Current HIV/AIDS Reports最新文献_第6页

Major Drug Resistance Mutations on Reverse Transcriptase Gene in Human Immunodeficiency Virus Type-1 in Indonesia: A Systematic Review 印度尼西亚 1 型人类免疫缺陷病毒逆转录酶基因的主要耐药性突变：系统综述

IF 4.6 2区医学

Current HIV/AIDS Reports Pub Date : 2024-01-20 DOI: 10.1007/s11904-023-00687-5

Nurjannah, Sri Jayanti, Francisca Srioetami Tanoerahardjo, Ummu Syauqah Al Musyahadah, Caecilia Hapsari Ceriapuri Sukowati, Muhammad Nasrum Massi

{"title":"Major Drug Resistance Mutations on Reverse Transcriptase Gene in Human Immunodeficiency Virus Type-1 in Indonesia: A Systematic Review","authors":"Nurjannah, Sri Jayanti, Francisca Srioetami Tanoerahardjo, Ummu Syauqah Al Musyahadah, Caecilia Hapsari Ceriapuri Sukowati, Muhammad Nasrum Massi","doi":"10.1007/s11904-023-00687-5","DOIUrl":"https://doi.org/10.1007/s11904-023-00687-5","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose of Review</h3>The prevalence of HIV-1 in Indonesia is on a concerning upward trajectory, with a concurrent rise in the development of drug-resistant strains, challenging the efficacy of antiretroviral therapy (ART). Many mutations have been found in the pol gene that makes HIV resistant to ART. We aim to review the major drug resistance mutations (DRMs) of reverse transcriptase (RT) of pol gene in HIV-1 cases in Indonesia.<h3 data-test=\"abstract-sub-heading\">Recent Findings</h3>A total of eleven articles reporting DRMs in HIV-1 subjects from various regions between 2015–2020 in Indonesia are included. The prevalence of major DRMs on the RT gene in studies included varies from 3.4% to 34%. The CRF01_AE subtype stands out as the predominant variant. Notably, the prevalence of major DRMs in ART-experienced individuals is 22.1%, while ART-naïve individuals show a lower rate of 4.4%. Among the RT gene mutations, M184I/V emerges as the most prevalent (10.5%) within the nucleos(t)ide reverse transcriptase inhibitors (NRTI) group, while K103N leads among the non-NRTI (NNRTI) group, with a frequency of 6.4%. Regionally, North Sulawesi records the highest prevalence of major DRMs in the RT gene at 21.1%, whereas Riau and Central Papua exhibit the lowest rates at 3.4%.<h3 data-test=\"abstract-sub-heading\">Summary</h3>Significant variations in drug resistance mutations within the RT gene across Indonesian regions highlight the importance of closely monitoring and evaluating the effectiveness of current antiretroviral therapy (ART) regimens. Considerably, more studies are needed to understand better and overcome the emergence of DRMs on HIV-1 patients in Indonesia.","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"26 1","pages":""},"PeriodicalIF":4.6,"publicationDate":"2024-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139508780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Digital Adaptive Behavioral Interventions to Improve HIV Prevention and Care: Innovations in Intervention Approach and Experimental Design. 改进艾滋病毒预防和护理的数字自适应行为干预：干预方法和实验设计的创新。

IF 4.6 2区医学

Current HIV/AIDS Reports Pub Date : 2023-12-01 Epub Date: 2023-11-04 DOI: 10.1007/s11904-023-00671-z

Inbal Nahum-Shani, Sylvie Naar

{"title":"Digital Adaptive Behavioral Interventions to Improve HIV Prevention and Care: Innovations in Intervention Approach and Experimental Design.","authors":"Inbal Nahum-Shani, Sylvie Naar","doi":"10.1007/s11904-023-00671-z","DOIUrl":"10.1007/s11904-023-00671-z","url":null,"abstract":"Purpose of review: Recent advances in digital technologies can be leveraged to adapt HIV prevention and treatment services to the rapidly changing needs of individuals in everyday life. However, to fully take advantage of these technologies, it is critical to effectively integrate them with human-delivered components. Here, we introduce a new experimental approach for optimizing the integration and adaptation of digital and human-delivered behavioral intervention components for HIV prevention and treatment.Recent findings: Typically, human-delivered components can be adapted on a relatively slow timescale (e.g., every few months or weeks), while digital components can be adapted much faster (e.g., every few days or hours). Thus, the systematic integration of these components requires an experimental approach that involves sequential randomizations on multiple timescales. Selecting an experimental approach should be motivated by the type of adaptive intervention investigators would like to develop, and the scientific questions they have about its construction.","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":" ","pages":"502-512"},"PeriodicalIF":4.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10988586/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71479218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Digital Interventions to Enhance PrEP Uptake and Adherence Through Stigma Reduction. 通过减少耻辱感来提高PrEP的接受和坚持的数字干预措施。

IF 4.6 2区医学

Current HIV/AIDS Reports Pub Date : 2023-12-01 Epub Date: 2023-12-07 DOI: 10.1007/s11904-023-00685-7

Jane J Lee, Juliann Li Verdugo, Anna Y Xiao, Katie Vo

{"title":"Digital Interventions to Enhance PrEP Uptake and Adherence Through Stigma Reduction.","authors":"Jane J Lee, Juliann Li Verdugo, Anna Y Xiao, Katie Vo","doi":"10.1007/s11904-023-00685-7","DOIUrl":"10.1007/s11904-023-00685-7","url":null,"abstract":"Purpose of review: Although pre-exposure prophylaxis (PrEP) is effective for reducing risk of HIV transmission, stigma persists as a barrier to HIV prevention. Digital technologies present opportunities to access hard-to-reach populations and increase the efficiency of established interventions. This review examines current digital interventions addressing stigma to improve PrEP-related outcomes.Recent findings: Digital technologies are increasingly used for HIV prevention and include a wide range of formats. Recent interventions focused on stigma and PrEP tend to engage mobile phone-related technology and focus on younger populations with particular attention to men who have sex with men and transgender women. Digital interventions that address stigma are promising for improving PrEP-related outcomes. No single technology currently demonstrates consistent superiority. Limited access to PrEP and heightened stigma in under-resourced countries present challenges for interventions supporting diverse communities. Further research should examine how digital interventions can reduce stigma beyond the individual level to enhance PrEP use and explore opportunities to improve and integrate approaches to stigma measurement.","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":" ","pages":"458-469"},"PeriodicalIF":4.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138498054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chatbots for HIV Prevention and Care: a Narrative Review. 艾滋病预防和护理的聊天机器人:叙述回顾。

IF 4.6 2区医学

Current HIV/AIDS Reports Pub Date : 2023-12-01 Epub Date: 2023-11-27 DOI: 10.1007/s11904-023-00681-x

Alastair van Heerden, Shannon Bosman, Dallas Swendeman, Warren Scott Comulada

{"title":"Chatbots for HIV Prevention and Care: a Narrative Review.","authors":"Alastair van Heerden, Shannon Bosman, Dallas Swendeman, Warren Scott Comulada","doi":"10.1007/s11904-023-00681-x","DOIUrl":"10.1007/s11904-023-00681-x","url":null,"abstract":"Purpose of review: To explore the intersection of chatbots and HIV prevention and care. Current applications of chatbots in HIV services, the challenges faced, recent advancements, and future research directions are presented and discussed.Recent findings: Chatbots facilitate sensitive discussions about HIV thereby promoting prevention and care strategies. Trustworthiness and accuracy of information were identified as primary factors influencing user engagement with chatbots. Additionally, the integration of AI-driven models that process and generate human-like text into chatbots poses both breakthroughs and challenges in terms of privacy, bias, resources, and ethical issues. Chatbots in HIV prevention and care show potential; however, significant work remains in addressing associated ethical and practical concerns. The integration of large language models into chatbots is a promising future direction for their effective deployment in HIV services. Encouraging future research, collaboration among stakeholders, and bold innovative thinking will be pivotal in harnessing the full potential of chatbot interventions.","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":" ","pages":"481-486"},"PeriodicalIF":4.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10719151/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138444240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of p53 in HIV Infection. p53在HIV感染中的作用。

IF 4.6 2区医学

Current HIV/AIDS Reports Pub Date : 2023-12-01 Epub Date: 2023-11-27 DOI: 10.1007/s11904-023-00684-8

Mahmoud Mohammad Yaseen, Nizar Mohammad Abuharfeil, Homa Darmani

{"title":"The Role of p53 in HIV Infection.","authors":"Mahmoud Mohammad Yaseen, Nizar Mohammad Abuharfeil, Homa Darmani","doi":"10.1007/s11904-023-00684-8","DOIUrl":"10.1007/s11904-023-00684-8","url":null,"abstract":"Purpose of review: This review aims to elucidate the multifaceted role of the tumor suppressor protein p53 in the context of HIV infection. We explore how p53, a pivotal regulator of cellular processes, interacts with various facets of the HIV life cycle. Understanding these interactions could provide valuable insights into potential therapeutic interventions and the broader implications of p53 in viral infections.Recent findings: Recent research has unveiled a complex interplay between p53 and HIV. Several reports have highlighted the involvement of p53 in restricting the replication of HIV within both immune and nonimmune cells. Various mechanisms have been suggested to unveil how p53 enforces this restriction on HIV replication. However, HIV has developed strategies to manipulate p53, benefiting its replication and evading host defenses. In summary, p53 plays a multifaceted role in HIV infection, impacting viral replication and disease progression. Recent findings underscore the importance of understanding the intricate interactions between p53 and HIV for the development of innovative therapeutic approaches. Manipulating p53 pathways may offer potential avenues to suppress viral replication and ameliorate immune dysfunction, ultimately contributing to the management of HIV/AIDS. Further research is warranted to fully exploit the therapeutic potential of p53 in the context of HIV infection.","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":" ","pages":"419-427"},"PeriodicalIF":4.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138444241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Learning from Persistent Viremia: Mechanisms and Implications for Clinical Care and HIV-1 Cure. 从持续性病毒血症中学习:临床护理和HIV-1治疗的机制和意义。

IF 3.7 2区医学

Current HIV/AIDS Reports Pub Date : 2023-12-01 Epub Date: 2023-11-13 DOI: 10.1007/s11904-023-00674-w

Fengting Wu, Francesco R Simonetti

{"title":"Learning from Persistent Viremia: Mechanisms and Implications for Clinical Care and HIV-1 Cure.","authors":"Fengting Wu, Francesco R Simonetti","doi":"10.1007/s11904-023-00674-w","DOIUrl":"10.1007/s11904-023-00674-w","url":null,"abstract":"Purpose of review: In this review, we discuss what persistent viremia has taught us about the biology of the HIV-1 reservoir during antiretroviral therapy (ART). We will also discuss the implications of this phenomenon for HIV-1 cure research and its clinical management.Recent findings: While residual viremia (RV, 1-3 HIV-1 RNA copies/ml) can be detected in most of people on ART, some individuals experience non-suppressible viremia (NSV, > 20-50 copies/mL) despite optimal adherence. When issues of drug resistance and pharmacokinetics are ruled out, this persistent virus in plasma is the reflection of virus production from clonally expanded CD4+ T cells carrying proviruses. Recent work has shown that a fraction of the proviruses source of NSV are not infectious, due to defects in the 5'-Leader sequence. However, additional viruses and host determinants of NSV are not fully understood. The study of NSV is of prime importance because it represents a challenge for the clinical care of people on ART, and it sheds light on virus-host interactions that could advance HIV-1 remission research.","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":" ","pages":"428-439"},"PeriodicalIF":3.7,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10719122/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89717248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Digital Epidemiological Approaches in HIV Research: a Scoping Methodological Review. HIV研究中的数字流行病学方法：范围界定方法综述。

IF 3.7 2区医学

Current HIV/AIDS Reports Pub Date : 2023-12-01 Epub Date: 2023-11-02 DOI: 10.1007/s11904-023-00673-x

Lindsay E Young, Yuanfeixue Nan, Eugene Jang, Robin Stevens

{"title":"Digital Epidemiological Approaches in HIV Research: a Scoping Methodological Review.","authors":"Lindsay E Young, Yuanfeixue Nan, Eugene Jang, Robin Stevens","doi":"10.1007/s11904-023-00673-x","DOIUrl":"10.1007/s11904-023-00673-x","url":null,"abstract":"Purpose of review: The purpose of this scoping review was to summarize literature regarding the use of user-generated digital data collected for non-epidemiological purposes in human immunodeficiency virus (HIV) research.Recent findings: Thirty-nine papers were included in the final review. Four types of digital data were used: social media data, web search queries, mobile phone data, and data from global positioning system (GPS) devices. With these data, four HIV epidemiological objectives were pursued, including disease surveillance, behavioral surveillance, assessment of public attention to HIV, and characterization of risk contexts. Approximately one-third used machine learning for classification, prediction, or topic modeling. Less than a quarter discussed the ethics of using user-generated data for epidemiological purposes. User-generated digital data can be used to monitor, predict, and contextualize HIV risk and can help disrupt trajectories of risk closer to onset. However, more attention needs to be paid to digital ethics and the direction of the field in a post-Application Programming Interface (API) world.","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":" ","pages":"470-480"},"PeriodicalIF":3.7,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10719139/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71421504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ongoing Healthcare Disparities in neuroHIV: Addressing Gaps in the Care Continuum. 正在进行的医疗保健差距神经艾滋病毒:解决差距的护理连续性。

IF 4.6 2区医学

Current HIV/AIDS Reports Pub Date : 2023-12-01 Epub Date: 2023-11-24 DOI: 10.1007/s11904-023-00683-9

Dan Tong Jia, Paloma M Carcamo, Monica M Diaz

引用次数: 0

Update on Central Nervous System Effects of the Intersection of HIV-1 and SARS-CoV-2. HIV-1与SARS-CoV-2交叉对中枢神经系统影响的研究进展

IF 4.6 2区医学

Current HIV/AIDS Reports Pub Date : 2023-12-01 Epub Date: 2023-11-11 DOI: 10.1007/s11904-023-00676-8

Ferron F Ocampo, Pathariya Promsena, Phillip Chan

引用次数: 0

Paradata: Measuring Engagement in Digital HIV Interventions for Sexual and Gender Minorities. Paradata：衡量性和性别少数群体参与数字艾滋病毒干预的程度。

IF 4.6 2区医学

Current HIV/AIDS Reports Pub Date : 2023-12-01 Epub Date: 2023-11-06 DOI: 10.1007/s11904-023-00679-5

Seul Ki Choi, Kathryn E Muessig, Lisa B Hightow-Weidman, José A Bauermeister

{"title":"Paradata: Measuring Engagement in Digital HIV Interventions for Sexual and Gender Minorities.","authors":"Seul Ki Choi, Kathryn E Muessig, Lisa B Hightow-Weidman, José A Bauermeister","doi":"10.1007/s11904-023-00679-5","DOIUrl":"10.1007/s11904-023-00679-5","url":null,"abstract":"Purpose of review: The goal of this review was to examine online engagement using paradata (i.e., intervention usage metrics) as part of the reporting of online behavioral HIV prevention and care interventions' findings. We underscore the importance of these data in examining intervention engagement and effectiveness.Recent findings: We focused on studies indexed in PubMed and published between April 1, 2017, and June 30, 2023, that reported the development and testing of online behavioral interventions for HIV prevention and/or care. Of the 689 extracted citations, 19 met the study criteria and provided engagement data - only six studies tested the association between engagement and intervention outcomes. Of these, four studies found a positive association between participants' engagement and improvements in HIV-related outcomes. Increasing attention is being paid to the collection and reporting of paradata within HIV online behavioral interventions. While the current evidence suggests a dose-response relationship due to user engagement on HIV outcomes, greater efforts to systematically collect, report, and analyze paradata are warranted.","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":" ","pages":"487-501"},"PeriodicalIF":4.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71479219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0