Cumhuriyet Science Journal最新文献_第3页

Comparison of Characteristics and Antimicrobial Activity of Synthesized Zinc Oxide And Magnetite Iron Oxide Nanoparticles Using Four Different Plant Extracts 比较使用四种不同植物提取物合成的氧化锌和磁铁矿氧化铁纳米粒子的特性和抗菌活性

Cumhuriyet Science Journal Pub Date : 2024-01-12 DOI: 10.17776/csj.1370606

Burcu Aydoğdu, Mehmet Aytar, İlkay Ünal

{"title":"Comparison of Characteristics and Antimicrobial Activity of Synthesized Zinc Oxide And Magnetite Iron Oxide Nanoparticles Using Four Different Plant Extracts","authors":"Burcu Aydoğdu, Mehmet Aytar, İlkay Ünal","doi":"10.17776/csj.1370606","DOIUrl":"https://doi.org/10.17776/csj.1370606","url":null,"abstract":"The aim of this study was to synthesize Zinc oxide (ZnO) and magnetite ıron oxide (Fe3O4) nanoparticles utilizing a precipitation method, employing plant extracts from Ocimum basilica(1), Cinnamomum zeylanicum(2), Lactarius salmonicolor(3) and Paeonia kesrouanensis(4) as reduction and stabilizing agents. Additionally, the antimicrobial activity of these nanoparticles against both gram-positive (S. aureus, ATCC 25923) and gram-negative (E. coli, ATCC 25922; P. aeroginosa, PAO1), bacteria as well as fungus (C. albicans 90028) was evaluated. The nanoparticles (NPs) were characterised by various analyses, including TEM, SEM, XRD, FTIR, DSL, and zeta potential. Based on the TEM image, the ZnONPs exhibited a cluster of flower-like structures, whereas the Fe3O4NPs displayed a spherical shape with a varying size distribution. The zeta potential values for ZnO NPs ranged from -5.35 to -16.9, while for Fe3O4NPs ranged from -7.43 to -20.7. All ZnO nanoparticles exhibited antimicrobial activity exclusively against the S. aureus strain, whereas Fe3O4NPs did not demonstrate any antibacterial effect.","PeriodicalId":10906,"journal":{"name":"Cumhuriyet Science Journal","volume":"35 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140509716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treatment of Sugar Industry Wastewater via Fenton Oxidation with Zero-Valent Iron 通过零价铁芬顿氧化法处理制糖业废水

Cumhuriyet Science Journal Pub Date : 2024-01-02 DOI: 10.17776/csj.1328817

Ceren Orak

引用次数: 0

Chemometric Determination of Parkinson's Drugs Containing Multiple Active Substances 含有多种活性物质的帕金森氏症药物的化学计量测定

Cumhuriyet Science Journal Pub Date : 2024-01-02 DOI: 10.17776/csj.1351879

Ayşe Merve Arslan, Güzide Pekcan

引用次数: 0

Investigation of Antiviral Activities of Nickel and Copper Complexes with Macrocyclic Ligands against Crimean-Congo Hemorrhagic Fever by In Silico Calculations 通过硅计算研究大环配体镍和铜配合物对克里米亚-刚果出血热的抗病毒活性

Cumhuriyet Science Journal Pub Date : 2023-12-28 DOI: 10.17776/csj.1375105

S. Erkan, N. Bulut, Duran Karakaş

{"title":"Investigation of Antiviral Activities of Nickel and Copper Complexes with Macrocyclic Ligands against Crimean-Congo Hemorrhagic Fever by In Silico Calculations","authors":"S. Erkan, N. Bulut, Duran Karakaş","doi":"10.17776/csj.1375105","DOIUrl":"https://doi.org/10.17776/csj.1375105","url":null,"abstract":"For the first time, electronic characteristics of potential drug candidates and their inhibitory activities have been linked thanks to this work. Synthesized copper and nickel complexes with trans-N1,N8-bis(2-cyanoethyl)-2,4,4,9,11,11-hexamethyl-1,5,8,12-tetraazacyclotetradecane (tet-bx) ligand, as well as the proposed hypothetical complexes, were properly examined by the appropriate calculation method in atomic and molecular dimensions. The appropriate calculation level was achieved by using the IR spectroscopic data of the tet-bx ligand. The experimental and calculated bond stretching frequencies were compared for synthesized complexes [Ni(tet-bx)](ClO4)2 (1), [Cu(tet-bx)](ClO4)2 (2), [Ni(tet-bx)(NCS)2] (3), and [Ni(tet-bx)(ClO4)Cl] (5). Some bond stretching frequencies of hypothetical complexes [Cu(tet-bx)(NCS)2] (4) and [Cu(tet-bx)(ClO4)Cl] (6) have also been proposed and their molecular structure were determined. To analyze the electronic behavior of the examined complexes at the atomic level, Fukui function indices (nucleophilic f+ and electrophilic f- populations) were determined. Furthermore, antibacterial and antiviral inhibition efficiency of the complexes against Crimean-Congo hemorrhagic fever has been investigated by docking studies","PeriodicalId":10906,"journal":{"name":"Cumhuriyet Science Journal","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139149365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of the Effect of Main Components of Wild Thyme on Covid-19 by Computational Methods 通过计算方法研究野生百里香主要成分对 Covid-19 的影响

Cumhuriyet Science Journal Pub Date : 2023-12-28 DOI: 10.17776/csj.1328641

Serpil Kaya, S. Erkan, Duran Karakaş

{"title":"Investigation of the Effect of Main Components of Wild Thyme on Covid-19 by Computational Methods","authors":"Serpil Kaya, S. Erkan, Duran Karakaş","doi":"10.17776/csj.1328641","DOIUrl":"https://doi.org/10.17776/csj.1328641","url":null,"abstract":"Aromatic plant species of the genus thymus have an important role as they have therapeutic properties such as antirheumatic, antiseptic, antispasmodic, antimicrobial, cardiac, carminative, diuretic and expectorant. It is also known that such plants strengthen the immune system and help cope with infectious diseases such as colds and flu. In this study, the effects of thymol, p-cymene, -terpinene, bornyl acetate, borneol, carvacrol, thymol methyl ether, thymol acetate, which are the main components of wild thyme (thymus serpyllum L.), on Covid-19 were investigated at the molecular level. Optimizations and molecular docking were done in Docking Server with the MMFF94 method. Major components of wild thyme were docked separately against 6LU7 protein representing the first gene form of Covid-19 and 7KDL protein representing the mutated form. Docking poses and binding energies between target proteins and wild thyme components were calculated. The results were compared with favipiravir, an antiviral drug developed against influenza virus and also used in the treatment of Covid-19. It was found that the thymol molecule, one of the main components of wild thyme, has the highest biological activity against both 6LU7 and 7KDL protein chains of Covid-19.","PeriodicalId":10906,"journal":{"name":"Cumhuriyet Science Journal","volume":"227 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139152679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Determining Efficiency of 15 OECD Countries Coping with Covid-19 using Data Envelopment Analysis after 2 Years of Pandemic 大流行两年后利用数据包络分析法确定 15 个经合组织国家应对 Covid-19 的效率

Cumhuriyet Science Journal Pub Date : 2023-12-28 DOI: 10.17776/csj.1225208

Esra Polat

{"title":"Determining Efficiency of 15 OECD Countries Coping with Covid-19 using Data Envelopment Analysis after 2 Years of Pandemic","authors":"Esra Polat","doi":"10.17776/csj.1225208","DOIUrl":"https://doi.org/10.17776/csj.1225208","url":null,"abstract":"Covid-19, emerged in Wuhan, a city of China, at the date of December 2019, it spread to the entire world soon and then by the World Health Organization (WHO) accepted as a pandemic. Today, still the coping with Covid-19 is the one of the significant topics of countries. In this study, the relative efficiencies of 15 OECD countries for coping with the pandemic is analyzed with Data Envelopment Analysis (DEA). Current health expenditure (% of GDP), Nurses and midwives (per 1 thousand people), Hospital beds (per 1 thousand people), Physicians (per 1 thousand people) variables used as inputs; Number of Total Cases (per 1 million people), Number of Deaths (per 1 million people) and Number of Tests (per 1 million people) variables used as outputs. Output oriented Charnes, Cooper and Rhodes (CCR) and Banker, Charnes and Cooper (BCC) DEA models are used, scale efficiency values are determined and potential improvement suggestions are given for inefficient countries. Austria, Mexico, South Korea, Spain and Türkiye are found to be both relative technical, total and scale efficient. It is also concluded that inefficient countries must use their input variables efficiently and number of Covid-19 tests is important for a country’s efficiency against Covid-19.","PeriodicalId":10906,"journal":{"name":"Cumhuriyet Science Journal","volume":"317 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139149008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design, Synthesis and Evaluation of Pyrrol-thiazole Derivatives as AChE and BuChE Inhibitory and Antioxidant Activities 作为 AChE 和 BuChE 抑制剂和抗氧化剂的吡咯噻唑衍生物的设计、合成和评估

Cumhuriyet Science Journal Pub Date : 2023-12-28 DOI: 10.17776/csj.1255826

U. Acar Çevik, Tuğba Erçetin

引用次数: 0

Investigation of Electrospun Polyacrylonitrile and Cellulose Acetate Smart Nanofibers Doped with Expanded Graphite for the Structure and Photothermal Effect 掺杂膨胀石墨的电纺聚丙烯腈和醋酸纤维素智能纳米纤维的结构和光热效应研究

Cumhuriyet Science Journal Pub Date : 2023-12-28 DOI: 10.17776/csj.1278533

Özgül Gök

{"title":"Investigation of Electrospun Polyacrylonitrile and Cellulose Acetate Smart Nanofibers Doped with Expanded Graphite for the Structure and Photothermal Effect","authors":"Özgül Gök","doi":"10.17776/csj.1278533","DOIUrl":"https://doi.org/10.17776/csj.1278533","url":null,"abstract":"In this study, photothermal effect by doping expanded graphite (EG) to smart nanofibers produced by electrospinning method was investigated. Fourier transform infrared (FT-IR) spectroscopy was exploited for chemical characterization. Thermal analysis experiments were carried out by heating and cooling curves. Surface morphology of the produced materials was investigated through scanning electron microscope (SEM). Contact angle was determined through contact angle measurement device. The appearance of the peak of the characteristic cyano group in the structure of Polyacrylonitrile (PAN) at 2237.02 cm-1 in the nanofibers having different percentages synthesized with EG and PAN was accepted as the evidence of PAN nanofibers formation. The temperature platforms in the heating/cooling curves exhibited that the temperature of the PAN and cellulose acetate (CA) nanofibers mixed with different EG percentage have higher than pristine nanofibers. The surfaces of the EG@PAN and EG@CA nanofibers were homogeneously distributed fibrous, excessive EG heterogeneously dispersed or electrosprayed in shape. The maximum contacts angles were measured as 67.96° and 52.88° for nanofibers synthesized with EG@CA and EG@PAN, respectively. As the result, the temperature of the nanofibers mixed EG at different percentages increased resulting from having the higher thermal conductivity of EG. Main goal of the study is both investigating photothermal effect in PAN and CA electrospun nanofibers doped with EG of activating heat accumulation property of the produced smart nanofibers for heat energy production from the solar. Thus, it will be possible to develop a new promising method in the production of the smart textile products that have the storage capacity of the solar energy.","PeriodicalId":10906,"journal":{"name":"Cumhuriyet Science Journal","volume":"27 17","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139148291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spectrophotometric Determination of Atorvastatin Based on Charge Transfer Reaction with Quinalizarin 基于与喹哪嗪的电荷转移反应的阿托伐他汀分光光度测定法

Cumhuriyet Science Journal Pub Date : 2023-12-28 DOI: 10.17776/csj.1327163

Fatih Yi̇ği̇t, Nurettin Tarkan, Mehmet Akdeni̇z, Figen Erek, I. Aydin

引用次数: 0

Evaluation of the Interactions of Cabozantinib with Topoisomerase Enzymes by in vitro Enzyme Activity Assays, and its Effects on Cancer Cell Proliferation 通过体外酶活性测定评估卡博替尼与拓扑异构酶的相互作用及其对癌细胞增殖的影响

Cumhuriyet Science Journal Pub Date : 2023-12-28 DOI: 10.17776/csj.1376788

Feyza Oflaz, Naz Ünal, Burcin Gungor, Pakize Cantürk

{"title":"Evaluation of the Interactions of Cabozantinib with Topoisomerase Enzymes by in vitro Enzyme Activity Assays, and its Effects on Cancer Cell Proliferation","authors":"Feyza Oflaz, Naz Ünal, Burcin Gungor, Pakize Cantürk","doi":"10.17776/csj.1376788","DOIUrl":"https://doi.org/10.17776/csj.1376788","url":null,"abstract":"The discovery of many drugs in recent years provides a definitive solution in the treatment of various diseases, but today, despite the discovery of many effective anticancer drugs, there are various types of cancer that have limitations in treatment and are still not completely curable. Since most of these limitations are due to cancer cells gaining resistance or compounds only being effective in certain types of cancer cells, the search for more effective anticancer drugs that are also effective in these types of cancer is inevitable. Cabozantinib is in medical use as a highly effective anticancer drug in various types of cancer, such as medullary thyroid cancer and kidney cancer. The anticancer properties of the Cabozantinib compound have attracted more attention in recent years, however, more studies are needed to define the anticancer activities of this compound. In our study, the interactions of Cabozantinib with topoisomerase enzymes, were demonstrated through in vitro enzyme activity tests, and the anti-proliferative effect of Cabozantinib was studied on MCF7, A549 and PC3 cell lines. By analyzing the interactions of the Cabozantinib with topoisomerases, the action mechanisms of the compound at the molecular level was evaluated.","PeriodicalId":10906,"journal":{"name":"Cumhuriyet Science Journal","volume":"16 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139150062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0