy substituted imidazo[2,1-b][1,3]thiazines","authors":"N. Slyvka, L. Saliyeva, S. Holota, M. Litvinchuk, S. Shishkina, M. Vovk","doi":"10.5267/j.ccl.2022.12.006","DOIUrl":"https://doi.org/10.5267/j.ccl.2022.12.006","url":null,"abstract":"Here derivatives of imidazo[2,1-b][1,3]thiazines are attractive objects for organic and medicinal chemists. In the present work chemoselective conditions for oxidation of the sulfur atom in the 6-(2-pyridinyloxy)substituted (benzo)imidazo[2,1-b][1,3]thiazines to the corresponding sulfoxides were proposed and their synthesis was performed. Synthesized sulfoxides exist in the diastereomeric mixture and individual diastereomers 2a-e and 3a-e were obtained using a chromatographic technique. The structure of compounds 2a-e and 3a-e were characterized using 1H, 13C NMR, LC-MS spectra, and X-ray analysis for derivative 2b. The anti-inflammatory activity screening in vivo was performed using the carrageenan model of inflammatory paw edema in white rats for all the diastereomeric mixtures and individual diastereomers. Diastereomer 2c possessed an anti-inflammatory effect with an inflammation inhibition index of 46.1% which was equal to the activity of the reference drug diclofenac sodium.","PeriodicalId":10942,"journal":{"name":"Current Chemistry Letters","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74743969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Screening of 3-acetylcoumarin derivatives as multifunctional biological agents 3-乙酰香豆素衍生物作为多功能生物制剂的筛选
Current Chemistry Letters Pub Date : 2023-01-01 DOI: 10.5267/j.ccl.2022.12.005
Anees Pangal, Pranav Tambe, K. Ahmed
{"title":"Screening of 3-acetylcoumarin derivatives as multifunctional biological agents","authors":"Anees Pangal, Pranav Tambe, K. Ahmed","doi":"10.5267/j.ccl.2022.12.005","DOIUrl":"https://doi.org/10.5267/j.ccl.2022.12.005","url":null,"abstract":"In this work, the multifunctional potential of four 3-acetylcoumarin derivatives was studied. The derivatives were significantly active against bacteria Staphylococcus aureus, Pseudomonas aeoginosa and fungal strain Candida albicans. The results of antioxidant activity assays were promising when compared to ascorbic acid. The in vitro anticancer activity was carried out using MTT assay on human cancer cell line COLO-205 and 3ACDT showed commendable antiproliferative activity along with appreciable tumor selectivity with distinct selectivity index. Moreover, ADMET properties of the compounds were determined using the pKCSM and SwissADME online tools and all compounds were found with good pharmacokinetic profile. Hence, from the obtained results from all the 3-acetylcoumarin derivatives, 3ACDT exhibited good therapeutical potential and can be optimized for lead development.","PeriodicalId":10942,"journal":{"name":"Current Chemistry Letters","volume":"112 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80805152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In vitro antimicrobial activity of extracts from Kydia calycina and in-silico molecular docking studies of some phytochemicals 萼花菊提取物体外抑菌活性及部分植物化学物质的硅分子对接研究
Current Chemistry Letters Pub Date : 2023-01-01 DOI: 10.5267/j.ccl.2023.1.005
Neha Dangi, Himanshu Mehendiratta, Shikha Sharma
{"title":"In vitro antimicrobial activity of extracts from Kydia calycina and in-silico molecular docking studies of some phytochemicals","authors":"Neha Dangi, Himanshu Mehendiratta, Shikha Sharma","doi":"10.5267/j.ccl.2023.1.005","DOIUrl":"https://doi.org/10.5267/j.ccl.2023.1.005","url":null,"abstract":"Drug-resistant microorganisms are a serious problem, particularly when more strains become immune to different antimicrobials. Antibiotic resistance has now developed in several microbes. Therefore, it is crucial to build new medications that are still efficient. The amount of funding that is often available for such progress is lower than what is necessary. Kydia calycina is a Malvaceae flowering plant used in traditional Indian medicine to cure several diseases, including infections. The goal of this study was to determine whether K. Calycina has antifungal and antibacterial properties. Infections are caused by the profusion of microbes in the environment; thus, plant products and active chemicals are employed to assess the antimicrobial property of the extracts and the inhibition zone of each extract on a range of bacterial and fungal strains. The results showed that when it was applied to the species that were studied, there was a considerable decrease in the growth of bacteria. The plant was subjected to a phytochemical analysis, which was completed. This plant may be employed in the quest for bioactive natural substances that might be used as leads in the creation of pharmaceuticals. The antimicrobial mechanism of action was investigated by molecular docking, and it was determined that Hibiscoquinone B and Hibiscone C showed both antibacterial and antifungal activity.","PeriodicalId":10942,"journal":{"name":"Current Chemistry Letters","volume":"305 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79836001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis, characterization and antibiotic evaluation of various biologically active derivatives of 4-Alkylpyrimidine-5-carbonitrile 4-烷基嘧啶-5-碳腈各种生物活性衍生物的合成、表征及抗生素评价
Current Chemistry Letters Pub Date : 2023-01-01 DOI: 10.5267/j.ccl.2023.3.002
P. H. Thanki, Dhaval V. Hingrajiya, J. Modha, Jalpa H. Vadgama
{"title":"Synthesis, characterization and antibiotic evaluation of various biologically active derivatives of 4-Alkylpyrimidine-5-carbonitrile","authors":"P. H. Thanki, Dhaval V. Hingrajiya, J. Modha, Jalpa H. Vadgama","doi":"10.5267/j.ccl.2023.3.002","DOIUrl":"https://doi.org/10.5267/j.ccl.2023.3.002","url":null,"abstract":"Extensive research work has been published on Tetrahydro and Dihydropyrimidine derivatives. Pyrimidine-5-Carbonitrile and its analogs have demonstrated a large number of activities. Some 6-Halogenosubstituted pyrimidine analogs have also been reported to be biologically active to a certain extent, but the literature survey reveals not much report on 6-alkylated pyrimidine derivatives. Targeting enhancement in biologically useful properties of a lead molecule through the association of it with active pharmacophoric groups or molecules is a conventional method in pharmaceutical research. With an aim to explore a better useful Dihydropyrimidine derivative, a newer 4-Alkylated-1,6-dihydropyrimidine analog (1) has been prepared. The lead molecule (1) has further been converted to amine derivative (2), hydrazino derivative (3) tri substituted s-triazinyl derivative (4), sulphonamide (5), Schiff’s base (6), a thiazolidinones (7), and 2-Azetidinones (8) respectively using various methods. Compounds 2, 4, 5, and 7 showed 50% and 8 showed 100% bacterial inhibition at 32μg/mL in single-point bacterial inhibition against various bacterial strains.","PeriodicalId":10942,"journal":{"name":"Current Chemistry Letters","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87097506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Removal of Zn, Pb, and Ni heavy metals from aqueous system using efficient modified-banana peel adsorbent 改性香蕉皮吸附剂去除水中重金属Zn、Pb和Ni的研究
Current Chemistry Letters Pub Date : 2023-01-01 DOI: 10.5267/j.ccl.2022.9.007
A. Gahlan, Shimaa Hosny, Ahmed Fathi, O. A. Fargaly
{"title":"Removal of Zn, Pb, and Ni heavy metals from aqueous system using efficient modified-banana peel adsorbent","authors":"A. Gahlan, Shimaa Hosny, Ahmed Fathi, O. A. Fargaly","doi":"10.5267/j.ccl.2022.9.007","DOIUrl":"https://doi.org/10.5267/j.ccl.2022.9.007","url":null,"abstract":"Heavy metals contamination of water is a serious and complex environmental problem due to rapid industrialization, bioaccumulation and non-degradability. Therefore, the reuse of agricultural waste in the process of purifying water from pollutants is an attractive and promising method. Almost inexpensive materials are used to purify water, thus achieving the desired economic and environmental goal. In this study banana peel (BP) was used before and after modification by 0.1M sulphuric acid (H2SO4) to enhance the removal of Zinc Zn(II), Lead Pb(II) and Nickel Ni(II). The effect of various parameters was studied Such as pH, contact time, adsorbent dosage and initial metal ion concentration at 5 ppm. All these parameters were studied in batch experiments for a comparative study. The removal percentage was found to be 84% Zn (II),78%Pb (II) and 72% Ni (II) before modification and 92% Zn (II) , 94% Pb (II) and 96% Ni (II) after modification at initial concentration of 5 ppm. The data obtained from sorption isotherms were described with Langmuir and Freundlich isotherm models but were found to be well fitted for the Langmuir model. The correlation coefficient values R2 for Langmuir were at the range (0.996-0.999) while that for Freundlich were at the range (0.912-0.972). The rate of adsorption follows Pseudo-second-order kinetics. This work proved the high banana peels efficiency as an adsorbent agent for heavy metals removal from aqueous solutions.","PeriodicalId":10942,"journal":{"name":"Current Chemistry Letters","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87447667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Toxicity of atrazine and metribuzin herbicides on earthworms (Aporrectodea caliginosa) by filter paper contact and soil mixing techniques 滤纸接触和土壤混合技术研究莠去津和莠去津除草剂对蚯蚓的毒性
Current Chemistry Letters Pub Date : 2023-01-01 DOI: 10.5267/j.ccl.2022.8.006
Mohamed R. Fouad, Adel Q. S. Shamsan, S. A. Abdel-Raheem
{"title":"Toxicity of atrazine and metribuzin herbicides on earthworms (Aporrectodea caliginosa) by filter paper contact and soil mixing techniques","authors":"Mohamed R. Fouad, Adel Q. S. Shamsan, S. A. Abdel-Raheem","doi":"10.5267/j.ccl.2022.8.006","DOIUrl":"https://doi.org/10.5267/j.ccl.2022.8.006","url":null,"abstract":"Herbicides used on a regular basis could endanger non-target species like earthworms. The aim of this work was to test the toxic effect of atrazine and metribuzin on Aporrectodea caliginosa by filter paper contact and soil mixing techniques. Atrazine had the highest intrinsic toxicity to earthworms, with LC50 of 0.026 µg mL-1 after 72 hr of treatment. While the LC50 of metribuzin was 0.063 µg mL-1 after 72 hr by filter paper contact test. LC50 was reduced from 11.121 to 3.118 and 164.824 to 19.113 μg g soil-1 in clay soil, from 32.221 to 17.33 and 324.141 to 41.028 μg g soil-1 in soil (1:1) and from 41.234 to 30.804 and 462.255 to 70.902 μg g soil-1 in sandy clay loam soil of atrazine and metribuzin after 5 and 10 day. Generally, atrazine is more toxic than metribuzin in both tests.","PeriodicalId":10942,"journal":{"name":"Current Chemistry Letters","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84958189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
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