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The Anti-proliferative Effect of Caffeic Acid and Dactolisib on Human Cervical Carcinoma HeLa Cell Line 咖啡酸和 Dactolisib 对人宫颈癌 HeLa 细胞株的抗增殖作用
Cumhuriyet Science Journal Pub Date : 2024-02-27 DOI: 10.17776/csj.1394831
Zeynep Busra Bolat
{"title":"The Anti-proliferative Effect of Caffeic Acid and Dactolisib on Human Cervical Carcinoma HeLa Cell Line","authors":"Zeynep Busra Bolat","doi":"10.17776/csj.1394831","DOIUrl":"https://doi.org/10.17776/csj.1394831","url":null,"abstract":"Cervical carcinoma is a common gynecological cancer with high mortality rate among women worldwide. Caffeic acid exerts an antiproliferative effect against cervical carcinoma. Dactolisib is a dual PI3K and mTOR inhibitor that has a therapeutic potential for cervical carcinoma. This study aimed to reveal the anti-proliferative effect of combination treatment of caffeic acid and Dactolisib on cervical carcinoma HeLa cell line. Cytotoxicity of caffeic acid and Dactolisib on HeLa cell line was assessed by MTS assay. Colony formation of HeLa cells treated with caffeic acid and Dactolisib was determined by staining colonies with crystal violet and visualizing under light microscope. Dactolisib decreased cell proliferation of HeLa cells in time and dose dependent manner. 5 μM caffeic acid did not show any significant change in cell viability of HeLa cells. Combination treatment of 5 μM caffeic acid and 0.5 μM Dactolisib showed decrease in cell viability of HeLa cells when compared to Dactolisib treated cells. Combination of caffeic acid and Dactolisib decreased colony diameter of HeLa cells significantly when compared to control group. Caffeic acid and Dactolisib shows anti-proliferative effect on human cervical carcinoma HeLa cell line, so further studies should be performed to reveal the mechanism of action.","PeriodicalId":10906,"journal":{"name":"Cumhuriyet Science Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140426013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Machine Learning Based Classification of the Halos in Light Nuclei Region 基于机器学习的光核区域光晕分类
Cumhuriyet Science Journal Pub Date : 2024-02-27 DOI: 10.17776/csj.1416907
S. Akkoyun
{"title":"Machine Learning Based Classification of the Halos in Light Nuclei Region","authors":"S. Akkoyun","doi":"10.17776/csj.1416907","DOIUrl":"https://doi.org/10.17776/csj.1416907","url":null,"abstract":"Experimental and theoretical studies on halo nuclei, whose nucleon binding energies are extremely weak, are among the most interesting topics of nuclear physics studies. By better defining and understanding this unusual behavior of these nuclei, our understanding of nuclear structure can be further improved. Although there are already a few experimentally proven halo nuclei in the literature, many others have found their place in the literature as candidate halo nuclei. In this study, the classification of halo nuclei was carried out using an artificial neural network approach. In the light nuclei region, the properties of nuclei, including halo nuclei, were discussed and the existing halo nuclei were classified. The success of the obtained results indicates that machine learning methods can be used for identifying halo nuclei. Thus, these methods are considered as one of the alternative tools to confirm the existence of new or candidate halo nuclei.","PeriodicalId":10906,"journal":{"name":"Cumhuriyet Science Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140427224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Row and Column Effects Modelling of Elderly Age Groups and Chronic Health Problem on COVID-19 关于 COVID-19 的老年人年龄组和慢性健康问题的行列效应模型
Cumhuriyet Science Journal Pub Date : 2024-02-27 DOI: 10.17776/csj.1325410
G. Altun, S. Aktaş
{"title":"Row and Column Effects Modelling of Elderly Age Groups and Chronic Health Problem on COVID-19","authors":"G. Altun, S. Aktaş","doi":"10.17776/csj.1325410","DOIUrl":"https://doi.org/10.17776/csj.1325410","url":null,"abstract":"Statistical analysis of COVID-19 data from China and NYC, using log-linear models, helps identifying high-risk groups like those aged over 65 and individuals with chronic health issues. According to the results of row effects model applied to the COVID-19 data set of China, we conclude that when the age group increases by one unit, the risk of getting COVID-19 disease is approximately 8 times higher for the patients having Chronic Obstructive Pulmonary Disease (COPD) than patients having hypertension, 9.37 times higher than patients with coronary heart disease, 13.37 times higher than patients having diabetes and cerebrovascular diseases and 10.16 times higher than patients having other diseases. According to the results of column effects model applied to the COVID-19 data set of NYC, we conclude that when the age group increases by one unit, the risk of death from the COVID-19 disease is approximately 2 times higher for the patients having choric health problem than the patients not having a chronic health problem. We believe that the empirical findings of the presented study will guide the policymakers to make provision for these disadvantageous groups for COVID-19 disease","PeriodicalId":10906,"journal":{"name":"Cumhuriyet Science Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140426402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Solvability of an Inverse Problem for an Elliptic-Type Equation 椭圆方程逆问题的可解性
Cumhuriyet Science Journal Pub Date : 2024-02-26 DOI: 10.17776/csj.1359651
Özlem Kaytmaz, Mustafa Yıldız
{"title":"Solvability of an Inverse Problem for an Elliptic-Type Equation","authors":"Özlem Kaytmaz, Mustafa Yıldız","doi":"10.17776/csj.1359651","DOIUrl":"https://doi.org/10.17776/csj.1359651","url":null,"abstract":"In this study, we consider an inverse problem of determining an unknown source function in the right-hand side of an elliptic equation which is ill-posed in the Hadamard sense. To investigate the solvability of the problem, we reduce it to a Dirichlet problem for a third-order partial differential equation with homogeneous boundary condition. Since the problem is linear, the proof of the uniqueness theorem is based on the Fredholm Alternative Theorem. We prove the existence of the solution to the problem by using the Galerkin method.","PeriodicalId":10906,"journal":{"name":"Cumhuriyet Science Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140429278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cytotoxic Effects of Theranekron D6 on HepG2 Heaptocellular Carcinoma Cells Theranekron D6 对 HepG2 细胞癌细胞的细胞毒性作用
Cumhuriyet Science Journal Pub Date : 2024-02-25 DOI: 10.17776/csj.1363685
Deniz Şumnulu
{"title":"Cytotoxic Effects of Theranekron D6 on HepG2 Heaptocellular Carcinoma Cells","authors":"Deniz Şumnulu","doi":"10.17776/csj.1363685","DOIUrl":"https://doi.org/10.17776/csj.1363685","url":null,"abstract":"Theranekron D6 is an alcholic extract of Tarantul cubensis. In this study, the cytotoxic effects of Theranekron D6 on HepG2 and on AML12 cells were investigated by MTT analyses. Gene expression analyses were performed by qRT-PCR. Apoptotic, necrotic, and healthy cells were viewed by a fluorescent microscope, and they were counted by a flow cytometry device. 143 µg/mL Theranekron D6 was calculated as an IC50 value for HepG2 cells, and it was applied to both cell lines. No significant increase in the amount of apoptotic and necrotic cells was observed at the AML12 cells, while both of them increased by 31.04% at the HepG2 cells by Therankron D6 application. The accuracy of flow cytometry data was confirmed through fluorescence microscope analyses. At the HepG2 cells, significant increases were observed at the expression levels of Bax (5.61 ± 0.34), Cas3 (2.74 ± 0.34), APAF1 (3.64 ± 0.44), and p53 (2.10 ± 0.3) genes, but at the AML12 cells, the expression levels of the same genes 1.14 ± 0.14, 0.54 ± 0.17, 0.71 ± 0.17, and 0.93 ± 0.3 not increased. Based on these data, it was concluded that Theranekron D6 may be a chemotherapy candidate for HepG2 cells.","PeriodicalId":10906,"journal":{"name":"Cumhuriyet Science Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140433751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dynamics of a Conformable Fractional Order Generalized Richards Growth Model on Star Network with N=20 Nodes 节点数为 N=20 的星型网络上的可变分数阶广义理查兹增长模型的动力学特性
Cumhuriyet Science Journal Pub Date : 2024-02-22 DOI: 10.17776/csj.1385759
Neriman Kartal
{"title":"Dynamics of a Conformable Fractional Order Generalized Richards Growth Model on Star Network with N=20 Nodes","authors":"Neriman Kartal","doi":"10.17776/csj.1385759","DOIUrl":"https://doi.org/10.17776/csj.1385759","url":null,"abstract":"In this study, we analyze dynamical behavior of the conformable fractional order Richards growth model. Before examining the analysis of the dynamical behavior of the fractional continuous time model, the model is reduced to the system of difference equations via utilizing piecewise constant functions. An algebraic condition that ensures the stability of the positive fixed point of the system is obtained. With the center manifold theory, the existence of a Neimark-Sacker bifurcation at the fixed point of the discrete-time system is proven and the direction of this bifurcation is determined. In addition, the discrete dynamical system is also studied on the star network with N=20 nodes. Analysis complex dynamics of Richards growth model into coupled dynamical network shows that the complex star network with N=20 nodes also exhibits Neimark-Sacker bifurcation about the fixed point concerning with parameter c. Numerical simulations are performed to demonstrate the stability, bifurcations and dynamic transition of the coupled network.","PeriodicalId":10906,"journal":{"name":"Cumhuriyet Science Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140439187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Functional Analysis of Variance: An Application to Stock Exchange 功能方差分析：证券交易所应用
Cumhuriyet Science Journal Pub Date : 2024-02-05 DOI: 10.17776/csj.1371399
Selin Öğütcü, Nuri Çelik
{"title":"Functional Analysis of Variance: An Application to Stock Exchange","authors":"Selin Öğütcü, Nuri Çelik","doi":"10.17776/csj.1371399","DOIUrl":"https://doi.org/10.17776/csj.1371399","url":null,"abstract":"The concept of \"functional data\" allows for the representation of data collected repeatedly over a period of time as a continuous function within a specific range on the time axis, rather than as discrete measurement points. Traditional statistical analysis has been adapted to accommodate functional data. This paper discusses the adaptation of one-way analysis of variance for functional data, covering parameter estimations and obtaining test statistics. As a numerical example, stock exchange values from various countries across different continents are used. The aim is to discern potential differences among countries based on these stock exchange values during the Covid-19 pandemic, utilizing one-way analysis of variance for functional data.","PeriodicalId":10906,"journal":{"name":"Cumhuriyet Science Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140461482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Production and Characterization of Ni0.50 Al0.50 and Ni0.55 Al0.45 Powders by Volume Combustion Synthesis 通过体积燃烧合成法生产 Ni0.50 Al0.50 和 Ni0.55 Al0.45 粉末并确定其特性
Cumhuriyet Science Journal Pub Date : 2024-02-01 DOI: 10.17776/csj.1280582
Gülizar Sarıyer, H. E. Çamurlu
{"title":"Production and Characterization of Ni0.50 Al0.50 and Ni0.55 Al0.45 Powders by Volume Combustion Synthesis","authors":"Gülizar Sarıyer, H. E. Çamurlu","doi":"10.17776/csj.1280582","DOIUrl":"https://doi.org/10.17776/csj.1280582","url":null,"abstract":"Nickel aluminide (NiAl) is an essential intermetallic material with a high melting point and excellent high temperature corrosion resistance. It is a solid solution of Ni and Al in 40-61 mol.% Ni range. In this study, Ni0.50Al0.50 and Ni0.55Al0.45 powders were formed by using nickel and aluminum elemental powders through volume combustion synthesis (VCS). MgO powder was utilized as the thermal diluent. According to adiabatic temperature calculations, MgO was added to the reactant mixture in 10-40 vol.% range for preventing the melting and sintering of the formed Ni0.50Al0.50 and Ni0.55Al0.45 particles. After VCS, the products were ground into powder form and leached in 3M HCl solution in order to remove the MgO particles. After VCS, the samples which were obtained with 10 - 30 vol.% MgO addition were quite hard and difficult to grind. This indicated the partial sintering of the formed particles. It was relatively easier to grind into powder form the samples which contained 40 vol.% MgO. Therefore, it was determined that the most suitable MgO ratio for the formation of Ni0.50Al0.50 and Ni0.55Al0.45 powders was 40 vol.%. Formed powders were mostly in 5-100 µm particle size range. The formation of single phase pure powders was confirmed by the XRD analyses. A shift of about 0.1 degrees to higher 2-theta values was determined in the XRD peaks of the Ni0.55Al0.45 powder as compared to the Ni0.50Al0.50 phase, after annealing the powders. The results were in agreement with the crystallographic data.","PeriodicalId":10906,"journal":{"name":"Cumhuriyet Science Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140469839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fluorescence Cell Imaging by Carbon Quantum Dots Derived from the Medicinal Plant Malva Sylvestris 药用植物锦葵提取的碳量子点的荧光细胞成像技术
Cumhuriyet Science Journal Pub Date : 2024-01-31 DOI: 10.17776/csj.1333574
Layth Shakir Mahmood, G. Arslan, I. Sargin, S. Karakurt
{"title":"Fluorescence Cell Imaging by Carbon Quantum Dots Derived from the Medicinal Plant Malva Sylvestris","authors":"Layth Shakir Mahmood, G. Arslan, I. Sargin, S. Karakurt","doi":"10.17776/csj.1333574","DOIUrl":"https://doi.org/10.17776/csj.1333574","url":null,"abstract":"Carbon quantum dots (CQDs) derived from biological samples exhibit low cytotoxicity and are often used as fluorescent agents for bioimaging cells or bacteria. In this study, fluorescent CQDs derived from Malva sylvestris, a wild edible medicinal plant (common mallow), were used to visualize the human epithelial cells (PNT1A). CQDs with strong blue photoluminescence were synthesized by microwave irradiation of dried M. sylvestris in water. CQDs' structural, morphological, surface features and photoluminescence properties were evaluated. In vitro, cytotoxicity assays revealed that carbon quantum dots from M. sylvestris have no cytotoxic effects on human epithelial cells. Non-cytotoxic and high photoluminescent CQDs from M. sylvestris can be exploited in bioimaging applications as a fluorophore agent","PeriodicalId":10906,"journal":{"name":"Cumhuriyet Science Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140471503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Strain-Dependent Antimicrobial and Antibiofilm effect of Cis and Trans-Vaccenic Acid against Pseudomonas Aeruginosa 顺式和反式长春花酸对铜绿假单胞菌的抗菌和抗生物膜作用取决于菌种
Cumhuriyet Science Journal Pub Date : 2024-01-31 DOI: 10.17776/csj.1341700
Ayşenur Yazıcı
{"title":"The Strain-Dependent Antimicrobial and Antibiofilm effect of Cis and Trans-Vaccenic Acid against Pseudomonas Aeruginosa","authors":"Ayşenur Yazıcı","doi":"10.17776/csj.1341700","DOIUrl":"https://doi.org/10.17776/csj.1341700","url":null,"abstract":"This study, it was aimed to investigate the antibacterial and antibiofilm activity of cis and trans-vaccenic acid against Pseudomonas aeruginosa. In the study, four different P. aeruginosa strains were used. Antibacterial activity was determined by microdilution and growth curve. The antibiofilm activity was determined by crystal violet assay. In addition, the effect of vaccenic acids on pyocyanin production was investigated. The minimum inhibitory concentration (MIC) of cis and trans-vaccenic acid against all strains was determined as 128-256 μg/mL, and the minimum biofilm inhibitory concentration (MBIC) value was 8-512 μg/mL. While vaccenic acids reduced cell growth in three strains, they also significantly inhibited pyocyanin production. In one strain, it inhibited biofilm formation without affecting cell growth. As a result, the presence of antibacterial and antibiofilm activity of cis and trans-vaccenic acid against P. aeruginosa was determined as potential agents in the fight against this bacteria.","PeriodicalId":10906,"journal":{"name":"Cumhuriyet Science Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140479153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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