Current Neuropharmacology最新文献_第9页

Role of Metalloproteinases in Diabetes-associated Mild Cognitive Impairment. 金属蛋白酶在糖尿病相关轻度认知障碍中的作用

IF 4.8 2区医学

Current Neuropharmacology Pub Date : 2024-01-01 DOI: 10.2174/1570159X22666240517090855

Vitoria Mattos Pereira, Suyasha Pradhanang, Jonathan F Prather, Sreejayan Nair

{"title":"Role of Metalloproteinases in Diabetes-associated Mild Cognitive Impairment.","authors":"Vitoria Mattos Pereira, Suyasha Pradhanang, Jonathan F Prather, Sreejayan Nair","doi":"10.2174/1570159X22666240517090855","DOIUrl":"10.2174/1570159X22666240517090855","url":null,"abstract":"Diabetes has been linked to an increased risk of mild cognitive impairment (MCI), a condition characterized by a subtle cognitive decline that may precede the development of dementia. The underlying mechanisms connecting diabetes and MCI involve complex interactions between metabolic dysregulation, inflammation, and neurodegeneration. A critical mechanism implicated in diabetes and MCI is the activation of inflammatory pathways. Chronic low-grade inflammation, as observed in diabetes, can lead to the production of pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), interleukin-1 beta (IL-1β), and interferon-gamma (IFNγ), each of which can exacerbate neuroinflammation and contribute to cognitive decline. A crucial enzyme involved in regulating inflammation is ADAM17, a disintegrin, and metalloproteinase, which can cleave and release TNF-α from its membrane-bound precursor and cause it to become activated. These processes, in turn, activate additional inflammation-related pathways, such as AKT, NF-κB, NLP3, MAPK, and JAK-STAT pathways. Recent research has provided novel insights into the role of ADAM17 in diabetes and neurodegenerative diseases. ADAM17 is upregulated in both diabetes and Alzheimer's disease, suggesting a shared mechanism and implicating inflammation as a possible contributor to much broader forms of pathology and pointing to a possible link between inflammation and the emergence of MCI. This review provides an overview of the different roles of ADAM17 in diabetes-associated mild cognitive impairment diseases. It identifies mechanistic connections through which ADAM17 and associated pathways may influence the emergence of mild cognitive impairment.","PeriodicalId":10905,"journal":{"name":"Current Neuropharmacology","volume":" ","pages":"58-74"},"PeriodicalIF":4.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11519823/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141497349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of Cav2.3 (R-type) Calcium Channel in Pain and Analgesia: A Scoping Review. Cav2.3（R 型）钙通道在疼痛和镇痛中的作用：范围综述》。

IF 4.8 2区医学

Current Neuropharmacology Pub Date : 2024-01-01 DOI: 10.2174/1570159X21666230811102700

Marcella de Amorim Ferreira, Juliano Ferreira

{"title":"Role of Cav2.3 (R-type) Calcium Channel in Pain and Analgesia: A Scoping Review.","authors":"Marcella de Amorim Ferreira, Juliano Ferreira","doi":"10.2174/1570159X21666230811102700","DOIUrl":"10.2174/1570159X21666230811102700","url":null,"abstract":"Background: Voltage-gated calcium channels (VGCCs) play an important role in pain development and maintenance. As Cav2.2 and Cav3.2 channels have been identified as potential drug targets for analgesics, the participation of Cav2.3 (that gives rise to R-type calcium currents) in pain and analgesia remains incompletely understood.Objective: Identify the participation of Cav2.3 in pain and analgesia.Methods: To map research in this area as well as to identify any existing gaps in knowledge on the potential role of Cav2.3 in pain signalling, we conducted this scoping review. We searched PubMed and SCOPUS databases, and 40 articles were included in this study. Besides, we organized the studies into 5 types of categories within the broader context of the role of Cav2.3 in pain and analgesia.Results: Some studies revealed the expression of Cav2.3 in pain pathways, especially in nociceptive neurons at the sensory ganglia. Other studies demonstrated that Cav2.3-mediated currents could be inhibited by analgesic/antinociceptive drugs either indirectly or directly. Some articles indicated that Cav2.3 modulates nociceptive transmission, especially at the pre-synaptic level at spinal sites. There are studies using different rodent pain models and approaches to reduce Cav2.3 activity or expression and mostly demonstrated a pro-nociceptive role of Cav2.3, despite some contradictory findings and deficiencies in the description of study design quality. There are three studies that reported the association of single-nucleotide polymorphisms in the Cav2.3 gene (CACNA1E) with postoperative pain and opioid consumption as well as with the prevalence of migraine in patients.Conclusion: Cav2.3 is a target for some analgesic drugs and has a pro-nociceptive role in pain.","PeriodicalId":10905,"journal":{"name":"Current Neuropharmacology","volume":" ","pages":"1909-1922"},"PeriodicalIF":4.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11284728/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9997845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Peripheral Nervous System Pain Modulation. 外周神经系统疼痛调节。

IF 4.8 2区医学

Current Neuropharmacology Pub Date : 2024-01-01 DOI: 10.2174/1570159X21666230803100400

Marcin Karcz, Christopher Gharibo

{"title":"Peripheral Nervous System Pain Modulation.","authors":"Marcin Karcz, Christopher Gharibo","doi":"10.2174/1570159X21666230803100400","DOIUrl":"10.2174/1570159X21666230803100400","url":null,"abstract":"The percutaneous technique of electrode insertion in the vicinity of the greater occipital nerves to treat occipital neuralgia was first described in the 1990s by Weiner and Reed. This subsequently stimulated awareness of peripheral nerve stimulation (PNS). The more recent advent emergence of a minimally invasive percutaneous approach by way of using ultrasound has further increased the interest in PNS as a viable alternative to more invasive techniques. PNS has become more popular recently and is increasingly used to treat various pain conditions. Its foundation is fundamentally based on the gate control theory, although the precise mechanism underlying its analgesic effect is still indefinite. Studies have demonstrated the peripheral and central analgesic mechanisms of PNS by modulating the inflammatory pathways, the autonomic nervous system, the endogenous pain inhibition pathways, and the involvement of the cortical and subcortical areas. Peripheral nerve stimulation exhibits its neuromodulatory effect both peripherally and centrally. Further understanding of the modulation of PNS mechanisms can help guide stimulation approaches and parameters to optimize the use of PNS. his chapter aims to review the background and mechanisms of PNS modulation. PNS is becoming one of the most diverse therapies in neuromodulation due to rapid evolution and expansion. It is an attractive option for clinicians due to the simplicity and versatility of procedures that can be combined with other neuromodulation treatments or used alone. It has a distinct role in the modulation of functional conditions.","PeriodicalId":10905,"journal":{"name":"Current Neuropharmacology","volume":" ","pages":"65-71"},"PeriodicalIF":4.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10716886/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9918197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Developmental Neuroendocrinology of Early-Life Stress: Impact on Child Development and Behavior. 早期生活压力的发育神经内分泌学：对儿童发育和行为的影响》。

IF 5.3 2区医学

Current Neuropharmacology Pub Date : 2024-01-01 DOI: 10.2174/1570159X21666230810162344

Nicolas C Nicolaides, Christina Kanaka-Gantenbein, Panagiota Pervanidou

{"title":"Developmental Neuroendocrinology of Early-Life Stress: Impact on Child Development and Behavior.","authors":"Nicolas C Nicolaides, Christina Kanaka-Gantenbein, Panagiota Pervanidou","doi":"10.2174/1570159X21666230810162344","DOIUrl":"10.2174/1570159X21666230810162344","url":null,"abstract":"Our internal balance, or homeostasis, is threatened or perceived as threatened by stressful stimuli, the stressors. The stress system is a highly conserved system that adjusts homeostasis to the resting state. Through the concurrent activation of the hypothalamic-pituitary-adrenal axis and the locus coeruleus/norepinephrine-autonomic nervous systems, the stress system provides the appropriate physical and behavioral responses, collectively termed as \"stress response\", to restore homeostasis. If the stress response is prolonged, excessive or even inadequate, several acute or chronic stress-related pathologic conditions may develop in childhood, adolescence and adult life. On the other hand, earlylife exposure to stressors has been recognized as a major contributing factor underlying the pathogenesis of non-communicable disorders, including neurodevelopmental disorders. Accumulating evidence suggests that early-life stress has been associated with an increased risk for attention deficit hyperactivity disorder and autism spectrum disorder in the offspring, although findings are still controversial. Nevertheless, at the molecular level, early-life stressors alter the chemical structure of cytosines located in the regulatory regions of genes, mostly through the addition of methyl groups. These epigenetic modifications result in the suppression of gene expression without changing the DNA sequence. In addition to DNA methylation, several lines of evidence support the role of non-coding RNAs in the evolving field of epigenetics. In this review article, we present the anatomical and functional components of the stress system, discuss the proper, in terms of quality and quantity, stress response, and provide an update on the impact of early-life stress on child development and behavior.","PeriodicalId":10905,"journal":{"name":"Current Neuropharmacology","volume":" ","pages":"461-474"},"PeriodicalIF":5.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10845081/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9974358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Basal Ganglia Downstream Control of Action - An Evolutionarily Conserved Strategy. 基底神经节作用的下游控制--一种进化中保留下来的策略。

IF 4.8 2区医学

Current Neuropharmacology Pub Date : 2024-01-01 DOI: 10.2174/1570159X21666230810141746

Johanna Frost-Nylén, William Scott Thompson, Brita Robertson, Sten Grillner

{"title":"The Basal Ganglia Downstream Control of Action - An Evolutionarily Conserved Strategy.","authors":"Johanna Frost-Nylén, William Scott Thompson, Brita Robertson, Sten Grillner","doi":"10.2174/1570159X21666230810141746","DOIUrl":"10.2174/1570159X21666230810141746","url":null,"abstract":"The motor areas of the cortex and the basal ganglia both contribute to determining which motor actions will be recruited at any moment in time, and their functions are intertwined. Here, we review the basal ganglia mechanisms underlying the selection of behavior of the downstream control of motor centers in the midbrain and brainstem and show that the basic organization of the forebrain motor system is evolutionarily conserved throughout vertebrate phylogeny. The output level of the basal ganglia (e.g. substantia nigra pars reticulata) has GABAergic neurons that are spontaneously active at rest and inhibit a number of specific motor centers, each of which can be relieved from inhibition if the inhibitory output neurons themselves become inhibited. The motor areas of the cortex act partially via the dorsolateral striatum (putamen), which has specific modules for the forelimb, hindlimb, trunk, etc. Each module operates in turn through the two types of striatal projection neurons that control the output modules of the basal ganglia and thereby the downstream motor centers. The mechanisms for lateral inhibition in the striatum are reviewed as well as other striatal mechanisms contributing to action selection. The motor cortex also exerts a direct excitatory action on specific motor centers. An overview is given of the basal ganglia control exerted on the different midbrain/brainstem motor centers, and the efference copy information fed back via the thalamus to the striatum and cortex, which is of importance for the planning of future movements.","PeriodicalId":10905,"journal":{"name":"Current Neuropharmacology","volume":" ","pages":"1419-1430"},"PeriodicalIF":4.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11097981/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9974363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuropathic Pain in Aged People: An Unresolved Issue Open to Novel Drug Approaches, Focusing on Painful Diabetic Neuropathy. 老年人神经性疼痛:一个未解决的问题开放的新药物方法，专注于疼痛性糖尿病神经病变。

IF 4.8 2区医学

Current Neuropharmacology Pub Date : 2024-01-01 DOI: 10.2174/1570159X21666230807103642

Nicoletta Marchesi, Foroogh Fahmideh, Alessia Pascale, Massimo Allegri, Stefano Govoni

{"title":"Neuropathic Pain in Aged People: An Unresolved Issue Open to Novel Drug Approaches, Focusing on Painful Diabetic Neuropathy.","authors":"Nicoletta Marchesi, Foroogh Fahmideh, Alessia Pascale, Massimo Allegri, Stefano Govoni","doi":"10.2174/1570159X21666230807103642","DOIUrl":"10.2174/1570159X21666230807103642","url":null,"abstract":"A majority of older patients suffer from neuropathic pain (NP) that significantly alters their daily activities and imposes a significant burden on health care. Multiple comorbidities and the risk of polypharmacy in the elderly make it challenging to determine the appropriate drug, dosage, and maintenance of therapy. Age-dependent processes play a contributing role in neuropathy given that diabetic neuropathy (DN) is the most common form of neuropathy. This narrative review is mainly focused on the drug treatment approach for neuropathy-associated pain in aged people including both drugs and dietary supplements, considering the latter as add-on mechanism-based treatments to increase the effectiveness of usual treatments by implementing their activity or activating other analgesic pathways. On one hand, the limited clinical studies assessing the effectiveness and the adverse effects of existing pain management options in this age segment of the population (> 65), on the other hand, the expanding global demographics of the elderly contribute to building up an unresolved pain management problem that needs the attention of healthcare providers, researchers, and health authorities as well as the expansion of the current therapeutic options.","PeriodicalId":10905,"journal":{"name":"Current Neuropharmacology","volume":" ","pages":"53-64"},"PeriodicalIF":4.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10716885/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10008302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stress, Environment and Early Psychosis. 压力、环境和早期精神病。

IF 5.3 2区医学

Current Neuropharmacology Pub Date : 2024-01-01 DOI: 10.2174/1570159X21666230817153631

Lida-Alkisti Xenaki, Stefanos Dimitrakopoulos, Mirjana Selakovic, Nikos Stefanis

{"title":"Stress, Environment and Early Psychosis.","authors":"Lida-Alkisti Xenaki, Stefanos Dimitrakopoulos, Mirjana Selakovic, Nikos Stefanis","doi":"10.2174/1570159X21666230817153631","DOIUrl":"10.2174/1570159X21666230817153631","url":null,"abstract":"Existing literature provides extended evidence of the close relationship between stress dysregulation, environmental insults, and psychosis onset. Early stress can sensitize genetically vulnerable individuals to future stress, modifying their risk for developing psychotic phenomena. Neurobiological substrate of the aberrant stress response to hypothalamic-pituitary-adrenal axis dysregulation, disrupted inflammation processes, oxidative stress increase, gut dysbiosis, and altered brain signaling, provides mechanistic links between environmental risk factors and the development of psychotic symptoms. Early-life and later-life exposures may act directly, accumulatively, and repeatedly during critical neurodevelopmental time windows. Environmental hazards, such as pre- and perinatal complications, traumatic experiences, psychosocial stressors, and cannabis use might negatively intervene with brain developmental trajectories and disturb the balance of important stress systems, which act together with recent life events to push the individual over the threshold for the manifestation of psychosis. The current review presents the dynamic and complex relationship between stress, environment, and psychosis onset, attempting to provide an insight into potentially modifiable factors, enhancing resilience and possibly influencing individual psychosis liability.","PeriodicalId":10905,"journal":{"name":"Current Neuropharmacology","volume":" ","pages":"437-460"},"PeriodicalIF":5.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10845077/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10012251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex-Dependent Synergism of an Edible THC: CBD Formulation in Reducing Anxiety and Depressive-like Symptoms Following Chronic Stress. 食用型四氢大麻酚：CBD 配方在减轻慢性压力后焦虑和抑郁类似症状方面的性别依赖性协同作用。

IF 4.8 2区医学

Current Neuropharmacology Pub Date : 2024-01-01 DOI: 10.2174/1570159X21666230912101441

Enzo Pérez-Valenzuela, Roger Hudson, Taygun Uzuneser, Marta De Felice, Hanna Szkudlarek, Walter Rushlow, Steven R Laviolette

{"title":"Sex-Dependent Synergism of an Edible THC: CBD Formulation in Reducing Anxiety and Depressive-like Symptoms Following Chronic Stress.","authors":"Enzo Pérez-Valenzuela, Roger Hudson, Taygun Uzuneser, Marta De Felice, Hanna Szkudlarek, Walter Rushlow, Steven R Laviolette","doi":"10.2174/1570159X21666230912101441","DOIUrl":"10.2174/1570159X21666230912101441","url":null,"abstract":"Cannabis has shown therapeutic potential in mood and anxiety-related pathologies. However, the two primary constituents of cannabis, cannabidiol (CBD) and Δ-9-tetrahydrocannabinol (THC) produce distinct effects on molecular pathways in neural circuits associated with affective disorders. Moreover, it has been proposed that the combination of THC: and CBD may have unique synergistic properties. In the present study, the effects of a 1:100 THC: CBD ratio edible formulation were tested in behavioural, neuronal and molecular assays for anxiety and depressive-like endophenotypes. Adult male and female Sprague-Dawley rats were stressed for 14 days. Then, for three weeks, open field, elevated plus maze, light/dark box, social interaction, sucrose preference, and the forced swim test were performed 90 minutes after acute consumption of CBD (30 mg/kg), THC (0.3 mg/kg), or 1:100 combination of THC:CBD. After behavioural tests, in vivo, neuronal electrophysiological analyses were performed in the ventral tegmental area and prefrontal cortex (PFC). Furthermore, western-blot experiments examined the expression of biomarkers associated with mood and anxiety disorders, including protein kinase B (Akt), glycogen synthase kinase-3 (GSK-3), BDNF, mTOR, D1, and D2 receptor in nucleus accumbens (NAc) and PFC.Edible THC:CBD produces significant anxiolytic and antidepressant effects only in stressed male rats. In most cases, the combination of THC and CBD had stronger effects than either phytochemical alone. These synergistic effects are associated with alterations in Akt/GSK3 and D2-R expression in NAc and BDNF expression in PFC. Furthermore, THC:CBD reverses chronic stress-induced alterations in PFC neuronal activity. These findings demonstrate a novel synergistic potential for THC:CBD edible formulations in stress-related pathologies.","PeriodicalId":10905,"journal":{"name":"Current Neuropharmacology","volume":" ","pages":"2059-2078"},"PeriodicalIF":4.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11333796/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10215348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pathomechanistic Networks of Motor System Injury in Amyotrophic Lateral Sclerosis. 肌萎缩侧索硬化症运动系统损伤的病理机制网络

IF 4.8 2区医学

Current Neuropharmacology Pub Date : 2024-01-01 DOI: 10.2174/1570159X21666230824091601

Bedaballi Dey, Arvind Kumar, Anant Bahadur Patel

{"title":"Pathomechanistic Networks of Motor System Injury in Amyotrophic Lateral Sclerosis.","authors":"Bedaballi Dey, Arvind Kumar, Anant Bahadur Patel","doi":"10.2174/1570159X21666230824091601","DOIUrl":"10.2174/1570159X21666230824091601","url":null,"abstract":"Amyotrophic Lateral Sclerosis (ALS) is the most common, adult-onset, progressive motor neurodegenerative disorder that results in death within 3 years of the clinical diagnosis. Due to the clinicopathological heterogeneity, any reliable biomarkers for diagnosis or prognosis of ALS have not been identified till date. Moreover, the only three clinically approved treatments are not uniformly effective in slowing the disease progression. Over the last 15 years, there has been a rapid advancement in research on the complex pathomechanistic landscape of ALS that has opened up new avenues for successful clinical translation of targeted therapeutics. Multiple studies suggest that the age-dependent interaction of risk-associated genes with environmental factors and endogenous modifiers is critical to the multi-step process of ALS pathogenesis. In this review, we provide an updated discussion on the dysregulated cross-talk between intracellular homeostasis processes, the unique molecular networks across selectively vulnerable cell types, and the multisystemic nature of ALS pathomechanisms. Importantly, this work highlights the alteration in epigenetic and epitranscriptomic landscape due to gene-environment interactions, which have been largely overlooked in the context of ALS pathology. Finally, we suggest that precision medicine research in ALS will be largely benefitted from the stratification of patient groups based on the clinical phenotype, onset and progression, genome, exposome, and metabolic identities.","PeriodicalId":10905,"journal":{"name":"Current Neuropharmacology","volume":" ","pages":"1778-1806"},"PeriodicalIF":4.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11284732/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10068498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Comprehensive Review on the Importance of MiRNA-206 in the Animal Model and Human Diseases. 全面回顾 MiRNA-206 在动物模型和人类疾病中的重要性。

IF 4.8 2区医学

Current Neuropharmacology Pub Date : 2024-01-01 DOI: 10.2174/1570159X21666230407124146

Wang Qi, Wei Guan

{"title":"A Comprehensive Review on the Importance of MiRNA-206 in the Animal Model and Human Diseases.","authors":"Wang Qi, Wei Guan","doi":"10.2174/1570159X21666230407124146","DOIUrl":"10.2174/1570159X21666230407124146","url":null,"abstract":"MicroRNA-206 (miR-206) is a microRNA that is involved in many human diseases, such as myasthenia gravis, osteoarthritis, depression, cancers, etc. Both inhibition effects and progression roles of miR-206 have been reported for the past few years. High expression of miR-206 was observed in patients with osteoarthritis, gastric cancer and epithelial ovarian cancer compared to normal people. The study also showed that miR-206 promotes cancer progression in breast cancer patients and avascular necrosis of the femoral head. Meanwhile, several studies have shown that expression levels of miR-206 were down-regulated in laryngeal carcinoma cell multiplication, as well as in hepatocellular carcinoma, non-small lung cancer and infantile hemangioma. Moreover, miR-206 was up-regulated in the mild stage of amyotrophic lateral sclerosis patients and then down-regulated in the moderate and severe stages, indicating that miR-206 has the double effects of starting and aggravating the disease. In neuropsychiatric disorders, such as depression, miR-206 also plays an important role in the progression of the disease; the level of miR-206 is most highly expressed in the brains of patients with depression. In the current review, we summarize the role of miR-206 in various diseases, and miR-206 may be developed as a new biomarker for diagnosing diseases in the near future.","PeriodicalId":10905,"journal":{"name":"Current Neuropharmacology","volume":" ","pages":"1064-1079"},"PeriodicalIF":4.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10964108/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9264064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0