3-乙酰香豆素衍生物作为多功能生物制剂的筛选

Q2 Chemistry

Current Chemistry Letters Pub Date : 2023-01-01 DOI:10.5267/j.ccl.2022.12.005

Anees Pangal, Pranav Tambe, K. Ahmed

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引用次数: 0

摘要

本文研究了4种3-乙酰香豆素衍生物的多功能化潜力。该衍生物对金黄色葡萄球菌、绿脓假单胞菌和白色念珠菌均有显著的抑制作用。与抗坏血酸相比，抗氧化活性测定的结果是有希望的。用MTT法对人癌细胞COLO-205进行体外抗肿瘤活性测定，结果表明3ACDT具有良好的抗增殖活性，且具有明显的肿瘤选择性。此外，使用pKCSM和SwissADME在线工具测定化合物的ADMET特性，发现所有化合物都具有良好的药代动力学特征。因此，从所有3-乙酰香豆素衍生物得到的结果来看，3ACDT具有良好的治疗潜力，可以优化用于先导物的开发。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Screening of 3-acetylcoumarin derivatives as multifunctional biological agents

In this work, the multifunctional potential of four 3-acetylcoumarin derivatives was studied. The derivatives were significantly active against bacteria Staphylococcus aureus, Pseudomonas aeoginosa and fungal strain Candida albicans. The results of antioxidant activity assays were promising when compared to ascorbic acid. The in vitro anticancer activity was carried out using MTT assay on human cancer cell line COLO-205 and 3ACDT showed commendable antiproliferative activity along with appreciable tumor selectivity with distinct selectivity index. Moreover, ADMET properties of the compounds were determined using the pKCSM and SwissADME online tools and all compounds were found with good pharmacokinetic profile. Hence, from the obtained results from all the 3-acetylcoumarin derivatives, 3ACDT exhibited good therapeutical potential and can be optimized for lead development.

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来源期刊

Current Chemistry Letters Chemistry-Chemistry (all)

CiteScore

4.90

自引率

0.00%

发文量

审稿时长

20 weeks

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